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locoregional Il-2 low dose applications for gastrointestinal tumors

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World journal of Gastroenterology 2005年第35期11卷 5525-5529页

作者： Zachary Krastev V Koltchakov R Tomova S Deredjian A Alexiev D Popov B Tomov jan-Willem Koten john jacobs Willem den otter Clinic of Gastroenterology Faculty of Medicine University Hospital Blvd. Iv.Geshov 15Sofia 1431Bulgaria Department of Pathobiology PO Box 80.178 3508 TD Utrecht The Netherlands Clinic of Gastroenterology Faculty of Medicine Univeisity Hospital Blvd. Iv.Geshov 15Sofia 1431Bulgaria

AIM： To explore the feasibility of local interleukin 2 （Il-2） in patients with different forms of abdominal cancer. This required experimentation with the time interval between Il-2 applications and the methods of application. METHODS： Sixteen patients with stages Ⅲ and Ⅳ of gastrointestinal malignancies （primary or metastatic） who were admitted to our Department of Gastroenterology were treated with Iocoregionally applied Il-2 in low doses. RESUlTS： No major problems applying Iocoregional Il-2 were encountered. In 6 out of 16 patients, a modest but clinically worthwhile improvement was obtained. Adverse effects were minimal. The therapeutic scheme was well tolerated, even in patients in a poor condition. CONClUSION： This study demonstrates the feasibility of low dose Iocoregional Il-2 application in advanced abdominal cancer. local Il-2 therapy gives only negligible adverse effects. The results suggest that it is important to apply intratumorally. local Il-2 may be given adjunct to standard therapeutic regimes and does not imply complex surgical interventions. These initial results are encouraging.

关键词： Interleukin-2 local Il-2 therapy Gastrointestinalcancer

卒中后轻偏瘫患者的步态恢复与踏车步行期间肌肉活动的短暂形式变化无关

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世界核心医学期刊文摘(神经病学分册) 2006年第4期 40-41页

作者： den otter A.R. Geurts A.C.H. Mulder Th. Duysens j. 陈海 Center for Human Movement Sciences University of Groningen A. Deusinglaan 1 9713 AV Groningen Netherlands

Objective: To establish whether functional recovery of gait in patients with post-stroke hemiparesis coincides with changes in the temporal patterning of lower extremity muscle activity and coactivity during treadmill walking. Methods: Electromyographic (EMG) data from both legs, maximum walking speed, the amount of swing phase asymmetry and clinical measures were obtained from a group of post-acute patients with hemiparesis, as early as possible after admission in a rehabilitation centre (mean time post-stroke 35 days) and 1, 3, 6, and 10 weeks later, while all patients participated in a regular rehabilitation program. EMG data from the first assessment were compared to those obtained from a group of healthy controls to identify abnormalities in the temporal patterning of muscle activity. Within subject comparisons of patient data were made over time to investigate whether functional gait recovery was accompanied by changes in the temporal patterns muscle (co-)activity. Results: EMG patterns during the first assessment showed a number of abnormalities on the paretic side, namely abnormally long durations of activity in biceps femoris (BF) during the single support (SS) phase and in gastrocnemius medialis (GM) during the first double support phase (DS1). Furthermore, in both legs a prolongation of the activity was seen in the rectus femoris (RF) during the SS phase. In addition, the duration of BF- RF coactivation was longer on the paretic side than it was in controls. Over time, the level of ambulatory independence, body mobility, and maximum walking speed increased significantly, indicating that substantial improvements in gait ability occurred. Despite these improvements, durations of muscle (co-) activity and the level of swing phase asymmetry did not change during rehabilitation. More specifically, timing abnormalities in muscle (co-)activity that were found during the first assessment did not change significantly, indicating that these aberrations were not an

关键词：卒中后轻偏瘫肌肉活动患者步态

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大鼠肝组织中普伐他汀的高效液相色谱法测定

药学学报 2001年第2期36卷 123-126页

作者：李新 otterK ZieglerA 浙江大学药学院药物分析与药物代谢研究室浙江杭州310006 InstituteofPharmacology

目的　建立反相色谱法测定普伐他汀在大鼠肝组织中的含量。方法　肝组织样品加普伐他汀和内标 (丙炎松 ) ,用BondElutC18小柱进行固相提取 ,然后用色谱方法分析。采用C18反相色谱柱 ,流动相为 0 0 35mol·l-1磷酸氢二钠缓冲液 (pH 3 0 ... 详细信息

目的　建立反相色谱法测定普伐他汀在大鼠肝组织中的含量。方法　肝组织样品加普伐他汀和内标 (丙炎松 ) ,用BondElutC18小柱进行固相提取 ,然后用色谱方法分析。采用C18反相色谱柱 ,流动相为 0 0 35mol·l-1磷酸氢二钠缓冲液 (pH 3 0 ) 乙腈 (15 5∶42 )。结果　普伐他汀的线性范围为 0 0 5 - 10 0 0 μg·g-1肝 ,回归方程为Y =0 1843X - 4 2 38× 10 -3(γ =0 9934) ;用普伐他汀标准液试验 ,最低检测限达 13ng·ml-1,定量限为 5 0ng·g-1肝(RSD lewis大鼠 (ig 2 0mg·kg-1)肝组织中普伐他汀的含量 ,并绘制了药时曲线。结论　方法灵敏。

关键词：普伐他汀反相高效液相色谱法固相提取

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免疫监视与自然抵抗的新概念及其评价

国际免疫学杂志 1987年第2期10卷 89-93页

作者： otter WD 王建一

长期以来,人们一直认为人体每天均有大量的新的肿瘤细胞产生,并由此推论出机体内可能存在着一个强有力的免疫监视或自然抵抗系统。这些系统以各种不同机制杀灭体内不断产生的大量肿瘤细胞。而老年人的高癌发病率也被认为是由于免疫系统... 详细信息

长期以来,人们一直认为人体每天均有大量的新的肿瘤细胞产生,并由此推论出机体内可能存在着一个强有力的免疫监视或自然抵抗系统。这些系统以各种不同机制杀灭体内不断产生的大量肿瘤细胞。而老年人的高癌发病率也被认为是由于免疫系统功能下降而使部分癌细胞获得免疫”逃逸”。但目前人们已认识到,每一机制所杀灭的肿瘤细胞群是有限的,因此这些机制不可能在长时期内每天杀伤大量的新生瘤细胞。此外,有证据表明当某些重要的自然抵抗和免疫监视

关键词：细胞毒性淋巴细胞白细胞瘤细胞效应细胞肿瘤病人吞噬细胞巨噬细胞思维形式概念

Recent Developments of Image Based Measurement Methods for Application to Transonic Flows in Industrial Wind Tunnels

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Chinese journal of Aeronautics 2006年第2期19卷 114-125页

作者： j.KOMPENHANS j.AGOCS Y.EGAMI R.ENGlER U.FEY H.FRAHNERT K.de GROOT U.HENNE T.KIRMSE C.KlEIN F.KlINGE R.KONRATH l.KOOP H.MATTNER D.otter D.PAllEK W.SACHS A.SCHRDER B.STASICKI German Aerospace Center (DlR) Institute of Aerodynamics and Flow Technology 37073 GttingenBunsenstrasse 10 Germany

The experimental investigation of unsteady complex flow fields in wind tunnels requires advanced measurement techniques. The most important of such image based measurement techniques are those for the measurement of planar flow velocity fields, planar pressure distribution, model location and deformation, model temperature and quantitative high speed flow visualization. The applications as carried out by DlR range from low speed flows to transonic flows, from high lift configurations to propellers and rotors, from wake vortex investigations in catapult facilities and water towing tanks to investigations of vortex break down phenomena on delta wings. The capability to use image based measurement techniques in transonic flows requires dedicated technical developments and experienced scientists due to the special environment of a transonic wind tunnel. In this paper an overview of the state-of-the art of the application of image based measurement techniques in transonic flows as performed by DlR＇s Institute of Aerodynamics and Flow Technology will be given.

关键词： industrial wind tunnel transonic flow image based measurement techniques pressure sensitive paint particle image velocimetry model deformation measurement techniques thermography non-standard video techniques

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免疫监视及自然抗瘤机制的评价

国际免疫学杂志 1986年第5期09卷 261-263页

作者： otter W D 朱炳法

一、引言:过去认为,一个人每天可产生许多新的肿瘤细胞,因而提出免疫监视和自然抗瘤机制以解释机体如何防止肿瘤发生.鉴于每天必须杀伤大量肿瘤细胞,故认为这种假设的免疫监视和自然抗瘤机制是强有力的.通过研究,阐明了体内确实存在着... 详细信息

一、引言:过去认为,一个人每天可产生许多新的肿瘤细胞,因而提出免疫监视和自然抗瘤机制以解释机体如何防止肿瘤发生.鉴于每天必须杀伤大量肿瘤细胞,故认为这种假设的免疫监视和自然抗瘤机制是强有力的.通过研究,阐明了体内确实存在着几种免疫的和自然的抗瘤机制;但也发现,被每种机制杀伤的肿瘤类型是有一定限制性,因而这些机

关键词：瘤细胞抗原性免疫监视细胞毒性

Monitoring the effects of land transformation on African clawless otters(Aonyx capensis)using fecal glucocorticoid metabolite concentrations as a measure of stress

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Integrative Zoology 2020年第4期15卷 293-306页

作者： Tshepiso l.MAjElANTlE Trevor MCINTYRE Andre GANSWINDT Mammal Research Institute Department of Zoology and EntomologyUniversity of PretoriaPretoriaSouth Africa Department of life and Consumer Sciences University of South AfricaPretoriaSouth Africa Endocrine Research laboratory Department of Anatomy and PhysiologyUniversity of PretoriaOnderstepoortSouth Africa Centre for Veterinary Wildlife Studies Faculty of Veterinary ScienceUniversity of PretoriaOnderstepoortSouth Africa

In a time of increasing environmental change caused by anthropogenic disturbance,there is a greater need to understand animal adaptations to manmade *** this regard,the measurement of stress-related endocrine markers provides a useful tool to examine the impact of environmental challenges and the physiological consequences for wildlife occupying such *** aims of the present study were to validate fecal glucocorticoid metabolite(fGCM)concentrations as a measure of stress using samples from a male African clawless otter(Aonyx capensis;n=1)and to compare fGCM concentrations of otters occurring in a transformed and in 2 natural areas in South *** the 5 different enzyme-immunoassays(EIA)tested,a cortisol and oxoetiocholanolone(measuring 11,17 dioxoandrostanes)EIA revealed the highest response(74%and 48%increase,respectively)30 and 24 hours after a stress event(translocation of a captive individual as part of its rehabilitation prior to release),respec*** both EIAs,fGCM concentrations were comparable for samples collected up to 3 h *** the cortisol EIA for subsequent analyses,fGCM concentrations of animals from the transformed area(n=20;mean[±SD]:0.468[±0.539]µg/g dry weight[DW])were significantly higher(P=0.013)than those from otters in the natural areas(n=17;0.242[±0.226]µg/g DW).These preliminary results suggest that African clawless otters may have increased adrenocortical activity that could be due to conditions linked to living in a transformed environment.

关键词： African clawless otter fecal glucocorticoid metabolites non-invasive hormone measurement stress urbanization

基于视频监控系统的欧亚水獭活动节律初报及红外相机监测效果评估

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生物多样性 2021年第6期29卷 770-779页

作者：韩雪松董正一赵格赵翔史湘莹吕植李宏奇山水自然保护中心北京100871 Department of Geography University of CambridgeCambridge CB21BN Department of Biology Lund UniversityLund 22362 北京大学环境科学与工程学院北京100871 北京大学生命科学学院自然保护与社会发展研究中心北京100871 青海省环境工程技术评估中心西宁810007

欧亚水獭(lutra lutra)是淡水生态系统保护的旗舰物种,目前三江源或为其在中国仅存的连片栖息地之一。然而,该区域欧亚水獭基础生态学信息尚属空白,已开展的工作也多依赖于红外相机而可靠性有待评估。本文基于2018–2020年间在青海玉树... 详细信息

欧亚水獭(lutra lutra)是淡水生态系统保护的旗舰物种,目前三江源或为其在中国仅存的连片栖息地之一。然而,该区域欧亚水獭基础生态学信息尚属空白,已开展的工作也多依赖于红外相机而可靠性有待评估。本文基于2018–2020年间在青海玉树通过视频监控系统和红外相机收集到的数据,在分析区内水獭活动节律的同时,对红外相机监测的有效性和准确性进行了评估。结果表明,在玉树,欧亚水獭在每日17时至次日9时活动频率较高,每年12月至次年6月间拍摄频率较高;繁殖期或随每年10月个体交配而开始,至次年6月幼崽独立而终止。红外相机约可捕获69.18%的水獭出现事件,且拍摄率随事件持续时间的延长而提高;通过红外相机可以准确地描述出水獭活动节律,仅有约半数红外相机影像可以准确还原事件主题(56.28%)和多只个体参与的事件中的个体数量(49.35%)。因此,在使用红外相机对欧亚水獭进行行为学研究时应对这一情况进行充分考虑。

关键词：欧亚水獭三江源视频监控系统红外相机活动节律繁殖行为

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