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Interindividual Age-Independent Differences in Human CX43 Impact Ventricular Arrhythmic risk

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research 2024年第3期6卷 417-432页

作者： Laura García-mendívil María Pérez-zabalza Antoni Oliver-Gelabert joséMaría Vallejo-Gil javier Fañanás-Mastral Manuel Vázquez-Sancho javier AndréBellido-Morales Alexánder Sebastián Vaca-Núñez Carlos Ballester-Cuenca Emiliano Diez Laura Ordovás Esther Pueyo Biomedical Signal Interpretation and Computational Simulation group(BSICoS) Aragón Institute of Engineering ResearchUniversity of ZaragozaZaragoza 50018Spain BSICoS Instituto de Investigación Sanitaria Aragón(IISA)Zaragoza 50018Spain Centro Universitario de la Defensa(CUD) Zaragoza 50090Spain. Department of Cardiovascular Surgery University Hospital Miguel ServetZaragoza 50009Spain. Institute of Experimental Medicine and Biology of Cuyo(IMBECU) CONICETMendoza 5500Argentina. Fundación Agencia Aragonesa para la Investigación y el Desarrollo(ArAID) Zaragoza 50018Spain. Biomedical research Networking Center in Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)Zaragoza 50018Spain.

Connexin 43 (CX43) is one of the major components of gap junctions, the structures responsible for the intercellular communication and transmission of the electrical impulse in the left ventricle. There is limited information on the histological changes of CX43 with age and their effect on electrophysiology, especially in humans. Here, we analyzed left ventricular biopsies from living donors starting at midlife to characterize age-related CX43 remodeling. We assessed its quantity, degree of lateralization, and spatial heterogeneity together with fibrotic deposition. We observed no significant age-related remodeling of CX43. Only spatial heterogeneity increased slightly with age, and this increase was better explained by biological age than by chronological age. Importantly, we found that CX43 features varied considerably among individuals in our population with no relevant relationship to age or fibrosis content, in contrast to animal species. We used our experimental results to feed computational models of human ventricular electrophysiology and to assess the effects of interindividual differences in specific features of CX43 and fibrosis on conduction velocity, action potential duration, and arrhythmogenicity. We found that larger amounts of fibrosis were associated with the highest arrhythmic risk, with this risk being increased when fibrosis deposition was combined with a reduction in CX43 amount and/or with an increase in CX43 spatial heterogeneity. These mechanisms underlying high arrhythmic risk in some individuals were not associated with age in our study population. In conclusion, our data rule out CX43 remodeling as an age-related arrhythmic substrate in the population beyond midlife, but highlight its potential as a proarrhythmic factor at the individual level, especially when combined with increased fibrosis.

关键词： CX43 rhythm Independent

Numerical Simulation of Bed Load and Suspended Load Sediment Transport Using Well-Balanced Numerical Schemes

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Communications on Applied Mathematics and Computation 2023年第2期5卷 885-922页

作者： j.C.González-Aguirre j.A.González-Vázquez j.Alavez-ramírez r.Silva M.E.Vázquez-Cendón División Acádemica de Ciencias Básicas Universidad Juárez Autónoma de TabascoCarr.Cunduacán-Jalpa de Mendéz KM.1CP 86690CunduacánTabascoMexico Universidad Autónoma Metropolitana-Unidad Iztapalapa Av.San Rafael Atlixco no.186Mexico CityMexico Instituto de Ingeniería Universidad Nacional Autónoma de México04510 Mexico CityMexico Departamento de Matemática Aplicada Universidade de Santiago de Compostela15706 Santiago de CompostelaSpain

Sediment transport can be modelled using hydrodynamic models based on shallow water equations coupled with the sediment concentration conservation equation and the bed con-servation *** complete system of equations is made up of the energy balance law and the Exner *** numerical solution for this complete system is done in a seg-regated ***,the hyperbolic part of the system of balance laws is solved using a finite volume *** ways to compute the numerical flux have been considered,the Q-scheme of van Leer,the HLLCS approximate riemann solver,and the last one takes into account the presence of non-conservative products in the *** discretisation of the source terms is carried out according to the numerical flux *** the second stage,the bed conservation equation is solved by using the approximation computed for the system of balance *** numerical schemes have been validated making comparisons between the obtained numerical results and the experimental data for some physical *** numerical results show a good agreement with the experimental data.

关键词： Sediment transport Suspended load Bed load Finite volume method Numerical simulation Well-balanced schemes

Status report of the NSCL/MSU ECr Ion Sources

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Chinese Physics C 2007年第S1期31卷 18-22页

作者： P.A.Závodszky B.mend D.Cole j.DeKamp M.Doleans G.Machicoane F.Marti P.Miller j.Moskalik W.Nurnberger j.Ottarson M.Steiner j.Stetson j.Vincent A.Zeller National Superconducting Cyclotron Laboratory Michigan State UniversityEast LansingMI 48824USA

Since the last ECr Workshop,NSCL/MSU has been involved in a vigorous ECr ion source r&D program,which resulted in the construction of an off-line test ECr ion source(ArTEMIS-B)for new beam development and ion optics *** the design and partial completion of a 3rd generation,fully supercon- ducting ECr ion source,SuSI has been *** paper is an overview of the construction projects and the different r&D activities performed with the existing ion *** activities include development of metallic ion beam production methods using evaporation with resistive and inductive ovens and sputtering of very refractory *** optics developments include testing different focusing elements(magnetic solenoid lens,electrostatic quadrupole triplet lens,Einzel lens,electrostatic double doublet quadrupole combined with an octupole lens),and different beam forming and diagnostics *** detailed results will be presented at the workshop in separate talks and posters.

关键词： ECr ion sources highly charged ions beam optics

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胃肠病学和肝病学杂志 2020年第5期29卷 571-575页

作者：张晓倩杨慧孟蝶张晓华山西医科大学第一医院感染科山西太原030001

目的观察核因子E2相关因子2(Nrf2)和血红素加氧酶-1(HO-1)在急性药物性肝损伤(acute drug-induced liver injury, ADILI)患者血清中的含量及临床意义。方法收集ADILI患者60例,及60名健康对照者的外周血并分离血清,采用ELISA法检测样本中... 详细信息

目的观察核因子E2相关因子2(Nrf2)和血红素加氧酶-1(HO-1)在急性药物性肝损伤(acute drug-induced liver injury, ADILI)患者血清中的含量及临床意义。方法收集ADILI患者60例,及60名健康对照者的外周血并分离血清,采用ELISA法检测样本中Nrf2及HO-1的含量,比较两组中Nrf2及HO-1的差异,并分析二者与疾病临床特征及生化指标的相关性。结果 Nrf2、HO-1在ADILI患者血清中的含量显著高于健康对照组,差异均有统计学意义(Prf2的含量显著高于肝细胞损伤型(P0.05);Nrf2、HO-1与肝损伤指标丙氨酸氨基转移酶(ALT)、天门冬氨酸转氨酶(AST)、总胆红素(TBIL)、直接胆红素(DBIL)及胆汁酸(TBA)呈负相关(P0.05);以Nrf2=516.14 U/L作为最佳截断值,预测ADILI疾病的敏感度为95.0%,特异度为77.1%,曲线下面积为0.918(Prf2、HO-1在ADILI患者血清中的含量明显升高,且与肝细胞损伤程度呈负相关,二者在血清中的水平可以作为ADILI疾病程度较为敏感的预测指标。

关键词：核因子E2相关因子2 血红素加氧酶-1 药物性肝损伤氧化应激

Smart Quarantine Environment Privacy through IoT Gadgets Using Blockchain

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Intelligent Automation & Soft Computing 2023年第3期35卷 3021-3036页

作者： Nitish Pathak Shams Tabrez Siddiqui Anjani Kumar Singha Heba G Mohamed Shabana Urooj Abhinandan r Patil Department of Information Technology Bhagwan Parshuram Institute of Technology(BPIT)GGSIPUNew Delhi110078India Department of Computer Science Jazan UniversityJazan45142Saudi Arabia Department of Computer Science Aligarh Muslim UniversityAligarh202002India Department of Electrical Engineering College of EngineeringPrincess Nourah bint Abdulrahman UniversityP O Box 84428Riyadh11671Saudi Arabia Sanjay Ghodawat University KolhapurMaharashtra416118India

The coronavirus,formerly known as COVID-19,has caused massive global *** a precaution,most governments imposed quarantine periods ranging from months to years and postponed signiﬁcantﬁnancial ***,governments around the world have used cutting-edge technologies to track citizens’*** of sensors were connected to IoT(Internet of Things)devices to monitor the catastrophic eruption with billions of connected devices that use these novel tools and apps,privacy and security issues regarding data transmission and memory space *** this study,we suggest a block-chain-based methodology for safeguarding data in the billions of devices and sen-sors connected over the *** trial secrecy and safety qualities are based on cutting-edge *** evaluate the proposed model,we recom-mend using an application of the system,a raspberry Pi single-board computer in an IoT system,a laptop,a computer,cell phones and the Ethereum smart contract *** models ability to ensure safety,effectiveness and a suitable budget is proved by the Gowalla dataset results.

关键词： ring signature blockchain IoT encryption smart contract decryption authentication privacy-preserving

牧场土壤含水率与坚实度空间变异与相关性分析

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农业机械学报 2009年第3期40卷 103-107,89页

作者：程强孙宇瑞林剑辉曾庆猛 Schulze Lammers P Schellberg j 中国农业大学信息与电气工程学院北京100083 北京林业大学工学院北京100083 波恩大学农业工程系德国波恩53115 波恩大学作物科学与资源保护研究所德国波恩53115

利用土壤水分/圆锥指数复合测量装置,应用精细农作技术体系网格定点测量与GPS定位,在一块面积约1.27 hm2的草地上获取了土壤含水率与坚实度空间分布基础数据,并针对采样过程中出现的数据缺失,用偏最小二乘法对数据进行修补。然后运用克... 详细信息

利用土壤水分/圆锥指数复合测量装置,应用精细农作技术体系网格定点测量与GPS定位,在一块面积约1.27 hm2的草地上获取了土壤含水率与坚实度空间分布基础数据,并针对采样过程中出现的数据缺失,用偏最小二乘法对数据进行修补。然后运用克里格插值法进行数字化成图,并在此基础上分别对含水率与坚实度的空间变异性及两者的相关性做了分析。

关键词：牧场草地土壤含水率坚实度空间变异相关性

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经脐单孔腹腔镜手术体会

中国内镜杂志 2011年第5期17卷 501-503页

作者：龚昭周程 W.j.KArCZ 胡思安阮剑严白莉湖北省武汉市第一医院肝胆外科湖北武汉430022 德国佛赖堡大学医学院普通外科德国佛赖堡79106

目的探讨经脐单孔腹腔镜手术的可行性。方法 37例患者均经脐单孔入路腹腔镜操作,完成胆囊切除26例,肝囊肿开窗术7例,阑尾切除术4例。结果 37例均顺利完成手术,平均手术时间56.6min,术后未置引流管、无出血、腹脓肿及切口感染等并发症。... 详细信息

目的探讨经脐单孔腹腔镜手术的可行性。方法 37例患者均经脐单孔入路腹腔镜操作,完成胆囊切除26例,肝囊肿开窗术7例,阑尾切除术4例。结果 37例均顺利完成手术,平均手术时间56.6min,术后未置引流管、无出血、腹脓肿及切口感染等并发症。术后2周复查无明显脐部手术瘢痕。结论经脐单孔腹腔镜外科技术在胆囊切除、肝囊肿开窗以及阑尾切除术中的应用是安全可行的,且美容效果好,术后疼痛轻。虽然较传统腹腔镜外科技术而言存在着相对难度较大、手术器械需完善等问题,仍是一种有创新性的手术思路和方法。

关键词：经脐手术单孔腹腔镜内镜技术胆囊切除术肝囊肿开窗术阑尾切除术

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“回归社区”与社区精神重建

深圳大学学报（人文社会科学版） 2004年第6期21卷 75-80页

作者：李左人四川省委党校四川成都610072

在工业化、城市化时代,“回归社区”能够在很大程度上修补和矫正现代化对人的扭曲与异化,避免市场经济发展给社会带来的负面影响,其目的在于让人们回归到人本的另一面———善良、互助与共生。“回归”既是对传统社区本质精神的皈依,又... 详细信息

在工业化、城市化时代,“回归社区”能够在很大程度上修补和矫正现代化对人的扭曲与异化,避免市场经济发展给社会带来的负面影响,其目的在于让人们回归到人本的另一面———善良、互助与共生。“回归”既是对传统社区本质精神的皈依,又是要超越传统的狭隘亲情和人际关系,走向更为广阔的人际互助。新的社区精神体现了群体精神与个性精神、传统精神与创新精神的结合,民主与自治精神的张扬,群众参与、领导垂范、长期实践是提炼和培育社区精神的正确路径。

关键词：社区精神失落重建

A New Method Based on rBFNN in SOC Estimation of HEV Battery

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A New Method Based on RBFNN in SOC Estimation of HEV Battery