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心血管MRI评估主动脉瓣狭窄病人的主动脉弹性:比较二叶型和三叶型主动脉瓣

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国际医学放射学杂志 2019年第4期 495-495页

作者：于洋 A.Singh M.A.Horsfield S.Bekele j.p.greenwood D.K.Dawson C.Berry Department of Cardiovascular Sciences University of Leicester and Cardiovascular Theme NIHR Leicester Biomedical Research Centre Glenfield Hospital

摘要目的比较二叶型主动脉瓣(BAV)和三叶型主动脉瓣(TAV)的主动脉瓣狭窄(AS)病人在MRI上的主动脉大小和弹性参数。方法 174例无症状中-重度AS病人[平均

关键词：主动脉瓣狭窄 MRI 主动脉弹性心血管

急性心肌梗死后行心血管MRI的时间选择对评估梗死特点及预测心室重构的影响

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国际医学放射学杂志 2011年第6期 588-588页

作者： A.N.Mather T.A.Fairbairn N.j.Artis j.p.greenwood S.plein 王霁朏 Multidisciplinary cardiovascular research centre Division of Cardiovascular and Neuronal RemodellingLeeds Institute of GeneticsHealth and TherapeuticsUniversity of LeedsG-floorJubilee WingLeeds General InfirmaryGreat George StreetLeeds LS1 3EXEngland

目的用心血管MRI研究心肌梗死的演变特点,评估急性心肌梗死后2d及1周的心血管MRI数据,哪个能更好地预测梗死3个月后的梗死面积及左室功能。材料与方法本研究经当地研究伦理委员会审查批准,并获得病人的书面知情同意书。再灌注的急性心... 详细信息

目的用心血管MRI研究心肌梗死的演变特点,评估急性心肌梗死后2d及1周的心血管MRI数据,哪个能更好地预测梗死3个月后的梗死面积及左室功能。材料与方法本研究经当地研究伦理委员会审查批准,并获得病人的书面知情同意书。再灌注的急性心肌梗死48例,分别在发病后

关键词：心肌梗死后心血管 MRI

Sediment generation and soil mound denudation in areas of high-density tree throw along a river valley in the jura Mountains, Switzerland

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journal of Mountain Science 2021年第2期18卷 377-391页

作者： philip greenwood jan BAUER Nikolaus j KUHN physical Geography&Environmental Change Research Group Department of Environmental SciencesUniversity of BaselKlingelbergstrasse 27Basel-4056Switzerland

A preliminary field-based investigation was undertaken in a small(<10 km^(2))river valley located in the mountainous jura region of northwest *** aims of the work were to assess sediment generation and annual sediment... 详细信息

A preliminary field-based investigation was undertaken in a small(jura region of northwest *** aims of the work were to assess sediment generation and annual sediment transport rates by tree throw on forested hillslopes,and to document surface hydrology characteristics on four fresh soil mounds associated with recent tree throws over a 24-day monitoring *** the soil mounds,average sediment recovery ranged from 7.7-28.2 g(dry weight),equivalent to a suspended sediment concentration of 145.2-327.8 g L^(-1),and runoff coefficients ranged from 1.0%-4.2%.Based on a soil bulk density value of 1,044 kg m^(-3),upslope runoff generation areas were denuded by an average 0.14 mm by the end of the 24-day monitoring period,representing an erosion rate equivalent to 2.1 mm yr^(-1).A ca.50 cm high soil mound could therefore feasibly persist for around 200-250 *** tree throw work,the dimensions of 215 individual tree throws were measured and their locations mapped in 12 separate locations along the river valley representing a cumulative area equivalent to 5.3 ha(***,43 per ha).Tree throws generated a total of 20.1 m^(3) of fine-sediment(process of tree throw was originally attributed to two extreme weather events that occurred in west and central Europe in late December *** the 18-year period since both storms,this represents an annual sediment transport rate of 2.7×10^(-5) m^(3) m^(-1) yr^(-1).Exploring the relationship with wind on fall direction,65.5%of tree throws(143)generally fell in a downslope direction irrespective of hillslope aspect on which they were *** infers that individual storms may not have been responsible for the majority of tree throws,but instead,could be associated with root *** the high density of tree throws and their relative maturity(average age 41 years),we hypothesise that once tr

关键词： Tree throw Hillslope processes Sediment generation mechanism Sediment transport rate Soil mound Ibach river valley

Effect of Genome-Wide Genotyping and Reference panels on Rare Variants Imputation

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journal of Genetics and Genomics 2012年第10期39卷 545-550页

作者： Hou-Feng Zheng Martin Ladouceur Celia M.T. greenwood j. Brent Richards Department of Medicine Human Genetics McGill University Montreal Quebec H3T 1E2 Canada Department of Epidemiology and Biostatistics Lady Davis Institute for Medical Research Jewish General Hospital Montreal Quebec H3T 1E2 Canada Research Center of Montreal Heart Institute Montreal Quebec HIT 1C8 Canada Department of Oncology McGill University Montreal Quebec H3T IE2 Canada Twin Research and Genetic Epidemiology King's College London London SE1 7EH United Kingdom

Common variants explain little of the variance of most common disease, prompting large-scale sequencing studies to understand the contribution of rare variants to these diseases. Imputation of rare variants from genome-wide genotypic arrays offers a cost-efficient strategy to achieve necessary sample sizes required for adequate statistical power. To estimate the performance of imputation of rare variants, we imputed 153 individuals, each of whom was genotyped on 3 different genotype arrays including 317k, 610k and 1 million single nucleotide polymorphisms （SNps）, to two different reference panels： HapMap2 and 1000 Genomes pilot March 2010 release （1KGpilot） by using IMpUTE version 2. We found that more than 94% and 84% of all SNps yield acceptable accuracy （info 〉 0.4） in HapMap2 and 1KGpilot-based imputation, respectively. For rare variants （minor allele frequency （MAF）〈5%）, the proportion of well- imputed SNps increased as the MAF increased from 0.3% to 5% across all 3 genome-wide association study （GWAS） datasets. The proportion of well-imputed SNps was 69%, 60% and 49% for SNps with a MAF from 0.3% to 5% for 1M, 610k and 317k, respectively. None of the very rare variants （MAF 〈 0.3%） were well imputed. We conclude that the imputation accuracy of rare variants increases with higher density of genome-wide genotyping arrays when the size of the reference panel is small. Variants with lower MAF are more difficult to impute. These findings have important implications in the design and replication of large-scale sequencing studies.

关键词： Genotype imputation Genome-wide association study 1000 Genome project HapMap Rare variant Common disease

Cattle behaviour classification from collar, halter, and ear tag sensors

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Information processing in Agriculture 2018年第1期5卷 124-133页

作者： A.Rahman D.V.Smith B.Little A.B.Ingham p.L.greenwood G.j.Bishop-Hurley Analytics program Data61CSIROAustralia productive and Adaptive Livestock Systems Agriculture and FoodCSIROAustralia NSW Department of primary Industries Beef Industry Centre Australia

In this paper,we summarise the outcome of a set of experiments aimed at classifying cattle behaviour based on sensor *** animal carried sensors generating time series accelerometer data placed on a collar on the neck at the back of the head,on a halter positioned at the side of the head behind the mouth,or on the ear using a *** purpose of the study was to determine how sensor data from different placement can classify a range of typical cattle *** were collected and animal behaviours(grazing,standing or ruminating)were observed over a common time *** features were computed from the sensor data and machine learning algorithms were trained to classify each *** accuracies were computed on separate independent test *** analysis based on behaviour classification experiments revealed that different sensor placement can achieve good classification accuracy if the feature space(representing motion patterns)between the training and test animal is *** paper will discuss these analyses in detail and can act as a guide for future studies.

关键词： Sensor data analytics Cattle behaviour classification Sensors for cattle behaviour tracking

Management of non-ST-segment elevation myocardial in-farction in patients aged≥80 years:a meta-analysis of ran-domized controlled trials

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journal of Geriatric Cardiology 2022年第10期19卷 789-790页

作者： Connor j Matthews joshua Kirby jonathan M Blaxill john p greenwood Abdul M Mozid jennifer A Rossington Murugapathy Veerasamy Nancy Wassef Stephen B Wheatcroft Heerajnarain Bulluck Yorkshire Heart Centre Leeds General InfirmaryLeeds Teaching Hospitals NHS TrustLeedsUnited Kingdom Leeds Institute of Cardiovascular and Metabolic Medicine University of LeedsLeedsUnited Kingdom

Coronary artery disease(CAD)is the major cause of morbidity and mortality in elderly patients.^([1])Despite this,elderly patients are under-represented in most trials of ***-ST-segment elevation myocardial infarction(NSTEMI)is a common cause of hospitalization among patients≥80 years of age,^([2])and with an aging global population,there is a pressing need to establish the optimal management strategy for these ***,we conducted a meta-analysis of all randomized control trials(RCTs)performed to date in patients≥80 years of age,comparing an initial invasive versus conservative strategy to provide insights into their optimal initial management strategy.

关键词： patients mortality analysis

Shifts in the Holstein dairy cow milk fat globule membrane proteome that occur during the first week of lactation are affected by parity

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journal of Animal Science and Biotechnology 2021年第2期12卷 534-548页

作者： Mallory C.Honan Megan j.Fahey Amanda j.Fischer-Tlustos Michael A.Steele Sabrina L.greenwood Department of Animal and Veterinary Sciences The University of VermontBurlingtonVT 05405USA Department of Animal Biosciences University of GuelphGuelphON N1G 2W1Canada Department of Agriculture Food&Nutritional ScienceUniversity of AlbertaEdmontonAB T6G 2P5Canada

Background:The milk fat globule membrane(MFGM)proteomes of colostrum and transition milk are rich sources of proteins that are likely important for neonatal calf *** addition,characterization of these proteomes could also yield valuable information regarding mammary gland physiology of the early postpartum lactating *** objectives of this research were to characterize the MFGM proteomes of colostrum and transition milk through sample collections at four timepoints postpartum,including the first milking(M1,colostrum),second milking(M2,transition milk),fourth milking(M4,transition milk),and fourteenth milking(M14,mature milk),and compare these proteomes between multiparous(Mp;n=10)and primiparous(pp;n=10)Holstein dairy *** MFGM proteins were labeled using Tandem Mass tagging and analyzed using liquid chromatography-tandem mass spectrometry(LC-MS/MS).protein identification was completed using MASCOT and Sequest in proteome Discoverer *** scaled abundance values were analyzed using pROC MIXED in SAS to determine the effects of milking(MIL),parity(pAR),and MIL×*** adaptive false-discovery rate(FDR)-adjusted p values were determined using pROC *** characterization and bioinformatic analysis were completed using a combination of pANTHER,Blast,and ***:A total of 104 common proteins were identified in each of the MFGM *** analysis revealed that 70.2%of identified proteins were affected by *** these,78.1%were lower in M14 compared with M1,including immune-related proteins lactotransferrin,lactadherin and *** affected 44.2%of *** the proteins affected by pAR,84.8%were higher in Mp cows compared with pp cows,including apolipoprotein E and histones 2A,2B,3,and 4 *** subfamily 1 member 1A and annexin 5 were higher in samples from pp ***×parity affected 32.7%of identified proteins,including lactotransferrin,gelsolin,vitamin D binding protein,and S100 ***

关键词： Colostrum LC-MS/MS parity

土-作物-大气系统中动态根系生长及水动力学模拟

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浙江大学学报（工学版） 2009年第11期43卷 2048-2053页

作者：杨德军张土乔 ZHANG Ke-feng greenwood Duncan j 郭帅浙江大学建筑工程学院浙江杭州310058 华威大学国际园艺研究中心英国沃里克CV359EF

针对土-作物-大气连续系统的土壤水动力学模型对根系动态生长的模拟不理想,通过引入最新的根系生长模型理论、根长密度分布函数以及联合国粮农组织推荐的计算蒸发及蒸腾总量的模型理论,与现有的模拟水土运动的有限元程序相耦合,建立模拟... 详细信息

针对土-作物-大气连续系统的土壤水动力学模型对根系动态生长的模拟不理想,通过引入最新的根系生长模型理论、根长密度分布函数以及联合国粮农组织推荐的计算蒸发及蒸腾总量的模型理论,与现有的模拟水土运动的有限元程序相耦合,建立模拟土-作物-大气系统的水动力学模型.基于荷兰实验农场的小麦实验数据的模拟结果表明,在不同时期、不同深度处土壤中水的体积分数与实验值比较吻合;由于降雨和蒸发的上边界影响,上部土壤中水的体积分数随时间变化较快;除接近地表的个别根长密度模拟点偏差较大外,总体来说根长及根长密度模拟结果与实验值比较吻合;蒸腾量和蒸发量的模拟结果可靠.建立的新模型合理,可以有效地模拟土-作物-大气系统中的根系生长及水动力学.

关键词：水动力学土-作物-大气系统根长密度分布有限元方法

properties of vapor-deposited and solution-processed targets for laser-driven inertial confinement fusion experiments

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Matter and Radiation at Extremes 2018年第6期3卷 312-321页

作者： D.R.Harding M.j.Bonino W.Sweet M.Schoff A.greenwood N.Satoh M.Takagi A.Nikroo Laboratory for Laser Energetics University of Rochester250 East River RoadRochesterNY 14623-1299USA Department of Chemical Engineering University of RochesterRochesterNY 14623-1299USA General Atomics 3550 General Atomics CourtSan DiegoCA 92121-1122USA Industrial Development Center Central Research LaboratoryHamamatsu Photonics K.K.Hamamatsu CityShizuoka Pref.431-1202Japan Institute of Laser Engineering Osaka University2e6 YamadaokaSuitaOsaka 565-0871Japan Lawrence Livermore National Laboratory P.O.Box 808LivermoreCA94550USA

Targets for low-adiabat direct-drive-implosion experiments on OMEGA must meet rigorous specifications and tight tolerances on the diameter,wall thickness,wall-thickness uniformity,and presence of surface *** these,restrictions on the size and number of defects(bumps and depressions)on the surface are the most *** properties of targets that are made using vapor-deposition and solution-based microencapsulation techniques are *** were characterized using confocal microscopy,bright-and dark-field microscopy,atomic force microscopy,electron microscopy,and *** technique has merits and limitations,and a combination of these techniques is necessary to adequately characterize a *** main limitation with the glow-discharge polymerization(GDp)method for making targets is that it produces hundreds of domes with a lateral dimension of 0.7-2 μ*** these targets reduces the size of some but not all domes,but it adds scratches and grooves to the ***-made polystyrene shells lack the dome features of GDp targets but have hundreds of submicrometer-size voids throughout the wall of the target;a few of these voids can be as large as~12 μm at the surface.

关键词： Vapor-deposition Direct-drive target OMEGA Target characterization Solution-based microencapsulation