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CT结肠成像检查的保险覆盖情况对结直肠癌总体筛查率的影响

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国际医学放射学杂志 2017年第6期 712-713页

作者： m.A.Smith j.m.weiss A.Potvien j.R.Schumacher R.E.Gangnon D.H.Kim 张广文 Department of Population Health Sciences University of Wisconsin-Madison School of Medicine and Public Health

摘要目的对于适合并应该进行结直肠癌筛查的高危人群,比较有保险覆盖CT结肠成像检查费用与保险不覆盖此检查费用的两类人群的总体结直肠癌筛查率有无差异。材

关键词：结直肠癌结肠成像筛查率 CT

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

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CT结肠成像筛查阴性的大队列研究中5年结直肠癌发病率

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国际医学放射学杂志 2012年第5期 496-496页

作者： D.H.Kim B.D.Pooler j.m.weiss P.j.Pickhardt 史玉振 Department of Radiology University of Wisconsin School of Medicine and Public HealthE3/311 Clinical Science Center600 Highland Ave.MadisonWI 53792-3252USA

摘要目的因为缺乏CT结肠成像(CTC)筛查阴性病人长期结果的数据,本研究的目的是评估5年内有结直肠癌临床表现而CTC表现为阴性的病人的发病率。方法纳入威斯康辛大学医疗系统14个月期间CTC筛查阴性的病人1050例,对包括提供者、结肠镜、影... 详细信息

摘要目的因为缺乏CT结肠成像(CTC)筛查阴性病人长期结果的数据,本研究的目的是评估5年内有结直肠癌临床表现而CTC表现为阴性的病人的发病率。方法纳入威斯康辛大学医疗系统14个月期间CTC筛查阴性的病人1050例,对包括提供者、结肠镜、影像学和病理学报告在内的电子医学病历(EmR)进行回顾性分析。记录结直肠癌以及其他严重的胃肠道肿瘤的发病率。

关键词： CT结肠成像胃肠筛查腺癌高级别腺瘤

结肠镜漏诊的结直肠息肉可经CT结肠成像发现并定位

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国际医学放射学杂志 2016年第2期 191-191页

作者： B.D.Pooler D.H.Kim j.m.weiss K.A.matkowskyj P.j.Pickhardt 郑丽 Department of Radiology University of Wisconsin School of Medicine and Public Health

摘要目的对已通过CT结肠成像方法检出,但后续未经非盲法结肠镜确诊的非微小结直肠息肉进行回顾性评价并总结其特征。材料与方法该研究通过伦理委员会审批,受检者均签署知情同意书。在113个月内对9 336名成人(平均年龄57.1岁)行CT结肠成... 详细信息

摘要目的对已通过CT结肠成像方法检出,但后续未经非盲法结肠镜确诊的非微小结直肠息肉进行回顾性评价并总结其特征。材料与方法该研究通过伦理委员会审批,受检者均签署知情同意书。在113个月内对9 336名成人(平均年龄57.1岁)行CT结肠成像检出非微小息肉(≥6 mm)2 606个。1 731个病灶于后续行非盲法结肠镜检查(内镜医师可以进一步通过CT结肠成像技术提供息肉的具体信息,

关键词：结肠镜检查结肠成像直肠息肉漏诊 CT

大于5 mm的息肉初次CT结肠镜筛查阴性后重复CT结肠镜的结直肠表现

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国际医学放射学杂志 2017年第2期 209-209页

作者： P.j.Pickhardt B.D.Pooler I.mbah j.m.weiss D.H.Kim 吴兰蒋宇 Department of Radiology University of Wisconsin School of Medicine and Public HealthE3/311 Clinical Science Center

摘要目的评价初次CT结肠镜筛查阴性后重复CT结肠镜的息肉检测率及类型。材料与方法一家医学中心于2010年前所做的5 640次CT结肠镜检查为阴性结果 (无大

关键词：结肠镜筛查息肉瘤样病变 mm CT

CT结肠成像检测平铺式病灶:临床、影像和病理特征对照研究

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国际医学放射学杂志 2014年第2期 173-173页

作者： P.j.Pickhardt V.P.Lam j.m.weiss G.D.Kennedy D.H.Kim 肖雅雯 Department of Radiology University of Wisconsin School of Medicine and Public Health E3/311 Clinical Science Center 600Highland Ave Madison WI 53792 -3252. Department of Radiology University of Wisconsin School of Medicine and Public Health E3/311 Clinical Science Center 600Highland Ave Madison WI 53792 -3252

目的旨在研究经CT结肠成像检测的平铺式病灶(carpet lesions)(侧方扩展距离≥3 cm的肿瘤)的临床特点、影像表现及病理特征。材料与方法本项回顾性研究符合

关键词：结肠成像病灶平铺式病理特征 CT

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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management of borderline and locally advanced pancreatic cancer:Where do we stand?

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World journal of Gastroenterology 2014年第9期20卷 2255-2266页

作者： jin He Andrew j Page matthew weiss Christopher L Wolfgang joseph m Herman Timothy m Pawlik Department of Surgery Johns Hopkins Hospital Baltimore MD 21287 United States Department of Radiation Oncology Johns Hopkins Hospital Baltimore MD 21287 United States

many patients with pancreas cancer present with locally advanced pancreatic cancer(LAPC).The principle tools used for diagnosis and staging of LAPC include endoscopic ultrasound,axial imaging with computed tomography and magnetic resonance imaging,and diagnostic *** definition of resectability has historically been vague,as there is considerable debate and controversy as to the definition of *** the patient with LAPC,there is some level of involvement of the surrounding vascular structures,which include the superior mesenteric artery,celiac axis,hepatic artery,superior mesenteric vein,or portal *** feasible,most surgeons would recommend possible surgical resection for patients with borderline LAPC,with the goal of an R0 *** initially unresectable LAPC,neoadjuvant should be strongly ***,these patients should be offered neoadjuvant therapy,and the tumor should be assessed for possible response and eventual *** efficacy of neoadjuvant therapy with this approach as a bridge to potential curative resection is broad,ranging from 3%-79%.The different modalities of neoadjuvant therapy include sin-gle or multi-agent chemotherapy combined with radiation,chemotherapy alone,and chemotherapy followed by chemotherapy with *** review focuses on patients with LAPC and addresses recent advances and controversies in the field.

关键词： Pancreas Locally advanced Chemotherapy Radiation Irreversible electroporation Pancreatic cancer