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Winkler Support Model and Nonlinear Boundary Conditions Applied to 3D Elastic Contact Problem Using the Boundary Element Method

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Acta Mechanica Solida Sinica 2019年第2期32卷 230-248页

作者： j.Vallepuga-Espinosa Lidia sanchez-Gonzalez Ivan Ubero-Martinez Departamento de Tecnologia Minera Topografiay de EstructurasUniversidad de LeonCampus de Vegazana s/n24071 LeonSpain Departamento de Ingenierias Mecanica Informatica y AeroespacialUniversidad de LeonCampus de Vegazana s/n24071 LeonSpain

This work presents a numerical methodology for modeling the Winkler supports and nonlinear conditions by proposing new boundary conditions. For the boundary conditions of Winkler support model, the surface tractions and the displacements normal to the surface of the solid are unknown, but their relationship is known by means of the ballast coefficient, whereas for nonlinear boundary conditions, the displacements normal to the boundary of the solid are zero in the positive direction but are allowed in the negative direction. In those zones, detachments of nodes might appear, leading to a nonlinearity, because the number of nodes that remain fixed or of the detached ones (under tensile tractions) is unknown. The proposed methodology is applied to the 3D elastic receding contact problem using the boundary element method. The surface t r actions and the displacements of the common int erface bet ween the two solids in contac t under the influence of different supports are calculated as well as the boundary zone of the solid where the new boundary conditions are applied. The problem is solved by a double-iterative met hod, so in the final solut ion, t here are no t r act ions or pene trations between the two solids or at the boundary of the solid where the nonlinear boundary conditions are Simula ted. The effectiveness of the proposed method is verified by examples.

关键词： Boundary element method Elastic contact problem Winkler support model Nonlinear boundary conditions

Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna jennifer Aguilar Emily Lee William j.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira M.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries on magnetic resonance imaging

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Neural Regeneration Research 2025年第11期20卷 3144-3150页

作者： Holly Flyger Samantha j.Holdsworth Alistair j.Gunn Laura Bennet Hamid Abbasi Mātai Medical Research Institute Tairāwhiti GisborneNew Zealand Department of Anatomy&Medical Imaging Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Center for Brain Research The University of AucklandAucklandNew Zealand Auckland Bioengineering Institute The University of AucklandAucklandNew Zealand

Moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental *** assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomarkers,neurological examination,and *** present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the early evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic *** review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a particular emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,particularly for infants treated with therapeutic hypothermia.A comprehensive literature search,from 2016 to 2024,identified 20 pertinent *** review highlights that while the optimal timing of magnetic resonance imaging scans is not clear,overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic *** challenges limit the timing consistency,particularly the need for intensive care and clinical ***,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after *** suggests that in the future it will be important to explore a wider range of times after hypo

关键词： magnetic resonance imaging neonatal hypoxic-ischemic encephalopathy neurodevelopmental outcomes prognostic biomarkers in neuroimaging scan timing therapeutic hypothermia

Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

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Neural Regeneration Research 2025年第5期20卷 1411-1413页

作者： Marcos j.Arauzo-Bravo Daniela Gerovska Matthias Schwab Alexandra Kretz Computational Biology and Systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for Science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell Biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

Characterization of the negative carbon isotope shift in segment C2,its global implications as a harbinger of OAEla

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Science China Earth Sciences 2017年第1期60卷 30-43页

作者： jander SOCORRO Florentin j-M. R. MAURRASSE Yosmel sanchez-HERNANDEZ Department Earth and Environment Florida International University 11200 SW 8 Street Miami FL 33199 USA

Lower Cretaceous C-isotope records show intermittent negative/positive spikes, and consistent patterns of coevalchemostratigraphic curves thus document shifts that signal simultaneous responses of temporal changes in the global carbon reservoir. The standard pattern registered by the δ13Corg and δ13Ccarb in Lower Aptian sediments includes distinct isotope segments C1 to C8 （Menegatti et al., 1998）. In the E1 Pui section, Organy Basin, Spain, C-isotope segment C2 is the longest interval preceding segments C3-C6 associated with oceanic anoxic event la （OAE la）, and reveals a distinct negative shift of-1.8‰ to -2.23‰ defining the C-isotope pattern within that interval. Total inorganic carbon （TIC）, total organic carbon （TOC）, δ13Corg, microfacies, n-alkanes show no difference before, during, or after the negative inflection. The biomarkers indicate that organic matter （OM） mainly originates from algal/microbial sources because short-chain length homologues （〈 nCtg） dominate, nC2o through nC25 indicate some contribution from aquatic vegetation, but little from higher plants （〉nC20, as also suggested by the terrestrial/aquatic ratio ofn-alkanes or （TAR） = [（nf27＋nf29＋nC31）/（nC15＋nCt7＋rlCt9）] （averages 0.085）. We suggest that conjoint pulses of contemporaneous LIPs （Ontong java） and massive explosive volcanism in northeast Asia, the Songliao Basin （SB-V）, best conform to plausible causes of the negative intra-C2 carbon isotopic excursion （CIE） at that time. Because of its apparent common occurrence the intra-C2 inflection could be a useful marker harbinger to the more pronounced CIE C3, the hallmark of OAE 1 a.

关键词： Oceanic Anoxic Event la (OAEla) Aptian Organy Basin Chemostratigraphy Pyrenees

Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua jo jonggeol Na j.jay Liu Young-ju Kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Carbon capture and utilization

MEC-based architecture for interoperable and trustworthy internet of moving things

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Digital Communications and Networks 2023年第1期9卷 270-279页

作者： jesus sanchez-Gomez Rafael Marin-Perez Ramon sanchez-Iborra Miguel Angel Zamora Department of Information and Communications Engineering University of MurciaMurciaSpain Odin Solutions S.L. MurciaSpain University Center of Defense San Javier Air Force BaseMurciaSpain

The expansion of the Internet of Moving Things(IoMT)leads to limitless and continuous working playgrounds exploited by highly dynamic end *** requires the adoption of multi-Radio Access Technologies(RATs)-based strategies to provide IoMT units with ubiquitous *** this end,the development of secure bootstrapping and authentication mechanisms is necessary to permit the secure operation of end *** the transmission and power limitations of these elements,current cryptographic solutions do not address these stringent *** that reason,in the study we present a Multi-Access Edge Computing(MEC)-based endto-end architecture that enables an efficient and secure authentication and key agreement between end devices and network servers over heterogeneous resource-limited networks such as the Low Power Wide Area Networks(LPWANs).Our proposal is based on the Authentication,Authorization,and Accounting(AAA)architecture and the recent Internet Engineering Task Force initiatives Static Context Header Compression and Low-Overhead *** results obtained from experimental tests reveal the validity of the proposal as it enables constrained IoMT devices to gain IPv6 connectivity as well as performs end-to-end secure authentication with notable reliability and controlled latency.

关键词： Internet of moving things LPWAN Authentication LO-CoAP-EAP SCHC

Agglomerate behavior in a recirculating fluidized bed with sheds： Effect of ring baffles

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Particuology 2018年第3期16卷 143-151页

作者： Francisco j. sanchez Careaga Cedric Briens Franco Berruti jennifer McMillan Murray Gray Institute for Chemicals and Fuels from Alternative Resources Western University 22312 Wonderland Rd. Hderton ON NO M2AO Canada Edmonton Research Centre Syncrude Canada Ltd 9421 17th Ave Edmonton AB T6N 1H4 Canada The Petroleum Institute PO Box 2533 Abu Dhabi UAE

The radioactive particle tracking technique was used to study the effect of internal ring baffles on wet agglomerate motion inside a cold flow recirculating fluidized bed. The study found that using such a baffle on its own or above the regular sheds helps reduce the fouling of the stripper section by increasing the residence time that the agglomerates spend above the baffle, thereby reducing the release of the vapors below the baffles that cause fouling of the sheds. Adding down-comers, or flux tubes, to the ring baffles degrades the performance of the baffles, Reducing the length of the flux tubes, so that they do not reach the bottom of the baffle lip results in a further degradation in baffle performance.

关键词： Radioactive particle tracking Fluidized bed Fluid coker Baffles