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一步法光学剥离工艺

电子工艺技术 1984年第10期 18-23页

作者： m.Hatzakis B.j.Canavello j.m.shaw

本文描述一种采用单层AZ型光刻胶紫外曝光法,实现金属化图形剥离加工的工艺。这个工艺包含抗蚀剂层可在曝光前也可在曝光后于氯苯或其它芳香族溶剂,如甲苯或苯中浸渍处理,浸渍时间可预定。显影后,抗蚀剂剖面变成适于金属化图形剥离加工... 详细信息

本文描述一种采用单层AZ型光刻胶紫外曝光法,实现金属化图形剥离加工的工艺。这个工艺包含抗蚀剂层可在曝光前也可在曝光后于氯苯或其它芳香族溶剂,如甲苯或苯中浸渍处理,浸渍时间可预定。显影后,抗蚀剂剖面变成适于金属化图形剥离加工的悬伸梁结构。似乎是溶剂和低分子量的树脂从AZ抗蚀剂中溶除是造成显影速度存在差别的原因。另外,浸渍时间及其温度的影响表明,浸渍是一个扩散过程。

关键词：抗蚀剂溶剂钻蚀剥离工艺显影速率氯苯氯代烃 AZ 一步法单步法计算方法光学

A tabletop, ultrashort pulse photoneutron source driven by electrons from laser wakefield acceleration

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matter and Radiation at Extremes 2017年第6期2卷 296-302页

作者： X.j.jiao j.m.shaw T.Wang X.m.Wang H.Tsai P.Poth I.Pomerantz L.A.Labun T.Toncian m.C.Downer B.m.Hegelich Center for High Energy Density Science University of TexasAustinTX 78712USA Institut fur Kernphysik Technische Universitat DarmstadtGermany The School of Physics and Astronomy Tel-Aviv UniversityTel-Aviv69978Israel

Relativistic electron beams driven by laser wakefield acceleration were utilized to produce ultrashort neutron *** experiment was carried out on the 38 fs,~0.5 j,800 nm Ti:Sapphire laser in the 10 TW UT 3 laser lab at University of Texas at *** target gas was a high density pulsed gas jet composed of 90%He and 10%N *** laser pulse with a peak intensity of 1.5×10^(18) W/cm^(2) interacted with the target to create a cylindrical plasma channel of 60 mm radius(FWHm)and 1.5 mm length(FWHm).Electron beams of~80 pC with the Gaussian energy distribution centered at 37 meV and a width of 30 meV(FWHm)were produced via laser wakefield *** fluences of~2.4×10^(6) per shot with hundreds of ps temporal length were generated through bremsstrahlung and subsequent photoneutron reactions in a 26.6 mm thick tungsten *** were compared with those of simulations using EPOCH and GEANT4,showing agreement in electron spectrum,neutron fluence,neutron angular distribution and conversion rate.

关键词： Neutron source LWFA Photoneutron reaction

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

The BRICS and Beyond： Insights into Human Development/Security from ＂Global Governance＂？

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Fudan journal of the Humanities and Social Sciences 2014年第3期7卷 381-394页

作者： Timothy m. shaw mcCormack Graduate School University of Massachusetts Boston 100 Morrissey BoulevardBoston MA 02125-3393 USA

The decade of the BRICS is leading to the reanalysis of global relations, encouraged by the simultaneous rise of emerging markets and decline of the eurozone PIIGS. But is the trajectory towards global reorder and/or disorder？ Development like capitalisms and regionalisms is increasingly diverse： heterogeneous transnational networks best approached through a global studies frame？ Together these factors impact the balance between developmental and fragile states in African as elsewhere. And there are debates about what is emerging： companies？ econo- mies？ states？ and/or societies？ meanwhile, the ＂global＂ increasingly includes informal and illegal economies, especially TOC, including transnational Chinese mafias. Transnational governance continues to widen its scope to include airline and container alliances as well as a trio of commissions on drugs.

关键词： BRICS Development Global governance Regionalisms. Transnational

The clip cage conundrum: Assessing the interplay of confinement method and aphid genotype in fitness studies

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Insect Science 2024年第5期31卷 1591-1602页

作者： Laura marcela martinez-Chavez joe m.Roberts Alison j.Karley Bethan shaw Tom W.Pope Centre for Crop and Environmental Science Agriculture and Environment DepartmentHarper Adams UniversityNewportShropshireUK Ecological Sciences The James Hutton InstituteInvergowrieDundeeUK Pest and Pathogen Ecology NIABEast MallingKentUK

Behavior and fitness are important ecological traits frequently measured in insect bioassays.A common method to measure them in soft-bodied herbivorous insects involves confining individuals to plant leaves using clip *** studies have pre-viously highlighted the negative effects of clip cages on leaf physiology,little is known about the impact that using this confinement method has on insect *** responses of different aphid genotypes/clones to different containment methods have not previously been *** we measured key fitness traits(intrinsic rate of natural increase,mean relative growth rate,time to reach reproductive adulthood and population doubling time)in the potato aphid,macrosiphum euphorbiae Thomas(Hemiptera:Aphididae),when confined to plants using two methods:(1)clip cages to confine aphids to individual strawberry leaves and(2)a mesh bag to confine aphids to whole strawberry *** study identified a strong negative impact on all the measured aphid fitness traits when using clip cages instead of mesh *** also identified genotype-specific differences in response to confinement method,where clip cage confinement differentially affected the fitness of a given aphid genotype compared to the same genotype on whole *** results suggest that clip cage use should be carefully considered when experiments seek to quantify insect fitness and that whole plants should be used wherever *** the prevalence of clip cage use in insect bioassays,our results highlight the need for cau-tion when interpreting the existing literature as confinement method significantly impacts aphid fitness depending on their genotype.

关键词： aphid clonal variation aphid fitness clip cages confinement method feed-ing site insect bioassays

Arctic sea-ice extent: No record minimum in 2023 or recent years

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 52-55页

作者： Ola m.johannessen Tor I.Olaussen Nansen Scientific Society BergenNorway Nansen Environmental and Remote Sensing Center BergenNorway

Arctic sea-ice extent reaches its minimum each year in September. On 11 September 2023 the minimum was 4.969 million square kilometers(***^(2)). This was not a record low, which occurred in 2012, when the minimum was 4.175 ***^(2), 0.794 ***^(2) less than the minimum in 2023. However, the ice extent had decreased by 0.432 ***^(2) compared with 2022. Nevertheless, the summer melting in 2023 was remarkably less than expected when considering the strong heat waves in the atmosphere and ocean, with record temperatures set around the world. In general, there is a high correlation between the long-term decrease in sea-ice extent and the increasing CO_(2) in the atmosphere, where the increase of CO_(2) in recent decades explains about 80% of the decrease in sea ice in September, while the remainder is caused by natural variability.

关键词： Sea ice Arctic minimum ice Climate

Temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries on magnetic resonance imaging

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Neural Regeneration Research 2025年第11期20卷 3144-3150页

作者： Holly Flyger Samantha j.Holdsworth Alistair j.Gunn Laura Bennet Hamid Abbasi mātai medical Research Institute Tairāwhiti GisborneNew Zealand Department of Anatomy&medical Imaging Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Center for Brain Research The University of AucklandAucklandNew Zealand Auckland Bioengineering Institute The University of AucklandAucklandNew Zealand

moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental *** assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomarkers,neurological examination,and *** present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the early evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic *** review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a particular emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,particularly for infants treated with therapeutic hypothermia.A comprehensive literature search,from 2016 to 2024,identified 20 pertinent *** review highlights that while the optimal timing of magnetic resonance imaging scans is not clear,overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic *** challenges limit the timing consistency,particularly the need for intensive care and clinical ***,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after *** suggests that in the future it will be important to explore a wider range of times after hypo

关键词： magnetic resonance imaging neonatal hypoxic-ischemic encephalopathy neurodevelopmental outcomes prognostic biomarkers in neuroimaging scan timing therapeutic hypothermia