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Brain-penetrating neurotrophic factor mimetics: HEr-096 as a disease-modifying therapy for Parkinson’s disease

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Neural regeneration research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural regeneration research 2025年第6期20卷 1711-1712页

作者： Haoqi sun shiqian shen robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Lactose hydrolyzing activity of the lactase immobilized polycaprolactone and silk fibroin-based nanofiber and nitrocellulose membrane

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Food Bioscience 2022年第5期49卷 569-575页

作者： sümeyye Yılmaz-Karaoglu Begüm Gürel-Gokmen Tugba Tunali-Akbay Vocational school of Health services Fenerbahce UniversityIstanbulTurkey Department of Basic medical sciences Dentistry FacultyMarmara University˙IstanbulTurkey

This study aimed to investigate the activity of lactase immobilized polycaprolactone and silk fibroin(PCL/sF)-based nanofiber and nitrocellulose membrane for the preparation of lactose-reduced ***/sF-based nanofiber was prepared by using the electrospinning *** lactase enzyme was immobilized using the physical adsorption method on both surfaces,and then the optimum operating temperature and pH of the immobilized enzymes were *** efficiency of the immobilized lactase enzyme was determined in both goat and cow *** nutrient content of milk was also analyzed before and after the incubation of nanofiber and membrane with *** lactose hydrolysis efficiency of the lactase immobilized nitrocellulose membrane was found to be higher than the lactase immobilized PCL/sF-based *** was hydrolyzed 59%in cow milk and 87%in goat milk by using lactase immobilized nitrocellulose membrane.42%of lactose was also hydrolyzed in cow milk and 21%was hydrolyzed in goat milk by using lactase immobilized PCL/sF-based ***,the use of these two bioactive surfaces did not change the fat and protein composition of both cow and goat *** conclusion,lactase immobilized nitrocellulose membrane was found to be more advantageous in the production of lactose-reduced milk than the lactase immobilized polycaprolactone/silk fibroin nanofiber.

关键词： Lactose reduced milk Immobilization Bioactive surface Electrospinning Lactose intolerance

Cross-focusing of two chirped Gaussian laser beams and THz wave generation in plasmas of multi-ion species under a weakly relativistic and ponderomotive regime

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Plasma science and Technology 2022年第10期24卷 1-11页

作者： m r jAFArI mILANI s rEZAEI m j jAFArI Photonics and Quantum Technologies research school Nuclear Science and Technology Research InstituteTehran 14665-678Iran Plasma and Fusion research school Nuclear Science and Technology Research InstituteTehran 14399-51113Iran

The generation of terahertz(THz)waves via the beating of two high-intensity chirped Gaussian lasers in a multi-ion-species plasma is numerically studied by taking into account the weak relativistic and ponderomotive regime of *** coupled differential equations for beamwidth parameters are extracted by introducing the dielectric function of such plasma and using WKB and paraxial ray *** amplitude of THz radiation at beat frequency resulting from the nonlinear current density induced by the beat ponderomotive force of the cross-focusing of beams was *** impacts of the chirp frequency parameter,initial laser intensity and initial ionic species density(specifically,the presence of singly and doubly charged ions)in the plasma on THz generation were *** numerical results reveal that THz radiation generation strongly depends on the chirp frequency parameter.A specific range of chirp frequencies exists for self-focusing as well as THz generation with a'turning point',where the THz emission reaches its maximum *** results show that the strength of self-focusing and consequently the generated THz radiation are reduced by increasing the density of doubly charged ionic species in the plasma due to the suppression of the nonlinear effects.

关键词： laser–plasma interaction THz generation chirped Gaussian laser beams

review on friction stir welding of dissimilar magnesium and aluminum alloys: scientometric analysis and strategies for achieving high-quality joints

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journal of magnesium and Alloys 2023年第11期11卷 4082-4127页

作者： mohamed m.Z.Ahmed mohamed m.El-sayed seleman Dariusz Fydrych Gürel ÇAm Department of mechanical Engineering College of Engineering at Al KharjPrince Sattam Bin Abdulaziz UniversityAl Kharj 11942Saudi Arabia Department of metallurgical and materials Engineering Faculty of Petroleum and Mining EngineeringSuez UniversitySuez 43512Egypt Faculty of mechanical Engineering and ship Technology Institute of Machines and Materials TechnologyGdańsk University of TechnologyGabriela Narutowicza Street 11/12Gdańsk 80-233Poland Department of mechanical Engineering Iskenderun Technical UniversityIskenderunHatay 31200Turkiye

magnesium and aluminum alloys continually attract interest as lightweight structural materials for transport applications. However, joining these dissimilar alloys is very challenging. The main obstacle that hinders progress in dissimilar mg-Al joining is the formation of brittle intermetallic compounds(ImCs). As a solid-state joining technique, FsW is an excellent candidate to attenuate the deleterious ImC effects in dissimilar Al-mg joining due to the inherent low heat inputs involved in the process. However, the ImCs, namely Al_(3)mg_(2) and Al_(12)mg_(17) phases, have also been reported to form during Al-mg dissimilar FsW;their amount and thickness depend on the heat input involved;thus,the weld parameters used. since the heat dissipated in the material during the welding process significantly affects the amount of ImCs,the heat input during FsW should be kept as low as possible to control and reduce the amount of ImCs. This review aims to critically discuss and evaluate the studies conducted in the dissimilar Al/mg FsW through a scientometric analysis and also with a focus on the strategies recently applied to enhance joint quality. The scientometric analysis showed that the main research directions in mg/Al FsW are the technological weldability of aluminum and magnesium during FsW, structural morphology, and mechanical properties of dissimilar welded joints. Considering the scope of application of the aforementioned joints, the low share of articles dealing with environmental degradation and operational cracking is surprising. This might be attributed to the need for well-developed strategies for obtaining high-quality and sustainable joints for applications. Thus, the second part of this review is conventional, focusing mainly on the new strategies for obtaining high-quality mg/Al joints. It can be concluded that in addition to the necessity to optimum welding parameters to suppress the excessive heat to limit the amount and thickness of ImC formed and improv

关键词： Friction stir welding(FsW) Al-alloys mg-alloys Dissimilar material welding Intermetallics Weld performance

Effect of Wood-drying Condensate on Emission of Volatile Organic Compounds and Bonding Properties of Fibreboard

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journal of Bionic Engineering 2020年第1期17卷 206-214页

作者： Nadir Ayrilmis Tolga Kapti Ali Gürel martin Ohlmeyer Department of Wood mechanics and Technology Forest FacultyIstanbul University-CerrahpasaIstanbul 34473Turkey Polisan Kimya san.A.(s). Dilovas(i)Organize Sanayi B(o)lgesi 1.K(i)s(i)m Liman Cad.No:7Dilovas(i)41455Turkey Forest research Institute Marmara RegionGeneral Directorate of Forestry of TurkeyIstanbul 34398Turkey Thünen-Institut für Holzforschung Thünen Institute of Wood ResearchLeuschnerstr.91 cHamburg 21031Germany

Potential use of condensate generated by cooling the steam obtained during high-frequency/vacuum drying step of hardwood lumber was *** liquid condensates were obtained from oak,beech and walnut *** liquid condensate was then used as a replacement for deionized water in the synthesis of Urea-Formaldehyde(UF)resin(5 wt%of total resin)using a laboratory scale *** Density Fibreboards(mDFs)were produced using control and modified *** of Volatile Organic Compounds(VOCs)from the mDFs were determined by micro Chamber *** bonding properties of the mDFs were determined according to European *** main VOC emissions from mDFs produced using UF resin containing the condensate were a-Pinene,b-Pinene,careen,and acetic acid,which were lower than those of the control mDF,except for the acetic acid emission of mDF with oak *** the tree species,the beech wood condensate gave the lowest VOC emissions(732μg·m^-3)from the mDFs,followed by the mDFs containing walnut wood condensate(852μg·m^-3),oak wood condensate(998μg·m^-3),and control mDF(3529μg·m^-3),***,the internal bond strength of mDFs containing the condensate was negatively impacted by the condensate(0.70 N·mm^-2 to 0.54 N·mm^-2 depending on the tree species).The results showed that the liquid wood-drying condensate which generally rel.ased to the ground could be efficiently used as an alternative to expensive VOCs scavenger used in the production of UF resin bonded *** may be one of the most efficient uses of the condensate in high value-added materials.

关键词： bionics condensate fibreboard urea-formaldehyde VOCs

swampland ds conjecture in mimetic f(r,T)gravity

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Communications in Theoretical Physics 2022年第8期74卷 101-115页

作者： s Noori Gashti j sadeghi s Upadhyay m r Alipour Department of Physics Faculty of Basic SciencesUniversity of Mazandaran PO Box 47416-95447BabolsarIran Department of Physics K.L.S.CollegeNawadaBihar 805110India Department of Physics Magadh UniversityBodh GayaBihar 824234India Inter-University Centre for Astronomy and Astrophysics(IUCAA) PuneMaharashtra 411007India school of Physics Damghan UniversityDamghan ***Iran

In this paper,we study a theory of gravity called mimetic f(r,T)in the presence of swampland ds *** this purpose,we introduce several inflation solutions of the Hubble parameter H(N)from f(r,T)=r+δT gravity model,in which r is ricci scalar,and T denotes the trace of the energy–momentum ***,δand N are the free parameter and a number of e-fold,*** we calculate quantities such as potential,Lagrange multiplier,slow-roll,and some cosmological parameters such as nsand *** we challenge the mentioned inflationary model from the swampland ds *** discuss the stability of the model and investigate the compatibility or incompatibility of this inflationary scenario with the latest Planck observable data.

关键词： mimetic f(r,T)gravity Lagrange multiplier swampland conjecture

Analysis of antisym metric cross-ply laminates using high-order shear deformation theories:a meshless approach

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Acta mechanica sinica 2020年第5期36卷 1078-1098,I0003页

作者： D.E.s.rodrigues j.Belinha L.m.j.s.Dinis r.m.Natal jorge Institute of science and Innovation in mechanical and Industrial Engineering 4200-465 PortoPortugal Department of mechanical Engineering School of EngineeringPolytechnic of Porto(ISEP)4200-072 PortoPortugal Department of mechanical Engineering Faculty of EngineeringUniversity of Porto(FEUP)4200-465 PortoPortugal

For many years finite element method(FEm)was the chosen numerical method for the analysis of composite ***,in the last 20 years,the scientific community has witnessed the birth and development of several meshless methods,which are more flexible and equally accurate numerical *** meshless method used in this work is the natural neighbour radial point interpolation method(NNrPIm).In order to discretize the problem domain,the NNrPIm only requires an unstructured nodal ***,using the Voronoi mathematical concept,it enforces the nodal connectivity and constructs the background integration *** NNrPIm shape functions are constructed using the radial point interpolation *** this work,the displacement field of composite laminated plates is defined by high-order shear deformation *** the end,several antisymmetric cross-ply laminates were analysed and the NNrPIm solutions were compared with the *** obtained results show the efficiency and accuracy of the NNrPIm formulation.

关键词： Antisymmetric cross-ply laminates High-order shear deformation theories meshless methods Naturalneighbour radial point interpolation method(NNrPIm)

structural and mechanical properties of Al–C–N films deposited at room temperature by plasma focus device

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Chinese Physics B 2016年第7期25卷 299-304页

作者： Z A Umar r Ahmad r s rawat m A Baig j siddiqui T Hussain National Centre for Physics Quaid-i-Azam University Campus Department of Physics GC University NssE National Institute of Education Nanyang Technological University Centre for Advanced studies in Physics GC University

The Al–C–N films are deposited on si substrates by using a dense plasma focus（DPF） device with aluminum fitted central electrode（anode） and by operating the device with CH_4/N_2 gas admixture ratio of 1：1. XrD results verify the crystalline Al N（111） and Al_3CON（110） phase formation of the films deposited using multiple shots. The elemental compositions as well as chemical states of the deposited Al–C–N films are studied using XPs analysis, which affirm Al–N, C–C, and C–N bonding. The FEsEm analysis reveals that the deposited films are composed of nanoparticles and nanoparticle agglomerates. The size of the agglomerates increases at a higher number of focus deposition shots for multiple shot depositions. Nanoindentation results reveal the variation in mechanical properties（nanohardness and elastic modulus）of Al–C–N films deposited with multiple shots. The highest values of nanohardness and elastic modulus are found to be about 11 and 185 GPa, respectively, for the film deposited with 30 focus deposition shots. The mechanical properties of the films deposited using multiple shots are related to the Al content and C–N bonding.

关键词： dense plasma focus XPs field emission scanning electron microscope elastic modulus