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miniSCIDOM: a scintillator-based tomograph for volumetric dose reconstruction of single laser-driven proton bunches

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High Power Laser Science and Engineering 2024年第2期12卷 41-50页

作者： A.Corvino M.Reimold E.Beyreuther F.-E.Brack F.Kroll j.Pawelke j.D.Schilz M.Schneider U.Schramm M.E.P.Umlandt K.Zeil T.Ziegler j.metzkes-ng Helmholtz-Zentrum Dresden–Rossendorf DresdenGermany Technische Universität Dresden DresdenGermany OncoRay–National Center for Radiation Research in Oncology Faculty of Medicine and University Hospital Carl Gustav CarusTUD Dresden University of TechnologyHelmholtz-Zentrum Dresden–RossendorfDresdenGermany Current affiliation:Institut Curie UniversitéPSLCNRS UMR3347OrsayFrance Current affiliation:Universitätsklinikum Freiburg FreiburgGermany

Laser plasma accelerators(LPAs)enable the generation of intense and short proton bunches on a micrometre scale,thus offering new experimental capabilities to research fields such as ultra-high dose rate radiobiology or material *** spectrally broadband,laser-accelerated proton bunches allow for tailored volumetric dose deposition in a sample via single bunches to excite or probe specific sample *** rising number of such experiments indicates a need for diagnostics providing spatially resolved characterization of dose distributions with volumes of approximately 1 cm^(3) for single proton bunches to allow for fast online *** we present the scintillator-based miniSCIDOM detector for online single-bunch tomographic reconstruction of dose distributions in volumes of up to approximately 1 cm^(3).The detector achieves a spatial resolution below 500μm and a sensitivity of 100 *** detector performance is tested at a proton therapy cyclotron and an LPA proton *** experiments’primary focus is the characterization of the scintillator’s ionization quenching behaviour.

关键词： beam monitoring detectors laser-driven proton beams scintillator-based diagnostics ultra-high dose rate

OCTOPOD:single-bunch tomography for angular-spectral characterization of laser-driven protons

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High Power Laser Science and Engineering 2023年第6期11卷 16-28页

作者： M.Reimold S.Assenbaum E.Beyreuther E.Bodenstein F.-E.Brack C.Eisenmann F.Englbrecht F.Kroll F.Lindner U.Masood j.Pawelke U.Schramm M.Schneider M.Sobiella M.E.P.Umlandt M.Vescovi K.Zeil T.Ziegler j.metzkes-ng Helmholtz-Zentrum Dresden-Rossendorf DresdenGermany Technische Universität Dresden DresdenGermany OncoRay-National Center for Radiation Research in Oncology DresdenGermany Ludwig-Maximilians-Universität München Garching/MünchenGermany Universitätsklinikum Freiburg FreiburgGermany

Laser-plasma accelerated(LPA)proton bunches are now applied for research fields ranging from ultra-high-dose-rate radiobiology to material ***,the capabilities to characterize the spectrally and angularly broad LPA bunches lag behind the rapidly evolving *** OCTOPOD translates the angularly resolved spectral characterization of LPA proton bunches into the spatially resolved detection of the volumetric dose distribution deposited in a liquid *** to 24 multi-pinhole arrays record projections of the scintillation light distribution and allow for tomographic reconstruction of the volumetric dose deposition pattern,from which proton spectra may be *** the OCTOPOD at a cyclotron,we show the reliable retrieval of various spatial dose deposition patterns and detector sensitivity over a broad dose ***,the OCTOPOD was installed at an LPA proton source,providing real-time data on proton acceleration performance and attesting the system optimal performance in the harsh laser-plasma environment.

关键词： laser-plasma acceleration of protons proton detector tomographic reconstruction

Mechanical and hydraulic properties of carbonate rock:The critical role of porosity

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journal of Rock Mechanics and Geotechnical Engineering 2023年第4期15卷 814-825页

作者： Kam ng j.Carlos Santamarina Department of Civil and Architectural Engineering and Construction Management University of WyomingLaramieWY82071USA Physical Science and Engineering Division King Abdullah University of Science and TechnologyThuwal23955-6900Saudi Arabia

Carbonate rocks are extensively used in civil infrastructure and play a critical role in geoenergy geoengineering,either as hydrocarbon reservoirs or potential repositories for CO_(2)geological *** genesis and diagenetic overprint determine the properties of carbonate *** study combines recent data gathered from Madison Limestone and an extensive dataset compiled from published sources to analyze the hydraulic and mechanical properties of limestone carbonate *** models and data analyses recognize the inherently granular genesis of carbonate rocks and explain the strong dependency of physical properties on *** asymptotically-correct power model in terms of(1-Ф/Ф*)a is a good approximation to global trends of unconfined stiffness E and unconfined compressive strength UCS,cohesive intercept in Mohr-Coulomb failure envelopes,and the brittle-toductile transition *** power model is the analytical solution for the mechanical properties of percolating granular *** adopted a limiting granular porosityФ*=0.5 for all models,which was consistent with the loosest packing of monosize *** fitted power model has exponent(α=2)in agreement with percolation theory and highlights the sensitivity of mechanical properties to *** and models confirm a porosity-independent ratio between unconfined stiffness and strength,and the ratio follows a log-normal distribution with mean(E/UCS)≈*** high angle of internal shear strength measured for carbonate rocks reflects delayed contact failure with increased confinement,and it is not sensitive to *** spans more than six orders of *** size controls pore size and determines the reference permeability k^(*)at the limiting porosityФ*=*** a given grain size from fine to coarse-grained dominant carbonates,permeability is very sensitive to changes in porosity,suggesting preferential changes in the internal pore network during compaction.

关键词： Rock porosity Carbonate permeability Rock unconfined stiffness Unconfined compressive strength(UCS)

Modeling the high-energy emission from the gamma-ray binary 1FGL j1018.6–5856

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Research in Astronomy and Astrophysics 2021年第8期21卷 46-58页

作者： A-Ming Chen Chowing ng jumpei Takata Yun-Wei Yu School of physics Huazhong University of Science and TechnologyWuhan 430074China Department of Physics The University of Hong KongPokfulam RoadHong KongChina College of Physical Science and Technology Central China Normal UniversityWuhan 430079China

1FGL j1018.6–5856 is a high mass gamma-ray binary containing a compact object orbiting around a massive star with a period of 16.544 *** the compact object is a pulsar,non-thermal emissions are likely produced by electrons accelerated at the termination shock,and may also originate from the magnetosphere and the un-shocked wind of the *** this paper,we investigate the non-thermal emissions from the wind and the shock with different viewing geometries and study the multi-wavelength emissions from 1FGL j1018.6–*** present the analysis results of the Fermi/LAT using nearly 10 years of *** phase-resolved spectra indicate that the Ge V emissions comprise a rather steady component that does not vary with orbital motion and a modulated component that shows flux maximum around inferior *** ke V/Te V light curves of 1FGL j1018.6–5856 also exhibit a sharp peak around inferior conjunction,which are attributed to the boosted emission from the shock,while the broad sinusoidal modulations could be originating from the deflected shock tail at a larger *** modulations of Ge V flux are likely caused by the boosted synchrotron emission from the shock and the IC emission from the unshocked pulsar wind,while the steady component comes from the outer gap of the pulsar ***,we discuss the similarities and differences of 1FGL j1018.6–5856 with other binaries,like LS 5039.

关键词： binaries:close gamma rays:stars X-rays:binaries radiation mechanisms:non-thermal

On pancreatic cancer screening by magnetic resonance imaging with the recent evidence by Del Chiaro and colleagues

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Chinese journal of Cancer Research 2015年第4期27卷 417-422页

作者： Yì-Xiáng j.Wáng jing-Shan Gong Romaric Loffroy Department of Imaging and Interventional Radiology Faculty of Medicine The Chinese University of Hong Kong Prince of Wales Hospital Department of Radiology Shenzhen People’s Hospital Second Clinical Medicine College of jinan University Department of Vascular Oncologic and Interventional Radiology Le2i UMR CNRS 6306 University of Dijon School of Medicine Bocage Teaching Hospital

Pancreatic cancer is a lethal disease because incidence and mortality rates are nearly *** 5-year survival rate in Western countries is 4%,the lowest among all types of cancer（1）.In China,pancreatic cancer is the sixth leading cause of death from malignant disease,with an overall cumulative 5-year survival rate of 1%to 3%（2,3）.

关键词： screening mortality intraductal cumulative lethal identical mucinous incidence familial pancreas

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

COUPLED VIBRATION OF STRUCTURAL THIN-WALLED CORES

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Acta Mechanica Solida Sinica 2000年第1期13卷 81-88页

作者： Shiu Cho ng j.S.Kuang Department of Civil Engineering Hong Kong University of Science and Technology

This paper presents an analysis of the coupled vibration of asymmetric core structures in tall buildings. The governing equation of free vibration and its corresponding eigenvalue problem, which is a set of equations for laterally flexural vibrations in two different directions coupled by a warping-St. Venant torsional vibration, are derived. Based on the Calerkin method, a generalized approximate method is developed for the analysis of coupled vibration and thus proposed for determining the natural frequencies and mode shapes of the structure in triply-coupled vibration. The results of the proposed method for the example structure show good agreement with those of the FEM analysis. The proposed method has been shown to provide a simple and rapid, yet accurate, means for coupled vibration analysis of core structures.

关键词： coupled vibration analysis asymmetric core structure Galerkin method natural frequency mode shape

Ranking parameters in urban energy models for various building forms and climates using sensitivity analysis

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Building Simulation 2023年第9期16卷 1587-1600页

作者： Aysegul Demir Dilsiz Kaitlynn ng jérôme Kämpf Zoltan Nagy Department of Civil and Architectural Engineering and Construction Management University of WyomingLaramie WYUSA Intelligent Environments Lab Department of CivilArchitectural and Environmental EngineeringThe University of Texas at AustinAustin TXUSA Energy Informatics Group Idiap Research Institute1920 MartignySwitzerland

Urban Building Energy Modelling(UBEM)allows us to simulate buildings’energy performances at a larger ***,creating a reliable urban-scale energy model of new or existing urban areas can be difficult since the model requires overly detailed input data,which is not necessarily publicly *** calibration is a necessary step to reduce the uncertainties and simulation results in order to develop a reliable and accurate *** to the concerns over computational resources and the time needed for calibration,a sensitivity analysis is often required to identify the key parameters with the most substantial impact before the calibration is deployed in ***,we study the sensitivity of uncertain input parameters that affect the annual heating and cooling energy demand by employing an urban-scale energy model,*** goal is to determine the relative influence of each set of input parameters and their interactions on heating and cooling loads for various building forms under different ***,we conduct a global sensitivity analysis for annual cooling and heating consumption under different climate *** upon this,we investigate the changes in input sensitivity to different building forms,focusing on the indices with the largest Total-order ***,we determine First-order indices and Total-order effects of each input parameter included in the urban building energy *** also provide tables,showing the important parameters on the annual cooling and heating demand for each climate and each building *** find that if the desired calibration process require to decrease the number of the inputs to save the computational time and cost,calibrating 5 parameters;temperature set-point,infiltration rate,floor U-value,*** U-value and roof U-value would impact the results over 55%for any climate and any building form.

关键词： global sensitivity analysis Sobol’method urban energy modeling building stocks energy modelling parameter screening Sobol’indices sustainable urban planning

The role of AVDR in linear cascade testing

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航空动力学报 2007年第6期22卷 933-944页

作者： Wing F.ng Department of Mechanical Engineering Virginia Polytechnic Instituteand State University

Linear cascade testing plays an important role in the research and development of turbomachinery and is widely used over the *** ideal cascade model of a turbomachinery blade row is *** actual linear cascade testing,the flow through the test section converges due to the development of the boundary layer and secondary flow along the sidewall surfaces of the test *** velocity density ratio(AVDR) is adopted to account for the deviation of the tested cascade flow from the ideal 2D *** numerous published cascade works,the influence of AVDR on cascade performance is seen to be complicated with many affecting factors,such as those related to cascade/blade geometry and flow ***,controlling AVDR is limited by the facility ***,real blade-to-blade flow in turbomachines is usually associated with AVDR greater than unity due to limited span of blades between the hub and shroud such that cascade testing without reducing AVDR could be favored *** these facets add complexity and diversification to the *** current paper reviews previous studies and results on *** understanding on the role of AVDR and recommendations on how to deal with it in linear cascade testing are provided.

关键词：线性叶栅试验轴向速度密度比空气流动叶栅特性