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magnetic Films on self-assembled Nanospheres

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复旦学报（自然科学版） 2007年第5期46卷 709-710页

作者： T.Ulbrich I.Guhr T.schrefl O.Hellwig s.van Dijken m.Albrecht Department of Physics University of Konstanz Department of Engineering materials University of SheffieldS1 3JD SheffieldUnited Kingdom Hitachi san jose research Center VTT micro and Nanoelectronics

1 results Nanoparticle media using arrays of monodisperse nanoparticles with high magneticanisotropy are assumed to be the ideal future magnetic recording media. However,key requirements like control of the magnetic anisotropy orientation along with magnetic domain isolation have not been achieved so far. Here, we report on a combination of a two-dimensional topographic pattern formed of self-assembled nanoparticles with sizes as small as 20 nm and magnetic multilayer film deposition[1]. The so formed n...

关键词： magnetic film self-assembled nanospheres

横波弹性成像能否鉴别儿童梗阻性肾积水与非梗阻性肾积水?

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国际医学放射学杂志 2015年第6期 590-591页

作者： j.r.Dillman E.A.smith m.s.Davenport m.A.DiPietro r.sanchez K.H.Kraft 谢双双 section of Pediatric radiology Department of RadiologyUniversity of Michigan Health System

摘要目的探讨以利尿性肾脏成像为标准,注射利尿剂前后超声。材料与方法本前瞻性横断面盲性对比研究经伦理委员会批准,获得父母知情同意,并符合HIPAA。2012年

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somatostatin 4 regulates growth and modulates gametogenesis in zebrafish

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Aquaculture and Fisheries 2019年第6期4卷 239-246页

作者： Chenchao sui jie Chen jing ma Wenting Zhao Adelino V.m.Canário rute s.T.martins International research Center for marine Biosciences Ministry of Science and TechnologyShanghai Ocean UniversityShanghai201306China Key Laboratory of Exploration and Utilization of Aquatic Genetic resources Ministry of EducationShanghai Ocean UniversityShanghai201306China National Demonstration Center for Experimental Fisheries science Education Shanghai Ocean UniversityShanghai201306China CCmAr/CImAr Centre of marine sciences University of the AlgarveGambelas Campus8005-139FaroPortugal

somatostatin(ssT)plays important roles in growth and *** teleost fishes six ssT encoding genes(sst1 to sst6)have been identified although few studies have addressed their *** we aim to determine the function of the teleost specific sst4 in the zebrafish.A CrIsPr/Cas9 sst4 zebrafish mutant with loss of function(sst4−/−)was produced which grew significantly faster and was heavier at the onset of gonadal maturation than the wild type(WT).Consistent with their faster growth,liver igf1,igf2a and igf2b expression was significantly upregulated in the sst4−/−fish compared to the *** examination of the ovaries and testis indicated that sst4−/−fish had slightly delayed testicular gametogenesis compared to the *** lower expression of igf3,amh,insl3,hsd17b3,hsd11b2,hsd20b,cyp11b and cyp17 was consistently observed in the sst4−/−*** contrast,the ovaries had lower expression of igf1,igf2a and cyp19a1a but increased expression of igf2b and *** gonadotrophin beta subunits(fshb and lhb)in the brain were downregulated indicating the brain-pituitary-gonadal axis was downregulated in the sst4−/−fish and suggesting that the steroid production is compromised in the maturing *** addition,analysis of sst1 and sst3 mrNA levels in sst4−/−fish suggests a dosage compensation effect of sst1 in the brain and ***,the results from the zebrafish sst4−/−line support the idea that sst4 is involved in the regulation of igf signalling,somatic growth and reproduction since steroidogenesis and gametogenesis at pubertal onset were compromised.

关键词： somatostatin 4 Gametogenesis Zebrafish Gonadotrophin Puberty

Liver Transplantation （LT） in Eastern Europe till 1998 and Ensuing Development in Prague, Czech republic

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胃肠病学 2000年第B8期5卷 122-123页

作者： j.spicák s.Vítko m.ryska rTruneěka m.Krawczyk F.Perner F.Bělina P.Taimr j.sperl H.Hmcárková Instit.Clin.Exper MedicinePragueCzechRep 不详

The aim of this study was to evaluate the development of LT in Eastern Europe. representatives of gastro- and hepatological societies answered a questionnaire comprising the most descriptive items of the issue of LT until 1998. The Baltic countries, together with 6 southernBalkan countries, moldovia and Belarus have not developed a programme of LT. In Ukraine, 7 LT were performed with 3 early deaths.

关键词：肝脏移植 LT 东欧布拉格 1998年捷克斯洛伐克胃部疾病肝脏疾病

Characteristics and wear behavior of cenosphere dispersed titanium matrix composite developed by powder metallurgy route

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Transactions of Nonferrous metals society of China 2014年第5期24卷 1379-1386页

作者： D.P.mONDAL j.D.mAjUmDAr m.D.GOEL G.GUPTA CsIr-Advanced materials and Processes research Institute Department of metallurgical and materials Engineering Indian Institute of Technology

The cenosphere dispersed Ti matrix composite was fabricated by powder metallurgy route, and its wear and corrosion behaviors were investigated. The results show that the microstructure of the fabricated composite consists of dispersion of hollow cenosphere particles in a-Ti matrix. The average pore diameter varies from 50 to 150 μm. The presence of porosities is attributed to the damage of cenosphere particles due to the application of load during compaction as well as to the hollow nature of cenospheres. A detailed X-ray diffraction profile of the composites shows the presence of Al2O3, siO2, TiO2 and α-Ti. The average microhardness of the composite （matrix） varies from HV 1100 to HV 1800 as compared with HV 240 of the as-received substrate. Wear studies show a significant enhancement in wear resistance against hardened steel ball and WC ball compared with that of commercially available Ti-6Al-4V alloy. The wear mechanism was established and presented in detail. The corrosion behavior of the composites in 3.56% NaCl （mass fraction） solution shows that corrosion potential （φcorr） shifts towards nobler direction with improvement in pitting corrosion resistance. However, corrosion rate of the cenosphere dispersed Ti matrix composite increases compared with that of the commercially available Ti-6Al-4V alloy.

关键词： Ti matrix composite sintering wear property corrosion microstructure

systematic development of ionizable lipid nanoparticles for placental mrNA delivery using a design of experiments approach

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Bioactive materials 2024年第4期34卷 125-137页

作者： rachel E.Young Katherine m.Nelson samuel I.Hofbauer Tara Vijayakumar mohamad-Gabriel Alameh Drew Weissman Charalampos Papachristou jason P.Gleghorn rachel s.riley Department of Biomedical Engineering Henry M.Rowan College of EngineeringRowan University201 Mullica Hill RdGlassboroNJ 08028United States school of Translational Biomedical Engineering&sciences Virtua College of Medicine&Life Sciences of Rowan University201 Mullica Hill RdGlassboroNJ 08028United States Department of Chemical and Biomolecular Engineering College of EngineeringUniversity of Delaware150 Academy StreetNewarkDE 19716United States Cooper medical school of rowan University Rowan University401 BroadwayCamdenNJ 08103United States Perelman school of medicine University of Pennsylvania3400 Civic Center BlvdPhiladelphiaPA 19104United States Department of mathematics College of Science&MathematicsRowan University201 Mullica Hill RdGlassboroNJ 08028United States Department of Biomedical Engineering College of EngineeringUniversity of Delaware590 Avenue 1743NewarkDE 19713United States

Ionizable lipid nanoparticles(LNPs)have gained attention as mrNA delivery platforms for vaccination against COVID-19 and for protein replacement *** enhance mrNA stability,circulation time,cellular uptake,and preferential delivery to specific tissues compared to mrNA with no carrier ***,LNPs are only in the beginning stages of development for safe and effective mrNA delivery to the placenta to treat placental ***,we develop LNPs that enable high levels of mrNA delivery to trophoblasts in vitro and to the placenta in vivo with no *** conducted a Design of Experiments to explore how LNP composition,including the type and molar ratio of each lipid component,drives trophoblast and placental *** data revealed that utilizing C12-200 as the ionizable lipid and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE)as the phospholipid in the LNP design yields high transfection efficiency in *** of lipid molar composition as a design parameter in LNPs displayed a strong correlation between apparent pKa and poly(ethylene)glycol(PEG)content,as a reduction in PEG molar amount increases apparent ***,we present one LNP platform that exhibits the highest delivery of placental growth factor mrNA to the placenta in pregnant mice,resulting in synthesis and secretion of a potentially therapeutic ***,our high-performing LNPs have no toxicity to both the pregnant mice and *** results demonstrate the feasibility of LNPs as a platform for mrNA delivery to the placenta,and our top LNP formulations may provide a therapeutic platform to treat diseases that originate from placental dysfunction during pregnancy.

关键词： Lipid nanoparticles(LNPs) Drug delivery Nucleic acids Placental growth factor(PlGF) Placenta Pregnancy Preeclampsia

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温度和氧对油酸在萤石表面吸附的影响

国外非金属矿 1988年第3期 27-33页

作者： j.s.HU m.mIsrA j.D.mILLEr 长沙矿冶研究院

本文论述在碱性溶液中用放射技术研究温度和氧对油酸在萤石表面吸附的影响。实验表明:在油酸化合物的表面明显凝聚有含水的油酸钙沉淀,而且,由于体系变化的作用,形成一定的吸附密度。吸附等温线有三个不同的区域:化学平衡区;吸附密度达... 详细信息

本文论述在碱性溶液中用放射技术研究温度和氧对油酸在萤石表面吸附的影响。实验表明:在油酸化合物的表面明显凝聚有含水的油酸钙沉淀,而且,由于体系变化的作用,形成一定的吸附密度。吸附等温线有三个不同的区域:化学平衡区;吸附密度达到最大值的油酸钙沉淀区;在较高油酸平衡浓度下吸附密度减小的第三区。根据上述实验结果,吸附似乎包括低平衡油酸浓度下的化学吸附层,其油酸浓度可不同于在矿粒表面的油酸钙沉淀的浓度,形成油酸钙沉淀的平衡浓度要大于5×10-6m,更重要的一点是,在较高温度和氧势条件下,适当改变吸附密度不能对在类似条件下观察到的、显著增大矿粒疏水性这一结果作出令人满意的解释。

关键词：油酸钙平衡浓度吸附等温线钙沉淀物化学吸附层超声波处理吸附反应溶度积吸附过程表面吸附

Construction of a broad-host-range Anderson promoter series and particulate methane monooxygenase promoter variants expand the methanotroph genetic toolbox

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synthetic and systems Biotechnology 2024年第2期9卷 250-258页

作者： Etash H.Bhat jessica m.Henard spencer A.Lee Dustin mcHalffey mahith s.ravulapati Elle V.rogers Logan Yu David skiles Calvin A.Henard Department of Biological sciences and BioDiscovery Institute University of North TexasDentonTXUSA

methanotrophic bacteria are currently used industrially for the bioconversion of methane-rich natural gas and anaerobic digestion-derived biogas to valuable *** bacteria may also serve to mitigate the negative effects of climate change by capturing atmospheric greenhouse *** genetic tools have previously been developed for genetic and metabolic engineering of ***,the available tools for use in methanotrophs are significantly underdeveloped compared to many other industrially relevant bacteria,which hinders genetic and metabolic engineering of these *** such,expansion of the methanotroph genetic toolbox is needed to further our understanding of methanotrophy and develop biotechnologies that leverage these unique microbes for mitigation and conversion of methane to valuable ***,we determined the copy number of three broad-host-range plasmids in methylococcus capsulatus Bath and methylosinus trichosporium OB3b,representing phylogenetically diverse Gammaproteobacterial and Alphaproteobacterial methanotrophs,***,we show that the commonly used synthetic Anderson series promoters are functional and exhibit similar relative activity in *** and *** OB3b,but the synthetic series had limited ***,we mutagenized the native *** particulate methane monooxygenase promoter and identified variants with activity that expand the activity range of synthetic,constitutive promoters functional not only in ***,but also in Escherichia ***,the tools developed here advance the methanotroph genetic engineering toolbox and represent additional synthetic genetic parts that may have broad applicability in Pseudomonadota bacteria.

关键词： methanotroph methane monooxygenase Promoter metabolic engineering synthetic biology

mapping non-laminar proton acceleration in laser-driven target normal sheath field

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High Power Laser science and Engineering 2022年第1期10卷 10-16页

作者： C.Y.Qin H.Zhang s.Li s.H.Zhai A.X.Li j.Y.Qian j.Y.Gui F.X.Wu Z.X.Zhang Y.Xu X.Y.Liang Y.X.Leng B.F.shen L.L.ji r.X.Li state Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Center of materials science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China CAs Center for Excellence in Ultra-intense Laser science Shanghai 201800China Department of Physics Shanghai Normal UniversityShanghai 200234China shanghaiTech University Shanghai 201210China

We report on experimental observation of non-laminar proton acceleration modulated by a strong magnetic field in laser irradiating micrometer aluminum *** results illustrate the coexistence of ring-like and filamentation *** implement the knife edge method into the radiochromic film detector to map the accelerated beams,measuring a source size of 30-110μm for protons of more than 5 *** diagnosis reveals that the ring-like profile originates from low-energy protons far off the axis whereas the filamentation is from the near-axis high-energy protons,exhibiting non-laminar ***-in-cell simulations reproduced the experimental results,showing that the short-term magnetic turbulence via Weibel instability and the long-term quasi-static annular magnetic field by the streaming electric current account for the measured beam *** work provides direct mapping of laser-driven proton sources in the space-energy domain and reveals the non-laminar beam evolution at featured time scales.

关键词： knife-edge technique laser-plasma interaction non-laminar proton source target normal sheath acceleration Weibel instability