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CXCR5^(+)PD-1^(++)CD4^(+)T cells colonize infant intestines early in life and promote B cell maturation

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Cellular & molecular Immunology 2023年第2期20卷 201-213页

作者： Ana jordan-Paiz Glòria martrus Fenja L.Steinert max Kaufmann Adrian F.Sagebiel Renée R.C.E.Schreurs Anne Rechtien martin E.Baumdick johannes m.jung Kimberly j.möller Lucy Wegner Cordula Grüttner Laura Richert Roland Thünauer jennifer Schroeder-Schwarz johannes Bvan Goudoever Teunis B.H.Geijtenbeek marcus Altfeld Steven T.Pals Daniel Perez Paul L.Klarenbeek Christian Tomuschat Guido Sauter Ingo Königs Udo Schumacher manuel A.Friese Nathaniel melling Konrad Reinshagen madeleine j.Bunders Department of Virus Immunology Leibniz Institute of VirologyHamburg20251Germany University medical Center Hamburg-Eppendorf Hamburg20246Germany Institute of Neuroimmunology and multiple Sclerosis Center for Molecular Neurobiology HamburgUniversity Medical Center Hamburg-EppendorfHamburg20251Germany Department of General Visceral and Thoracic SurgeryUniversity Medical Center Hamburg-EppendorfHamburg20246Germany Department of Experimental Immunology Amsterdam Infection&Immunity InstituteAmsterdam University Medical CenterUniversity of AmsterdamAmsterdam1105 AZThe Netherlands Department of Pediatrics Emma Children’s HospitalAmsterdam University Medical CenterUniversity of Amsterdam and Vrije Universiteit AmsterdamAmsterdam1105 AZThe Netherlands I.Department of medicine University Medical Center Hamburg-EppendorfHamburg20246Germany Partner Site Hamburg-Lübeck-Borstel-Riems German Center for Infection Research(DZIF)Hamburg20246Germany University of Bordeaux Institut National de la Santéet de la Recherche MédicaleBordeaux Population Health Research Center UMR1219 and INRIA SISTM TeamBordeaux33000France Institute of Anatomy and Experimental morphology University Medical Center Hamburg-EppendorfHamburg20246Germany Department of Pathology Amsterdam University Medical CenterUniversity of AmsterdamAmsterdam1105 AZThe Netherlands Department of Rheumatology and Clinical Immunology and Department of Experimental Immunology Amsterdam Infection&Immunity InstituteAmsterdam University Medical CenterUniversity of AmsterdamAmsterdam1007 MBThe Netherlands Amsterdam Rheumatology&Immunology Center Amsterdam University Medical CenterUniversity of AmsterdamAmsterdam1105 AZThe Netherlands Department of Pediatric Surgery University Medical Center Hamburg-EppendorfHamburg20246Germany Institute of Pathology University Medical Center Hamburg-EppendorfHamburg20246Germany Department of Pediatric Surgery Altona Children’s HospitalHamburg22763Germany III.Department of medicine University M

Gastrointestinal infections are a major cause for serious clinical complications in *** induction of antibody responses by B cells is critical for protective immunity against infections and requires CXCR5+PD-1++CD4+T cells(TFH cells).We investigated the ontogeny of CXCR5+PD-1++CD4+T cells in human *** CXCR5+PD-1++CD4+T cells were absent in fetal intestines,CXCR5+PD-1++CD4+T cells increased after birth and were abundant in infant intestines,resulting in significant higher numbers compared to *** findings were supported by scRNAseq analyses,showing increased frequencies of CD4+T cells with a TFH gene signature in infant intestines compared to ***-cultures of autologous infant intestinal CXCR5+PD-1+/−CD4+T cells with B cells further demonstrated that infant intestinal TFH cells were able to effectively promote class switching and antibody production by B *** together,we demonstrate that functional TFH cells are numerous in infant intestines,making them a promising target for oral pediatric vaccine strategies.

关键词： TFH cells B cells Antibodies Intestine Pediatrics

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高品质和灵活性的新型并条机

国际纺织导报 2011年第9期39卷 26-26,28页

作者： j.mller 薛进 Rieter Ingolstadt公司

通过一个变频控制的主驱动,Rieter Ingolstadt公司在RSB-D上实现了灵活调节和高品质成条。Cleantube装置可清洁圈条,并在原料变化时快速调节条筒中条子的分布。

关键词：并条机 Cleantube装置条子品质灵活性

配有1000mm直径大条筒换筒装置的双眼并条机

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国际纺织导报 2013年第12期41卷 22-24页

作者： j.müller 曾文敏立达公司

立达公司不带自调匀整的双眼SB-D 22并条机,配备特有的换筒装置,条筒直径达1 000 mm,可确保最大的机器效率,最高出条速度为1 100 m/min,减少了纺纱厂的人力、场地和能源的消耗。

关键词：双眼并条机条筒换筒装置

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RSB-D 35自调匀整并条机

国际纺织导报 2005年第8期33卷 8-8,10-11页

作者： j.müller 俞雯立达因戈尔施塔特纺纱机械公司

介绍了RSB-D35自调匀整并条机的特性。与无自调匀整器的双头并条机相比,RSB-D35并条机生产效率高,纱线质量好,可提高后道加工的经济效益。

关键词：并条机自调匀整器效率 RSB-D35

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新型单头并条机

国际纺织导报 2018年第12期46卷 14-16页

作者： j.müller 朱瑜(译) 孟粉叶(校) 立达公司瑞士不详

2016年秋季,瑞士立达公司在中国上海及印度孟买举办的亚洲纺织机械展览会(ITmA)上首次向全球推出其新型RSB-D 50型单头并条机。新一代RSB-D 50型单头并条机的优点是运行成本低、棉条质量高,操作、维护简单。

关键词： RSB-D50型单头并条机纱条纱线并条 Ecorized 牵伸系统 Cleancoil圈条机

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鲁尔锌公司电锌厂浸出渣利用的经验

中国有色冶金 1980年第6期 48-50页

作者： Dieter j.mller ,余楚蓉

目前世界锌产量的70%以上是电解法产出的。由于目前锌浮选精矿含铁约为6～8%,因此产出大量浸出渣,这类浸出渣几乎毫无例外地必须堆存在价值昂贵的渣场中。近20年来电锌生产的发展基本上是按以下

关键词：浸出渣特伦鲁尔德国电锌黄铁矾法

Frequency-dependent viscoelasticity effects on the wave attenuation performance of multi-layered periodic foundations

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Applied mathematics and mechanics(English Edition) 2024年第3期45卷 407-424页

作者： m.SAFI m.VAKILIFARD m.j.mAHmOODI Faculty of Civil Water&Environmental EngineeringShahid Beheshti UniversityTehran ***Iran Faculty of mechanical and Energy Engineering Shahid Beheshti UniversityTehran ***Iran

In this paper,layered periodic foundations(LPFs)are numerically examined for their responses to longitudinal and transverse modes in the time and frequency *** different unit-cells,i.e.,2-layer,4-layer,and 6-layer unit-cells,comprising concrete/rubber,concrete/rubber/steel/rubber,and concrete/rubber/steel/rubber/lead/rubber materials,respectively,are taken into ***,the viscoelasticity behavior of the rubber is modeled with two factors,i.e.,a frequency-independent(FI)loss factor and a linear frequency-dependent(FD)loss *** the extraction of the complex dispersion curves and the identification of the band gaps(BGs),the simulations of wave transmission in the time and frequency domains are performed using the COmSOL *** parametric studies evaluate the effects of the rubber viscoelasticity models on the dispersion curves and the wave transmission for the longitudinal and transverse *** results show that considering the rubber viscoelasticity enhances the wave attenuation ***,the transverse-mode damping is more sensitive to the viscoelasticity model than its longitudinal *** 6-layer unit-cell LPF exhibits the lowest BG,ranging from 4.8 Hz to 6.5 Hz.

关键词： layered metamaterial periodic foundation complex dispersion curve wave transmission diagram

Selection of digital fabrication technique in the construction industry--A multi-criteria decision-making approach

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Frontiers of Structural and Civil Engineering 2024年第7期18卷 977-997页

作者： m.P.SALAImANImAGUDAm j.jAYAPRAKASH Department of Structural and Geotechnical Engineering School of Civil EngineeringVellore Institute of TechnologyVellore 632014India

Digital fabrication techniques,in recent decades,have provided the basis of a sustainable revolution in the construction ***,selecting the digital fabrication method in terms of manufacturability and functionality requirements is a complex *** paper presents alternatives and criteria for selection of digital fabrication techniques by adopting the multi-criteria decision-making *** alternatives considered in the study are concrete three-dimensional(3D)printing,shotcrete,smart dynamic casting,material intrusion,mesh molding,injection concrete 3D printing,and thin forming *** criteria include formwork utilization,reinforcement incorporation,geometrical complexity,material enhancement,assembly complexity,surface finish,and build *** demonstrates different multi-criteria decision-making techniques,with both subjective and objective weighting *** given ranking is based on the current condition of digital fabrication in the construction *** study reveals that in the selection of digital fabrication techniques,the criteria including reinforcement incorporation,build area,and geometrical complexity play a pivotal role,collectively accounting for nearly 70% of the overall *** the evaluated techniques,concrete 3D printing emerged as the best performer,however the shotcrete and mesh molding techniques in the second and third positions.

关键词： digital fabrication multicriteria decision-making concrete 3D printing

Lattice Boltzmann method formulation for simulation of thermal radiation effects on non-Newtonian Al_(2)O_(3) free convection in entropy determination

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Applied mathematics and mechanics(English Edition) 2024年第6期45卷 1085-1106页

作者： m.NEmATI m.SEFID A.KARImIPOUR A.j.CHAmKHA Faculty of mechanical Engineering Yazd UniversityYazd ***Iran Department of mechanical Engineering Najafabad BranchIslamic Azad UniversityNajafabad ***Iran Faculty of Engineering Kuwait College of Science and TechnologyDoha 35004Kuwait

The simultaneous investigation on the parameters affecting the flow of electrically conductive fluids such as volumetric radiation,heat absorption,heat generation,and magnetic field(mF)is very vital due to its existence in various sectors of industry and *** present research focuses on mathematical modeling to simulate the cooling of a hot component through power-law(PL)nanofluid convection *** temperature reduction of the hot component inside a two-dimensional(2D)inclined chamber with two different cold wall shapes is *** formulation of the problem is derived with the lattice Boltzmann method(LBm)by code writing via the FORTRAN *** variables such as the radiation parameter(0–1),the Hartmann number(0–75),the heat absorption/generation coefficient(−5–5),the fluid behavioral index(0.8–1.2),the Rayleigh number(103–105),the imposed mF angle(0°–90°),the chamber inclination angle(−90°–90°),and the cavity cold wall shape(smooth and curved)are *** findings indicate that the presence of radiation increases the mean Nusselt number value for the shear-thickening,Newtonian,and shear thinning fluids by about 6.2%,4%,and 2%,*** most cases,the presence of nanoparticles improves the heat transfer(HT)rate,especially in the cases where thermal conduction dominates *** is the lowest cooling performance index and mF effect for the cavity placed at an angle of 90°.The application in the design of electronic coolers and solar collectors is one of the practical cases of this numerical research.

关键词： thermal performance analysis heat absorption/generation power-law(PL)Al_(2)O_(3)nanofluid magnetohydrodynamics natural convection volumetric radiation inclined cavity