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Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla s.sousa Andreia Monteiro António j.salgado Nuno A.silva Life and Health sciences Research Institute(ICVs) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVs/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh s.Nugent Uniformed services University of the Health sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

阿列克谢耶夫《聊斋志异》译本的译者行为批评分析

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外语学刊 2025年第1期 92-98页

作者：雷丽斯黑龙江大学高级翻译学院哈尔滨150080

《聊斋志异》是我国古代短篇小说的艺术丰碑,由苏联汉学家阿列克谢耶夫完成的俄语选译本在俄罗斯完成经典化。本文以阿列克谢耶夫译本为例,运用文本细读法,从翻译内外二分化视野,对译者行为进行批评分析。研究发现,在翻译外层面上,译者... 详细信息

《聊斋志异》是我国古代短篇小说的艺术丰碑,由苏联汉学家阿列克谢耶夫完成的俄语选译本在俄罗斯完成经典化。本文以阿列克谢耶夫译本为例,运用文本细读法,从翻译内外二分化视野,对译者行为进行批评分析。研究发现,在翻译外层面上,译者身份、译者与作者之间的“知己关系”等因素促使译者行为偏向作者/原文一端;在翻译内层面上,译者运用多种翻译手段最大限度地实现了对作者/原文的求真,同时在求真的基础上,使译文对读者/社会务实,译者行为合理度较佳。

关键词：译者行为批评《聊斋志异》阿列克谢耶夫译者行为典籍翻译

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A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

Effects of γ-irradiation and Deformation Temperature on Tensile Properties of Pb-2 mass% sb Alloy

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journal of Iron and steel Research International 2016年第7期23卷 733-738页

作者： gh MOHAMMED s.EI-GAMAL Physics Department Faculty of ScienceNorthern Borders University Physics Department Faculty of EducationAin Shams University

Effects ofγ-irradiation and deformation temperature（T）on the tensile properties of Pb-2mass% sb alloys were *** samples were annealed at 458 Kfor 2hin air,then water quenched after they wereγ-irradiated（the different doses were 0.5,1.0,1.5,and 2.0 MGy）.The tensile properties were performed using stress-strain measurements at a constant strain rate（1.2×10^（-3） s^（-1））and at different T（303-393K）.It was found that at constant dose,the fracture stress（σF）decreases while the fracture strain（εF）increases as *** particular T,σFincreases whileεFdecreases with increasing *** strain-hardening exponent（n）,which is the slope of the relation between ln（σ）and ln（ε）of the parabolic part of the stress-strain curve,was determined and its values increase as Tincreases and decrease as the dose *** value of the activation energy increases as the dose increases from 0.07 eV for un-irradiated sample to 0.1eV for the 2 MGy-irradiated *** values are in accordance with that needed for dislocation movement and ordering *** interpretation of the results was given,based on the creation of point and line defects due toγ-irradiation,and that results in a distribution of beta phase（sb-phase）,leading to a difficulty in the movement of dislocations,so there is an increase in alloy hardness.

关键词： γ-irradiation deformation temperature tensile property Pb-2 mass% sb alloy

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Deductive way of reasoning about the internet As level topology

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Chinese Physics B 2015年第11期24卷 633-642页

作者： Dávid szabó Attila Korsi józsef Bíró András Gulyás High speed Networks Laboratory Budapest University of Technology and Economics MTA-BME Information systems Research Group Budapest University of Technology and Economics MTA-BME Future Internet Research Group Budapest University of Technology and Economics

Our current understanding about the As level topology of the Internet is based on measurements and inductive-type models which set up rules describing the behavior （node and edge dynamics） of the individual Ases and generalize the consequences of these individual actions for the complete As ecosystem using induction. In this paper we suggest a third, deductive approach in which we have premises for the whole As system and the consequences of these premises are determined through deductive reasoning. We show that such a deductive approach can give complementary insights into the topological properties of the As graph. While inductive models can mostly reflect high level statistics （e.g., degree distribution, clustering, diameter）, deductive reasoning can identify omnipresent subgraphs and peering likelihood. We also propose a model, called YEAs, incorporating our deductive analytical findings that produces topologies contain both traditional and novel metrics for the As level Internet.

关键词： internet topology complex network analysis model

肺炎支原体肺炎MsCT三维重建的临床应用及征象分析

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中国CT和MRI杂志 2025年第1期23卷 70-71页

作者：王思思姜兵湖南省第二人民医院(湖南省脑科医院)检验科湖南长沙410021 湖南省第二人民医院(湖南省脑科医院)放射科湖南长沙410021

目的总结肺炎支原体肺炎(MPP)的多层螺旋CT(MsCT)三维重建的临床应用及CT征象。方法收集120例MPP患者胸部MsCT图像,行多切面重建,分析其CT征象。结果 120例MPP患者中,MsCT显示阳性115例,阴性5例,MsCT三维重建对MPP的诊断准确度达96%(11... 详细信息

目的总结肺炎支原体肺炎(MPP)的多层螺旋CT(MsCT)三维重建的临床应用及CT征象。方法收集120例MPP患者胸部MsCT图像,行多切面重建,分析其CT征象。结果 120例MPP患者中,MsCT显示阳性115例,阴性5例,MsCT三维重建对MPP的诊断准确度达96%(115/120),115例MsCT支原体肺炎肺内病灶分布均与支气管走行一致(100%),多叶段(≥2)分布75例(67.82%),单叶段分布40例(34.78%),支气管及细支气管管壁增厚110例(95.65%)、树芽征105例(91.3%)、树雾征97例(84.34%)、实变70例(60.87%)、病灶内支气管粘液栓33例(28.7%)。结论支原体肺炎主要影像表现是支气管及细支气管管壁增厚、树芽征、树雾征,病灶与支气管走行一致,呈多叶段分布,次要影像表现为实变、支气管黏液栓,MsCT三维重建有助于的肺炎支原体肺炎诊断。

关键词：肺炎支原体肺炎体层摄影术 X线计算机三维重建诊断鉴别

Numerical investigation of Reynolds number and scaling effects in microchannels flows

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journal of Hydrodynamics 2017年第4期29卷 647-658页

作者： s.A.si salah E.G.Filali s.Djellouli Faculty of Mechanical and Process Engineering Houari Boumedienne University

Compared with conventional channels, experiments of microchannel often exhibit some controversial findings and sometimes even opposite trends, most notably the effects of the Reynolds number and the scaled channel height on the Poiseuille number. The experimental method has still been constrained by two key facts, firstly the current ability to machine microstructures and secondly the limitation of measurement of parameters related to the Poiseuille number. As a consequence, numerical method was adopted in this study in order to analyze a flow in two-dimensional rectangular microchannels using water as working fluid. Results are obtained by the solution of the steady laminar incompressible Navier-stokes equations using control volume finite element method（CVFEM） without pressure correction. The computation was made for channel height ranging from 50 ？m to 4.58 ？m and Reynolds number varying from 0.4 to 1 600. The effect of Reynolds number and channel heights on flow characteristics was investigated. The results showed that the Poiseuille numbers agree fairly well with the experimental measurements proving that there is no scale effect at small channel height. This scaling effect has been confirmed by two additional simulations being carried out at channel heights of 2.5 ？m and 0.5 ？m, respectively and the range of Reynolds number was extended from 0.01 up to 1 600. This study confirm that the conventional analysis approach can be employed with confidence for predicting flow behavior in microchannels when coupled with carefully matched entrance and boundary conditions in the dimensional range considered here.

关键词： Rectangular microchannel Poiseuille number control volume finite element method(CVFEM) laminar flow minichannels