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Declining metabolic scaling parallels an ontogenetic change from elongate to deep-bodied shapes in juvenile Brown trout

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Current Zoology 2023年第3期69卷 294-303页

作者： jorge-Ruben sanchez-Gonzalez Alfredo G.Nicieza Department of Organisms andSystems Biology University of Oviedo33006O OviedoSpain Biodiversity Research Institute(IMIB) University of Oviedo-Principality of Asturias-CSIC33600 MieresSpain Department of Animal Science-Wildlife Section University of Lleida25006 LleidaSpain

Body shape and metabolic rate can be important determinants of animal performance,yet often their effects on influential traits are evaluated in a non-integrated *** creates an important gap because the integration between shape and metabolism may be crucial to evaluate metabolic scaling ***,we measured standard metabolic rate in 1-and 2-years old juvenile brown trout Salmo trutta,and used a geometric morphometrics approach to extricate the effects of ontogeny and size on the link between shape and metabolic *** evidenced near-isometric ontogenetic scaling of metabolic rate with size,but also a biphasic pattern driven by a significant change in metabolic scaling,from positive to negative ***,the change in metabolic allometry parallels an ontogenetic change from elongate to deep-bodied *** is consistent with the dynamic energy budget(DEB)and surface area(SA)theories,but not with the resource transport network theory which predicts increasing allometric exponents for trends towards more robust,three-dimensional *** addition,we found a relationship between body shape and size independent metabolic rate,with a positive correlation between robustness and metabolic rate,which fits well within the view of Pace-of-Life Syndromes(POLS).Finally,our results align with previous studies that question the universality of metabolic scaling exponents and propose other mechanistic models explaining the diversity of metabolic scaling relationships or emphasizing the potential contribution of ecological factors.

关键词： biphasic allometric scaling metabolic rate ontogenetic allometry shape surface-area trout

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Fused empirical mode decomposition and wavelets for locating combined damage in a truss-type structure through vibration analysis

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journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第9期14卷 615-630页

作者： Arturo GARCIA-PEREZ juan P. AMEZQUITA-sanchez Aurelio DOMINGUEZ-GONZALEZ Ramin SEDAGHATI Roque OSORNIO-RIOS Rene j. ROMERO-TRONCOSO HSPdigital-CA Telematica-Procesamiento Digital de Se ales DICIS Universidad de Guanajuato Carr. Salamanca-Valle km 3.5+1.8 Palo Blanco 36885 Salamanca Gto. Mexico HSPdigital CA Mecatronica Facultad de Ingeniería Campus San Juan del Río Universidad Autonoma de Queretaro Moctezuma 249 Col. San Cayetano 76807 San Juan del Río Qro. Mexico Department of Mechanical and Industrial Engineering Concordia University1455 de Maisonneuve Boulevard West Montreal QC H3G 1M8 Canada

Structural health monitoring (SHM) is a relevant topic for civil systems and involves the monitoring, data processing and interpretation to evaluate the condition of a structure, in order to detect damage. In real structures, two or more sites or types of damage can be present at the same time. It has been shown that one kind of damaged condition can interfere with the detection of another kind of damage, leading to an incorrect assessment about the structure condition. Identifying combined damage on structures still represents a challenge for condition monitoring, because the reliable identification of a combined damaged condition is a difficult task. Thus, this work presents a fusion of methodologies, where a single wavelet-packet and the empirical mode decomposition (EMD) method are combined with artificial neural networks (ANNs) for the automated and online identification-location of single or multiple-combined damage in a scaled model of a five-bay truss-type structure. Results showed that the proposed methodology is very efficient and reliable for identifying and locating the three kinds of damage, as well as their combinations. Therefore, this methodology could be applied to detection-location of damage in real truss-type structures, which would help to improve the characteristics and life span of real structures.

关键词： Truss structure Vibration Spectral analysis Wavelet packet transform Empirical mode decomposition Artificialneural network (ANN)

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Pharmacogenetics of hepatocellular carcinoma and cholangiocarcinoma

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Cancer Drug Resistance 2019年第3期2卷 680-709页

作者： Marta Alonso-Peña Anabel sanchez-Martin Paula Sanchon-sanchez Meraris Soto-Muñiz Ricardo Espinosa-Escudero jose j.G.Marin Experimental Hepatology and Drug Targeting(HEVEFARM) IBSALUniversity of SalamancaSalamanca 37007Spain Center for the Study of Liver and Gastrointestinal Diseases(CIBERehd).Carlos III National Institute of Health Madrid 28029Spain.

Primary liver cancers constitute the fourth most deadly group of *** poor prognosis is due in part to the pre-existence and/or development,often during treatment,of powerful mechanisms accounting for the poor response of cancer cells to antitumor *** include both impaired gene expression and the appearance of spliced variants,polymorphisms and mutations,affecting the function of genes leading to the reduction in intracellular concentrations of active agents,changes in molecular targets and survival pathways,altered tumor microenvironment and phenotypic *** present review summarizes available information regarding the role of germline and somatic mutations affecting drug transporters,enzymes involved in drug metabolism,organelles and signaling molecules related to liver cancer chemoresistance.A more complete picture of the actual complexity of this problem is urgently needed for carrying out further pharmacogenomic studies aimed to improve the management of patients suffering from hepatocellular carcinoma or cholangiocarcinoma.

关键词： Anticancer drug chemoresistance chemotherapy cholangiocarcinoma germline mutation hepatoma liver cancer somatic mutation

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Enhanced recovery for liver transplantation: recommendations from the 2022 International Liver Transplantation Society Consensus Conference: towards better clinical care in transplant hepatology

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 512-515页

作者： Yu jun Wong Noreen Singh Norberto sanchez-Fernandez Aldo j.Montano-Loza Division of Gastroenterology and Liver Unit University of Alberta HospitalEdmontonCanada Division of Transplantation Department of SurgeryUniversity of Alberta HospitalEdmontonCanada

Liver transplantation(LT)was first performed over six decades ago and is currently the standard of care for patients with end-stage liver disease and life-threatening *** have been significant advances in the area of LT;however,it remains a highly morbid,restrictive,expensive and resource-intensive intervention(1).Early recovery for LT(***)is a multimodal concept aimed at promoting faster recovery in patients undergoing *** development of a dedicated protocol for early recovery following LT has been challenging due to the complexity of developing a treatment approach,patient comorbidities associated with decompensated cirrhosis,and low case volume.

关键词： Liver transplantation(LT) outcome recovery

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Design,fabrication,characterization and reliability study of CMOS-MEMS Lorentz-force magnetometers

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Microsystems & Nanoengineering 2022年第5期8卷 17-41页

作者： j.j.Valle j.M.Sánchez-Chiva D.Fernández j.Madrenas Department of Electronic Engineering Universitat Politècnica de CatalunyaJordi Girona 1 i 3Edifici C408034 BarcelonaSpain Sorbonne Université CNRSLaboratoire de Recherche en Informatique(LIP6)UMR76064 place Jussieu75005 ParisFrance Institut de Física d’Altes Energies(IFAE) The Barcelona Institute of Science and Technology(BIST)Edifici Cn.Facultat Ciències NordUniversitat Autónoma de Barcelona08193 Bellaterra(Barcelona)Spain

This article presents several design techniques to fabricate micro-electro-mechanical systems(MEMS)using standard complementary metal-oxide semiconductor(CMOS)*** were applied to fabricate high yield CMOS-MEMS shielded Lorentz-force magnetometers(LFM).The multilayered metals and oxides of the back-end-of-line(BEOL),normally used for electronic routing,comprise the structural part of the *** most important fabrication challenges,modeling approaches and design solutions are *** that predict the Q factor,sensitivity,Brownian noise and resonant frequency as a function of temperature,gas pressure and design parameters are presented and validated in characterization tests.A number of the fabricated magnetometers were packaged into Quad Flat No-leads(QFN)*** show this process can achieve yields above 95%when the proper design techniques are *** CMOS not being a process for MEMS manufacturing,estimated performance(sensitivity and noise level)is similar or superior to current commercial magnetometers and others built with MEMS ***,typical offsets present in Lorentz-force magnetometers were prevented with a shielding electrode,whose efficiency is ***,several reliability test results are presented,which demonstrate the robustness against high temperatures,magnetic fields and acceleration shocks.

关键词： Lorentz magnetometer characterization

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Consolidation of AA 7075-2 wt% ZrO2 Composite Powders by Severe Plastic Deformation via ECAP

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Acta Metallurgica Sinica(English Letters) 2016年第10期29卷 895-901页

作者： S. E. Hernandez-Martinez j. j. Cruz-Rivera R. Martinez-sanchez C. G. Garay-Reyes j. A. Mufioz-Bolanos j. M. Cabrera j.L.Hernández-Rivera Instituto de Metalurgia Universidad Autonoma de San Luis Potosi Sierra Leona 550 78210 San Luis Potosi Mexico Centro de Investigacion en Materiales Avanzados (CIMAV) Miguel de Cervantes 120 31109 Chihuahua Mexico Departamento de Ciencia de Materiales e Ingenieria Metalurgica Universitat Politecnica de Catalunya Av Diagonal 647 08028 Barcelona Spain Fundacion CTM Centro Tecnologico Plaza de la Ciencia 208243 Manresa Spain CONACYT Research Fellow-Instituto de Metalurgia Universidad Autonoma de San Luis Potosi- Sierra Leona 550 78210 San Luis Potosf Mexico

The powders of the AA 7075-ZRO2 were mixed by mechanical milling, but it was found that the system presents a few disadvantages when processed by conventional sintering and hot extrusion, since intermetallic phases between ZrO2 particles and alloying elements were formed. Equal channel angular pressing （ECAP） processing was proposed as an alternative method to consolidate the composite where there is no intermetallic formation. The analysis of the ECAP process showed that the intermediate temperature （220℃） produced a higher consolidation level than conventional sintering and hot extrusion （400 and 500℃, respectively）. This fact was supported by relative density analysis. In the case of the sintered and hot-extruded sample, the relative density exhibited a value of 0.95, while ECAP sample showed a value of 0.98. Hardness values show that microstructural refinement obtained during mechanical milling was preserved during ECAP processing even when it was carded out at 220℃.

关键词： Metal matrix composites (MMCs) Powder consolidation Severe plastic deformation (SPD)

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Strain-induced band gap engineering in layered TiS3

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Nano Research 2018年第1期11卷 225-232页

作者： Robert Biele Eduardo Flores jose Ramon Ares Carlos sanchez Isabel j. Ferrer Gabino Rubio-Bollinger Andres Castellanos-Gomezs Roberto D'Agosta Nano-Bio Spectroscopy Group and European Theoretical Spectroscopy Facility (EFSF) Universidad del Pals Vasco 20018 San Sebastidn Spain Materials of Interest in Renewable Energies Group (MIRE Group) Dpto. de Fisica de Materiales Universidad Aut6noma de Madrid 28049 Madrid Spain Instituto de Ciencia de Materiales "Nicolds Cabrera" Campus de Cantoblanco 28049 Madrid Spain Dpto. de Ffsica de la Materia Condensada Condensed Matter Physics Center (IFIMAC) Universidad Aut6noma de Madrid Campus de Cantoblanco 28049 Madrid Spain Instituto de Ciencia de los Materiales de Madrid (ICMM-CSIC) Cantoblanco 28049 Madrid Spain IKERBASQUE Basque Foundation for Science 48013 Bilbao Spain

By combining ab initio calculations and experiments, we demonstrate how the band gap of the transition metal trichalcogenide TiS3 can be modified by inducing tensile or compressive strain. In addition, using our calculations, we predicted that the material would exhibit a transition from a direct to an indirect band gap upon application of a compressive strain in the direction of easy electrical transport. The ability to control the band gap and its nature could have a significant impact on the use of TiS3 for optical applications. We go on to verify our prediction via optical absorption experiments that demonstrate a band gap increase of up to 9% （from 0.99 to 1.08 eV） upon application of tensile stress along the easy transport direction.

关键词： band gap engineering titanium trisulfide 2-D materials strain

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Severe morbidity after pancreatectomy is accurately pre dicte d by preoperative pancreatic resection score(PREPARE): A prospective validation analysis from a medium-volume center

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Hepatobiliary & Pancreatic Diseases International 2018年第6期17卷 559-565页

作者： Mario Rodriguez-Lopez Francisco j. Tejero-Pintor Baltasar Perez-Saborido Asterio Barrera-Rebollo Martin Bailon-Cuadrado David Pacheco-sanchez General and Digestive Surgery Department Rio-Hortega University Hospital

Background: Major morbidity in pancreatic surgery remains high. Different scores for predicting complications have been described. Preoperative pancreatic resection(PREPARE) score is based on objective preoperative variables and offers good predictive accuracy for Clavien ≥ III complications. This study aimed to validate this score and analyze other preoperative variables in a prospective study performed in a medium-volume center. Methods: A total of 50 pancreatic resections were included. Preoperative variables were registered and PREPARE was calculated. The main outcome was severe morbidity(Clavien ≥ III) up to 30 days after discharge. The secondary outcomes were length of stay(LOS) and readmission. Statistical validation was performed to compare severe morbidity rate among the scores categories. Association with other preoperative variables(not included in PREPARE) was also tested. Results: Of the 50 pancreatic resections, the severe morbidity was 34.0%, with median LOS of 11 days. Readmission rate was 25.5%. Severe morbidity rates according to PREPARE categories were 18.5% in lowrisk group, 41.7% in intermediate-risk group, and 63.6% in high-risk group, respectively( P = 0.023). The accuracy was 72%(Hosmer–Lemeshow, P = 0.86). ROC curve was obtained both for PREPARE score expressed as incremental values and categorized as the three risk groups, showing an area under curve(AUC) of 0.736(95% CI: 0.586–0.887; P = 0.007) and 0.712(95% CI: 0.555–0.869; P = 0.015), respectively. PREPARE was significant in multivariate analysis. Median LOS was statistically higher as PREPARE category increases(9, 11 and 15 days in low-, intermediate-and high-risk groups, respectively; P = 0.009). Readmission was not associated with any variables. Conclusions: PREPARE behaves as an independent risk factor for severe morbidity after pancreatic surgery. Score validation shows good accuracy prediction. Increasing PREPARE category is also associated with longer LOS.

关键词： Pancreatic surgery Morbidity Complications Preoperative pancreatic resection score Validation

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Impaired immune reaction and increased lactate and C-reactive protein for early prediction of severe morbidity and pancreatic fistula after pancreatoduodenectomy

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Hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 58-67页

作者： Mario Rodriguez-Lopez Francisco j.Tejero-Pintor Martin Bailon-Cuadrado Asterio Barrera-Rebollo Baltasar Perez-Saborido David Pacheco-sanchez General and Digestive Surgery Department Rio-Hortega University Hospital

Background: Prediction of complications after pancreatoduodenectomy (PD) remains of interest. Blood parameters and biomarkers during rst and second postoperative days (POD1, POD2) may be early indi- cators of complications. Methods: This case-control study included 50 patients. Baseline, POD1 and POD2 values of leukocytes, neutrophils, lymphocytes, platelets, hemoglobin, C-reactive protein (CRP), procalcitonin and arterial lactate were compared between individuals presenting Clavien ≥ III morbidity, pancreatic stula (PF) or clinically relevant PF (CRPF) and those without these morbidities. Common variables reaching signi cance were further analyzed in order to calculate a predictive score. Results: Severe morbidity, PF and CRPF rates were 28.0%, 26.0% and 14.0%, respectively. Patients with severe morbidity had lower leukocytes on POD2 (P=0.04). Patients with PF presented higher CRP on POD2 (P=0.001), higher lactate on POD1 (P=0.007) and POD2 (P=0.008), and lower lymphocytes on POD1 (P=0.007) and POD2 (P=0.008). Patients with CRPF had lower leukocytes and neutrophils on POD1 (P =0.048, P =0.038), lower lymphocytes on POD1 (P =0.001) and POD2 (P =0.003), and higher CRP on POD2 (P =0.001). Baseline parameters and procalcitonin obtained no statistical associations. Score was de ned according to lymphocytes on POD1 < 650/μL and CRP on POD2 ≥ 250 mg/L allocating patients in 3 risk categories. PF and CRPF rates were statistically higher as risk category increased (P<0.001). Receiver operating characteristic curves and Hosmer Lemeshow tests showed a good accuracy. Conclusions: Impaired immunological reaction during early postoperative period (lower leukocytes and, particularly, lymphocytes) in response to surgical aggression would favor complications after PD. Likewise, acidosis (higher arterial lactate) could behave as risk factor of PF. An elevated CRP on POD2 is also an early biomarker of PF. Our novel score based on postoperative lymphocyte count and CRP seems reliable

关键词： Pancreatoduodenectomy Morbidity Pancreatic fistula Biomarker Prediction Score

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Protein Shuttle between Nucleus and Cytoplasm:New Paradigms in the ABI5-dependent ABA Responses

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Molecular Plant 2019年第11期12卷 1425-1427页

作者： Inmaculada sanchez-Vicente Pablo Albertos Oscar Lorenzo Dpto.de Botanica y Fisiologia Vegetal Instituto Hispano-Luso de Investigaciones Agrarias(CIALE)Facultad de BiologiaUniversidad de SalamancaC/Rio Duero 1237185 SalamancaSpain Present address:Biotechnology in Horticultural Crops TU Munchen-WeihenstephanLiesel-Beckmann-Strasse 185354 FreisingGermany

Plant survival depends on seed germination,progression through post-germinative developmental checkpoints,and adaptation to abiotic *** these processes underlie a tightly controlled regulation by the stress hormone abscisic acid(ABA)at different levels,even though the main research focuses on changes in transcript and protein ***,protein fate undergoes complex readjustments that allow signal transduction to be integrated into physiological *** them,protein redox status,stability,capacity of oligomerization,formation of complexes,and subcellular compartmentalization become key points for plant reprogramming against stresses to acquire an optimal *** this Spotlight,we highlight and discuss the latest advances in dissecting the mechanisms driving protein dynamics of nucleocytoplasmic trafficking in the cell and its relevance for regulating the stability of ABI5 and the ABI5-dependent AB A signaling pathway(Figure 1).

关键词： Figure driving programming

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