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Brain-penetrating neurotrophic factor mimetics: HEr-096 as a disease-modifying therapy for Parkinson’s disease

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Neural regeneration research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural regeneration research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen robert j.Thomas m.Brandon Westover can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Analysis and modeling of Slope Stability in the Three-Gorges Dam reservoir (China)——The case of Huangtupo landslide

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journal of mountain Science 2011年第2期8卷 166-175页

作者： r.COjEAN Y.j.ca Centre de Géosciences Mines-ParisTech Paris France Changjiang Institute of Survey Planning Design & Research CWRC Wuhan China

The water level in the Three Gorges Dam reservoir is expected to change between the elevations of 145 m and 175 m, as a function of the flood control implementation and the intensity of the annual flood. As a matter of fact, the hydraulical and mechanical loadings, related to the water level modifications, will result in alterations in the slope stability conditions. The town of Badong (Hubei), of 20 000 inhabitants, is one of the towns which was submerged by the impoundment of the reservoir. As a consequence, the new town of Badong was constructed on a nearby site which appeared to be partly an unstable site. A part of this site corresponds to an old landslide, the Huangtupo landslide, the base of which had to be submerged by the water of the reservoir. The analysis of the Huangtupo landslide, taking into account various events scenarios, drainage and reinforcement measures and monitoring devices, allows to illustrate the general process implemented all along the reservoir in order to mitigate the landslide hazard.

关键词： Three Gorges Dam landslide modelling

Crystal Growth of[ca3Al(OH)6·12H2O]2·(SO4)3·2H2O (Ettringite) Studied Under microgravity Conditions

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journal of Wuhan University of Technology(materials Science) 2020年第5期35卷 893-899页

作者： meier m r lEI l rinkenburger A Plank j Technische Universitat miinchen Chair for Construction Chemistry85747 GarchingLichtenbergstrafie 4Germany

On parabolic flights,the growth of ettringite,[ca3Al(OH)6·12H2O]2·(SO4)3·2H2O,a major reaction product of cement with water which forms instantaneously,was crystallized under microgravity conditions and *** the experiments,ca(OH)2/Al2(SO4)3 solutions were combined and reacted for 10?s,followed by immediate filtration of the suspension and subsequent quenching with *** the ettringite crystals,the size,aspect ratios,quantity and morphology were determined and the results were compared with those from identical experiments performed under terrestric *** microgravity,generally smaller crystals (l-2.9 μm) precipitated in larger amount than under normal gravity (l-3.5 μm).The aspect ratios of the crystals grown under terrestric or microgravity condition were comparable at about *** is assumed that the reason for the smaller ettringite crystals is the absence of convection leading to more initial nuclei,but slower crystal growth which is diffusion ***,no preference relative to the ion transport to the different faces of the crystals *** results contribute to the understanding of the mineralization of inorganic salts under microgravity conditions for which hitherto only a handful of examples were reported.

关键词： crystallization ettringite microgravity morphology nucleation

Composition and evolution of the continental crust:retrospect and prospect

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Geoscience Frontiers 2022年第5期13卷 1-15页

作者： j.l.r.Touret m.Santosh j.m.Huizenga Institut de minéralogie Physique des MatériauxCosmochimieSorbonne Universités4 Place JussieuF-75005 ParisFrance 121 rue de la réunion 75020 ParisFrance School of Earth Sciences and resources China University of GeosciencesBeijing 100083China Department of Earth Science University of AdelaideAdelaideSA 5005Australia Faculty of Environmental Sciences and Natural resource management Norwegian University of Life SciencesP.O.Box 5003NO-1432ÅsNorway EGrU(Economic Geology research Centre) James Cook UniversityTownsvilleQueensland 4811Australia Department of Geology University of JohannesburgPO Box 524Auckland Park 2006South Africa

Until the middle of the 20th century,the continental crust was considered to be dominantly *** hypothesis was revised after the Second World War when several new studies led to the realization that the continental crust is dominantly made of metamorphic *** rocks were emplaced at peak metamorphic conditions in domains,which can be defined by geophysical *** to medium-grade metamorphic rocks constitute the upper crust,granitic migmatites and intrusive granites occur in the middle crust,and the lower crust,situated between the Conrad and moho discontinuities,comprises charnockites and *** continental crust acquired its final structure during metamorphic episodes associated with mantle upwelling,which mostly occurred in supercontinents prior to their disruption,during which the base of the crust experienced ultrahigh temperatures(>1000℃,ultrahigh temperature granulite-facies metamorphism).Heat is provided by underplating of mantle-derived mafic magmas,as well as by a massive influx of low H_(2)O activity mantle fluids,***-density CO_(2) and highsalinity *** fluids are initially stored in ultrahigh temperature domains,and subsequently infiltrate the lower crust,where they generate anhydrous granulite mineral *** brines can reach upper crustal levels,possibly even the surface,along major shear zones,where granitoids are generated through brine streaming in addition to those formed by dehydration melting in upper crustal levels.

关键词： Brines CO_(2) Continental crust Granulite lower crust

High-temperature granulites and supercontinents

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Geoscience Frontiers 2016年第1期7卷 101-113页

作者： j.l.r.Touret m.Santosh j.m.Huizenga Institut de mineralogie Physique des MateriauxCosmochimie(IMPMC)Sorbonne Universites et UPMC Univ Paris 06UMR CNRS 7590Museum National d'Histoire NaturelleIRD UMR 2064 Place JussieuF-FS005 ParisFrance School of the Earth Sciences and resources China University of Geosciences(Beijing)29 Xueyuan RoadBeijing 100083China Economic Geology research Institute(EGrU) College of ScienceTechnology and EngineeringJames Cook UniversityTownsvilleQueensland4811Australia Unit for Environmental Sciences and management North-West UniversityPrivate Bag X60012520South Africa

The formation of continents involves a combination of magmatic and metamorphic processes. These processes become indistinguishable at the crust-mantle interface, where the pressure-temperature（P-T）conditions of（ultra） high-temperature granulites and magmatic rocks are similar. Continents grow laterally, by magmatic activity above oceanic subduction zones（high-pressure metamorphic setting）, and vertically by accumulation of mantle-derived magmas at the base of the crust（high-temperature metamorphic setting）. Both events are separated from each other in time; the vertical accretion postdating lateral growth by several tens of millions of years. Fluid inclusion data indicate that during the high-temperature metamorphic episode the granulite lower crust is invaded by large amounts of low H2O-activity fluids including high-density CO2 and concentrated saline solutions（brines）. These fluids are expelled from the lower crust to higher crustal levels at the end of the high-grade metamorphic event. The final amalgamation of supercontinents corresponds to episodes of ultra-high temperature metamorphism involving large-scale accumulation of these low-water activity fluids in the lower *** accumulation causes tectonic instability, which together with the heat input from the subcontinental lithospheric mantle, leads to the disruption of supercontinents. Thus, the fragmentation of a supercontinent is already programmed at the time of its amalgamation.

关键词： Continents Supercontinents magmatism and metamorphism Fluids Tectonics

中低危人群中动脉粥样硬化的患病率和分布情况:基于全身mr血管成像的研究

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国际医学放射学杂志 2018年第4期 478-479页

作者： m.A.lambert j.r.weir-m.ca.l m.Salsano S.j.Gandy D.levin 温小娟 Division of molecular and Clinical medicine College of MedicineUniversity of Dundee

目的量化心血管疾病中低风险人群中无症状动脉粥样硬化的负担和分布情况。材料与方法前瞻性纳入2008年6月—2013年2月期间10年心血管疾病风险低于20%的1 528名参与者。利用双注射四站采集技术对受试者行3.0 T全身mr血管成像（mrA）检查... 详细信息

目的量化心血管疾病中低风险人群中无症状动脉粥样硬化的负担和分布情况。材料与方法前瞻性纳入2008年6月—2013年2月期间10年心血管疾病风险低于20%的1 528名参与者。利用双注射四站采集技术对受试者行3.0 T全身mr血管成像（mrA）检查。根据最大狭窄程度对31个动脉节段进行评分。对可评估的动脉节段的数量进行归纳校正以提供标准化的动脉粥样硬化评分（SAS）。采用多元线性回归方法评估危险因素对发生动脉粥样硬化的影响。结果共计1 513名受试者[男性577名（37.9%）,平均年龄53.5岁,范围40～83岁]完成实验。在46 903个潜在的可分析节段中有46 601（99.4%）个节段可分析统计。其中,2 468个节段（5%）显示狭窄,且1 649个节段（3.5%）狭窄程度mrA可以识别人群早期血管疾病。尽管在每一血管水平血管疾病的发病率都很低,但在低到中等心血管疾病风险的人群中个人水平血管病变仍很常见。

关键词：动脉粥样硬化血管成像 mr

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冠状动脉CT血流储备分数失败率的决定因素

国际医学放射学杂志 2019年第6期 726-727页

作者： G.Pontone j.r.weir-m.ca.l A.Baggiano A.Del Torto l.Fusini m.Guglielmo 许棚棚 Department of cardiovascular Imaging Centro Cardiologico MonzinoIRCCS

摘要目的计算冠状动脉CT血流储备分数(FFrCT)的失败率并寻找技术上与FFrCT计算不成功相关的因素。材料与方法本研究纳入评估无创性FFrCT在冠状动脉诊疗中的

关键词：冠状动脉失败率 CT

Isla San Pedro Nolasco as a late miocene intrusive record at the eastern margin of the Gulf of california:Insights from geological,geochemical and geochronological studies

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Geoscience Frontiers 2022年第3期13卷 100-114页

作者： l.A.Velderrain-rojas j.r.Vidal-Solano l.m.Alva-Valdivia r.Vega-Granillo m.lópez-martinez Departamento de Geología División de Ciencias Exactas y NaturalesUniversidad de SonoraC.P.83000 HermosilloSonoraMexico laboratorio de Paleomagnetismo Instituto de GeofísicaUniversidad Nacional Autónoma de MéxicoCircuito de la Investigación CientíficaC.P.04510 MéxicoD.F.Mexico Departamento de Geología División de Ciencias de la TierraCentro de Investigación Científica y de Educación Superior de EnsenadaBaja CaliforniaMexico

Isla San Pedro Nolasco(ISPN)is a structural high bounded by inactive dextral oblique-slip faults in the east-central part of the Gulf of california rift zone and is composed of intrusive rocks not exposed on other Gulf of california *** we present the reconnaissance results from geological mapping,as well as first geochemical and geochronological data for the ISPN intrusive *** intrusive rocks compose a sheet-like body of intermediate and felsic composition intruded by an intermediate and acidic dike *** intrusive rocks(host and dikes)range in age from ca.9 ma to 10 ma(^(40)Ar/^(39)Ar)and show a hydrous ferromagnesian mineral association(amphibole and biotite)with a calc-alkalic and transitional *** hydrated mineralogical association has not been recognized in the coeval rocks along the onshore western margin of the North American plate(coastal Sonora).However,such hydrous mineralogical association is found in the coeval rift transitional volcanic rocks from the Baja california microplate at Santa rosalía and Bahía de losÁngeles–Bahía de lasÁ*** ISPN continental block,at least 40 km long,has been pulled apart by transtensional faulting of the late miocene Gulf of california shear zone before the westward migration of the North America-Pacific plate boundary at ca.3–2 ***,ISPN became isolated as an island during the late miocene flooding of the Gulf of california seaway.

关键词： PAC-NAm plate boundary Gulf of california Intrusive rocks Isla San Pedro Nolasco