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红外 1995年第4期16卷 26-29,25页

作者： j.p.wolf 顾聚兴德国Elight激光系统GmbH的创立者之一

符合工业标准的激光雷达系统发掘出越来越多的工业应用。

关键词：全固体差分激光雷达系统测量污染物质

动力无限介质-结构相互作用分析的双渐近多向透射边界

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世界地震工程 1995年第4期11卷 58-66页

作者： j.p.wolf C.Song 顾仲春

1 前言在分析动力无限介质-结构相互作用的直接法中,人工边界以内的介质,用譬如象有限元来离散。为了表示没有被明显模拟的从人工边界直到无限远处的那部分介质的影响,必须在人工边界上列出合适的边界条件。这一相互作用的力-位移的严... 详细信息

1 前言在分析动力无限介质-结构相互作用的直接法中,人工边界以内的介质,用譬如象有限元来离散。为了表示没有被明显模拟的从人工边界直到无限远处的那部分介质的影响,必须在人工边界上列出合适的边界条件。这一相互作用的力-位移的严格关系,在空间和时间上都是完整的。已经建立了几种叫做透射边界的方法。

关键词：动力无限介质结构相互作用透射边界

Encapsulating peritoneal sclerosis

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World journal of Gastroenterology 2018年第28期24卷 3101-3111页

作者： Christopher j Danford Steven C Lin Martin p Smith jacqueline L wolf Division of Gastroenterology and Hepatology Beth Israel Deaconess Medical Center Harvard Medical School Department of Radiology Beth Israel Deaconess Medical Center Harvard Medical School

Encapsulating peritoneal sclerosis(EpS) is a debilitating condition characterized by a fibrocollagenous membrane encasing the small intestine, resulting in recurrent small bowel obstructions. EpS is most commonly associated with long-term peritoneal dialysis, though medications, peritoneal infection, and systemic inflammatory disorders have been implicated. Many cases remain idiopathic. Diagnosis is often delayed given the rarity of the disorder combined with non-specific symptoms and laboratory findings. Although cross-sectional imaging with computed tomography of the abdomen can be suggestive of the disorder, many patients undergo exploratory laparotomy for diagnosis. Mortality approaches 50% one year after diagnosis. Treatment for EpS involves treating the underlying condition or eliminating possible inciting agents(i.e. peritoneal dialysis, medications, infections) and nutritional support, frequently with total parenteral nutrition. EpSspecific treatment depends on the disease stage. In the inflammatory stage, corticosteroids are the treatment of choice, while in the fibrotic stage, tamoxifen may be beneficial. In practice, distinguishing between stages may be difficult and both may be used. Surgical intervention, consisting of peritonectomy and enterolysis, is timeconsuming and high-risk and is reserved for situations in which conservative medical therapy fails in institutions with surgical expertise in this area. Herein we review the available literature of the etiology, pathogenesis, diagnosis, and treatment of this rare, but potentially devastating disease.

关键词： Abdominal cocoon Sclerosing encapsulating peritonitis peritoneal sclerosis peritonectomy Enterolysis peritoneal dialysis Tamoxifen Corticosteroids

phloem-Mobile AuxlIAA Transcripts Target to the Root Tip and Modify Root Architecture

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journal of Integrative plant Biology 2012年第10期54卷 760-772页

作者： Michitaka Notaguchi Shmuel wolf William j.Lucas Department of plant Biology College of Biological SciencesUniversity of CaliforniaDavisCA 95616USA jST ERATO Higashiyama Live-Holonics project Nagoya UniversityFuro-choChikusa-kuNagoyaauAichi 464-8602Japan The Robert H.Smith Institute of plant Sciences and Genetics in Agriculture and the Otto Warburg Minerva Center for Agricultural Biotechnology The Hebrew University of JerusalemThe Robert H.Smith Faculty of AgricultureFood and EnvironmentRehovot 76100Israel

In plants, the phloem is the component of the vascular system that delivers nutrients and transmits signals from mature leaves to developing sink tissues. Recent studies have identified proteins, mRNA, and small RNA within the phloem sap of several plant species. It is now of considerable interest to elucidate the biological functions of these potential long-distance signal agents, to further our understanding of how plants coordinate their developmental programs at the whole-plant level. In this study, we developed a strategy for the functional analysis of phloem-mobile mRNA by focusing on IAA transcripts, whose mobility has previously been reported in melon （Cucumis melo cv. Hale＇s Best jumbo）. Indoleacetic acid （IAA） proteins are key transcriptional regulators of auxin signaling, and are involved in a broad range of developmental processes including root development. We used a combination of vasculature-enriched sampling and hetero-grafting techniques to identify IAA18 and IAA28 as phloemmobile transcripts in the model plant Arabidopsis thaliana. Micro-grafting experiments were used to confirm that these IAA transcripts, which are generated in vascular tissues of mature leaves, are then transported into the root system where they negatively regulate lateral root formation. Based on these findings, we present a model in which auxin distribution, in combination with phloem-mobile Aux/IAA transcripts, can determine the sites of auxin action.

关键词： Arabidopsis AUX/IAA lateral root development grafting phloem-mobile transcript.

Assessing the impact of heavy rainfall on the Newcastle upon Tyne transport network using a geospatial data infrastructure

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Resilient Cities and Structures 2023年第2期2卷 24-41页

作者： Kristina wolf Richard j.Dawson jon p.Mills phil Blythe Craig Robson jeremy Morley Newcastle University Newcastle upon Tyne NE17RU Tyne and WearUK Tyndall Centre for Climate Change Research Newcastle upon Tyne NE17RU Tyne and WearUK Ordnance Survey Explorer HouseAdanac DriveSouthampton SO160AS HampshireUK

Extreme weather conditions can adversely impact transport networks and driver behaviour,leading to variations in traffic volumes and travel times and increased accident *** services that need to navigate to an accident site in the shortest possible time require real-time location-based weather and traffic information to coordinate their *** therefore require historical and high-resolution temporal real-time data to identify districts and roads that are prone to different types of incidents during inclement weather and to better support emergency services in their ***,real-time assessment of the current transport network requires a dense sensor network that can provide high-resolution data using internet-enabled *** this research,we demonstrate how we obtain historical time-series and real-time data from sensors oper-ated by the Tyne and Wear Urban Traffic and Management Control Centre and the Urban Observatory based at Newcastle upon Tyne,*** the study,we assess the impact of rainfall on traffic volume and travel time,and the cascading impacts during a storm event in Newcastle during early October *** also estimate the economic cost of the storm,with regards to transport disruption,as the cost of travel,using the“value of time”based on Department for Transport guidelines(2021).Using spatial-temporal analysis,we chose three locations to demonstrate how traffic parameters varied at different times throughout the *** identified increases in travel times of up to 600%and decreases in traffic volume of up to 100%when compared to historical ***,we assessed cascading impacts at important traffic locations and their broader implications for city *** estimated that the storm’s economic impact on one sensor location increased by up to 370%of the reference *** analysing historical and real-time data,we detected and explained patterns in the data that would have remained uncovered if they had been e

关键词： Rainfall Cascading impacts IoT Smart city Geospatial data infrastructure

Fertility and sexual life of men after their forties and in older age

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Asian journal of Andrology 2001年第1期3卷 1-7页

作者： wolf-Bernhard Schill Department of Dermatoloyg and Andrology Hessian Center of Reprocuctive Medicine Justus Liebig University Giessen Germany

Owing to the demographic development, the aging male will require more consideration in future. In contrast to arapid decline of estradiol during menopause in women, the process of aging in the male is retarded and subject to highindividual variations. Impairment of spermatogenesis is observed as a continuous process occurring over decades. How-ever, only about 50% of men in their eighties show complete loss of fertility. In principle, spermatogenesis may be re-tained well into senescence. Of importance for the individual health condition is the fact that the number of Leydig cellsdeclines with advancing age. Thus, altered sex hormone concentrations in aging men result from both functional distur-bances and a gradual reduction in Leydig cells. Furthermore, an impaired feed-back mechanism of the pituitary-gonadalaxis occurs, with disappearance of the circadian testosterone (T) rhythm. LH and FSH levels are increased, and a re-duced bioavailability of sex hormones is observed. Lower total testosterone concentrations in men over 60 years are ac-companied by clinical signs of reduced virility, such as decreased muscle mass and strength as well as reduced sexualhair growth and libido. An age-related decline in androgen secretion and plasma testosterone levels therefore suggeststhe use of androgen supplementation. However, there is a lack of risk-benefit long-term studies. Increased research inthe male is mandatory to meet the requirements of the aging population. This should include the availability of preciseepidemiological data about the frequency of partial androgen deficiency in aging males (pADAM).(Asian j Androl 2001 Mar; 3: 1-7)

关键词： aging spermatogenesis androgens testosterone supplementation

Dynamics and functions of E‑cadherin complexes in epithelial cell and tissue morphogenesis

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Marine Life Science & Technology 2023年第4期5卷 585-601页

作者： Na Zhang Matthias Häring Fred wolf jörg Großhans Deqing Kong Department of Biology Philipps University35043 MarburgGermany Göttingen Campus Institute for Dynamics of Biological Networks(CIDBN) Georg August University Göttingen37073 GöttingenGermany

Cell–cell adhesion is at the center of structure and dynamics of epithelial tissue.E-cadherin–catenin complexes mediate Ca^(2+)-dependent trans-homodimerization and constitute the kernel of adherens *** the basic function of cell–cell adhesion,recent progress sheds light the dynamics and interwind interactions of individual E-cadherin–catenin complex with E-cadherin superclusters,contractile actomyosin and mechanics of the cortex and *** nanoscale architecture of E-cadherin complexes together with cis-interactions and interactions with cortical actomyosin adjust to junctional tension and mechano-transduction by reinforcement or weakening of specific features of the *** post-translational modifications such as phosphorylation and glycosylation have been implicated,their role for specific aspects of in E-cadherin function has remained ***,we provide an overview of the E-cadherin complex in epithelial cell and tissue morphogenesis focusing on nanoscale architectures by super-resolution approaches and post-translational modifications from recent,in particular in vivo,***,we review the computational modelling in E-cadherin complexes and highlight how computational modelling has contributed to a deeper understanding of the E-cadherin complexes.

关键词： Nanoscale architectures phosphorylation Glycosylation Computational modelling

Investigation of environmental and land use impacts in forested permafrost headwaters of the Selenga-Baikal river system,Mongolia-Effects on discharge,water quality and macroinvertebrate diversity

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International Soil and Water Conservation Research 2021年第4期9卷 605-619页

作者： Martin pfeiffer Georg Küstner Erdenetsetseg Erdenesukh wolf von Tümpling jürgen Hofmann Department of Biogeography University of BayreuthUniversitätsstraße 3095447 BayreuthGermany Department of Aquatic Ecosystem Analysis and Management(ASAM) Helmholtz Centre for Environmental Research-UFZBrückstraße 3a39114 MagdeburgGermany Department of Ecology National University of MongoliaBaga toiruu 47Ulaanbaatar 210646Mongolia Department of Animal Ecology and Tropical Biology BiocenterJulius-Maximilians-Universität WürzburgAm Hubland97074 WürzburgGermany National Dong Hwa University No.1Sec.2Da Hsueh Rd.ShoufengHualien 97401Taiwan Central Laboratory for Water Analytics&Chemometrics Helmholtz Centre for Environmental Research-UFZBrückstrasse 3a39114 MagdeburgGermany Büro für Integrierten Gewässerschutz-BiG Werner-Voß-Damm 54 b12101 BerlinGermany

Headwater streams play a major role for provision of ecosystem services,*** *** investigated a high-altitude headwater catchment of the Kharaa River(including 411st-order rivers)to understand the impact of land cover(especially forest cover),environment and human usage on runoff,chemical water quality and macroinvertebrate fauna in a river basin under discontinuous permafrost conditions in an arid,sparsely populated region of *** verify our hypotheses that different landuses and environmental impacts in permafrost headwaters influence water quality,we investigated 105 sampling sites,37 of them at intermittent stream sections without water *** was positively impacted by land cover types steppe,grassland and forest and negatively by shrubland,forest burnt by wild fires(indicating a reduction of permafrost)and *** quality was affected by altitude,longitude and latitude,shrub growth and water *** diversity of macroinvertebrates was driven by water temperature,iron content of the water,flow velocity,and subbasin size(adjusted R^(2)=0.54).Sample plots clustered in three groups that differed in water chemistry,macroinvertebrate diversity,species composition and *** study confirms that steppes and grasslands have a higher contribution to runoff than forests,forest cover has a positive impact on water quality,and diversity of macroinvertebrates is higher in sites with less nutrients and *** excellent ecological status of the upper reaches of the Kharaa is severely threatened by forest fires and human-induced climate change and urgently needs to be conserved.

关键词： Ecosystem services Ephemeroptera-plecoptera-Trichoptera (EpT)complex GIS-based analysis IWRM-MoMo project Land use land cover(LULC) Natural reference state Runoff Self-purification capacity Stream water chemistry

Data-driven prediction of plate velocities and plate deformation of explosive reactive armor

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Defence Technology（防务技术） 2022年第12期18卷 2141-2149页

作者： Marvin Becker Andreas Klavzar Thomas wolf Melissa Renck Institute of Saint-Louis 5 Rue du Général Cassagnou68330Saint LouisCedexFrance Ecole Centrale de Lille CitéScientifique59651Villeneuve d'AscqCedexFrance

Explosive reactive armor(ERA)is currently being actively developed as a protective system for mobile devices against ballistic threats such as kinetic energy penetrators and shaped-charge *** mobility,the aim is to design a protection system with a minimal amount of required *** efficiency of an ERA is sensitive to the impact position and the timing of the ***,different designs have to be tested for several impact scenarios to identify the best *** analytical models are not predicting the behavior of the ERA accurately enough and experiments,as well as numerical simulations,are too time-consuming,a data-driven model to estimate the displacements and deformation of plates of an ERA system is proposed *** ground truth for the artificial neural network(ANN)is numerical simulation results that are validated with *** ANN approximates the plate positions for different materials,plate sizes,and detonation point positions with sufficient accuracy in *** a future investigation,the results from the model can be used to estimate the interaction of the ERA with a given ***,a measure for the effectiveness of an ERA can be ***,an optimal ERA can be designed and analyzed for any possible impact scenario in negligible time.

关键词： Artificial neural network Explosive reactive armor Finite element simulation particle simulation Flash X-ray

COmbination of Targeted temperature management and Thrombectomy after acute Ischemic Stroke(COTTIS):a pilot study

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Stroke & Vascular Neurology 2024年第3期9卷 258-267页

作者： jürgen Bardutzky Rainer Kollmar Forat Al-Rawi johann Lambeck Mohammad Fazel Christian Taschner wolf-Dirk Niesen Department of Neurology and Neurophysiology Medical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburgGermany Neurology and Neurointensive Care Darmstadt HospitalDarmstadtGermany BrainCool AB LundSweden Department of Neuroradiology Medical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburgGermany

Background To evaluate the feasibility and safety of a fast initiation of cooling to a target temperature of 35℃by means of transnasal cooling in patients with anterior circulation large vessel occlusion(LVO)undergoing endovascular thrombectomy(EVT).Methods patients with an LVO onset ofpatient was intubated for EVT and continued until an oesophageal target temperature of 35℃was *** was maintained with surface cooling for 6-hour postrecanalisation,followed by active rewarming(+0.2℃/hour).The primary outcome was defined as the time required to reach 35℃,while secondary outcomes comprised clinical,radiological and safety *** Twenty-two patients(median age,77 years)were included in the study(14 received additional thrombolysis,4 additional stenting of the proximal internal carotid artery).The median time intervals were 309min for last-seen-normal-to-groin,58min for door-to-cooling-initiation,65min for door-to-groin and 123min for *** target temperature of 35℃was reached within 30min(range 13–78min),corresponding to a cooling rate of 2.6℃/*** recanalisation,86%of the patients had a body temperature of≤35℃.The median National Institutes of Health Stroke Scale at admission was 15 and improved to 2 by day 7,and 68%of patients had a good outcome(modified Rankin Scale 0–2)at 3 *** complications included asymptomatic bradycardia(32%),pneumonia(18%)and asymptomatic haemorrhagic transformation(18%).Conclusion The combined application of hypothermia and thrombectomy was found to be feasible in sedated and ventilated *** events were comparable to those previously described for EVT in the absence of *** effect of this procedure will next be evaluated in the randomised COmbination of Targeted temperature management and Thrombectomy after acute Ischemic Stro

关键词： maintained continued initiated