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Design,fabrication,characterization and reliability study of CmOs-mEms Lorentz-force magnetometers

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microsystems & Nanoengineering 2022年第5期8卷 17-41页

作者： j.j.Valle j.m.sánchez-Chiva D.Fernández j.madrenas Department of Electronic Engineering Universitat Politècnica de CatalunyaJordi Girona 1 i 3Edifici C408034 BarcelonaSpain sorbonne Université CNRSLaboratoire de Recherche en Informatique(LIP6)UMR76064 place Jussieu75005 ParisFrance Institut de Física d’Altes Energies(IFAE) The Barcelona Institute of Science and Technology(BIST)Edifici Cn.Facultat Ciències NordUniversitat Autónoma de Barcelona08193 Bellaterra(Barcelona)Spain

This article presents several design techniques to fabricate micro-electro-mechanical systems(mEms)using standard complementary metal-oxide semiconductor(CmOs)*** were applied to fabricate high yield CmOs-mEms shielded Lorentz-force magnetometers(LFm).The multilayered metals and oxides of the back-end-of-line(BEOL),normally used for electronic routing,comprise the structural part of the *** most important fabrication challenges,modeling approaches and design solutions are *** that predict the Q factor,sensitivity,Brownian noise and resonant frequency as a function of temperature,gas pressure and design parameters are presented and validated in characterization tests.A number of the fabricated magnetometers were packaged into Quad Flat No-leads(QFN)*** show this process can achieve yields above 95%when the proper design techniques are *** CmOs not being a process for mEms manufacturing,estimated performance(sensitivity and noise level)is similar or superior to current commercial magnetometers and others built with mEms ***,typical offsets present in Lorentz-force magnetometers were prevented with a shielding electrode,whose efficiency is ***,several reliability test results are presented,which demonstrate the robustness against high temperatures,magnetic fields and acceleration shocks.

关键词： Lorentz magnetometer characterization

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh s.Nugent Uniformed services University of the Health sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Weak Continuity of Riemann Integrable Functions in Lebesgue-Bochner spaces

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Acta mathematica sinica,English series 2010年第2期26卷 241-248页

作者： j.m.CALABUIG j.RODRíGUEZ E.A.snchez-PREZ Instituto Universitario de matemlica Pura y Aplicada Universidad Politcnica de Valencia

In general, Banach space-valued Riemann integrable functions defined on [0, 1] （equipped with the Lebesgue measure） need not be weakly continuous almost everywhere. A Banach space is said to have the weak Lebesgue property if every Riemann integrable function taking values in it is weakly continuous almost everywhere. In this paper we discuss this property for the Banach space LX^1 of all Bochner integrable functions from [0, 1] to the Banach space X. We show that LX^1 has the weak Lebesgue property whenever X has the Radon-Nikodym property and X＊ is separable. This generalizes the result by Chonghu Wang and Kang Wan [Rocky mountain j. math., 31（2）, 697-703 （2001）] that L^1[0, 1] has the weak Lebesgue property.

关键词： Riemann integral Bochner integral Lebesgue-Bochner space weak Lebesgue property

sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi sun shiqian shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Expert perspectives on GIs use in spanish geographic education

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International journal of Digital Earth 2022年第1期15卷 1204-1218页

作者： I.j.Buzo-sánchez C.mínguez m.L.De Lázaro-Torres IEs san Roque BadajozSpain Geography Department Universidad Complutense de MadridMadridSpain Geography Department UNEDMadridSpain

The emergence of new technological tools for territorial analysis,such as cloud-based GIs,or GIs viewers,compels us to closely examine its usefulness in geographic education. specifically,it raises the professors and teachers’ questions: what to teach? how to teach? and what will students learn? This research responds to these three questions by interviewing spanish experts who know how to use these tools to teach geography at university and secondary school levels. The Delphi technique was applied to achieve this,which established consensus and led to the following results from experts’ own experience: (1) that GIs help to understand territory in an experiential and non-memoristic way and (2) they enable the development of spatial thinking. This paper concludes that changes in methodologies and integrate technical knowledge into teacher training are needed.

关键词： Geography Delphi GIs competencies spatial thinking

The spectrum of building block conformers sustains the biophysical properties of clinically-oriented self-assembling protein nanoparticles

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science China materials 2022年第6期65卷 1662-1670页

作者： Eric Voltà-Durán julieta m sánchez Hèctor-López-Laguna Eloi Parladé Laura sánchez-García Alejandro sánchez-Chardi Ario de marco Ugutz Unzueta Esther Vázquez Antonio Villaverde Institut de Biotecnologia i de Biomedicina Universitat Autònoma de BarcelonaBellaterra 08193BarcelonaSpain Departament de Genètica i de microbiologia Universitat Autònoma de BarcelonaBellaterra 08193BarcelonaSpain CIBER de Bioingeniería Biomateriales y Nanomedicina(CIBER-BBN) Bellaterra 08193BarcelonaSpain Instituto de Investigaciones Biológicas y Tecnológicas(IIBYT)(CONICET-Universidad Nacional de Córdoba) ICTA&Cátedra de Química BiológicaDepartamento de QuímicaFCEFyNUNC.Av.Velez Sarsfield 1611X 5016GCA CórdobaArgentina servei de microscòpia Universitat Autònoma de BarcelonaBellaterra 08193BarcelonaSpain Departament de Biologia Evolutiva Ecologia i Ciències AmbientalsFacultat de BiologiaUniversitat de Barcelona08028 BarcelonaSpain Laboratory for Environmental and Life sciences University of Nova GoricaNova Gorica 5000Slovenia Biomedical Research Institute sant Pau(IIB sant Pau) Sant Antoni Ma Claret 16708025 BarcelonaSpain

Histidine-rich peptides confer self-assembling properties to recombinant proteins through the supramolecular coordination with divalent *** fact allows the cost-effective,large-scale generation of microscopic and macroscopic protein materials with intriguing biomedical *** such materials,resulting from the simple bioproduction of protein building blocks,homomeric nanoparticles are of special value as multivalent interactors and drug ***,we have here identified that the assembly of a given His-tagged protein might render distinguishable categories of self-assembling protein *** fact has been scrutinized through the nanobody-containing fusion proteins Em1-GFP-H6 and A3C8-GFP-H6,whose biosynthesis results in two distinguishable populations of building *** one of them,the assembling and disassembling is controllable by ***,a second population immediately self-assembles upon purification through a non-regulatable pathway,rendering larger nanoparticles with specific biological *** structural analyses of both model proteins and nanoparticles revealed important conformational variability in the building *** fact renders different structural and functional categories of the final soft materials resulting from the participation of energetically unstable intermediates in the oligomerization *** data illustrate the complexity of the Hismediated protein assembling in recombinant proteins but they also offer clues for a better design and refinement of protein-based nanomedicines,which,resulting from biological fabrication,show an architectonic flexibility unusual among biomaterials.

关键词： recombinant proteins self-assembling protein materials nanoparticles biomaterials

Effect of Noisy Fitness in Real-Time strategy Games Player Behaviour Optimisation Using Evolutionary Algorithms

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journal of Computer science & Technology 2012年第5期27卷 1007-1023页

作者： Antonio m. mora Antonio Fernndez-Ares juan j. merelo Pablo García-snchez Carlos m. Fernandes Computer Architecture and Technology Department University of Granada Institute for systems and Robotics Technical University of Lisbon

This paper investigates the performance and the results of an evolutionary algorithm （EA） specifically designed for evolving the decision engine of a program （which, in this context, is called bot） that plays Planet Wars. This game, which was chosen for the Google Artificial Intelligence Challenge in 2010, requires the bot to deal with multiple target planets, while achieving a certain degree of adaptability in order to defeat different opponents in different scenarios. The decision engine of the bot is initially based on a set of rules that have been defined after an empirical study, and a genetic algorithm （GA） is used for tuning the set of constants, weights and probabilities that those rules include, and therefore, the general behaviour of the bot. Then, the bot is supplied with the evolved decision engine and the results obtained when competing with other bots （a bot offered by Google as a sparring partner, and a scripted bot with a pre-established behaviour） are thoroughly analysed. The evaluation of the candidate solutions is based on the result of non-deterministic battles （and environmental interactions） against other bots, whose outcome depends on random draws as well as on the opponents＇ actions. Therefore, the proposed GA is dealing with a noisy fitness function. After analysing the effects of the noisy fitness, we conclude that tackling randomness via repeated combats and reevaluations reduces this effect and makes the GA a highly valuable approach for solving this problem.

关键词： real-time strategy game genetic algorithm noisy fitness player behaviour optimisation parameter adaptation

Fetkin-hydro,a new thermo-hydrological algorithm for low-temperature thermochronological modeling

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Geoscience Frontiers 2021年第3期12卷 186-200页

作者： Francisco sánchez Andres Barrea Federico m.Dávila Andres mora Centro de Investigaciones en Ciencias de la Tierra(CICTERRA) CONICET-UNCFCEFyNCiudad UniversitariaAv.Vélez Sarsfield 16115000 CórdobaArgentina Facultad de matemática AstronomíaFísica y Computación(FAMAF)Ciudad UniversitariaAv.Medida Allende 21445000 CórdobaArgentina Ecopetrol BotafogoRio de JaneiroBrazil

Despite two decades of major advances in the field of thermochronological modeling,state-of-the-art numerical implementations still rely mostly on burial and exhumation processes to explain radiometric *** though such an approach has proved valuable,failing to account for other first-order geological variables has led to misinterpretations and therefore,calls for a *** this study a new version of the Fetkin(finite element temperature kinematics,Ecopetrol)program is *** new algorithm couples time-dependent hydrological and thermal calculations,thus rendering thermochronological ages that,instead of being solely dependent on the kinematical evolution of a system,conditioning by the fluid flow is also *** contrast with previous thermochronological models,this work considers the influence of effective stress on rock properties(porosity and permeability)and therefore,in thermal *** analyses addressing relevant geological questions show not only the versatility of the code but also,new perspectives on forward low-temperature thermochronological *** circulation through pure-sandstone settings produce colder thermal architectures than those obtained in impermeable *** in cooling ages from models with and without fluid circulation are up to 5 myr.A 4-fold variation in thrusting rates(0.5 km/myr to 2 km/myr)produces a 15-myr difference in cooling ages in models with fluid flow,which contrasts to much lower differences,only 2 myr,in domains without(or minimal)fluid circulation.2D thermal solutions in fold-bend-fold thrust belts composed of sandstones remain static despite substantial relief development by kinematic folding.A case-study from Western Argentina,in the Andean Precordillera,confirms the plausibility of the numerical algorithm here posed and raises new questions on the first-order thermal controls in settings under deformation.

关键词： Thermochronology Hydrogeology Fluid flow Numerical modeling