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Molecular Plant 2019年第1期12卷 71-85页

作者： Rocio sanchez-Montesino Laura Bouza-Morcillo julietta Marquez Melania Ghita Salva Duran-Nebreda Luis Gomez Michael j.Holdsworth George Bassel Luis Onate-sanchez Centro de Biotecnologia y Genomica de Plantas Universidad Politecnica de Madrid-lnstituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria Campus de MontegancedoPozuelo de AlarconMaddd 28223Spain School of Biosciences University of NottinghamLoughborough LE12 5RDUK School of Biosciences University of BirminghamBirmingham B15 23-rUK Departamento de Sistemas y Recursos Naturales E.T.S.I.MontesForestal y del Medio NaturalCampus de Moncloa28040 MadridSpain

A key component of seed germination is the interplay of mechanical forces governing embryo growth and the surrounding restraining endosperm *** cell separation is therefore thought to play a critical role in the control of this developmental *** we demonstrate that in Arabidopsis thaliana seeds,endosperm cell expansion is a key component of *** cells expand to accommodate embryo growth prior to *** show that this is an actively regulated process supported by spatiotemporal control of the cell expansion gene EXPANSIN 2 (EXPA2).The NAC transcription factors NAC25 and NACIL were identified as upstream regulators of EXPA2 expression,gibbereliinmediated endosperm expansion,and seed *** DELLA protein RGL2 repressed activation of the EXPA2 promoter by NAC25/*** together,our findings uncover a key role of the GA/ DELLA-NAC25/NACIL-EXPA2 network in regulating endosperm cell expansion to control the seed-toseedling transition.

关键词： cell expansion cell-wall remodeling enzymes endosperm expansin NAC transcription factors seed germination

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal j.Goldschmidt-Clermont Aisha Khan George jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander j.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi james D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

A perceptual quality metric for 3D triangle meshes based on spatial pooling

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Frontiers of Computer Science 2018年第4期12卷 798-812页

作者： Xiang FENG Wanggen WAN Richard Yi Da XU Haoyu CHEN Pengfei LI j. Alfredo sanchez School of Communication and Information Engineering Shanghai University Shanghai 200444 China Faculty of Engineering and Information Technology University of Technology Sydney Sydney NSW 2007 Australia Institute of Smart City Shanghai University Shanghai 200444 China Department of Computing Electronics and Mechatronics Universidad de las Americas Puebla (UDLAP) Cholula 72820 Mexico

In computer graphics, various processing operations are applied to 3D triangle meshes and these processes often involve distortions, which affect the visual quality of surface geometry. In this context, perceptual quality assessment of 3D triangle meshes has become a crucial issue. In this paper, we propose a new objective quality metric for assessing the visual difference between a reference mesh and a corresponding distorted mesh. Our analysis indicates that the overall quality of a distorted mesh is sensitive to the distortion distribution. The proposed metric is based on a spatial pooling strategy and statistical descriptors of the dis- tortion distribution. We generate a perceptual distortion map for vertices in the reference mesh while taking into account the visual masking effect of the human visual system. The proposed metric extracts statistical descriptors from the dis- tortion map as the feature vector to represent the overall mesh quality. With the feature vector as input, we adopt a support vector regression model to predict the mesh quality score. We validate the performance of our method with three publicly available databases, and the comparison with state-of-the-art metrics demonstrates the superiority of our method. Experimental results show that our proposed method achieves a high correlation between objective assessment and subjective scores.

关键词： mesh visual quality assessment spatial pooling statistical descriptors support vector regression visual masking

Comments on "Non-existence of Shilnikov chaos in continuous-time systems"

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Applied Mathematics and Mechanics(English Edition) 2013年第9期34卷 1175-1176页

作者： A.ALGABA F.FERNANDEZ-sanchez M.MERINO A.j.RODRIGUEZ-LUIS Departamento de Matematicas Centro de Investigacion de Fisica Teorica y Matematica FIMATUniversity of Huelva Departamento de Matematica Aplicada II E.S.IngenierosUniversity of Sevilla Camino de los Descubrimientos s/n

A paper, ＂Non-existence of Shilnikov chaos in continuous-time systems＂ was published in the journal Applied Mathematics and Mechanics （English Edition）. The authors gave sufficient conditions for the non-existence of homoclinic and heteroclinic orbits in an nth-order autonomous system. Unfortunately, we show in this comment that the proof presented is erroneous and the result is invalid. We also provide two counterexamples of the wrong criterion stated by the authors.

关键词： homoclinic chaos heteroclinic chaos non-existence of Shilnikov chaos

Taxonomy-based differences in feeding guilds of fish

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Current Zoology 2020年第1期66卷 51-56页

作者： javier sanchez-HERNANDEZ Departamento de Zooloxla Xenetica e Antropoloxfa FlsicaFacultade de BioloxfaUniversidade de Santiago de CompostelaCampus Vida s/nSantiago de CompostelaEspana

It has been taken for granted that feeding guilds and behavior in animals are linked to the taxonomic relatedness of species,but empirical evidence supporting such relationship is virtually *** examine the importance of taxonomy on trophic ecology,I here present the first well-resolved dietary taxonomy analysis based on feeding guilds(predation,herbivory,and filtering)among families and genera within the fish order *** relatedness in feeding did not vary with ecosystem dimension(marine ***).Although predation dominates among Perciformes fishes,this study shows that in most cases taxonomic units(family or genus)are composed by species with several feeding *** species are more similar in feeding compared with species that are taxonomically more distant demonstrating that there is a greater variation of feeding guilds within families than ***,there is no consistency in feeding guilds between family-and genus-level *** study provides empirical support for the notion that genera are more informative than families,underlining that family-level taxonomy should be avoided to infer feeding habits of fish species at finer taxonomic ***,the choice of taxonomic resolution(family or genus level)in ecological studies is key to avoid information loss and misleading results.I conclude that high-rank taxonomic units(i.e.,above the generic level)are not appropriate to test research hypotheses about the feeding of fish.

关键词： aquatic systems clades FishBase global datasets taxonomic sufficiency trophic ecology

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Harnessing artificial intelligence for identifying conflicts of interest in research

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World journal of Methodology 2025年第1期15卷 6-8页

作者： Abdulqadir j Nashwan Department of Nursing&Midwifery Research Hamad Medical CorporationDoha 3050Qatar

This editorial explores the transformative potential of artificial intelligence(AI)in identifying conflicts of interest(COIs)within academic and scientific *** harnessing advanced data analysis,pattern recognition,and natural language processing techniques,AI offers innovative solutions for enhancing transparency and integrity in *** editorial discusses how AI can automatically detect COIs,integrate data from various sources,and streamline reporting processes,thereby maintaining the credibility of scientific findings.

关键词： Artificial intelligence Conflicts of interest Transparency Research integrity Natural language processing

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn j.W.So Konstantin Feinberg Marina Manoraj jenny Cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

OxLDL induced p53-dependent apoptosis by activating p38MAPK and PKCδ signaling pathways in j774A.1 macrophage cells

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journal of Molecular Cell Biology 2011年第5期3卷 316-318页

作者： Claudio Giovannini Rosaria Varì Beatrice Scazzocchio Massimo sanchez Carmela Santangelo Carmelina Filesi Massimo D'Archivio Roberta Masella Veterinary Public Health and Food Safety Italian National Institute of Health Viale Regina Elena 299 Rome 00161 Italy Cell Biology and Neuroscience Departments Italian National Institute of Health Viale Regina Elena 299 Rome 00161 Italy

Dear Editor,The sub-endothelial retention of lipoproteins is one of the key events that trigger the atherosclerosis ***-density lipoprotein(LDL)particles trapped within the arterial wall are prone to progressive oxidation by monocytes/*** LDL(oxLDL)is present in atherosclerotic lesions,and has been suggested to play a significant role in atherogenesis(Nishi et al.,2002).

关键词： p38MAPK arterial p53

Redox Regulation of Glycogen Biosynthesis in the Cyanobacterium Synechocystis sp. PCC 6803： Analysis of the AGP and Glycogen Synthases

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Molecular Plant 2014年第1期7卷 87-100页

作者： Sandra Diaz-Troya Luis Lopez-Maury Ana Maria sanchez-Riego Miguel Roldan Francisco j. Florencio Instituto de Bioquimica Vegetal y Fotosintesis Universidad de Sevilla-CSIC Americo Vespucio 49 E-41092 Sevilla Spain

Glycogen constitutes the major carbon storage source in cyanobacteria, as starch in algae and higher plants. Glycogen and starch synthesis is linked to active photosynthesis and both of them are degraded to glucose in the dark to maintain cell metabolism. Control of glycogen biosynthesis in cyanobacteria could be mediated by the regulation of the enzymes involved in this process, ADP-glucose pyrophosphorylase （AGP） and glycogen synthase, which were identified as putative thioredoxin targets. We have analyzed whether both enzymes were subjected to redox modification using purified recombinant enzymes or cell extracts in the model cyanobacterium Synechocystis sp. PCC 6803. Our results indicate that both AGP and glycogen synthases are sensitive to copper oxidation. However, only AGP exhibits a decrease in its enzymatic activity, which is recovered after reduction by DTT or reduced thioredoxin （TrxA）, suggesting a redox control of AGP. In order to elucidate the role in redox control of the cysteine residues present on the AGP sequence （C45, C185, C320, and C337）, they were replaced with serine. All AGP mutant proteins remained active when expressed in Synechocystis, although they showed different electrophoretic mobility profiles after copper oxidation, reflecting a complex pattern of cysteines interaction.

关键词： cyanobacteria glycogen Synechocystis thioredoxin redox regulation.