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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal j.Goldschmidt-Clermont Aisha Khan George jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander j.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi james D.Guest miller School of medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Effect of nanoparticle(Pd, Pd/Pt, Ni) deposition on high temperature hydrogenation of Ti-v alloys in gaseous flow containing CO

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Progress in Natural Science:materials International 2017年第1期27卷 93-98页

作者： S.Suwarno m.Williams j.K.Solberg v.A.Yartys Department of mechanical Engineering Institut Teknologi Sepuluh Nopember Department of materials Science and Engineering NTNU Institute for Energy Technology University of the Western Cape

The hydrogenation properties of Ti-v hydrides coated with nanoparticles have been studied in gaseous mixtures of argon and hydrogen with and without additions of 1% CO. Nanoparticles of Pd, Ni, and co-deposited Pd/Pt with particle sizes of;0–60 nm were formed by electroless deposition on the hydride surfaces. The alloy resistance to CO could be significantly improved by particle deposition. Large amounts of hydrogen were absorbed in a CO-containing gas when Ni and Pd/Pt deposition had been applied, while pure Pd deposition had no positive effect. Ni was found to have a stronger effect than those of Pd/Pt and Pd, possibly because of the size effect of Ni nanoparticles.

关键词： metal hydride Titanium vanadium Nanoparticle Palladium Nickel Platinum Carbon monoxide

Structural,morphological,optical and photoluminescent properties of spray-deposited ZnSe thin film

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journal of Semiconductors 2014年第11期35卷 5-9页

作者： G.m.Lohar S.K.Shinde v.j.Fulari Holography and material Research Laboratory Department of PhysicsShivaji University

ZnSe thin films are successfully deposited by spray pyrolysis deposition technique. Deposited thin films are characterized by X-ray diffraction study, and it reveals that spray-deposited ZnSe thin films are polycrystalline with hexagonal crystal structure. Surface morphology is carried out by scanning electron microscopy. It shows cotton-like morphology, and optical properties, such as absorbance, transmittance, reflectance, band gap, refrac- tive index, extinction coefficient are studied. Photoluminescence shows strong emission at 497 nm. Also, spray- deposited ZnSe thin films are hydrophilic in nature, which is shown by contact angle meter.

关键词： spray pyrolysis technique photoluminescence hydrophilicity ZnSe

Eigenvalue Solver for Fluid and Kinetic Plasma models in Arbitrary magnetic Topology

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Communications in Computational Physics 2016年第6期20卷 136-155页

作者： D.A.Baver j.R.myra m.v.Umansky Lodestar Research Corporation Boulder Colorado 80301USA Lawrence Livermore National Laboratory USA

ArbiTER(Arbitrary Topology Equation Reader)is a new code for solving linear eigenvalue problems arising from a broad range of physics and geometry *** primary application area envisioned is boundary plasma physics in magnetic confinement devices;however ArbiTER should be applicable to other science and engineering fields as *** code permits a variable numbers of dimensions,making possible application to both fluid and kinetic *** use of specialized equation and topology parsers permits a high degree of flexibility in specifying the physics and geometry.

关键词： Plasma eigensolver finite difference method finite element method SLEPc PETSc field-line following coordinates snowflake divertor

Ferromagnetic Resonance in Gd/Co multilayer

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Chinese Physics Letters 2001年第7期18卷 973-975页

作者： A.v.Svalov j.m.Barandiarán v.O.vas’kovskiy G.v.Kurlyandskaya L.Lezama N.G.Bebenin j.Gutiérrez D.Schmool Ural State University Lenin Ave.51620083 EkaterinburgRussia Universidad del PaIs vasco UPv-EHU Facultad de Ciencias Apdo.64448080 BilbaoSpain Institute of metal Physics Ural Division of RASKovalevskaya str.18GSP-170620219 EkaterinburgRussia Laboratory de magnetisme et d’Optique ptique CNRSUniversitéde Versailles-Saint Quentin-CNRSBatiment Fermat45 Avenue des Etats-Unis78035 Versalles CedexFrance

magnetometric and ferromagnetic resonance(mFR)measurements have been performed on the polycrystalline multilayered structure,[Gd(7.5 nm)/Co(3 nm)]*** temperature dependence of magnetization of the sample suggests a compensation temperature Tcomp in the region of 240 K,implying that the Co and Gd layers are antiferromagnetically *** FmR curves are strongly temperature dependent,particularly in the vicinity of Tcomp.

关键词： magnetization ferromagnetic polycrystalline

Interlayer Coupling in Co/Ti/（Gd-Co）/Ti Artificial Layered Ferrimagnet

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Chinese Physics Letters 2005年第12期22卷 3169-3172页

作者： A. v. Svalov A. Fernández v. O. vas'kovskiy m. Tejedor R. Lopez Anton j. m. Barandiarán G. v. Kurlyandskaya Institute of Physics and Applied mathematics Ural State University Lenin Avenue 51 620083 Ekaterinburg Russia Departamento de Fisica Universidad de Oviedo Avenida Calvo Sotelo s/n 33007 Oviedo Asturias Spain Departamento de Electricidad y Electronica Facultad de Ciencia y Tecnologia Universidad del Pais Vasco UPV/EHU PO Box 644 48080 Bilbao Spain

The magnetic properties and the structure of [Co/Ti/Gd0.36 Co0.64/Ti]4/Co multilayers are investigated by means of torque magnetometer, vibrating sample magnetometer and transverse magneto-optic Kerr effect （TmOKE） measurements and the atomic force microscopy. Due to interlayer exchange interaction, Co and Gd-Co layers form a macroscopic ferrimagnetic system. The change in the sign of the TmOKE hysteresis loops near the compensation temperature and field induced magnetic phase transitions are found. The latter can be characterized by a critical field which shows a linear variation with the temperature. The magnetic properties of these multilayers from many points of view are similar to those of bulk ferrimagnets.

关键词： THIN-FILmS mULTILAYERS

Chemical characterisation of particulate matter in urban transport modes

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journal of Environmental Sciences 2021年第2期33卷 51-61页

作者： vania martins Carolina Correia Ines cunha-Lopes Tiago Faria Evangelia Diapouli manousos Ioannis manousakas Konstantinos Eleftheriadis Susana marta Almeida Centro de Ciencias e Tecnologias N ucleares Instituto Superior TecnicoLisbonPortugal Institute of Nuclear and Radiological Sciences and Technology Energy and SafetyN.C.S.R.'Demokritos'AthensGreece

Traffic is a main source of air pollutants in urban areas and consequently daily peak exposures tend to occur during *** exposure to particulate matter(Pm)was monitored while cycling and travelling by bus,car and metro along an assigned route in Lisbon(Portugal),focusing on Pm_(2.5) and Pm_(1)0(Pm with aerodynamic diameterm,respectively)mass concentrations and their chemical *** vehicles,the indoor-outdoor interplay was also *** Pm_(2.5) mean concentrations were 28±5,31±9,34±9 and 38±21μg/m 3 for bus,bicycle,car and metro modes,*** carbon concentrations when travelling by car were 1.4 to 2.0 times higher than in the other transport modes due to the closer proximity to exhaust *** are marked differences in Pm chemical composition depending on transport *** particular,Fe was the most abundant component of metro Pm,derived from abrasion of rail-wheel-brake *** concentrations of Zn and Cu in cars and buses were related with brake and tyre wear particles,which can penetrate into the *** the motorised transport modes,Fe,Zn,Cu,Ni and K were correlated,evidencing their common traffic-related *** average,the highest inhaled dose of Pm_(2.5) was observed while cycling(55μg),and the lowest in car travels(17μg).Cyclists inhaled higher doses of Pm_(2.5) due to both higher inhalation rates and longer journey times,with a clear enrichment in mineral *** presented results evidence the importance of considering the transport mode in exposure assessment studies.

关键词： Traffic Commuting Air pollution Particle chemistry Indoor-outdoor interplay Inhaled dose

Floristic composition and edaphic relationships in ferruginous campo rupestre reference ecosystems

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journal of mountain Science 2024年第3期21卷 719-733页

作者： G.Wilson FERNANDES Letícia RAmOS Dario C.PAIvA jéssica cunha-BLUm vanessa matos GOmES Daniel NEGREIROS Ecologia Evolutiva&Biodiversidade Departamento de GenéticaEcologia e Evolução/ICBUniversidade Federal de Minas Gerais31270-901Belo HorizonteMGBrazil Knowledge Center for Biodiversity 31270-901Belo HorizonteMGBrazil Department of Biological Sciences Institute of EnvironmentFlorida International UniversityMiamiFL 33199USA Programa de Pós Graduação em Biodiversidade e Uso dos Recursos Naturais Universidade Estadual de Montes ClarosMontes ClarosMGBrazil Laboratório de Estudo das Relações Solo-Planta Departamento de SolosUniversidade Federal Rural do Rio de JaneiroSeropédicaRGBrazil

Land use change and occupation have led to modifications in the environment causing loss of biodiversity and ecosystem services throughout the *** environments with high economic relevance,such as the ferruginous campo rupestre(rupestrian grassland known as Canga in Brazil),are even more susceptible to severe impacts due to their extreme habitat conditions and low *** determination of reference ecosystems based on the intrinsic characteristics of the ecosystem is essential for conservation as well as to the implementation of ecological *** proposed the reference ecosystem of the three main types of habitats of the ferruginous campo rupestre based on their floristic *** described the floristic composition of each habitat and evaluated the physicochemical properties of the soils and the relationship between plants and *** three habitats showed high diversity of plant species and many endemic species,such as Chamaecrista choriophylla,Cuphea pseudovaccinium,Lychnophora pinaster,and vellozia *** distribution of vegetation was strongly related with the edaphic characteristics,with a set of species more adapted to high concentration of base saturation,fine sand,organic carbon,and iron,while another set of species succeeded in more acidic soils with higher S and silt *** provide support for the contention that the ferruginous campo rupestre is a mosaic of different habitats shaped by intrinsic local *** to recognize the floristic composition of each particular habitat can lead to inappropriate restoration,increased habitat homogenization and increased loss of biodiversity and ecosystem *** study also advances the knowledge base for building the reference ecosystem for the different types of ferruginous campo rupestre habitats,as well as a key database for highlighting those species contribute most to community assembly in this diverse and threatened tropical mountain ecosystem.

关键词： Canga Ecological restoration Extreme ecosystem Non-forest ecosystems Rupestrian grassland Taxon environment relationships

Guest editorial-soil erosion assessment, tools and data: A special issue from the Global Symposium on soil Erosion 2019

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International Soil and Water Conservation Research 2020年第4期8卷 333-336页

作者： Clara Lefèvre Richard m.Cruse Lucia Helena cunha dos Anjos Costanza Calzolari Nigussie Haregeweyn Global Soil Partnership Secretariat Food and Agriculture Organization of the United NationsViale delle Terme di CaracallaRomeItaly Department of Agronomy Iowa State UniversityAmesIA500011USA Department of Soils Federal University of Rio de JaneiroSeropédicaRJ23890-000Brazil Intergovernmental Technical Panel on Soils Food and Agriculture Organization of the United NationsRomeItaly CNR Institute for Bioeconomy Sesto FiorentinoItaly International Platform for Dryland Research and Education Tottori University1390 HamasakaTottori680-0001Japan

This special issue on soil erosion assessment,tools and data creation,consolidation and harmonization presents advances in soil erosion research with a focus on new tools that are being used to assess soil erosion *** publication includes eleven selected contributions presented at the Global Symposium on Soil Erosion(GSER,15-17 may 2019,Rome,Italy)dealing with erosion indicators'improvement,the use of remote sensing,nuclear techniques and geochemical fingerprinting as promising methods to assess soil losses,management practices that reduce soil erosion in vineyards and olive groves plantations and their modelling,and national and regional erosion assessments.

关键词： soil erosion dealing