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Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： Xiaoqin Li jian Xiang Lu Qiu Xiaohan Chen Yinkun Zhao Yujue Wang Qu yue Taotao Gao Wenlong Liu Dan Xiao Zhaoyu jin Panpan Li Institute for Advanced Study Chengdu University School of mechanical Engineering Chengdu University College of Food and Biological Engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of materials Science and Engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AZIBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AZIBs.

关键词： Solvation

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基于形态学的采摘系统视觉控制研究

农机化研究 2025年第3期47卷 197-201页

作者：刘悦国家农产品现代物流工程技术研究中心济南250103 山东省农产品贮运保鲜技术重点实验室济南250103

以进一步提升采摘机器人系统的作业效率为目标,选取形态学算法作为支撑机理与参考基点,针对采摘系统的视觉控制展开设计。考虑采摘系统的模块分工与功能组成,搭建形态学图像检测与处理模型,并进行系统的整体布局与软硬件模块匹配,形成... 详细信息

以进一步提升采摘机器人系统的作业效率为目标,选取形态学算法作为支撑机理与参考基点,针对采摘系统的视觉控制展开设计。考虑采摘系统的模块分工与功能组成,搭建形态学图像检测与处理模型,并进行系统的整体布局与软硬件模块匹配,形成以形态学运算处理规则为主的采摘机器人控制系统。采摘作业控制试验结果表明:基于形态学的采摘系统视觉控制设计方案正确可行,在形态学运算程序的精准执行下,图像特征区别效率与目标识别准确率均得到明显改善,视觉定位时间误差相对降低了3.19%,整体系统的综合效率可达92.30%,满足智能采摘的设计要求。系统各组件运行平稳,采摘回放动作柔性可靠,可为类似智能收获装置创新优化提供一定的参考。

关键词：采摘机器人形态学算法视觉控制图像特征区别效率智能采摘

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

黄芩素可缓解蛛网膜下腔出血后神经元的铁死亡

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中国组织工程研究 2025年第1期29卷 52-57页

作者：朱婷岳婷婷崔悦鲁悦李伟杭春华南京中医药大学鼓楼临床医学院江苏省南京市210008 南京大学医学院附属鼓楼医院神经外科江苏省南京市210008

背景:铁死亡是一种区别于凋亡、坏死等新型细胞程序性死亡的方式,主要由累积的脂质过氧化引起,已被证实参与蛛网膜下腔出血后的病理过程。黄芩素是一种铁螯合剂,能够抑制脂质过氧化反应,但其在蛛网膜下腔出血后早期脑损伤中缓解神经元... 详细信息

背景:铁死亡是一种区别于凋亡、坏死等新型细胞程序性死亡的方式,主要由累积的脂质过氧化引起,已被证实参与蛛网膜下腔出血后的病理过程。黄芩素是一种铁螯合剂,能够抑制脂质过氧化反应,但其在蛛网膜下腔出血后早期脑损伤中缓解神经元铁死亡的作用仍未明确。目的:探讨黄芩素治疗蛛网膜下腔出血后对神经元铁死亡的影响及机制。方法:提取孕16-17 d C57BL/6L胎鼠大脑皮质神经元细胞,运用血红蛋白刺激原代神经元模拟体外蛛网膜下腔出血模型。采用CCK-8法检测5,15,25,50,100μmol/L黄芩素作用24 h后原代神经元细胞的活力,确定黄芩素的最适浓度。然后将原代神经元细胞分为对照组、血红蛋白组、血红蛋白+黄芩素组,利用试剂盒检测细胞内活性氧和丙二醛水平,RT-PCR检测铁死亡相关标记物PTGS2、SLC7A11、谷胱甘肽过氧化物酶4的mRNA表达;进一步将原代神经元细胞分为对照组、SLC7A11抑制剂Erastin组、血红蛋白组、血红蛋白+黄芩素组、血红蛋白+黄芩素+Erastin组,Western blot检测铁死亡相关标记物SLC7A11和谷胱甘肽过氧化物酶4的蛋白表达。结果与结论:(1)选取25μmol/L黄芩素作为后续实验浓度;(2)与血红蛋白组相比,血红蛋白+黄芩素组丙二醛和活性氧水平显著下降(P m RNA表达显著下降,SLC7A11和谷胱甘肽过氧化物酶4的m RNA表达显著升高(P <0.000 1);(4)SLC7A11抑制剂Erastin能在一定程度上逆转黄芩素改善的铁死亡作用(P <0.05);(5)结果表明,黄芩素可通过SLC7A11/GPX4通路缓解蛛网膜下腔出血后神经元细胞的铁死亡。

关键词：蛛网膜下腔出血黄芩素铁死亡神经元 Erastin 小鼠

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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从领域到属性:亲环境行为测量的问题及建议

心理科学进展 2025年第1期33卷 163-175页

作者：张玥董艺佳蒋奖华北电力大学经济与管理学院北京102206 香港城市大学社会与行为科学系香港北京师范大学心理学部应用实验心理北京市重点实验室心理学国家级实验教学示范中心(北京师范大学)北京100875

已有研究开发了大量的亲环境行为测量工具,涉及量表、个体行为范式和群体博弈范式,其中大多数测量工具是基于行为领域设计,节约、出行、垃圾处理、消费和公域行为是5个最常被提及的领域。现有依据行为领域的亲环境行为测量方式存在标准... 详细信息

已有研究开发了大量的亲环境行为测量工具,涉及量表、个体行为范式和群体博弈范式,其中大多数测量工具是基于行为领域设计,节约、出行、垃圾处理、消费和公域行为是5个最常被提及的领域。现有依据行为领域的亲环境行为测量方式存在标准化程度低及测量结果推广性受限的问题,这主要是由于缺少对行为属性这一行为决定性特征的关注。未来研究应基于行为属性选用和开发标准化测量工具,并选取多种真实行为作为效标进行效度检验。

关键词：亲环境行为行为领域行为属性测量

司法职业教育教学学术研究的理论阐释与行动方案

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职业技术 2025年第1期24卷 32-38页

作者：李悦深圳职业技术大学经济学院深圳518055

司法职业教育所对接的并非市场经济意义的产业,专门人才培养有必要着眼于法治工作队伍“长尾”,满足基层法律服务和法律职业辅助等地方法治建设的实际需要。为培养德法兼修的法治人才,需在教学中开展“将教学界定为学术”的教学学术研... 详细信息

司法职业教育所对接的并非市场经济意义的产业,专门人才培养有必要着眼于法治工作队伍“长尾”,满足基层法律服务和法律职业辅助等地方法治建设的实际需要。为培养德法兼修的法治人才,需在教学中开展“将教学界定为学术”的教学学术研究。司法职业教育的教学学术研究在同行评价基础上,开展司法职业教育的理论构建和教学实施活动,促进教学质量提升的同时实现教师发展。基于我国司法职业教育师资队伍存在的学历层次和技能构成问题,论证了在司法职业教育领域开展教学学术研究的高度必要性和现实可能性,提出激发教师开展教学学术研究动力、加强理论与实践融合共进、明确教学学术研究效果的评价标准,从而助力教学学术研究的最终落地。

关键词：司法职业教育教学学术研究学生参与教学学术实践

A two-step approach to investigate the effect of rating curve uncertainty in the Elbe decision support system

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journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第9期9卷 1229-1238页

作者： yue-ping XU Harriette HOLZHAUER martijn j. BOOIj Hong-yue SUN Institute of Hydrology and Water Resources Department of Civil Engineering Zhejiang University Hangzhou 310027 China Water Engineering and management Faculty of Engineering Technology University of Twente 7500 AE Ensehede the Netherlands Institute of Harbor Coast and Offshore Engineering Department of Civil Engineering Zhejiang University Hangzhou 310027 China

For river basin management, the reliability of the rating curves mainly depends on the accuracy and time period of the observed discharge and water level data. In the Elbe decision support system (DSS), the rating curves are combined with the HEC-6 model to investigate the effects of river engineering measures on the Elbe River system. In such situations, the uncertainty originating from the HEC-6 model is of significant importance for the reliability of the rating curves and the corresponding DSS results. This paper proposes a two-step approach to analyze the uncertainty in the rating curves and propagate it into the Elbe DSS: analytic method and Latin Hypercube simulation. Via this approach the uncertainty and sensitivity of model outputs to input parameters are successfully investigated. The results show that the proposed approach is very efficient in investigating the effect of uncertainty and can play an important role in improving decision-making under uncertainty.

关键词： Elbe decision support system (DSS) Two-step approach Uncertainty HEC-6 model