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pharmacological Tie2 activation in kidney transplantation

World journal of Transplantation 2016年第3期6卷 573-582页

作者： Kristina Thamm Florence Njau paul Van Slyke Daniel j Dumont joon-Keun park hermann Haller Sascha David Department of Nephrology and Hypertension Medical School Hannover Vasomune Therapeutics Inc Biological Sciences Sunnybrook Research Institute

AIM To investigate the therapeutic potential of vasculotide(VT)- a Tie2 activating therapeutic- in kidney *** We performed a murine MHC-mismatched renal transplant model(C57Bl/6 male into Balb/c female) with 60 min cold and 30 min warm ischemia time. 500 ng VT was administered i.p. to donor mice 1 h before organ removal. In addition, recipients received 500 ng VT i.p. directly and 3 d after surgery. Survival was monitored and remaining animals were sacrificed 28 d after transplantation. In this model, we analyzed:(1) organ function;(2) Kaplan-Meier survival;(3) organ damage(periodic acid Schiff staining) via semi-quantitative scoring [0-4(0 = no injury/inflammation to 4 = very severe injury/inflammation)];(4) expression of renal endothelial adhesion molecules(ICAM-1) viaimmunofluorescence(IF) staining, immunoblotting and q pCR;(5) infiltration of inflammatory cells(IF Gr-1, F4/80); and(6) fibrosis via staining of α-smooth muscle actin(αSMA), Sirius red staining and immunoblotting of SMAD3 *** Exogenous activation of Tie2 with VT resulted in diminished expression of peritubular and glomerular endothelial adhesion molecules. Consequently, infiltration of inflammatory cells(analyzed as ICAM-1, Gr-1 and F4/80 positive cells) was reduced in VT-treated mice compared to controls. Additionally, VT was protective against fibrogenesis after kidney transplantation. Trends towards lower serum creatinine(vehicle: 142 ± 17 μmol/L vs VT: 94 ± 23 μmol/L), urea(vehicle: 76 ± 5 mmol/L vs VT: 60 ± 8 mmol/L) and lactate dehydrogenase(vehicle: 1288 ± 383 iU vs VT: 870 ± 275 iU) were observed on day 6 after transplantation. Kaplan-Meier survival analysis showed improved survival rates in the VT-treated mice that did not reach statistical significance(27% vs 54%, p = 0.24, n = 11 per group). Exogenous activation of Tie2 via VT might reduce infiltration of inflammatory cells into renal tissue thereby protecting the transplant from early graft dysfunction

关键词： Vasculotide Tie2 Kidney transplantation Endothelium Angiopoietin

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高炉生产完全自动化——仅仅是展望吗?

高炉生产完全自动化——仅仅是展望吗?

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2001中国钢铁年会

作者： Guenther Brunnbauer Franz Lasinger Dr. Bernhard Rummer j. Mauhart H.Nogratnig hermann Druckenthaner Bernhard Schuerz Dr. Martin Schaler Dr. Angelika Klinger Gerhard pillmair 奥钢联林茨钢厂奥钢联林茨钢厂奥钢联林茨钢厂奥钢联林茨钢厂奥钢联林茨钢厂奥钢联工程技术公司（VAI）奥钢联工程技术公司（VAI）奥钢联工程技术公司（VAI）奥钢联工程技术公司（VAI）奥钢联工业服务公司（VAIS）

工程设计公司奥钢联工程技术公司（VAI）和钢铁生产企业奥钢联林茨钢厂共同开发了一套闭环高炉自动化系统,在VAiron商标下进行市场推广。目前该系统方案正在后者的主要高炉车间运行。它基于先进的工艺模型、人工智能、巩固的软件应用、...

工程设计公司奥钢联工程技术公司（VAI）和钢铁生产企业奥钢联林茨钢厂共同开发了一套闭环高炉自动化系统,在VAiron商标下进行市场推广。目前该系统方案正在后者的主要高炉车间运行。它基于先进的工艺模型、人工智能、巩固的软件应用、图表和使用者界面反操作诀窍。VAiron针对所有高炉运行过程中有可能产生的工艺条件进行连续和完全的诊断,内接的闭环控制系统在必要时执行纠正任务。决策过程的详细描述确保了充分透明的运行条件。由此达到了完全自动化和稳定的高炉生产,稳定的铁水质量及大幅降低的生产成本。

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The interplay between (electro)chemical and (chemo)mechanical effects in the cycling performance of thiophosphate-based solid-state batteries

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Materials Futures 2022年第1期1卷 122-134页

作者： jun Hao Teo Florian Strauss Felix Walther Yuan Ma Seyedhosein payandeh Torsten Scherer Matteo Bianchini jürgen janek Torsten Brezesinski Battery and Electrochemistry Laboratory Institute of NanotechnologyKarlsruhe Institute of Technology(KIT)Hermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany Institute of physical Chemistry&Center for Materials Research Justus-Liebig-University GiessenHeinrich-Buff-Ring 1735392 GiessenGermany KNMF Laboratory for Micro-and Nanostructuring Institute of NanotechnologyKarlsruhe Institute of Technology(KIT)Hermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany BASF SE Carl-Bosch-Str.3867056 LudwigshafenGermany

Solid-state batteries(SSBs)are a promising next step in electrochemical energy storage but are plagued by a number of *** this study,we demonstrate the recurring issue of mechanical degradation because of volume changes in layered Ni-rich oxide cathode materials in thiophosphate-based ***,we explore superionic solid electrolytes(SEs)of different crystallinity,namely glassy 1.5Li_(2)S-0.5p_(2)S_(5)-LiI and argyrodite Li_(6)pS_(5)Cl,with emphasis on how they affect the cyclability of slurry-cast cathodes with NCM622(60%Ni)or NCM851005(85%Ni).The application of a combination of ex situ and in situ analytical techniques helped to reveal the benefits of using a SE with a low Young’s *** a synergistic interplay of(electro)chemical and(chemo)mechanical effects,the glassy SE employed in this work was able to achieve robust and stable interfaces,enabling intimate contact with the cathode material while at the same time mitigating volume *** results emphasize the importance of considering chemical,electrochemical,and mechanical properties to realize long-term cycling performance in high-loading SSBs.

关键词： solid-state battery slurry casting lithium thiophosphate electrolyte Ni-rich NCM cathode degradation

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Investigation of human organoid retina with digital holographic transmission matrix measurements

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Light(Advanced Manufacturing) 2022年第2期3卷 33-47页

作者： Nektarios Koukourakis Felix Wagner Stefan Rothe Mike O.Karl jürgen W.Czarske Laboratory for Measurement and Sensorsystem Technique TU DresdenDresdenGermany Competence Center for Biomedical Laser Systems(BIOLAS) TU DresdenDresdenGermany Center for Regenerative Therapies Dresden(CRTD) TU DresdenDresdenGermany German Center for Neurodegenerative Diseases(DZNE)Dresden DresdenGermany Faculty of physics TU DresdenDresdenGermany Excellence Cluster physics of Life(poL) TU DresdenDresdenGermany

Advanced manufacturing of retinal organoid samples from human induced pluripotent stem cells represents a promising way to study the development of retinal *** retina is an epithelium composed of different cell layers with unique optical properties and detects light by photoreceptor neurons for visual *** are still many challenges in detecting early and distinct cellular changes in retinal *** this paper,we study the capability of the optical transmission matrix,which fully describes the transition of a light field propagating through a scattering *** its rich information content,the transmission matrix is commonly just used for light delivery through scattering *** holography is employed to measure the complex light-field information of the transmitted *** demonstrate that singular value decomposition of the transmission matrix allows to discriminate phantom tissues with varying scattering *** apply these findings to retinal organoid *** of the protonophore carbonyl cyanide m-chloro-phenylhydrazone(CCCp),a known inducer of retinal damage in animals,caused cell death and structural changes in human retinal organoids,which resulted in distinct changes in the transmission *** data indicate that the analysis of the transmission matrix can distinguish pathologic changes of the retina towards the development of imaging-based biomarkers.

关键词： Transmission matrix Digital holography Retina Organoids Neurodegeneration Cell death

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Remarkable catalysis of spinel ferrite XFe2O4(X=Ni,Co,Mn,Cu,Zn)nanoparticles on the dehydrogenation properties of LiAlH_(4):An experimental and theoretical study

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journal of Materials Science & Technology 2022年第16期111卷 189-203页

作者： Sheng Wei jiaxi Liu Yongpeng Xia Huanzhi Zhang Riguang Cheng Lixian Sun Fen Xu pengru Huang Federico Rosei Aleskey A.pimerzin Hans jüergen Seifert Hongge pan School of Material Science&Engineering Guangxi Key Laboratory of Information Materials and Guangxi Collaborative Innovation Center of Structure and Property for New Energy and MaterialsGuilin University of Electronic TechnologyGuilin 541004China School of Mechanical&Electrical Engineering Guilin University of Electronic TechnologyGuilin 541004China CentreÉnergie Matériaux et TélécommunicationsInstitut National de la Recherche Scientifique1650 Boul.Lionel BouletVarennesJ3×1S2QuébecCanada Samara State Technical University Samara443100Russia Institute for Applied Materials Karlsruhe Institute of TechnologyHermann von Helmholtz Platz 176344 Eggenstein LeopoldshafenGermany School of New Energy Science and Technology Xi’an Technological UniversityXi’an 710021China

Safe,compact,lightweight and cost-effective hydrogen storage is one of the main challenges that need to be addressed to effectively deploy the hydrogen ***_(4),as a solid-state hydrogen storage material,presents several advantages such as high hydrogen storage capacity,low price and abundant ***,neither thermodynamic nor kinetic properties of dehydrogenation for LiAlH_(4)can fulfill the requirements of practical ***,a series of spinel ferrite nanoparticles such as XFe_(2)O_(4)(X=Ni,Co,Mn,Cu,Zn,Fe)were prepared by using the modified thermal decomposition method,and then doped into LiAlH_(4)by using ball *** results show that LiAlH_(4)doped with 7 wt%NiFe_(2)O_(4)starts to release hydrogen at 69.1°C,and the total amount of hydrogen released is 7.29 wt%before 300°*** activation energies of the two-step hydrogen release reactions of LiAlH_(4)doped with 7 wt%NiFe_(2)O_(4)are 42.32 kj mol^(-1)and 71.42 k j mol,which are 59.0%and 63.6%lower than those of as-received LiAlH_(4),*** the density functional theory(DFT)calculations,we reveal that both the presence of Ni FeOand in-situ formed AlNiin ball-milling decrease the desorption energy barrier of Al-H bonding in LiAlH_(4)and accelerate the breakdown of Al-H bonding through the interfacial charge transfer and the dehybridization of the Al-H ***,the experimental and theoretical results open a new avenue toward designing high effective catalysts applied to LiAlH_(4)as a candidate for hydrogen storage.

关键词： Hydrogen storage Lithium aluminum Spinel ferrite nanoparticles

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传统的封装技术与新型的无键合丝的烧结功率模块的性能比较

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电力电子 2011年第5期9卷 51-54页

作者： p.Beckedahl M.hermann M.Kind M.Knebel j.Nascimento A.Wintrich 王培清 Semikron Elektronik GmbH & Co.KG Germany 清华大学

功率模块的封装受日益增加的需求所驱动,它要求提高功率密度,改进可靠性和进一步降低成本。已知传统软钎焊连接和键合丝的可靠性限制了有效功率密度的增加,功率密度的增加使得较高结温和将来宽带隙器件的利用成为可能。银烧结今天已经... 详细信息

功率模块的封装受日益增加的需求所驱动,它要求提高功率密度,改进可靠性和进一步降低成本。已知传统软钎焊连接和键合丝的可靠性限制了有效功率密度的增加,功率密度的增加使得较高结温和将来宽带隙器件的利用成为可能。银烧结今天已经开始取代从芯片到DBC基板的软焊连接,留下了一个主要的可靠性瓶颈:芯片顶部接触面的键合丝。消除了功率模块的键合丝在工业界和学术界已经讨论了好几年。大多数新的封装方法是基于软钎焊连接和嵌入式互联技术。本论文提供的新型封装技术(SKiN技术)详细叙述银烧结连接正在扩大应用到所有的剩余的现代功率模块的互连中去。除了功率芯片双面烧结外,整个DBC板烧结到散热器上。与传统的封装技术相比,最终器件具有很高的功率密度并显示出了卓越的热、电和可靠性性能。

关键词：封装技术烧结功率传统软钎焊连接

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肖邦练习曲

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2001年

作者：（波）肖邦曲）（）埃瓦尔德·齐默尔曼（Ewald Zimmermann）版本编订（）赫尔曼·凯勒（hermann Keller）指法编订

本曲谱内容包括：“练习曲OpUS 10 献于F·李斯特”、“练习曲OpUS 25 献于古尔伯爵夫人”等。

ISBN: (纸本)7103024138

本曲谱内容包括：“练习曲OpUS 10 献于F·李斯特”、“练习曲OpUS 25 献于古尔伯爵夫人”等。

关键词：钢琴练习曲波兰

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引导幻想与肌肉松弛在常规结肠直肠切除术中的应用:一项随机、对照、半盲试验

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世界核心医学期刊文摘（胃肠病学分册） 2006年第3期2卷 31-31页

作者： Haase O. Schwenk W. hermann C. Müller j.M. 廖新华 Klinik Allgemein- Visceral- Geffl-undur Thoraxchirurgie Universitre Medizin Berlin Campus CharitéMitte Schumannstrasse 20/21 D-10117 Berlin Germany.Dr

pURpOSE: The aim of this study was to investigate whether brief psychologic interventions to reduce perioperative stress may improve the postoperative course of patients undergoing abdominal surgery. METHODS: We used a randomized, controlled, partially blinded trial to evaluate the differential effectiveness of two brief psychologic interventions (guided imagery and progressive muscle relaxation) on analgesic requirement, pain perception, pulmonary function, duration of postoperative ileus, and fatigue after conventional resection of colorectal carcinoma in elderly cancer patients. RESULTS: Sixty patients (20 guided imagery, 22 relaxation, 18 control) were evaluated. Acceptance of the brief psychologic interventions was high and 90 percent of the patients indicated that they would recommend it to other patients. Analgesic consumption (p = 0.6) and subjective pain intensity at rest (p = 0.3) and while coughing (p = 0.3) were not different between groups. Recovery of pulmonary function, duration of postoperative ileus, and subjective postoperative fatigue were also not influenced. When the data from intervention groups were pooled, again no benefits were detected compared with the control group. CONCLUSIONS: Brief psychologic interventions such as guided imagery and relaxation yielded a very positive patient response but did not show a clinically relevant influence on the postoperative physiologic course of elderly patients undergoing conventional resections of colorectal cancer.

关键词：结肠直肠切除术肌肉松弛结肠直肠癌半盲手术期间疼痛感受术后肠梗阻腹部手术生理学过程功

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3.0 Tesla vs 1.5 Tesla breast magnetic resonance imaging in newly diagnosed breast cancer patients

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World journal of Radiology 2013年第8期5卷 285-294页

作者： Reni S Butler Christine Chen Reena Vashi Regina j Hooley Liane E philpotts Department of Diagnostic Radiology Yale University School of Medicine Department of Diagnostic Radiology Memorial Hermann Healthcare System

AIM:To compare 3.0 Tesla(T) vs 1.5T magnetic resonance(MR) imaging systems in newly diagnosed breast cancer ***:Upon Institutional Review Board approval,a Health Insurance portability and Accountability Actcompliant retrospective review of 147 consecutive 3.0T MR examinations and 98 consecutive 1.5T MR examinations in patients with newly diagnosed breast cancer between 7/2009 and 5/2010 was *** patients who underwent neoadjuvant chemotherapy in the 3.0T group were *** occult suspicious lesions(BIRADS Code 4 and 5) additional to the index cancer in the ipsilateral and contralateral breast were *** characteristics and pathologic diagnoses were recorded,and results achieved with both systems *** significance was analyzed using Fisher’s exact ***:In the 3.0T group,206 suspicious lesions were identified in 55%(75/136) of patients and 96%(198/206) of these lesions were *** the 1.5T group,98 suspicious lesions were identified in 53%(52/98) of patients and 90%(88/98) of these lesions were *** results yielded additional malignancies in 24% of patients in the 3.0T group vs 14% of patients in the 1.5T group(33/136 vs 14/98,p = 0.07).Average size and histology of the additional cancers was *** patients who had a suspicious MR imaging study,additional cancers were found in 44% of patients in the 3.0T group vs 27% in the 1.5T group(33/75 vs 14/52,p = 0.06),yielding a higher positive predictive value(ppV) for biopsies performed with the 3.0T ***:3.0T MR imaging detected more additional malignancies in patients with newly diagnosed breast cancer and yielded a higher ppV for biopsies performed with the 3.0T system.

关键词： Breast Breast cancer Cancer staging Outcome Magnetic resonance imaging Breast magnetic resonance imaging 3 Tesla Technical

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结肠镜、高分辨力超声和台式MRI技术在小鼠急性结肠炎模型中的应用

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国际医学放射学杂志 2015年第6期 608-608页

作者： j.Walldorf M.hermann M.porzner S.pohl H.Metz K.Mder 陈丽华 Department of Internal Medicine I Martin Luther University Halle-Wittenberg

摘要目的建立和评估(彩色多普勒)高分辨力超声(hr US)和台式MRI(bt MRI)作为一种新的方法来监测实验性结肠炎。材料与方法对不伴有结肠炎小鼠(n=15),伴有急性

关键词： MRI US 急性结肠炎高分辨力超声小鼠小家鼠

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