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Spectrum and visual outcomes of Vogt-Koyanagi-Harada disease in Argentina

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International journal of Ophthalmology(English edition) 2017年第1期10卷 98-102页

作者： Veronica E.Giordano Ariel Schlaen Martin j.Guzman-sanchez Cristobal Couto Department of Ophthalmology Inflammatory Eye Diseases ServiceHospital de Clinicas Jose de San MartinBuenos Aires C1120AARArgentina Department of Ophthalmology Oculoplastic ServiceAssociation for the Prevention of Blindness in MexicoVicente Garcia Torres 46San Lucas 04030CoyoacanMexico CityMexico

AIM： To review all cases of Vogt-Koyanagi-Harada （VKH） disease in an Inflammatory Eye Disease Service in Argentina and to describe the clinical profile and outcomes of ***： The records from patients with VKH disease between january 1980 and December 2008 were retrospectively analyzed for clinical profile, complications, and treatment. Patients were classified according to their initial treatment in group 1： high corticosteroid dose [≥1 mg/（kg·d）] within 2wk of illness onset; group 2： high corticosteroid dose, 2 to 4wk of onset and group 3： patients who received the high dose after 1mo of illness onset, patients who received lower oral doses than 1 mg/（kg·d） without regarding the time of beginning of the ***： A total of 210 eyes of 105 patients were included. The mean age at presentation was 32.6±13y （range： 10-74y）, and 86.7% were female. The mean duration of follow up was 144±96.6mo. Patients in the group 1 had significantly higher visual acuity than the other groups （P〈0.0001）, none had （loss of, or no） light perception at the end of follow up, whereas 24.7% patients in group 3 ended in light perception （P〈0.004）.CONCLUSION： Patients with early high dose corticosteroid treatment have better visual acuity and fewer complications. Proper timing in referral and treatment is critical for better visual outcome in VKH disease.

关键词： Vogt-Koyanagi-Harada disease Argentine population clinical spectrum treatment

Context-dependency in medicine:how neuronal excitability influences the impact of dopamine on cognition

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Neural Regeneration Research 2025年第11期20卷 3225-3226页

作者： Mahboubeh Ahmadi Nahid Rouhi javad Mirnajafi-Zadeh Bechara j.Saab Department of Physiology Faculty of Medical SciencesTarbiat Modares UniversityTehranIran Mobio Interactive Pte.Ltd. SingaporeRepublic of Singapore

Dopamine,often termed the"feel-good"neurotransmitter,plays a crucial role in myriad physiological and psychological brain *** dopamine is primarily associated with pleasure,reward,and motivation,its effects can be quite complex;and this complexity is further compounded when examining how dopamine functions in typical versus disease-affected neural *** pa rticula r,epilepsy,characte rized by heightened brain excitability,is linked to cognitive dysfunction,and dopamine is implicated in elements of both its pathology and *** has been successful in describing the synaptic abnormalities believed to contribute to memory issues in epilepsy,aiding in the search for effective therapies for what persists as a major medical issue.

关键词： dopamine epilepsy primarily

Editorial for “Special Issue on the 2019 and 2020 iGEM proceedings”

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Synthetic and Systems Biotechnology 2022年第3期7卷 878-879页

作者： Roger Rubio-sanchez Steering Group of iGEM Academia&Research Network iGEM Community ProgramiGEM Foundation45 Prospect StreetCambridgeMA02139USA Department of ChemistryMolecular Sciences Research HubImperial College LondonLondonW120BZUnited Kingdom Steering Group of iGEM Academia&Research Network iGEM Community ProgramiGEM Foundation45 Prospect StreetCambridgeMA02139USA.

Synthetic biology comprises engineering design principles to build biological and biomimetic devices with versatile *** Special Issue is composed of contributions with roots in the 2019 and 2020 international Genetically Engineered Machine(iGEM)competitions,and present platforms that enable the implementation of SynBio to bio-medicine,bio-remediation,and *** field of synthetic biology provides a vast and interdisciplinary engineering playground,where researchers harness a wide range of molecular building blocks and machinery to assemble devices that span from bio-engineered organisms displaying new and interesting functionalities[1]to synthetic-cell mimics able to coordinate bio-inspired behaviours[2].SynBio is thus a versatile and comprehensive toolkit for novel technologies with a unique potential for societal impact.

关键词： materials. versatile coordinate

The influence of nanotopography on cell behaviour through interactions with the extracellular matrix-A review

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Bioactive Materials 2022年第9期7卷 145-159页

作者： jiajun Luo Matthew Walker Yinbo Xiao Hannah Donnelly Matthew j.Dalby Manuel Salmeron-sanchez Centre for the Cellular Microenvironment University of GlasgowGlasgowG128LTUK

Nanotopography presents an effective physical approach for biomaterial cell manipulation mediated through material-extracellular matrix *** extracellular matrix that exists in the cellular microenvironment is crucial for guiding cell behaviours,such as determination of integrin ligation and interaction with growth *** interactions with the extracellular matrix regulate downstream mechanotransductive pathways,such as rearrangements in the cytoskeleton and activation of signal *** adsorption onto nanotopography strongly influences the conformation and distribution density of extracellular matrix and,therefore,subsequent cell *** this review,we first discuss the interactive mechanisms of protein physical adsorption on ***,we summarise advances in creating nanotopographical features to instruct desired cell ***,we focus on the cellular mechanotransductive pathways initiated by *** review provides an overview of the current state-of-the-art designs of nanotopography aiming to provide better biomedical materials for the future.

关键词： Nanotopography Cell-material interaction Protein adsorption Biomaterials

Plasmon-induced dual-wavelength operation in a Yb^(3+) laser

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Light(Science & Applications) 2019年第1期8卷 1042-1050页

作者： Laura sanchez-Garcia Mariola O.Ramirez Rosa Maria Sole joan j.Carvajal Francesc Diaz Luisa E.Bausa Deparment Fisica de Materiales Instituto Nicolas Cabrera and Condensed Matter Physics Center(IFIMAC)Universidad Autonoma de Madrid28049 MadridSpain Universitat Rovira i Virgili Departament Quimica Fisica i InorganicaFisica i Cristal·lografia de Materials i Nanomaterials(FiCMA-FiCNA)-EMaSE-43007 TarragonaSpain

Expanding the functionalities of plasmon-assisted lasers is essential for emergent applications in nanoscience and ***,we report on a novel ability of plasmonic structures to induce dual-wavelength lasing in the near-infrared region in a Yb^(3+) solid-state *** means of the effects of disordered plasmonic networks deposited on the surface of a Yb^(3+)-doped nonlinear RTP crystal,room-temperature dual-wavelength lasing,with a frequency difference between the lines in the THz range,is *** dual-wavelength laser is produced by the simultaneous activation of two lasing channels,namely,an electronic-and a phonon-terminated laser *** latter is enabled by the out-of-plane field components that are generated by the plasmonic structures,which excite specific Raman ***,multiline radiation at three different wavelengths is demonstrated in the visible spectral region via two self-frequency conversion processes,which occur in the vicinities of the plasmonic *** results demonstrate the potential of plasmonic nanostructures for inducing drastic modifications in the operational mode of a solid-state laser and hold promise for applications in a variety of fields,including multiplexing,precise spectroscopies,and THz radiation generation via a simple and cost-effective procedure.

关键词： laser lasing dual

Microstructures in a Nb-Cr-V-W-Ta high entropy alloy during annealing

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journal of Materials Science & Technology 2020年第18期52卷 66-72页

作者： S.K.Varma Francelia sanchez C.V.Ramana Department of Metallurgical Materials and Biomaterials EngineeringThe University of Texas at El PasoEl PasoTX 79968-0520USA Mechanical Engineering Department The University of Texas at El PasoEl PasoTX 79968-0520USA

A Nb-Cr-V-W-Ta high entropy alloy has been subjected to annealing treatment at 600,700 and 800℃in air for 6 *** different phases have been identified based on their composition in the as received *** annealing treatment does not alter the phase analysis and compositions except for the W-rich phase where minor changes in the composition have been *** is considered as an experimental evidence of sluggish diffusivity associated with *** of phase transformation during the heating and the minimal changes in observed compositions of the phases is an indication of the resistance to diffusion offered by the elements of the high entropy *** electron microscopy(SEM),energy dispersive spectroscopy(EDS)and color X-ray elemental mapping have been used to conduct this research.

关键词： HEA Microstructures in a Nb-Cr-V-W-Ta high entropy alloy during annealing

Triboelectric nanogenerator based on electrodeposited Ag octahedral nano-assemblies

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journal of Energy Chemistry 2023年第8期83卷 478-495,I0012页

作者： M.Edith Navarro-Segura Margarita sanchez-Dominguez Ana Arizmendi-Morquecho j.Alvarez-Quintana Group of Colloidal and Interfacial Chemistry Applied to Nanomaterials and Nanoformulations Centro de Investigacion en Materiales Avanzados S.C Unidad MonterreyAlianza Norte#202Autopista Monterrey-Aeropuerto Km.10.C.P.66628 ApodacaNuevo LeonMexico GENES-Group of Embedded Nanomaterials for Energy Scavenging Centro de Investigacion en Materiales Avanzados S.C.Unidad MonterreyAlianza Norte#202Autopista Monterrey-Aeropuerto Km.10.C.P.66628 ApodacaNuevo LeonMexico

The tremendous potential of triboelectric generators-TENGs for converting mechanical energy into electrical energy places them as one of the most promising energy harvesting technologies. In this work, the fabrication of enhanced performance TENGs using Ag octahedron nano-assemblies on ITO as electrodes significantly increases the electric charge collection of the induced tribocharges. Thereby, nanostructured electrical contacts coated with Ag macroscale nano-assemblies with octahedral features were obtained by the electrodeposition technique on flexible PET/ITO substrates. Consequently, the nanostructured triboelectric generator-TENG exhibited 65 times more maximum output power, and almost 10 times more open circuit output voltage than that of a TENG with non-nanostructured contacts passing from μW to m W capabilities, which was attributed to the increment of intrinsic interface states due to a higher effective contact area in the former. Likewise, output performances of TENGs also displayed an asymptotic behavior on the output voltage as the operating frequency of the mechanical oscillations increased, which is attributed to a decrement in the internal impedance of the device with frequency. Furthermore, it is shown that the resulting electrical output power can successfully drive low power consumption electronic devices. On that account, the present research establishes a promising platform which contributes in an original way to the development of the TENGs technology.

关键词： Triboelectric generator Nanostructured electrodeposited electrodes Ag octahedral nanoassemblies Electrode surface structure

Sub-10nm nanogap fabrication on suspended glassy carbon nanofibers

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Microsystems & Nanoengineering 2020年第1期6卷 1306-1315页

作者： Arnoldo Salazar Samira Hosseini Margarita sanchez-Dominguez Marc j.Madou Alejandro Montesinos-Castellanos Sergio O.Martinez-Chapa School of Engineering and Sciences Tecnologico de MonterreyEugenio Garza Sada 2501MonterreyNL 64849Mexico Centro de Investigacion en Materiales Avanzados S.C.(CIMAV)Unidad Monterrey Parque de Investigacion e Innovacion TecnologicaApodacaNL 66628Mexico Department of Mechanical and Aerospace Engineering University of California IrvineEngineering Gateway 4200IrvineCA 92697USA

Glassy carbon nanofibers(GCNFs)are considered promising candidates for the fabrication of nanosensors for biosensing ***,in part due to their great stability,carbon electrodes with sub-10 nm nanogaps represent an attractive platform for probing the electrical characteristics of *** fabrication of sub-10 nm nanogap electrodes in these GCNFs,which is achieved by electrically stimulating the fibers until they break,was previously found to require fibers shorter than 2µm;however,this process is generally hampered by the limitations inherent to photolithographic *** this work,to obtain nanogaps on the order of 10 nm without the need for sub-2µm GCNFs,we employed a fabrication strategy in which the fibers were gradually thinned down by continuously monitoring the changes in the electrical resistance of the fiber and adjusting the applied voltage *** further reduce the nanogap size,we studied the mechanism behind the thinning and eventual breakdown of the suspended GCNFs by controlling the environmental conditions and pressure during the *** this approach,which includes performing the experiments in a high-vacuum chamber after a series of carbon dioxide(CO 2)purging cycles,nanogaps on the order of 10nm were produced in suspended GCNFs 52µm in length,much longer than the~2µm GCNFs needed to produce such small gaps without the procedure employed in this ***,the electrodes showed no apparent change in their shape or nanogap width after being stored at room temperature for approximately 6 months.

关键词： fibers carbon electrical

Trombe walls with porous medium insertion and their influence on thermal comfort in flats in Cusco,Peru

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Energy and Built Environment 2024年第2期5卷 194-210页

作者： Patrick Facelli sanchez Lisset Mercado Hancco Department of Civil Engineering Faculty of Architecture and Civil EngineeringUniversidad Nacional de San Antonio Abad del Cusco08003 CuscoPeru

The Trombe wall is a passive indirect heating system which should be used in Cusco,Peru to improve thermal conditions against the typical frosts and low temperatures during winter in the high Andean *** to this problem,the use of a modified Trombe wall with insertion of porous medium is proposed to improve thermal comfort in flat buildings in *** research aims to analyse and compare the performance of dwellings without Trombe wall,with traditional Trombe wall,and with Trombe wall with glass and plastic pellets insertion in thermal comfort ***■CFD was used to simulate and analyse the *** simulation was performed with three prototype flats(55 m^(2),75 m^(2) and 95 m^(2))for six months of the *** the results obtained,the level of thermal comfort in the traditional scenarios is low with an average PMV of-1.86,in the scenarios with Trombe wall is good and in the scenarios with Trombe wall with insertion of porous medium is slightly better than the previous one,reaching an average PMV of+0.10 and a temperature of 21.90℃.The study carried out is important because it represents an efficient eco-sustainable heating alternative that improves the thermal comfort sensation in houses during the coldest months of the year.

关键词： Trombe wall thermal comfort porous medium residential buildings computational fluid dynamics