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Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael j.lee Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark l.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Chaos,Transport and Mesh Convergence for Fluid Mixing

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Acta Mathematicae Applicatae Sinica 2008年第3期24卷 355-368页

作者： H. lim Y. Yu j. Glimm X.l. li D.H. sharp Department of Applied Mathematics and Statistics Stony Brook University Stony Brook NY 11794-3600 USA Computational Science Center Brookhaven National Laboratory Upton N~ 11793-6000 USA los Alamos National laboratory Los Alamos NM USA

Chaotic mixing of distinct fluids produces a convoluted structure to the interface separating these fluids. For miscible fluids （as considered here）, this interface is defined as a 50% mass concentration isosurface. For shock wave induced （Richtmyer-Meshkov） instabilities, we find the interface to be increasingly complex as the computational mesh is refined. This interfacial chaos is cut off by viscosity, or by the computational mesh if the Kolmogorov scale is small relative to the mesh. In a regime of converged interface statistics, we then examine mixing, i.e. concentration statistics, regularized by mass diffusion. For Schmidt numbers significantly larger than unity, typical of a liquid or dense plasma, additional mesh refinement is normally needed to overcome numerical mass diffusion and to achieve a converged solution of the mixing problem. However, with the benefit of front tracking and with an algorithm that allows limited interface diffusion, we can assure convergence uniformly in the Schmidt number. We show that different solutions result from variation of the Schmidt number. We propose subgrid viscosity and mass diffusion parameterizations which might allow converged solutions at realistic grid levels.

关键词： Schmidt number mass diffusion turbulence multiphase flow

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james l.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Effect of surface layer softening from previous electrochemical corrosion on electrochemical cold drawing of Q235 steel bar

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journal of Iron and Steel Research International 2022年第5期29卷 819-835页

作者： j.l.Guo T.j.Chen State Key laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of TechnologyLanzhou730050GansuChina

The effects of H_(2)SO_(4)concentration and current in electrochemical corrosion on surface layer softening or plasticizing of Q235 steel bar and their effects on subsequent electrochemical cold drawing(ECD)were *** results indicate that the electrochemical corrosion can soften or plasticize the surface layer of Q235 steel bar and then make the subsequent ECD be conducted more *** softening degree and thickness of the surface layer are continuously enhanced with increasing corrosion rate,i.e.,increasing H_(2)SO_(4)concentration or current,due to the generation of more vacancy clusters in deeper regions of surface *** vacancy clusters then relax dislocations through being absorbed during ECD,and the formation and movement of additional dislocation flux are thereby enhanced,resulting in the further obvious decrease in the drawing *** is also due to the enhanced formation and movement of additional dislocation flux that the dislocation density and thus the hardness of the surface layer are decreased,as well as that the texture structure is *** behaviors are enhanced as the corrosion rate increases.

关键词： Electrochemical corrosion Electrochemical cold drawing Surface layer softening Vacancy Additional dislocation flux

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热空气对感染加勒比实蝇阳桃的检疫处理

植物检疫 1993年第3期7卷 190-192页

作者： sharp.j.l. Hallman.G.j. 刘兴西安动植物检疫局

佛罗里达州生产的阳桃因感染加勒比实蝇 Anastrepha suspensa(loew)必须经过检疫处理才许运往得克萨斯州和加里福尼亚州或出口日本。以往检疫处理多用低温贮存法(Gould 和 sharp 1990)、热水浸泡法(Hallman 和 sharp,1989)和蒸气热杀法(... 详细信息

佛罗里达州生产的阳桃因感染加勒比实蝇 Anastrepha suspensa(loew)必须经过检疫处理才许运往得克萨斯州和加里福尼亚州或出口日本。以往检疫处理多用低温贮存法(Gould 和 sharp 1990)、热水浸泡法(Hallman 和 sharp,1989)和蒸气热杀法(Hallman,1990)。低温贮存法需历时15天才能奏效,而热水浸泡和蒸气热杀常使水果受伤,失去商品价值。

关键词：阳桃检疫加勒比实蝇

laser induced photo-detachment of O2 in DC discharge

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Plasma Science and Technology 2018年第7期20卷 98-105页

作者： j r legorreta j l patiNo f b yousif Centro de Investigacion en Ciencias Universidad Autonoma del Estado de Morelos.Av.UniversidadNo.1001 Col.Chamilpa Cuemavaca MorelosMexico

Determination of the negative ion number density of O2 and O in a DC discharge of oxygen plasma was made employing langmuir probe in conjunction with eclipse laser photo- detachment technique. The temporal evolution of the extra electrons resulting from the photo- detachment of O2- and O- were used to evaluate the negative ion number density. The ratio of O2 number density to O varied from 0.03 to 0.22. Number density of both O~ and O increased with increasing power and decreased as the pressure was increased. Electron number density was evaluated from the electron energy distribution function （EEDF） using the I-V recorded characteristic curves. Electron temperature between 2 and 2.7 eV were obtained. Influence of the 02（al△g） metastable state is discussed.

关键词： electronegative plasma electron temperature langmuir probe negative ion number density

Efficient Orbit Propagation of Orbital Elements Using Modified Chebyshev Picard Iteration Method

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Computer Modeling in Engineering & Sciences 2016年第1期111卷 65-81页

作者： j.l.Read A.Bani Younes j.l.junkins Graduate Research Assistant Texas A&M UniversityCollege StationTXUSA. Assistant Professor Khalifa UniversityAbu DhabiUAE. Distinguished Professor Texas A&M UniversityCollege StationTXUSA.

This paper focuses on propagating perturbed two-body motion using orbital elements combined with a novel integration *** previous studies show that Modified Chebyshev Picard Iteration(MCPI)is a powerful tool used to propagate position and velocity,the present results show that using orbital elements to propagate the state vector reduces the number of MCPI iterations and nodes required,which is especially useful for reducing the computation time when including computationally-intensive calculations such as Spherical Harmonic gravity,and it also converges for>5.5x as many revolutions using a single segment when compared with cartesian *** for the Classical Orbital Elements and the Modified Equinoctial Orbital Elements(the latter provides singularity-free solutions)show that state propagation using these variables is inherently well-suited to the propagation method *** benefits are achieved using a segmentation scheme,while future expansion to the two-point boundary value problem is expected to increase the domain of convergence compared with the cartesian *** is an iterative numerical method used to solve linear and nonlinear,ordinary differential equations(ODEs).It is a fusion of orthogonal Chebyshev function approximation with Picard iteration that approximates a long-arc trajectory at every *** studies have shown that it outperforms the state of the practice numerical integrators of ODEs in a serial computing environment;since MCPI is inherently massively parallelizable,this capability is expected to increase the computational efficiency of the method presented.

关键词： Propagation Integration Orbital Mechanics Classical Elements Modified Equinoctial Chebyshev Picard Iteration MCPI Polynomials Initial Value Problem IVP.

Numerical studies towards practical large-eddy simulation

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journal of Thermal Science 2007年第4期16卷 328-336页

作者： j.Boudet j.Caro l.Shao E.lév(?)que lMFA laboratoire

large-eddy simulation developments and validations are presented for an improved simulation of turbulent internal flows. Numerical methods are proposed according to two competing criteria： numerical qualities （precision and spectral characteristics）, and adaptability to complex configurations. First, methods are tested on academic test-cases, in order to abridge with fundamental studies. Consistent results are obtained using adaptable finite volume method, with higher order advection fluxes, implicit grid filtering and ＂low-cost＂ shear-improved Smagorinsky model. This analysis particularly focuses on mean flow, fluctuations, two-point correlations and spectra. Moreover, it is shown that exponential averaging is a promising tool for lES implementation in complex geometry with deterministic unsteadiness. Finally, adaptability of the method is demonstrated by application to a configuration representative of blade-tip clearance flow in a turbomachine.

关键词： lES adaptable methods validation