检索结果-南通市图书馆

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

18F-FDG-PET/CT双期成像不能提高非小细胞肺癌病人淋巴结分期的准确性

在线全文

学校读者我要写书评

暂无评论

国际医学放射学杂志 2016年第5期 597-597页

作者： j.m.m.rogasch I.G.Steffen S.Riedel I.Apostolova H.Wertzel H.j.Achenbach 耿立娜 Department of Radiology and Nuclear medicine University Hospital MagdeburgOtto-von-Guericke University Magdeburg

摘要目的探讨双时间点成像(DTPI)对非小细胞肺癌(NSCLC)治疗前淋巴结(LN)分期的诊断效能。方法这是一项包括47例非小细胞肺癌病人的回顾性研究,病人采用18F-脱氧葡萄糖(FDG)PET行DTPI检查(早期和延迟期)。迭代法重建PET数据(点扩散函数... 详细信息

摘要目的探讨双时间点成像(DTPI)对非小细胞肺癌(NSCLC)治疗前淋巴结(LN)分期的诊断效能。方法这是一项包括47例非小细胞肺癌病人的回顾性研究,病人采用18F-脱氧葡萄糖(FDG)PET行DTPI检查(早期和延迟期)。迭代法重建PET数据(点扩散函数+时间飞越法)。PET检查的

关键词：非小细胞淋巴结淋巴组织 PET 肺癌病人 FDG

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Arctic sea-ice extent: No record minimum in 2023 or recent years

在线全文

学校读者我要写书评

暂无评论

Atmospheric and Oceanic Science Letters 2025年第1期18卷 52-55页

作者： Ola m.johannessen Tor I.Olaussen Nansen Scientific Society BergenNorway Nansen Environmental and Remote Sensing Center BergenNorway

Arctic sea-ice extent reaches its minimum each year in September. On 11 September 2023 the minimum was 4.969 million square kilometers(***^(2)). This was not a record low, which occurred in 2012, when the minimum was 4.175 ***^(2), 0.794 ***^(2) less than the minimum in 2023. However, the ice extent had decreased by 0.432 ***^(2) compared with 2022. Nevertheless, the summer melting in 2023 was remarkably less than expected when considering the strong heat waves in the atmosphere and ocean, with record temperatures set around the world. In general, there is a high correlation between the long-term decrease in sea-ice extent and the increasing CO_(2) in the atmosphere, where the increase of CO_(2) in recent decades explains about 80% of the decrease in sea ice in September, while the remainder is caused by natural variability.

关键词： Sea ice Arctic minimum ice Climate

Thermoelastic Analysis of Non-uniform Pressurized Functionally Graded Cylinder with Variable Thickness Using First Order Shear Deformation Theory(FSDT) and Perturbation method

在线全文

学校读者我要写书评

暂无评论

Chinese journal of mechanical Engineering 2015年第6期28卷 1149-1156页

作者： KHOSHGOFTAR m j mIRZAALI m j RAHImI G H Faculty of mechanical Engineering Tarbiat Modares University Department of mechanical Engineering Faculty of Engineering Arak University Department of mechanical Engineering Politecnico di Milano

Recently application of functionally graded materials（FGms） have attracted a great deal of interest. These materials are composed of various materials with different micro-structures which can vary spatially in FGms. Such composites with varying thickness and non-uniform pressure can be used in the aerospace engineering. Therefore, analysis of such composite is of high importance in engineering problems. Thermoelastic analysis of functionally graded cylinder with variable thickness under non-uniform pressure is considered. First order shear deformation theory and total potential energy approach is applied to obtain the governing equations of non-homogeneous cylinder. Considering the inner and outer solutions, perturbation series are applied to solve the governing equations. Outer solution for out of boundaries and more sensitive variable in inner solution at the boundaries are considered. Combining of inner and outer solution for near and far points from boundaries leads to high accurate displacement field distribution. The main aim of this paper is to show the capability of matched asymptotic solution for different non-homogeneous cylinders with different shapes and different non-uniform pressures. The results can be used to design the optimum thickness of the cylinder and also some properties such as high temperature residence by applying non-homogeneous material.

关键词： non-homogenous cylinder First order Shear Deformation Theory matched asymptotic method perturbation method functionally graded material

Frequency-dependent viscoelasticity effects on the wave attenuation performance of multi-layered periodic foundations

在线全文

学校读者我要写书评

暂无评论

Applied mathematics and mechanics(English Edition) 2024年第3期45卷 407-424页

作者： m.SAFI m.VAKILIFARD m.j.mAHmOODI Faculty of Civil Water&Environmental EngineeringShahid Beheshti UniversityTehran ***Iran Faculty of mechanical and Energy Engineering Shahid Beheshti UniversityTehran ***Iran

In this paper,layered periodic foundations(LPFs)are numerically examined for their responses to longitudinal and transverse modes in the time and frequency *** different unit-cells,i.e.,2-layer,4-layer,and 6-layer unit-cells,comprising concrete/rubber,concrete/rubber/steel/rubber,and concrete/rubber/steel/rubber/lead/rubber materials,respectively,are taken into ***,the viscoelasticity behavior of the rubber is modeled with two factors,i.e.,a frequency-independent(FI)loss factor and a linear frequency-dependent(FD)loss *** the extraction of the complex dispersion curves and the identification of the band gaps(BGs),the simulations of wave transmission in the time and frequency domains are performed using the COmSOL *** parametric studies evaluate the effects of the rubber viscoelasticity models on the dispersion curves and the wave transmission for the longitudinal and transverse *** results show that considering the rubber viscoelasticity enhances the wave attenuation ***,the transverse-mode damping is more sensitive to the viscoelasticity model than its longitudinal *** 6-layer unit-cell LPF exhibits the lowest BG,ranging from 4.8 Hz to 6.5 Hz.

关键词： layered metamaterial periodic foundation complex dispersion curve wave transmission diagram

Use of silica nanopowder to accelerate CO_2 sorption by Ca(OH)_2

在线全文

学校读者我要写书评

暂无评论

Particuology 2013年第4期11卷 448-453页

作者： m.A.S.Quintanilla j.m.Valverde Faculty of Physics University of SevilleAvenida Reina Mercedes s/n

Promising technologies have recently emerged to capture CO2 from postcombustion flue gas and to enhance the production of hydrogen from natural gas by steam-methane reforming, on the basis of sorp- tion of CO2 by Ca-based powders. The rate of CO2 sorption on Ca-based powders is limited by both carbonation kinetics and transport of CO2 to unreacted sorption sites. Ca-based powders may exhibit cohesive aggregation, thus hindering gas-solids contact efficiency. In our work, we tested the sorption rate of powder samples prepared by dry mixing of a cohesive Ca（OH）2 powder with a silica nanopowder used as additive. The silica nanopowder serves to improve the dispersibility of Ca（OH）2. Consequently, when a CO2 enriched gas and the modified sorbent are brought into contact, the rate of CO2 sorption is enhanced in the initial fast phase of interest for practical applications.

关键词： FluidizationFine powdersCO2 sorptionNanoparticles

Cross-focusing of two chirped Gaussian laser beams and THz wave generation in plasmas of multi-ion species under a weakly relativistic and ponderomotive regime

在线全文

学校读者我要写书评

暂无评论

Plasma Science and Technology 2022年第10期24卷 1-11页

作者： m R jAFARI mILANI S REZAEI m j jAFARI Photonics and Quantum Technologies Research School Nuclear Science and Technology Research InstituteTehran 14665-678Iran Plasma and Fusion Research School Nuclear Science and Technology Research InstituteTehran 14399-51113Iran

The generation of terahertz(THz)waves via the beating of two high-intensity chirped Gaussian lasers in a multi-ion-species plasma is numerically studied by taking into account the weak relativistic and ponderomotive regime of *** coupled differential equations for beamwidth parameters are extracted by introducing the dielectric function of such plasma and using WKB and paraxial ray *** amplitude of THz radiation at beat frequency resulting from the nonlinear current density induced by the beat ponderomotive force of the cross-focusing of beams was *** impacts of the chirp frequency parameter,initial laser intensity and initial ionic species density(specifically,the presence of singly and doubly charged ions)in the plasma on THz generation were *** numerical results reveal that THz radiation generation strongly depends on the chirp frequency parameter.A specific range of chirp frequencies exists for self-focusing as well as THz generation with a'turning point',where the THz emission reaches its maximum *** results show that the strength of self-focusing and consequently the generated THz radiation are reduced by increasing the density of doubly charged ionic species in the plasma due to the suppression of the nonlinear effects.

关键词： laser–plasma interaction THz generation chirped Gaussian laser beams

Nanostructured grinding wheels for ultra-precision engineering applications

在线全文

学校读者我要写书评

暂无评论

Nanotechnology and Precision Engineering 2021年第3期4卷 63-75页

作者： m.j.jackson Integrated Studies College of Technology and AviationKansas State UniversitySalinaKansas 67401USA

manufacturers face challenges when dealing with abrasives that lose roundness,wear excessively,and suffer from pitting of the surface of the grinding wheel that needs rectification using dressing *** abrasive grits manufactured by hybrid fusion processes and by sintering/extrusion/printing processes are found to reduce pitting quite *** phenomenon of wheel collapse is increasing and cycle times developed during the grinding of aerospace alloys are much smaller compared to using conventional *** paper reviews the phenomenon of wheel collapse induced by pitting and takes a critical look at the production and analysis of hybrid fused and printed/sintered abrasives.A mathematical analysis is carried out of the diffusion of primary and secondary phases due to mechanical and ultrasonic agitation with the aim of producing abrasive grits with improved strength and *** developments in extruded,printed,and sintered grits for use in precision grinding applications are critically *** paper concludes by explaining how such abrasives are used in practice by industrial manufacturers of high-precision products.

关键词： Nanotechnology Abrasives Alloys Finishing Grinding machining