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Treatment and prevention of epilepsy in onchocerciasis-endemic areas is urgently needed

Infectious Diseases of Poverty 2024年第1期13卷 85-89页

作者： Robert Colebunders joseph nelson Siewe Fodjo Olivia Kamoen Luis-jorge Amaral Amber Hadermann Chiara Trevisan Mark j.taylor julia Gauglitz Achim Hoerauf Yasuaki Sato Katja Polman Maria-Gloria Basanez Dan Bhwana Thomson Lakwo Gasim Abd-Elfarag Sebastien D.Pion Global Health Institute University of AntwerpAntwerpBelgium Department of neurology Heilig Hart ZiekenhuisLierBelgium Department of Public Health Institute of Tropical MedicineAntwerpBelgium Liverpool School of Tropical Medicine LiverpoolUK Department of Computer Science University of AntwerpAntwerpBelgium Institute of Medical Microbiology Immunology and ParasitologyUniversity Hospital BonnBonnGermany German Center for Infection Research(DZIF) Partner Site Bonn-CologneBonnGermany School of Global Humanities and Social Sciences Nagasaki UniversityNagasakiJapan MRC Centre for Global Infectious Disease Analysis and London Centre for neglected TropicalDisease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonLondonUK national Institute for Medical Research TangaTanzania Vector Control Division Ministry of HealthKampalaUganda School of Public Health University of JubaJubaSouth Sudan Access for Humanity JubaSouth Sudan French national Research Institute for Sustainable Development MontpellierFrance

Background There is increasing epidemiological evidence supporting the association between onchocerciasis and seizures, reinforcing the concept of onchocerciasis-associated epilepsy (OAE). The aim of this paper is to provide an update on the new knowledge about OAE and to propose recommendations to the World Health Organization how to address this public health *** text During the 2nd International Workshop on OAE held on 19-21 September, 2023, in Antwerp, Belgium, participants recognised OAE as a substantial yet neglected public health problem, particularly in areas of sub-Saharan Africa where onchocerciasis remains hyperendemic. Evidence from prospective population-based studies suggest that strengthening onchocerciasis elimination efforts leads to a significant reduction of OAE incidence. There is a need to validate an OAE case definition to estimate the burden of disease and identify onchocerciasis-endemic areas requiring intensification of onchocerciasis elimination programmes and integration of epilepsy care. It is expected that raising awareness about OAE will boost the population uptake of ivermectin. The implementation of a community-based epilepsy treatment programme offering free anti-seizure medications (ASMs) has shown high effectiveness in reducing the frequency of seizures and improving the overall quality of life of people with *** To reduce OAE burden, enhanced collaboration between onchocerciasis and mental health programmes at community, national, and international levels is required. Urgent efforts are needed to ensure the uninterrupted provision of free ASMs in onchocerciasis-endemic areas. Furthermore, OAE should be included in the quantification of the onchocerciasis disease burden.

关键词： Onchocerciasis Morbidity Burden of disease Prevention Ivermectin Epilepsy nodding syndrome Treatment Children Policy

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A REDUCED ORDER SCHWARZ METHOD FOR nOnLInEAR MULTISCALE ELLIPTIC EQUATIOnS BASED On TWO-LAYER nEURAL nETWORKS

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journal of Computational Mathematics 2024年第2期42卷 570-596页

作者： Shi Chen Zhiyan Ding Qin Li Stephen j.Wright Mathematics Department University of Wisconsin-MadisonMadisonWI 53706USA Department of Mathematics University of California-BerkeleyBerkeley CA 94720USA Mathematics Department and Discovery Institute University of Wisconsin-Madison MadisonWI 53706USA Computer Sciences Department University of WisconsinMadisonWI 53706USA

neural networks are powerful tools for approximating high dimensional data that have been used in many contexts,including solution of partial differential equations(PDEs).We describe a solver for multiscale fully nonlinear elliptic equations that makes use of domain decomposition,an accelerated Schwarz framework,and two-layer neural networks to approximate the boundary-to-boundarymap for the subdomains,which is the key step in the Schwarz ***,the boundary-to-boundary map requires solution of boundary-value elliptic problems on each *** leveraging the compressibility of multiscale problems,our approach trains the neural network offline to serve as a surrogate for the usual implementation of the boundary-to-boundary *** method is applied to a multiscale semilinear elliptic equation and a multiscale p-Laplace *** both cases we demonstrate significant improvement in efficiency as well as good accuracy and generalization performance.

关键词： nonlinear homogenization Multiscale elliptic problem neural networks Do-main decomposition

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Universal insertion of molecules in ionic compounds under pressure

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national Science Review 2024年第1期11卷 120-128页

作者： Feng Peng Yanming Ma Chris j.Pickard Hanyu Liu Maosheng Miao College of Physics and Electronic Information Luoyang Normal University Department of Chemistry and Biochemistry California State University Northridge State Key Laboratory of Superhard Materials & Key Laboratory of Material Simulation Methods and Software of Ministry of Education College of Physics Jilin University International Center of Future Science Jilin University Department of Materials Science & Metallurgy University of Cambridge Advanced Institute for Materials Research Tohoku University Department of Earth Science University of California Santa Barbara

Using first-principles calculations and crystal structure search methods, we found that many covalently bonded molecules such as H2, n2, CO2, nH3, H2O and CH4may react with naC l, a prototype ionic solid,and form stable compounds under pressure while retaining their molecular structure. These molecules,despite whether they are homonuclear or heteronuclear, polar or non-polar, small or large, do not show strong chemical interactions with surrounding na and Cl ions. In contrast, the most stable molecule among all examples, n2, is found to transform into cyclo-n5-anions while reacting with naC l under high pressures. It provides a new route to synthesize pentazolates, which are promising green energy materials with high energy density. Our work demonstrates a unique and universal hybridization propensity of covalently bonded molecules and solid compounds under pressure. This surprising miscibility suggests possible mixing regions between the molecular and rock layers in the interiors of large planets.

关键词： molecule-solid hybrid materials high-pressure crystal structure prediction density functional theory planet interior

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Exploring dielectric phenomena in sulflower-like nanostructures via Monte Carlo technique

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Communications in Theoretical Physics 2024年第4期76卷 188-198页

作者： n Saber Z Fadil Hussein Sabbah A Mhirech B Kabouchi L Bahmad Chaitany jayprakash Raorane Siva Sankar Sana Hassan Fouad Mohamed Hashem Laboratory of Condensed Matter and Interdisciplinary Sciences(LaMCScI) Research Unit Labelled CNRSTURL-CNRST-17.Faculty of SciencesPO Box 1014Mohammed Ⅴ University in RabatMorocco College of Engineering and Technology American University of the Middle EastEgaila 54200Kuwait School of Chemical Engineering Yeungnam UniversityGyeongsan38541Republic of Korea Applied Medical Science Department Community CollegeKing Saud UniversityPO Box 11433Riyadh Saudi Arabia Department of Dental Health College of Applied Medical SciencesKing Saud UniversityPO Box 12372RiyadhSaudi Arabia

This research focuses on the electric behavior of a mixed ferrielectric sulflower-like *** structure includes a core with spin S_(i)^(Z)-1 atoms and a shell with spin σ_(j)^(Z)-5/2 *** Blume–Capel model and the Monte Carlo technique(MCt)with the Metropolis algorithm are *** are established for absolute zero,investigating stable spin configurations correlated with various physical *** MCt method explores phase transition behavior and electric hysteresis cycles under different physical parameters.

关键词： sulfower-like nanostructure dielectric characteristics Monte Carlo technique phase transition phase diagrams electric hysteresis

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Why ecosystem characteristics predicted from remotely sensed data are unbiased and biased at the same time-and how this affects applications

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Forest Ecosystems 2024年第1期11卷 24-31页

作者： Goran Ståhl Terje Gobakken Svetlana Saarela Henrik j.Persson Magnus Ekstrom Sean P.Healey Zhiqiang Yang johan Holmgren Eva Lindberg Kenneth nystrom Emanuele Papucci Patrik Ulvdal Hans OleØrka Erik næsset Zhengyang Hou Håkan Olsson Ronald E.McRoberts Department of Forest Resource Management Swedish University of Agricultural Sciences90183UmeåSweden Faculty of Environmental Sciences and natural Resource Management Norwegian University of Life SciencesÅsNorway USDA Forest Service Rocky Mountain Research StationOgdenUTUSA The Key Laboratory for Silviculture and Conservation of Ministry of Education Beijing Forestry UniversityBeijing100083China Department of Forest Resources University of MinnesotaSt.PaulMNUSA

Remotely sensed data are frequently used for predicting and mapping ecosystem characteristics,and spatially explicit wall-to-wall information is sometimes proposed as the best possible source of information for ***,wall-to-wall information typically relies on model-based prediction,and several features of model-based prediction should be understood before extensively relying on this type of *** such feature is that model-based predictors can be considered both unbiased and biased at the same time,which has important implications in several areas of *** this discussion paper,we first describe the conventional model-unbiasedness paradigm that underpins most prediction techniques using remotely sensed(or other)auxiliary *** this point of view,model-based predictors are typically ***,we show that for specific domains,identified based on their true values,the same model-based predictors can be considered biased,and sometimes severely *** suggest distinguishing between conventional model-bias,defined in the statistical literature as the difference between the expected value of a predictor and the expected value of the quantity being predicted,and design-bias of model-based estimators,defined as the difference between the expected value of a model-based estimator and the true value of the quantity being *** show that model-based estimators(or predictors)are typically design-biased,and that there is a trend in the design-bias from overestimating small true values to underestimating large true ***,we give examples of applications where this is important to acknowledge and to potentially make adjustments to correct for the design-bias *** argue that relying entirely on conventional model-unbiasedness may lead to mistakes in several areas of application that use predictions from remotely sensed data.

关键词： Bias Model-based inference Design-based inference

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Impact of device resistances in the performance of graphene‑based terahertz photodetectors

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Frontiers of Optoelectronics 2024年第2期17卷 87-97页

作者： O.Castelló Sofía M.López Baptista K.Watanabe T.Taniguchi E.Diez j.E.Velázquez-Pérez Y.M.Meziani j.M.Caridad j.A.Delgado-notario Department of Applied Physics University of Salamanca37008 SalamancaSpain Unidad de Excelencia en Luz y Materia Estructurada(LUMES) University of Salamanca37008 SalamancaSpain Research Center for Electronic and Optical Materials National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Research Center for Materials nanoarchitectonics National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan nanotechnology Group USAL-NanolabUniversity of Salamanca37008 SalamancaSpain

In recent years,graphene field-effect-transistors(GFETs)have demonstrated an outstanding potential for terahertz(THz)photodetection due to their fast response and *** features are essential to enable emerging THz applications,including 6G wireless communications,quantum information,bioimaging and ***,the overall performance of these photodetectors may be utterly compromised by the impact of internal resistances presented in the device,so-called access or parasitic *** this work,we provide a detailed study of the influence of internal device resistances in the photoresponse of high-mobility dual-gate GFET *** dual-gate architectures allow us to fine tune(decrease)the internal resistance of the device by an order of magnitude and consequently demonstrate an improved responsivity and noise-equivalent-power values of the photodetector,*** results can be well understood by a series resistance model,as shown by the excellent agreement found between the experimental data and theoretical *** findings are therefore relevant to understand and improve the overall performance of existing high-mobility graphene photodetectors.

关键词： Graphene THz Photodetector Field-effect transistor Plasmonic

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The replication crisis and its relevance to Earth Science studies:Case studies and recommendations

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Geoscience Frontiers 2024年第4期15卷 304-314页

作者： Stephen j.Puetz Kent C.Condie Kurt Sundell nick M.W.Roberts Christopher j.Spencer Slah Boulila Qiuming Cheng 475 Atkinson Dr Suite 704HonoluluHI 96814USA new Mexico Institute of Mining and Technology SocorroNM 87801USA Idaho State University PocatelloID 83209USA Geochronology and Tracers Facility British Geological SurveyKeyworthNottingham NG125GGUK Queen’s University Department of Geological Sciences and Geological EngineeringKingstonOntario K7L 3N6Canada Sorbonne Université CNRSInstitut des Sciences de la Terre ParisParisFrance State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesWuhan 430074China

numerous scientific fields are facing a replication crisis,where the results of a study often cannot be replicated when a new study uses independent *** issue has been particularly emphasized in psychology,health,and medicine,as incorrect results in these fields could have serious consequences,where lives might be at *** other fields have also highlighted significant replication problems,the Earth Sciences seem to be an *** paucity of Earth Science research aimed at understanding the replication crisis prompted this ***,this work aims to fill that gap by seeking to replicate geological results involving various types of *** identify and discuss 11 key variables for replicating U-Pb age distributions:independent data,global sampling,proxy data,data quality,disproportionate non-random sampling,stratigraphic bias,potential filtering bias,accuracy and precision,correlating time-series segments,testing assumptions and divergent analytical methods,and analytical *** while this work primarily focuses on U-Pb age distributions,most of these factors(or variations of them)also apply to other geoscience ***,some of the discussions involve time-series consisting ofεHf,δ18O-zircon,14C,10Be,marineδ13C,and marineδ*** then provide specific recommendations for minimizing adverse effects related to these factors,and in the process enhancing prospects for replicating geological results.

关键词： Replication crisis Replicability Independent data Global time-series Globality index Filtered data

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Individual differences in boldness positively correlate with heart rate in orb-weaving spiders of genus Larinioides

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Current Zoology 2014年第3期60卷 387-391页

作者： taylor A. SHEARER j.n.than n. PRUIT Department of Biological Sciences University of Pittsburgh Pittsburgh Pennsylvania 15260 USA

Recent years have seen a dramatic increase in the number of studies devoted to consistent individual differences in behavior, termed ＂behavioral syndromes＂ or animal ＂personality＂. In particular, ecologists and evolutionary biologists alike seek to explore the functional consequences of individuals＇ personalities and explanations for their general maintenance. Understand ing the mechanistic underpinnings to personality is arguably key to a deeper understanding of their functional consequences and maintenance. In particular, consistent individual differences in metabolic rate have been proposed as a general explanation for the maintenance of consistent individual differences in boldness, aggressiveness, and activity level. In this paper we explore whether consistent individual differences in boldness are associated with heat rate, a proxy for metabolic rate, in two species of orbweaving spider： Larinioides cornutus and L. patagiatus. We first documented consistent individual differences in boldness in L. cornutus but not L. patagiatus, as estimated by individuals＇ latency to resume movement following an aversive stimulus. We also measured individuals＇ heart rate twice in a separate situation. We then tested for an association between individuals＇ boldness and their heart rate during these two events. We found that increased boldness was associated with increased heart. Thus, indi viduals that resumed movement quickly following an aversive stimulus also exhibited faster heart rates. Our studies provide fur ther evidence that consistent individual differences in key physiological attributes, like metabolic rate, might be a general mecha nism underlying consistent individual differences in behavior .

关键词： Araneae Aggression Pace of life syndrome Temperament

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Wind power potential over northern South America using ERA5-Land global reanalysis

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Clean Energy 2024年第2期8卷 104-112页

作者： Heli A.Arregocés Guillermo j.Bonivento Roberto Roj.n. Grupo de Investigación GISA Facultad de IngenieríaUniversidad de La GuajiraRiohachaColombia Grupo Procesos Fisicoquímicos Aplicados Facultad de IngenieríaUniversidad de Antioquia SIU/UdeACalle 70 No.52-21MedellínColombia

The northernmost region of South America has great potential for wind energy production and is a strategic area for the energy tran*** analysed data from ERA5-Land global reanalysis from 1980 to 2020 to determine the wind power potential in this *** aim was to identify areas with a high potential for wind energy that could be used to supply energy in case of drought in the region or increases in fuel *** compared data from 19 meteorological stations located in Colombia with ERA5-Land reanalysis data to generate reliable information for the feasibility and operation of wind *** to our analysis,the Colombian Caribbean and Coastal Plain have monthly average wind speeds at 90 m ranging from 4.85 to 10.34 m/s and 3.79 to 6.62 m/s,*** on wind power density calculations,these regions have the highest wind power density in our study,with a monthly average of between 250 and 399 W/m^(2).The Caribbean Region had a 69%increase in wind power density from j.n.ary to july compared with the annual *** wind power density in the plains increased from j.n.ary to March,while the Mountain Region had higher anomalies from May to *** Alta Guajira and ParaguanáPeninsula have great potential to generate wind energy due to their privileged geographical *** ERA5 offers valuable information about wind availability in time and space,it cannot represent the influence of local effects on wind patterns for the Mountain Region.

关键词： onshore wind power wind power potential ERA5-Land global reanalysis wind speed

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Human Eosinophil Cell Manipulation by Optical Tweezers

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Open journal of Biophysics 2024年第3期14卷 330-338页

作者： Pavel Yale jean Michel Edoukoua Konin Abadê Ange-Boris n’guessan Michel Abaka Kouacou jérémie T. Zoueu Laboratoire dInstrumentation Image et Spectroscopie (L2IS) Institut National Polytechnique Houphout-Boigny (INPHB) Yamoussoukro Cte dIvoire Laboratoire de Chimie et de Physique Appliques Sciences et Techniques Universit Alassane Ouattara Bouak Cte dIvoire

In this work, lateral deformation of human eosinophil cell during the lateral indentation by an optically trapped microbead of diameter 4.5 µm is studied. The images were captured using a CCD camera and the Boltzmann statistics method was used for force calibration. Using the Hertz model, we calculated and compared the elastic moduli resulting from the lateral force, showing that the differences are important and the force should be considered. Besides the lateral component, the setup also allows us to examine the lateral cell-bead interaction. The mean values of the properties obtained, in particular the elastic stiffness and the shear stiffness, were Eh = (37.76 ± 2.85) µn/m and Gh = (12.57 ± 0.32) µn/m. These results show that the lateral indentation can therefore be used as a routine method for cell study, because it enabled us to manipulate the cell without contact with the laser.

关键词： Optical Tweezers Human Eosinophil Cell Indentation Shear Stiffness

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