检索结果-南通市图书馆

1981年

作者： (英)A.s.V.伯格、j.F.米切尔

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

《二语研究的操作》评介

现代外语 2005年第4期28卷 422-425页

作者：左红珊 j. D. Brown T. s. Rodgers 华中科技大学广东外语外贸大学不详

"公欲善其事,必先利其器",是我国的古训,即言工具、方法的重要性.外语教学研究也要讲究方法,设计好、实施好的科研能够揭示事物的本质,加深我们对问题的理解.

关键词：外语教学研究语言学研究评介操作与国际接轨迅速发展外语教育外语研究方法类型数据类型

Dendritic cells in hepatitis C virus infection:Key players in the IFNL3-genotype response

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2014年第47期20卷 17830-17838页

作者： Kate s O'Connor jacob George David Booth Golo Ahlenstiel Institute for Immunology and Allergy Research Westmead Millennium InstituteUniversity of SydneySydneyNSW 2145Australia storr Liver Unit Westmead Millennium Institute and Westmead HospitalUniversity of SydneySydneyNSW 2145Australia

Recently,single nucleotide polymorphisms,in the vicinity of the interferon lambda 3(IFNL3)gene have been identified as the strongest predictor of spontaneous and treatment induced clearance of hepatitis C virus(HCV)*** then,increasing evidence has implicated the innate immune response in mediating the IFNL3 genotype *** cells(DCs)are key to the host immune response in HCV infection and their vital role in the IFNL3 genotype effect is *** have identified subclasses of DCs,particularly myeloid DC2s and potentially plasmacytoid DCs as the major producers of IFNL3 in the setting of HCV *** the complexities of dendritic cell biology and the conflicting current available data,this review aims to summarize what is currently known regarding the role of dendritic cells in HCV infection and to placeit into context of what is know about lambda interferons and dendritic cells in general.

关键词： Hepatitis C virus Interferon lambda 3 Dendritic cells Plasmacytoid dendritic cells Myeloid dendritic cells Innate immunity

FLT3基因突变与骨髓增生异常综合征的预后

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国组织工程研究与临床康复 2007年第3期11卷 518-521页

作者：李树王杰李惠中国刑警学院法医教研室辽宁省沈阳市110035 沈阳医学院生物化学及分子生物学教研室辽宁省沈阳市110034 沈阳医学院

目的:FLT3跨膜区内部串联重复突变是与白血病发生相关的FLT3基因中最常见的突变类型。本实验旨在探讨FLT3跨膜区内部串联重复突变与骨髓增生异常综合征预后的关系及其临床意义。方法:实验于中国刑警学院法医教研室、沈阳医学院生物化学... 详细信息

目的:FLT3跨膜区内部串联重复突变是与白血病发生相关的FLT3基因中最常见的突变类型。本实验旨在探讨FLT3跨膜区内部串联重复突变与骨髓增生异常综合征预后的关系及其临床意义。方法:实验于中国刑警学院法医教研室、沈阳医学院生物化学及分子生物学教研室完成。选择1998-03/2005-10于中国医科大学及沈阳医学院附属医院血液科门诊或住院治疗的患者58例作为实验组,经免疫学、细胞遗传学和分子生物学检查确诊均为骨髓增生异常综合征患者。男37例,女21例,平均年龄19岁,均自愿参加。形态学分型中58例骨髓增生异常综合征患者中难治性贫血13例、难治性贫血伴环状铁粒幼细胞增多4例、难治性贫血伴原始细胞增多20例、转变中的难治性贫血伴原始细胞增多12例、慢性粒-单核细胞性白血病9例。对照组为同期就诊非白血病患者及健康供者10例。①DNA提取:患者骨髓或健康志愿者外周血标本采用淋巴细胞分离液分离单核细胞,传统酚/氯仿/异丙醇法提取DNA。②PCR引物设计:针对FLT3基因内部重复串联结构主要发生在11号外显子,在11号外显子近端和远端分别设计引物11F和11R,扩增产物为133bp。同时设计对照组β-actin引物actin F和actin R,扩增产物为305bp。③PCR扩增及电泳PCR:反应体系包括上、下游引物各0.2μmol/L,dNTPs 0.25mmol/L,Taq DNA聚合酶2.5U,模板DNA 200ng。反应条件为94℃变性3min后进行35个循环,最后72℃延伸10min。取扩增产物,经2%琼脂糖凝胶电泳观察结果。④测序及Blast分析。结果:骨髓增生异常综合征患者58例和对照组10例全部进入结果分析。①58例骨髓增生异常综合征患者中19例FLT3表达阳性,阳性率为32.78%。19例FLT3基因检测阳性患者,有5例出现FLT3跨膜区内部串联重复突变,阳性率为2.74%,其中慢性粒-单核细胞性白血病2例、难治性贫血伴原始细胞过多过度型3例。②测序及Blast比对分析显示,外显子11区均有跨膜区内部串联重复突变,各例的复制区域不同,长短不等(19～39bp)。③临床资料显示,5例伴有FLT3跨膜区内部串联重复突变的髓增生异常综合征患者中有4例在短时期内(1～5个月)转化为急性髓系白血病。结论:髓增生异常综合征患者存在有跨膜区内部串联重复突变。该突变可以作为骨髓增生异常综合征白血病化的重要标志。

关键词：骨髓增生异常综合征免疫学突变基因

Big data technology in infectious diseases modeling,simulation,and prediction after the COVID-19 outbreak

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

智慧医学(英文) 2023年第2期3卷 85-96页

作者： Honghao shi jingyuan Wang jiawei Cheng Xiaopeng Qi Hanran ji Claudio j struchiner Daniel AM Villela Eduard V Karamov Ali s Turgiev school of Computer science and Engineering Beihang UniversityBeijing 100191China Center for Global Public Health Chinese Center for Disease Control and PreventionBeijing 102211China Fundação Getúlio Vargas Rio de JaneiroBrazil Instituto de Medicina social Hesio Cordeiro Universidade do Estado do Rio de JaneiroRio de JaneiroBrazil Programa de Computação Científica Fundação Oswaldo CruzRio de JaneiroBrazil Gamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health Russia National Medical Research Center of Phthisiopulmonology and Infectious Diseases of the Russian Ministry of Health Russia

After the outbreak of COVID-19,the interaction of infectious disease systems and social systems has challenged traditional infectious disease modeling *** from the research purpose and data,researchers im-proved the structure and data of the compartment model or used agents and artificial intelligence based models to solve epidemiological *** terms of modeling methods,the researchers use compartment subdivi-sion,dynamic parameters,agent-based model methods,and artificial intelligence related *** terms of factors studied,the researchers studied 6 categories:human mobility,nonpharmaceutical interventions(NPIs),ages,medical resources,human response,and *** researchers completed the study of factors through modeling methods to quantitatively analyze the impact of social systems and put forward their suggestions for the future transmission status of infectious diseases and prevention and control *** review started with a research structure of research purpose,factor,data,model,and *** on the post-COVID-19 infectious disease prediction simulation research,this study summarized various improvement methods and analyzes matching improvements for various specific research purposes.

关键词： Infectious disease model Data embedding social system Dynamic Modeling the social systems

Imidoyl Radicals for the synthesis of Chromenoquinolines and Naphthyridines

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International journal of Organic Chemistry 2018年第3期8卷 319-334页

作者： Karen C. Vizcaíno-Escobedo j. Adrián sánchez-Carrillo Martha Albores-Velasco Facultad de Química Universidad Nacional Autónoma de México Ciudad Universitaria Ciudad de México México

The stability of imidoyl radicals prepared from 2-(2-alkenyloxy)-phenyl selenoimidates and 2-(2-allylamino)-phenyl selenoimidates and their intramolecular free radical cyclization through the slow addition of tri-N-butyltin hydride and AIBN to obtain 4-chromanones and 4-quinolones were studied. The extension of the methodology to N-phenyl substituted imidoyl selenoates produced tandem cyclizations of the imidoyl radical with the allyl substituent, followed for a second cyclization of the intermediate radical with the aromatic substituent to produce dihydro-chromenoquinolines or tetrahy-dro-dibenzonaphtyridines. Further oxidation with DDQ produced: 6H-chromeno [4,3,b] quinoline and 7-methyl-6H-chromenoquinoline from 2-alkenylamino-phenylbenzamide and 5,6-dihydro-dibenzo [b,h][1,6] naphthyridine and 5,6-dihydro-7-methyl-dibenzo [b,h][1,6] naphthyridine from 2-2-(alkylamino)-N-phenylbenzamides. The cyclization of 2-(N,***)-N-phenylnicotinamide selenoate obtained from 2-aminonicotinic acid, produced 5,6-dihidro-benzo[b]pyrido2,3-h] [1,6] naphthyridine.

关键词： Imidoyl Radicals Quinolones Chromenoquinolines Naphthyridines Dibenzonaphtyridines

An Early Cretaceous gold mineralization event in the Triassic West Qinling orogen revealed from U-Pb titanite dating of the Ma'anqiao gold deposit

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

science China Earth sciences 2023年第2期66卷 316-333页

作者： Chongguo HE jianwei LI Daniel j.KONTAK Xiaoye jIN Yafei WU Hao HU Bo ZU Xueling YU shaorui ZHAO shiguang DU Yunlong ZHU Huan TAO state Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesWuhan430074China school of Earth Resources China University of GeosciencesWuhan430074China Harquail school of Earth sciences Laurentian UniversitySudburyOntarioP3E 2C6Canada

The West Qinling orogen in central China,formed from continental collision between the North China and Yangtze cratons in the Late Triassic,hosts numerous gold deposits with a total Au endowment of about 2000 *** deposits were emplaced at ca.250-195 Ma and are genetically associated with the Triassic *** in situ U-Pb titanite dating with laser ablation inductively coupled plasma mass spectrometry indicates the Ma’anqiao gold deposit in the northern portion of this orogen has a distinctive age and under a contrasting tectonic *** structurally controlled gold deposit is hosted in Late Ordovician to Early silurian sub-greenschist facies metasedimentary *** gold mineralization is hosted in quartz-pyritepyrrhotite veins and pyrite-pyrrhotite disseminations in hydrothermally altered rocks,which are crosscut by K-feldspar-calcitechlorite±pyrite ***,present both in the disseminated sulfide ores and later veins,was used for in situ U-Pb *** from three disseminated sulfide ore samples with Th and U averaging 27.46 and 39.31 ppm(1 ppm=1μg g^(-1)),respectively,yielded lower-intercept ages of 121.1±3.1 to 120.7±3.5 Ma(2σ)in the Tera-Wasserburg *** from three later vein samples with much lower Th and U concentrations averaging 2.74 and 16.21 ppm,respectively,yielded overlapping ages of 120.8±3.2 to 120.3±5.8 Ma(2σ).These new titanite U-Pb ages tightly constrain the formation of the Ma’anqiao gold deposit at ca.121-120 Ma and,when combined with independent geological data,indicate it is not related to the Triassic Qinling ***,its formation is attributed to lithospheric thinning and destruction of the North China craton during the Late jurassic to Early Cretaceous which has generated numerous gold deposits along the southern margin of this *** catastrophic event caused extensive magmatism in large areas of the North Qinling terrane and northern edge of the West Qinling orogen immediately to the sout

关键词： Titanite U-Pb dating Early Cretaceous Orogenic gold deposit Ma’anqiao West Qinling orogen

Carbonic Anhydrase III s-Glutathionylation Is Necessary for Anti-Oxidant Activity

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Yangtze Medicine 2018年第4期2卷 244-254页

作者： P. Roy M. Ireland s. Roy j. Craft C. Bartholomew Department of Biological & Biomedical sciences School of Health & Life Sciences Glasgow Caledonian University City Campus Glasgow UK

Carbonic anhydrase isozyme CA3 protects cells against oxidative stress. Ectopic expression of murine Ca3, but not Ca2, protects proto-oncogene Evi1 expressing Rat1 fibroblast cells (ca3low) against hydrogen peroxide (H2O2) induced stress. Ca3 is s-glutathionylated via glutathione adducts with cysteines 181 and 186. substitution of both Ca3 cysteines with serine fails to protect cells from oxidative stress. Insertion of cysteine at 181 and 186 in Ca2 is insufficient for conferring efficient anti-oxidant activity. This shows for the first time that s-glutathionylation of cys181 and cys186 residues is required for Ca3 anti-oxidant activity but that additional factors are also required.

关键词： CA3 CAIII Carbonic Anhydrase III s-Glutathionylation Apoptosis Anti-Oxidant

Presence of Multidrug-Resistant E. coli, Enterococcusspp. and salmonellaspp. in Lakes and Fountains of Porto, Portugal

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Water Resource and Protection 2013年第11期5卷 1117-1126页

作者： Carlos E. Flores Luís Loureiro Lucinda j. Bessa Paulo Martins da Costa 1ICBAs-Abel salazar Biomedical sciences Institute University of Porto Porto Portugal 2CIIMAR-Interdisciplinary Center for Marine and Environmental Research University of Porto Porto Portugal 1ICBAs-Abel salazar Biomedical sciences Institute University of Porto Porto Portugal 2Faculty of Sciences (FCUP) University of Porto Porto Portugal CIIMAR-Interdisciplinary Center for Marine and Environmental Research University of Porto Porto Portugal Tulane University School of Public Health and Tropical Medicine New Orleans USA

Urban lakes and fountains provide recreational activities that could facilitate the contact between humans, animals and biological agents. The objective of this work was to assess the water quality and safety of 17 lakes and 13 fountains in the city of Porto (Portugal), by detecting the presence of Escherichia coli, enterococci and salmonella spp., and analyzing their antimicrobial resistance. (For more information,please refer to the pdf.)

关键词： Antimicrobial Resistance Enterococcus spp. Escherichia coli salmonella spp. Fountains Lakes

COUTURE CLAsH Inside shenzhen Fashion Week 2018

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

城市漫步（GBA版） 2018年第4期 22-22页

作者： bailey Hu Peter Code 不详

This past March,models strutted,swayed,glared,pouted and,every so often,smiled during shenzhen's annual couture extravaganza.

关键词： shenzhen Inside smile