检索结果-南通市图书馆

Genes & Diseases 2024年第3期11卷 140-143页

作者： Albert R.Wang Andrew m.Baschnagel Zijian ni Sean R.Brennan Hypatia K.Newton Darya Buehler Christina Kendziorski Randall j.Kimple Gopal lyer Department of Human Oncology University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA Department of Biomedical Engineering University of Wisconsin-MadisonMadisonWI 53705USA University of Wisconsin Carbone Cancer Center MadisonWI 53705USA Department of Biostatistics and medical Informatics University of Wisconsin-MadisonMadisonWI 53706USA Department of Biology Tufts UniversityMedfordMA 02155USA Department of Pathology and Laboratory medicine University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA

Androgen receptor(AR)is a major transcription factor that plays a role in inflammatory response including interleukin-6(IL6)signaling.1 While AR regulation through paracrine loop signaling in prostate tissue is well-studied,its impact through an IL6 autocrine loop in the lung has not been wellstudied despite the organ's response to respiratory viral *** inhibition and RNA knockdown of AR identified a bZIP transcription factor mAF to be a common target of inflammation using these perturbations in lung cells.

关键词： inflammation lung respiratory

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

胰腺手术:多学科评价手术中超声的应用价值

国际医学放射学杂志 2013年第3期 271-271页

作者： j.m.ni mhuircheartaigh m.R.Sun m.P.Callery B.Siewert C.m.Vollmer R.A.Kane 尹学青 Department of Radiology Beth Israel Deaconess Medical Center

目的为了综合评价不同类型胰腺手术中超声应用的价值。材料与方法本研究是经伦理审查委员会批准并符合HIPAA,免签病人知情同意书的回顾性分析。研究对象为单个医疗中心10年内胰腺手术中应用超声或腹腔镜超声者,放射科医生与胰腺外科医... 详细信息

目的为了综合评价不同类型胰腺手术中超声应用的价值。材料与方法本研究是经伦理审查委员会批准并符合HIPAA,免签病人知情同意书的回顾性分析。研究对象为单个医疗中心10年内胰腺手术中应用超声或腹腔镜超声者,放射科医生与胰腺外科医生共同收集每例病人的手术记录、影像学资料及术后临床过程中的病例资料,并记录最初诊断、手术方式及最终的病理结果。将术中超声及腹腔镜超声的应用价值分为0～3分共4个等级,建立一个相对价值评分体系。对比相同得分组内的手术方式和病理结果。分类变量采用χ2检验或Fisher检验。结果 189例手术中进行了193次术中超声或术中腹腔镜超声检查。102例男性,87例女性。平均年龄57.8岁(18～86岁)。所有术中或腹腔镜超声检查价值得分情况如下:0分,3.6%;1分,11.9%;2分,31.1%;3分,53.4%。较高的得分(3分,60次)最常见的作用是能促使手术方案的改变。较高的得分与胰腺炎手术相关性最大(P<0.01)。手术结果表明,术中胰腺肿瘤分期通常导致低价值得分。所有得0分的病例均为胰腺恶性肿瘤腹腔镜手术(分期或胰腺活检)。结论术中超声或腹腔镜超声可作为在多种胰腺相关手术过程中的有效手段,不同的手术类型中可显示各自的价值。

关键词：手术中超声得分应用价值胰腺

Dynamics of iron and aluminum storages in a subtropical forest headwater stream

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

journal of mountain Science 2024年第7期21卷 2193-2205页

作者： YI Qiumeng mA Diting PENG Yan ZHAO Zemin YUAN Chaoxiang YUAN ji ni Xiangyin WU Fuzhong YUE Kai AN Nannan Key Laboratory of Humid Subtropical Eco-geographical Processes of ministry of Education School of Geographical SciencesFujian Normal UniversityFuzhou 350117China Fujian Sanming Forest Ecosystem National Observation and Research Station Sanming 365002China

The forest headwater streams are important hubs for connecting terrestrial and aquatic ecosystems,with plant litter and sediments as the major carriers for material migrations;however,until now we knew little about the dynamics of trace elements such as iron(Fe)and aluminum(Al)in forest headwater ***,we quantitatively identified the spatiotemporal dynamics of Fe and Al storages in plant litter and sediments and their influencing factors in a subtropical forest headwater stream,and assessed the potential pollution *** results showed that:(1)the mean concentrations of Fe and Al in plant litter(sediments)were 5.48 and 8.46(7.39 and 47.47)g·kg^(-1),and the mean storages of Fe and Al in plant litter(sediments)were 0.26 and 0.43(749.04 and 5030.90)g·m^(-2),respectively;(2)the storages of Fe and Al in plant litter and sediments significantly fluctuated from january to December,and showed a decreasing pattern from the source to mouth;and(3)storages of Fe and Al had no significant correlation with riparian forest type and the present of tributary and the Fe and Al storages in plant litter were mainly affected by water temperature and water alkalinity,and their storages in sediments were mainly affected by water temperature and frequency of rainfall;and(4)there were no anthropogenic pollution in Fe and Al in the forest headwater *** study revealed the primary factors of concentrations and storages of Fe and Al in plant litter and sediments in a forest headwater stream,which will improve our understanding of the role of headwater streams in forest nutrient storage and cycling along with hydrological processes.

关键词： Plant litter Sediments Storage Forest headwater stream Stream characteristics Trace element

SARS-CoV-2 RBD and Its Variants Can Induce Platelet Activation and Clearance:Implications for Antibody Therapy and Vaccinations against COVID-19

在线全文

学校读者我要写书评

暂无评论

Research 2024年第3期2023卷 1-15页

作者： Xiaoying ma jady Liang Guangheng Zhu Preeti Bhoria Aron A.Shoara Daniel T.macKeigan Christopher j.Khoury Sladjana Slavkovicl Lisha Lin Danielle Karakas Ziyan Chen Viktor Prifti Zhenze Liu Chuanbin Shen Yuchong Li Cheng Zhang jiayu Dou Zack Rousseau jiamin Zhang Tiffany ni Xi Lei Pingguo Chen Xiaoyu Wu Hamed Shaykhalishahi Samira mubareka Kim AConnelly Haibo Zhang Ori Rotstein Heyu ni Department of Laboratory medicine and Pathobiology University of TorontoTorontoONCanada Department of Laboratory medicine Keenan Research Centre for Biomedical Science of St.Michael’s HospitalTorontoONCanada Toronto Platelet Immunobiology Group TorontoONCanada Department of Physiology University of TorontoTorontoONCanada CCOA Therapeutics Inc. TorontoONCanada Canadian Blood Services Centre for Innovation TorontoONCanada The State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory DiseaseThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Department of Laboratory medicine The Second Affliated Hospital of Guangzhou University of Chinese MedicineGuangzhouChina Advanced Pharmaceutics&Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoTorontoONCanada Department of medical microbiology and Infectious Disease Sunnybrook Health Science CentreToronto ONCanada Department of medicine University of TorontoTorontoONCanada Division of Cardiology.St.michael's Hospital TorontoONCanada Department of Anesthesiology and Pain medicine and Division of Critical Care medicine University of TorontoTorontoONCanada interdepartmental Division of Critical Care medicine University of TorontoTorontoONCanada Department of Surgery University of Toronto TorontoONCanada.

The COVID-19 pandemic caused by SARS-CoV-2 virus is an ongoing global health *** cases of COVID-19 and the rare cases of COVID-19 vaccine-induced-thrombotic-thrombocytopenia(VITT)are both associated with thrombosis and thrombocytopenia;however,the underlying mechanisms remain inadequately *** infection and vaccination utilize the spike protein receptor-binding domain(RBD)of *** found that intravenous injection of recombinant RBD caused significant platelet clearance in *** investigation revealed the RBD could bind platelets,cause platelet activation,and potentiate platelet aggregation,which was exacerbated in the Delta and Kappa *** RBD–platelet interaction was partially dependent on theβ3 integrin as binding was significantly reduced inβ3−/−***,RBD binding to human and mouse platelets was significantly reduced with relatedαIIbβ3 antagonists and mutation of the RGD(arginine-glycine-aspartate)integrin binding motif to RGE(arginine-glycine-glutamate).We developed anti-RBD polyclonal and several monoclonal antibodies(mAbs)and identified 4F2 and 4H12 for their potent dual inhibition of RBD-induced platelet activation,aggregation,and clearance in vivo,and SARS-CoV-2 infection and replication in Vero E6 *** data show that the RBD can bind platelets partially thoughαIIbβ3 and induce platelet activation and clearance,which may contribute to thrombosis and thrombocytopenia observed in COVID-19 and *** newly developed mAbs 4F2 and 4H12 have potential not only for diagnosis of SARS-CoV-2 virus antigen but also importantly for therapy against COVID-19.

关键词： Antibody diagnosis vaccine

Concentration of Copper, Zinc, Lead, Cadmium, and nickel in the Incinerator Bottom Ash in Five County Hospitals in Kenya

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Geoscience and Environment Protection 2024年第6期12卷 90-114页

作者： muriithi j. Githinji Paul m. Njogu Zipporah Nganga mohamed Karama Institute of Tropical medicine and Infectious Diseases (ITROmID) Jomo Kenyatta University of Agriculture and Technology (JKUAT) Nairobi Kenya Institute of Energy and Environmental Technology Jomo Kenyatta University of Agriculture and Technology (JKUAT) Nairobi Kenya Academic Research and Student Affairs South Eastern Kenya University Kitui Kenya School of Public Health Amref International University Nairobi Kenya

Healthcare wastes contain potentially harmful microorganisms, inorganic and organic compounds that pose a risk to human health and the environment. Incineration is a common method employed in healthcare waste management to reduce volume, quantity, toxicity as well as elimination of microorganisms. However, some of the substances remain unchanged during incineration and become part of bottom ash, such as heavy metals and persistent organic pollutants. monitoring of pollution by heavy metals is important since their concentrations in the environment affect public health. The goal of this study was to determine the levels of Copper (Cu), Zinc (Zn) Lead (Pb), Cadmium (Cd) and nickel (ni) in the incinerator bottom ash in five selected County hospitals in Kenya. Bottom ash samples were collected over a period of six months. Sample preparation and treatment were done using standard methods. Analysis of the heavy metals were done using atomic absorption spectrophotometer, model AA-6200. One-Way Analysis of Variance (ANOVA) was performed to determine whether there were significant differences on the mean levels of Cu, Zn, Pd, Cd and ni in incinerator bottom ash from the five sampling locations. A post-hoc Tukey’s Test (HSD) was used to determine if there were significant differences between and within samples. The significant differences were accepted at p ≤ 0.05. To standardize the results, overall mean of each metal from each site was calculated. The metal mean concentration values were compared with existing permissible levels set by the WHO. The concentrations (mg/kg) were in the range of 102.27 - 192.53 for Cu, Zn (131.68 - 2840.85), Pb (41.06 - 303.96), Cd (1.92 - 20.49) whereas ni was (13.83 - 38.27) with a mean of 150.76 ± 77.88 for Copper, 131.66 ± 1598.95 for Zinc, 234.60 ± 262.76 for Lead, 12.256 ± 10.86 for Cadmium and 29.45 ± 18.24 for nickel across the five sampling locations. There were significant differences between levels determined by one-way ANOVA of Zn (

关键词： Healthcare Waste Disposal Public Health Environment Incineration Heavy metals Bottom Ash

Hepatitis C:a successful story of cure

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science Bulletin 2016年第24期61卷 1884-1887页

作者： Yi ni Department of Infectious Diseases Molecular VirologyUniversity Hospital Heidelberg 69120 Heidelberg Germany

On September 23, the 2016 Lasker-DeBakey clinical medical research award ceremony was celebrated in New York City. This annual prize has been awarded by the Lasker Foundation for over 71 years, and it is the most prestigious biomedical award in the United States, popu- larly known as ＂America＇s Nobel Prize＂. Indeed, 87 Lasker laureates have received the Nobel Prize, including 41 within the last 30 years （one example is the Chinese pharmaceutical chemist Youyou Tu, who won the 2011 Lasker-DeBakey award and four years later received the Nobel Prize）. This year, the honor went to Ralf F. W. Bartenschlager （Heidelberg University, Germany）, Charles m. Rice （Rockefeller University, NY, USA）, and michael j. Sofia （Arbutus Biopharma, PA, USA） for the development of cell culture system to study the replication of Hepatitis C virus （HCV） and for the use of this system to develop drugs capable of eliminating Hepatitis C.

关键词：丙型肝炎病毒 michael 故事治愈诺贝尔奖生物制药开发能力培养系统

Characterization of ASTER GDEm elevation data over vegetated area compared with lidar data

在线全文

学校读者我要写书评

暂无评论

International journal of Digital Earth 2015年第3期8卷 198-211页

作者： Wenjian ni Guoqing Sun Kenneth j.Ranson State Key Laboratory of Remote Sensing Science Institute of Remote Sensing and Digital EarthChinese Academy of SciencesBeijingChina Department of Geographical sciences University of MarylandCollege ParkMDUSA Biospheric Sciences Branch NASA’s Goddard Space Flight CenterGreenbeltMDUSA

Current researches based on areal or spaceborne stereo images with very high resolutions(<1 m)have demonstrated that it is possible to derive vegetation height from stereo *** second version of the Advanced Spaceborne... 详细信息

Current researches based on areal or spaceborne stereo images with very high resolutions(m)have demonstrated that it is possible to derive vegetation height from stereo *** second version of the Advanced Spaceborne Thermal Emission and Reflection Radiometer Global Digital Elevation model(ASTER GDEm)is the state-of-the-art global elevation data-set developed by stereo ***,the resolution of ASTER stereo images(15 m)is much coarser than areal stereo images,and the ASTER GDEm is compiled products from stereo images acquired over 10 *** forest disturbances as well as forest growth are inevitable in 10 years time *** this study,the features of ASTER GDEm over vegetated areas under both flat and mountainous conditions were investigated by comparisons with lidar *** factors possibly affecting the extraction of vegetation canopy height considered include(1)co-registration of DEms;(2)spatial resolution of digital elevation models(DEms);(3)spatial vegetation structure;and(4)terrain *** results show that the accurate coregistration between ASTER GDEm and national elevation dataset(NED)is necessary over mountainous *** correlation between ASTER GDEm minus NED and vegetation canopy height is improved from 0.328 to 0.43 by degrading resolutions from 1 arc-second to 5 arc-second and further improved to 0.6 if only homogenous vegetated areas were considered.

关键词： vegetation canopy height ASTER GDEm NED photogrammetry stereo-mapping

基于正交切削逆识别井下管柱的johnson-Cook本构模型

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中南大学学报（自然科学版） 2024年第3期55卷 939-950页

作者：祝效华周博文敬俊叶文勇田洋倪宗清西南石油大学机电工程学院四川成都610500 中国石油集团川庆钻探工程有限公司钻采工程技术研究院陕西西安710018 低渗透油气田勘探开发国家工程实验室陕西西安710018

在有限元仿真金属切削过程中,本构模型是仿真的基础,目前井下生产管柱j55油管材料的本构模型参数尚不明确,为此,提出一种基于正交切削理论逆识别油管材料johnson-Cook(j-C)本构模型参数的方法。首先,通过准静态拉伸试验得到油管材料的应... 详细信息

在有限元仿真金属切削过程中,本构模型是仿真的基础,目前井下生产管柱j55油管材料的本构模型参数尚不明确,为此,提出一种基于正交切削理论逆识别油管材料johnson-Cook(j-C)本构模型参数的方法。首先,通过准静态拉伸试验得到油管材料的应力-应变曲线,根据曲线拟合确定j55油管的初始屈服强度A、应变硬化系数B和应变硬化因子n;其次,通过正交切削试验获得切削力以及进给力,根据正交切削试验和平行剪切区模型,计算正交切削过程主剪切区中的流动应力、应变、应变率以及切削温度,并将这些参数与计算出的A、B、n代入j-C模型中,得到多组应变率敏感性参数C以及热软化效应参数m,从而确定其约束范围;第三,采用自适应权重粒子群算法在约束范围中搜索出参数C和m的最优值,进而确定j55油管材料本构模型参数;最后,使用逆识别法得出的j-C本构模型进行有限元仿真,将仿真结果与试验结果进行了对比。研究结果表明:与试验相比,有限元仿真的切削力和进给力最大相对误差分别为14.4%和13.64%,有限元仿真模拟温度与实际测量温度的最大相对误差为10.57%,仿真模型和实际切削过程在切屑形态上表现出了一致规律,验证了逆识别方法可行性和本构模型的可靠性。

关键词： j55油管本构模型逆向识别正交切削有限元仿真

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

大型预训练语言模型基础逻辑能力测评研究

曲阜师范大学学报（自然科学版） 2024年第3期50卷 89-95页

作者：倪睿康肖达高鹏曲阜师范大学网络空间安全学院山东省曲阜市273165 北京邮电大学网络空间安全学院北京市100876

针对数量问题、集合关系、量词问题和常识推理等4类基本逻辑推理问题,构建少样本学习模板,对数据集进行自动生成扩展,设计了11个逻辑推理子任务.采用语境学习和提示微调2种少样本学习方法,从模型、测试、任务3个维度测试了GPT-Neo-1.3B... 详细信息

针对数量问题、集合关系、量词问题和常识推理等4类基本逻辑推理问题,构建少样本学习模板,对数据集进行自动生成扩展,设计了11个逻辑推理子任务.采用语境学习和提示微调2种少样本学习方法,从模型、测试、任务3个维度测试了GPT-Neo-1.3B、GPT-j-6B、GPT-3-Curie、GPT-3-Davinci等模型的逻辑推理能力.结果表明,GPT-3模型在数量问题、量词问题和常识推理问题方面相对优秀,GPT-Neo与GPT-j模型在集合关系问题上更具优势.相较于语境学习,对预训练模型进行提示微调能显著提升预测能力.

关键词：自然语言处理预训练语言模型语境学习提示微调少样本学习

维普期刊数据库博看期刊

退火热处理对Cr_(3)C_(2)-FeCrBSi涂层摩擦磨损性能的影响

在线全文

学校读者我要写书评

暂无评论

表面技术 2024年第1期53卷 65-77页

作者：姜自滔杨康辛越易新林张世宏王硕煜倪振航安徽工业大学先进金属材料绿色制备与表面技术教育部重点实验室安徽马鞍山243002 安徽马钢表面技术股份有限公司安徽马鞍山243000

目的针对冷轧辊表面的循环应力、摩擦磨损的特殊服役环境,设计空气燃料超音速火焰喷涂(HVAF)制备Cr_(3)C_(2)-FeCrBSi复合涂层来提高工件表面的硬度和耐磨性。方法利用HVAF技术在冷轧辊用合金钢板表面制备不同尺寸陶瓷颗粒混合的Cr_(3... 详细信息

目的针对冷轧辊表面的循环应力、摩擦磨损的特殊服役环境,设计空气燃料超音速火焰喷涂(HVAF)制备Cr_(3)C_(2)-FeCrBSi复合涂层来提高工件表面的硬度和耐磨性。方法利用HVAF技术在冷轧辊用合金钢板表面制备不同尺寸陶瓷颗粒混合的Cr_(3)C_(2)-Fe CrBSi的复合涂层,并在600、700、800℃进行退火处理后得到退火态涂层。利用XRD、SEm、显微硬度计、电子拉伸试验机、盘式摩擦磨损试验机和接触疲劳试验机,考察了不同陶瓷含量和不同退火温度下涂层的相组成、组织结构、机械性能、摩擦磨损性能和接触疲劳失效形式。结果喷涂态涂层的显微硬度、结合强度随着Cr_(3)C_(2)含量的增加先上升后下降。当陶瓷相质量分数为10%时,复合涂层最佳,显微硬度、结合强度分别为459.6HV0.3、42.8 mPa。选取Cr_(3)C_(2)(质量分数10%)-FeCrBSi涂层经过退火处理后,涂层的硬度、断裂韧性、抗磨损性能均有提升,其中摩擦因数由原先的0.89降低至0.80~0.75。此外在700℃下退火3 h得到的涂层,显微硬度可达490.3HV0.3,断裂韧性由2.81 mPa·m1/2提升至3.15 mPa·m1/2,磨损率为6.80×10^(-14) m^(3)/(N·m),与喷涂态涂层相比,磨损率降低了15%。喷涂态、退火态涂层的磨损机制均为磨粒磨损。接触疲劳试验结果表明,退火态复合涂层的接触疲劳失效形式主要有剥落和分层,同时剥落失效情况下涂层的接触疲劳寿命更长,可达2.07×10^(5)转。结论 Cr_(3)C_(2)-Fe Cr BSi复合涂层良好的抗磨损和耐接触疲劳性能主要取决于Cr_(3)C_(2)硬质耐磨颗粒的加入。而退火热处理可以促进涂层向平衡态的转变、同时析出的二次碳化物(Cr, Fe)7C3起到沉淀强化的作用,使得退火态涂层具有更好的抗摩擦磨损性能。

关键词： HVAF 冷轧辊退火摩擦磨损接触疲劳