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Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Fourier Analysis with Respect to Bilinear maps

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Acta mathematica Sinica,English Series 2009年第4期25卷 519-530页

作者： O. BLASCO j.m. CALABUIG Department of mathematics Universitat de Valencia Burjassot 46100 Valencia Spain Department of Applied mathematics Universidad Politdcnica de Valencia 46022 Valencia Spain

Several results about convolution and about Fourier coefficients for X-valued functions defined on t he torus satisfying the condition sup ｜｜y｜｜=1∫-π^π｜｜ B （f （e^iθ）, y）｜｜dθ/2π〈 ∞ for a bounded bil... 详细信息

关键词： vector-valued functions Pettis integral Bochner integrals Fourier type

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单级回热器变工况优化设计

工程热物理学报 2014年第11期35卷 2134-2139页

作者：王龙一吴镁张胜甘智华 j.m.pfotenhauer 浙江大学制冷与低温研究所杭州310027 威斯康辛大学麦迪逊分校机械工程学系

通过回热器数值计算程序REGEN深入理解回热器模型,计算回热器内部各项损失。基于各参数间的强弱关系讨论了回热器的优化设计流程。在此基础上,针对35 K、60 K和80 K温区及30~300 Hz频率,给出了回热器中质量流量、长度、填料以及充气压... 详细信息

通过回热器数值计算程序REGEN深入理解回热器模型,计算回热器内部各项损失。基于各参数间的强弱关系讨论了回热器的优化设计流程。在此基础上,针对35 K、60 K和80 K温区及30~300 Hz频率,给出了回热器中质量流量、长度、填料以及充气压力对制冷效率COP的影响关系图,以期对回热器的工程实践提供指导。

关键词：回热式低温制冷机回热器 REGEN 优化高频

Recrystallization and Grain Growth in Austenitic Stainless Steels: a Statistical Approach

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journal of materials Science & Technology 2003年第Z1期19卷 119-121页

作者： A.Di Schino G.Abbruzzese j.m. Kenny materials Engineering Center University of Perugia Loc. Pentima Bassa TERNI Italy Centro Sviluppo Materiali Italy Materials Engineering Center University of Perugia Loc. Pentima Bassa TERNI Italy

A mathematical model, able to describe the recrystallization and grain growth in metals, has been developed. Taking into account the classical constitutive equations of the Taylor′s theory, the model involves only two free parameters (the dislocation density and the initial number of nuclei). Results from the model are here discussed in comparison with measurements performed on an AISI 304 stainless steel. The predictions of the model are in good agreement with experimental results. As cross check of the model prediction, the independent parameter "dislocation density"was found to properly correlate to the mechanical properties of the steel and to X-ray diffraction measurements,according to Taylor′s and Debye′s relations respectively.

关键词： Recrystallization, Grain growth, Stainless steels

Ion Channels at the Nucleus： Electrophysiology meets the Genome

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molecular Plant 2010年第4期3卷 642-652页

作者： Antonius j.m. matzkea Thomas m. Weiger marjori matzke Gregor mendel Institute of molecular Plant Biology Austrian Academy of Sciences Dr. Bohr-Gasse 3 A-1030 Vienna Austria Department of Cell Biology University of Salzburg A-5020 Salzburg Austria

The nuclear envelope is increasingly viewed from an electrophysiological perspective by researchers interested in signal transduction pathways that influence gene transcription and other processes in the nucleus. Here, we describe evidence for ion channels and transporters in the nuclear membranes and for possible ion gating by the nuclear pores. We argue that a systems-level understanding of cellular regulation is likely to require the assimilation of nuclear electrophysiology into molecular and biochemical signaling pathways.

关键词： Ion channel nuclear Ca^+2 signaling nuclear electrophysiology nuclear membrane nuclear pore.

methodology of factorial design deriving guidelines for simulation of growth curve and production of sugars by Spirulina (Arthrospira) maxima

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journal of Central South University of Technology 2001年第4期8卷 228-233页

作者： NIE Zhen yuan XIA jin lan LEVERT j.m. Institute of Bioengineering Department of Mineral EngineeringCentral South UniversityChangsha 410083China Service de Chimie et Biochimie Appliquées FacultéPolytechnique de MonsMons 7000Belgique

It is practical, economic and sometimes essential to derive rules or conclusions by performing lesser runs of experiments. In this part, a methodology based on 2 f factorial design was brought up to derive guidelines to simulate growth curve and production of sugars by Spirulina (Arthrospira) maxima . The growth curve or accumulation process of sugars was idealized by sets of straight lines limited by phase transfers of growth or accumulation of sugars. Normal analyses of the critical values of the transfers were used to derive their linear relationships with the initial conditions of the experimental factors. These linear functions were called guidelines and were used to simulate the growth curve or accumulation of sugars. Generalization of the guideline technique was determined by the kinetic limitation of nutrient nitrogen or sulfur that was dependent upon their stoichiometric deficiency directly derived from their initial values in the medium. This method uses the initial conditions of culture and does not need measurements of concentrations of nitrate, sulfate and pigments during cultivation. It is a practical and useful alternative way to trace and predict approximately the growth curve and production of sugars by S. maxima .

关键词： factorial design guideline simulation growth production of sugar Arthrospira Spirulina maxima

Instability and sensitivity analysis of flows using OpenFOAm~

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Chinese journal of Aeronautics 2016年第2期29卷 316-325页

作者： Liu Qiong F. Gomez j.m. Perez V. Theofilis School of Aeronautics Universidad PolitOcnica de Madrid Plaza Cardinal Cisneros 3 Madrid E-28040 Spain Department of mechanical and Aerospace Engineering Monash University Victoria 3800 Australia

The present contributions deal with the development and implementation of the direct and adjoint incompressible Navie-Stokes equations in a matrix-free time-stepping context making use of the open-source OpenFOAm~ （open source field operation and manipulation） C ＋＋ tool- box. It is shown that a few minor modifications in the source code can enable these multi-purpose computational fluid dynamics （CFD） solvers to carry out global instability analysis of three- dimensional flows of engineering interest, exploiting all additional capabilities of such codes. The strength of this methodology is demonstrated through the analysis of an interesting selection of ooen and wall-bounded flows.

关键词： Adjoint-based analysis Computational fluid dynam-ics Flow instability OpenFOAm Time-stepping method