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Revealing Tissue Heterogeneity and Spatial Dark Genes from Spatially Resolved Transcriptomics by Multiview Graph Networks

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Research 2024年第2期6卷 629-645页

作者： Ying li Yuejing lu chen Kang Peiluan li luonan chen School of Mathematics and Statistics Henan University of Science and TechnologyLuoyang471023China longmen laboratory LuoyangHenan471003China Key laboratory of Systems Biology Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai201100China Key laboratory of Systems Health Science of Zhejang Province Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou310000China School of life Science and Technology ShanghaiTech UniversityShanghai201100.China

Spatially resolved transcriptomics(SRT)is capable of comprehensively characterizing gene expression patterns and providing an unbiased image of spatial *** fully understand the organizational complexity and tumor immune escape mechanism,we propose stMGATF,a multiview graph attention fusion model that integrates gene expression,histological images,spatial location,and gene *** better extract information,stMGATF exploits SimClRv2 for visual feature exaction and employs edge feature enhanced graph attention networks for the learning potential embedding of each view.A global attention mechanism is used to adaptively integrate 3 views to obtain low-dimensional *** to diverse SRT datasets,stMGATF is robust and outperforms other methods in detecting spatial domains and denoising data even with different resolutions and *** particular,stMGATF contributes to the elucidation of tissue heterogeneity and extraction of 3-dimensional expression ***,considering the associations between genes in tumors,stMGATF can identify the spatial dark genes ignored by traditional methods,which can be used to predict tumor-driving transcription factors and reveal tumor immune escape mechanisms,providing theoretical evidence for the development of new immunotherapeutic strategies.

关键词： Spatial integrate driving

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Epidemiology of insertional and midportion Achilles tendinopathy in runners:A prospective cohort study

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journal of Sport and Health Science 2024年第2期13卷 256-263页

作者： Wenbo chen Kyra l.A.Cloosterman Sita M.A.Bierma-Zeinstra Marienke van Middelkoop Robert-jan de Vos Department of Orthopaedic Surgery and Sports Medicine Erasmus MC University Medical CenterRotterdam 3015GDthe Netherlands Department of General Practice Erasmus MC University Medical CenterRotterdam 3015GDthe Netherlands Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200040China

Background:Achilles tendinopathy(AT)is a common problem among *** is only limited evidence for risk factors for AT,and most studies have not defined the AT *** study has compared the incidence and risk factors between insertional AT and midportion AT,though they are considered *** study aimed to assess incidence and risk factors of AT based on data from a large prospective *** secondary aim was to explore differences in risk factors between insertional and midportion ***:Participants were recruited from among registered runners at registration for running *** were completed at baseline,1 month before the event,1 week before the event,and 1 month after the *** concerning demographics,training load,registered events,and running-related injuries were collected at *** follow-up questionnaires collected information about new injuries.A pain map was used to diagnose midportion and insertional *** primary outcome was the incidence of *** logistic regression analysis was applied to identify risk factors for the ***:We included 3379 participants with a mean follow-up of 20.4 *** incidence of AT was 4.2%.The proportion of insertional AT was 27.7%and of midportion AT was 63.8%;the remaining proportion was a combined type of insertional and midportion *** had a significantly higher incidence(5%,95%confidence interval(95%CI):4.1%-6.0%)than women(2.8%,95%CI:2.0%-3.8%).AT in the past12 months was the most predominant risk factor for new-onset AT(odds ratio(OR)=6.47,95%CI:4.27-9.81).This was similar for both subcategories of AT(insertional:OR=5.45,95%CI:2.51-11.81;midportion:OR=6.96,95%CI:4.24-11.40).Participants registering for an event with a distance of 10/10.55 km were less likely to develop a new-onset AT(OR=0.59,95%CI:0.36-0.97)or midportion AT(OR=0.47,95%CI:0.23-0.93).Higher age had a significant negative association with insertional AT(OR=0.97,95%CI:0.9

关键词： Achilles tendon injury Incidence Risk factor Running-related injury

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Sources appointment and health risks of PM_(2.5)-bound trace elements in a coastal city of southeastern China

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journal of Environmental Sciences 2024年第4期138卷 561-571页

作者： Ziyi lin Xiaolong Fan Gaojie chen Youwei Hong Mengren li lingling Xu Baoye Hu chen Yang Yanting chen Zhiqian Shao jinsheng chen Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Key lab of Urban Environment and Health Institute of Urban EnvironmentChinese Academy ofSciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China Minnan Normal University Zhangzhou 363000China

To gain a comprehensive understanding of sources and health risks of trace elements in an area of China with high population densities and low PM_(2.5)concentrations,15 trace elements(Al,K,Ca,Ti,V,Cr,Mn,Fe,Ni,Cu,Zn,As,Sn,Ba,Pb)in PM_(2.5)were monitored from December 2020 to November 2021 in a representative city,*** concentrations of trace elements in Xiamen displayed an obvious seasonal variation and were dominated by K,Fe,Al,Ca and *** on Positive Matrix Factorization analysis,source appointment revealed that the major sources of trace elements in Xiamen were traffic,dust,biomass and firework combustion,industrial manufacture and shipping *** to health risk assessment combined with the source appointment results,it indicated that the average noncarcinogenic risk was below the threshold and cancer risk of four hazardous metals(Cr,Ni,As,Pb)exceeded the threshold(10^(-6)).Traffic-related source had almost half amount of contribution to the health risk induced by PM_(2.5)-bound trace *** the dust transport period or Spring Festival period,the health risks exceeded an acceptable threshold even an order of magnitude higher,suggesting that the serious health risks still existed in low PM_(2.5)environment at certain *** risk assessment reminded that the health risk reduction in PM_(2.5)at southeastern China should prioritize traffic-related hazardous trace elements and highlighted the importance of controlling vehicles emissions in the future.

关键词： PM_(2.5)-bound trace elements Seasonal variations Source appointment Health risks Traffic-related source

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Effects of layer interactions on instantaneous stability of finite Stokes flows

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Applied Mathematics and Mechanics(English Edition) 2024年第1期45卷 69-84页

作者： chen ZHAO Zhenli chen C.T.MUTASA Dong lI School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China

The stability analysis of a finite Stokes layer is of practical importance in flow control. In the present work, the instantaneous stability of a finite Stokes layer with layer interactions is studied via a linear stability analysis of the frozen phases of the base flow. The oscillations of two plates can have different velocity amplitudes, initial phases, and frequencies. The effects of the Stokes-layer interactions on the stability when two plates oscillate synchronously are analyzed. The growth rates of two most unstable modes when δ lmost equal, and δ = δ*/h*, where δ*and h*are the Stokes-layer thickness and the half height of the channel, respectively. However, their vorticities are different. The vorticity of the most unstable mode is symmetric, while the other is asymmetric. The Stokes-layer interactions have a destabilizing effect on the most unstable mode when δ lizing effect when δ > 0.68. However, the interactions always have a stabilizing effect on the other unstable mode. It is explained that one of the two unstable modes has much higher dissipation than the other one when the Stokes-layer interactions are strong. We also find that the stability of the Stokes layer is closely related to the inflectional points of the base-flow velocity profile. The effects of inconsistent velocity-amplitude, initial phase, and frequency of the oscillations on the stability are analyzed. The energy of the most unstable eigenvector is mainly distributed near the plate of higher velocity amplitude or higher oscillation frequency. The effects of the initial phase difference are complicated because the base-flow velocity is extremely sensitive to the initial phase.

关键词： finite Stokes layer instantaneous stability Stokes-layer interaction asynchronous oscillation

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Progress on Bionic Textured Cutting Tools:A Review and Prospects

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journal of Bionic Engineering 2024年第1期21卷 19-55页

作者： Hong Wei Guangjun chen Zhuang chen Zhiwei Yu jiashuai Huang Tianjin Key laboratory of High Speed Cutting and Precision Processing Tianjin 300222China School of Mechanical Engineering Tianjin University of Technology and EducationTianjin 300222China

Cutting tools are known as the“productivity”of the manufacturing industry,which affects the production efficiency and quality of the workpiece,and has become the focus of research and attention in academia and ***,traditional cutting tools often suffer from adhesion or wear during the cutting process,which considerably reduces the cutting efficiency and service life of the tools,and makes it difficult to meet current production *** solve the above problems,scholars have introduced bionics into the tool’s design,applying the microscopic structure of the biological surface to the tool surface to alleviate the tool’s *** paper mainly summarizes the research progress of bionic textured cutting ***,categorize whether the bionic texture design is inspired by a single organism or multiple ***,it is discussed that the non-smooth surface of the biological surface has five characteristics:hydrophilic lubricity,wear resistance,drag reduction and hydrophobicity,anti-adhesion,and arrangement,and the non-smooth structure of these different characteristics are applied to the surface of the tool is designed with bionic ***,the cutting performance of bionic textured cutting tools is *** anti-friction and wear-resisting mechanism of bionic textured cutting tools is ***,some pending problems and perspectives have been proposed to provide new inspirations for the design of bionic textured cutting tools.

关键词： Bionic textured cutting tools Biological microstructure characteristics Cutting performance Anti-friction and wear-resisting mechanism

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NSNO:Neumann Series Neural Operator for Solving Helmholtz Equations in Inhomogeneous Medium

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journal of Systems Science & Complexity 2024年第2期37卷 413-440页

作者： chen Fukai lIU Ziyang lIN Guochang chen junqing SHI Zuoqiang Department of Mathematical Sciences Tsinghua UniversityBeijing 100084China Yau Mathematical Sciences Center Tsinghua UniversityBeijing 100084China Yanqi lake Beijing Institute of Mathematical Sciences and Applications Beijing 101408China

In this paper,the authors propose Neumann series neural operator(NSNO)to learn the solution operator of Helmholtz equation from inhomogeneity coefficients and source terms to *** equation is a crucial partial differential equation(PDE)with applications in various scientific and engineering ***,efficient solver of Helmholtz equation is still a big challenge especially in the case of high ***,deep learning has shown great potential in solving PDEs especially in learning solution *** by Neumann series in Helmholtz equation,the authors design a novel network architecture in which U-Net is embedded inside to capture the multiscale *** experiments show that the proposed NSNO significantly outperforms the state-of-the-art FNO with at least 60%lower relative l^(2)-error,especially in the large wavenumber case,and has 50%lower computational cost and less data ***,NSNO can be used as the surrogate model in inverse scattering *** tests show that NSNO is able to give comparable results with traditional finite difference forward solver while the computational cost is reduced tremendously.

关键词： Helmholtz equation inverse problem neumann series neural network solution operator

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Isotopic characteristics and source analysis of atmospheric ammonia during agricultural periods in the Xichuan area of the Danjiangkou Reservoir

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journal of Environmental Sciences 2024年第2期136卷 460-469页

作者： Xiaoshu chen Tongqian Zhao Chunyan Xiao Xiaoming Guo Feihong chen Institute of Resources and Environment Henan Polytechnic UniversityJiaozuo 454000China

Nitrogen deposition is an important means of exogenous nitrogen input in reservoir *** activities around the reservoir lead to a sharp increase in the concentration of ammonia in the atmosphere,which poses a threat to the reservoir water *** the contribution of agricultural ammonia release to atmospheric NH_(x)(gaseous NH_(3)and particulate NH_(4)^(+)),in the reservoir area can provide a theoretical foundation for local reactive nitrogen *** collected atmospheric NH_(3)and NH_(4)^(+)samples during the agricultural periods and analyzed the isotopic characteristics of atmospheric NH_(x)and the contribution rates of different ammonia sources in the Xichuan area of the Danjiangkou *** results showed that the initialδ~(15)N values of NH_(3)(-30.0‰to–7.2‰)and particulate NH_(4)^(+)(–33‰to+4.9‰for finer and coarser particles,respectively)are different,and their contribution ratios from dissimilar ammonia sources are also different,among which NH_(4)^(+)is more susceptible to meteorological ***,since the atmospheric NH_(x)in the Xichuan area is mainly gaseous NH_(3),the final sources of atmospheric ammonia nitrogen source depend on gaseous NH_(3).Agricultural sources(59%-74%)were the main NH_(3)sources in this *** them,the fertilizer use emission was dominant;it had the highest contribution rate in summer during the agricultural period and a more prominent impact in areas with less human *** regulation of the application of high-ammonia releasing fertilizer,especially during the agricultural period in summer,is an effective way to reduce the threat of atmospheric ammonia to water health.

关键词： Danjiangkou reservoir Atmospheric ammonia nitrogen Isotope Ammonia source analysis Agricultural sources

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Numerical simulation on the multiphase flow and reoxidation of the molten steel in a two-strand tundish during ladle change

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International journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1540-1553页

作者： jingcheng Wang Zhentong liu Wei chen Hongliang chen lifeng Zhang School of Mechanical Engineering Yanshan UniversityQinhuangdao 066004China School of Materials Science and Engineering Tianjin UniversityTianjin 300350China School of Mechanical and Materials Engineering North China University of TechnologyBeijing 100144China

A 3D mathematical model was proposed to investigate the molten steel–slag–air multiphase flow in a two-strand slab continuous casting(CC)tundish during ladle *** study focused on the exposure of the molten steel and the subsequent reoxidation *** exposure of the molten steel was calculated using the coupled realizable k–εmodel and volume of fluid(VOF)*** diffusion of dissolved oxygen was determined by solving the user-defined scalar(UDS)***,the user-defined function(UDF)was used to describe the source term in the UDS equation and determine the oxidation rate and oxidation *** effect of the refilling speed on the molten steel exposure and dissolved oxygen content was also *** the refilling speed during ladle change reduced the refilling time and the exposure duration of the molten ***,the elevated refilling speed enlarged the slag eyes and increased the average dissolved oxygen content within the tundish,thereby exacerbating the reoxidation *** addition,the time required for the molten steel with a high dissolved oxygen content to exit the tundish varied with the refilling *** the inlet speed was 3.0 m·s^(-1)during ladle change,the molten steel with a high dissolved oxygen content exited the outlet in a short period,reaching a maximum dissolved oxygen content of 0.000525wt%.Conversely,when the inlet speed was 1.8 m·s^(-1),the maximum dissolved oxygen content was 0.000382wt%.The refilling speed during the ladle change process must be appropriately decreased to minimize reoxidation effects and enhance the steel product quality.

关键词： tundish ladle change reoxidation multiphase flow numerical simulation

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Precipitation transformation pathway and mechanical behavior of nanoprecipitation strengthened Fe-Mn-Al-C-Ni austenitic low-density steel

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journal of Materials Science & Technology 2024年第7期174卷 157-167页

作者： Y.F.An X.P.chen l.Mei P.Ren D.Wei W.Q.Cao College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Guangxi Engineering Research Center for Characteristic Metallic Powder Materials School of Electronic EngineeringGuangxi University of Science and TechnologyLiuzhou 545006China Central Iron&Steel Research Institute Beijing 100081China

Precipitation strengthening has been widely adopted in austenitic low-density steel owing to excellent hardened *** approach generally employs the coherentκ′carbides and non-coherent B2 *** the precipitation transformation pathway is decisive for further optimizing the microstructures under specific engineering ***,the detailed precipitation sequence of Fe-28Mn-11Al-1C-5Ni(wt%)austenitic low-density steel as well as its influence on mechanical prop-erties during aging process is systematically *** results reveal that nano-sizedκ′carbides domains(2 nm)exist in the solution-treated *** aging at 500℃for 1 h,the cuboidalκ′carbides(15-20 nm)uniformly disperse in austenite ***,after aging at 700℃for 15 min,the coarsenκ′carbides(30-35 nm)inhomogeneously distribute and align preferentially along the〈100〉***,extending the aging time to 60 min,the needle-type B2 particles replace theκ′carbides due to the enrichment of Ni elements at the phase boundaries among the austenite andκ′*** aging at 900℃,κ′carbides entirely dissolve into the austenite matrix,and the intragranular B2 particles are the sole precipitates in the austenite matrix and follow the K-S orientation relationship with *** work hardening capability seriously deteriorates due to the shearing ofκ′carbides by gliding *** the intragranular B2 particles preserve excellent work hardening rate by dislocations bow-out *** present work is meaningful for guiding the design of new generation dual-nano precipitation austenitic lightweight steel.

关键词： lightweight steel κ′-carbides B2 particles Work hardening capability

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Heat Transfer Characteristics of a Microchannel Heat Sink with Highly-Dense Micro-jet Arrays

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journal of Thermal Science 2024年第3期33卷 1148-1160页

作者： ZHANG Yu chen Xiaoyan MIAO lin chen liang HOU Yu State Key laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an710049China Beijing Aerospace Technology Institute Beijing100083China

This paper proposed a new structure of highly-dense micro-jet arrays for hybrid jet-impingement/microchannel heat sinks(~120 jet per cm^(2) with jet width of 0.35 mm).Parametric study is performed to investigate the influence of structure and flow parameters on the convective heat transfer of water jet cooling in confined *** simulation results show that the optimal jet width,jet spacing and impingement distance are around 0.2 mm,0.2 mm and 0.3 mm,respectively,which can achieve a low thermal resistance as well as a relatively low pressure *** analysis of the heat transfer pathways shows that the micro-fin jet structures can extend the impinging heat transfer area and conduct a considerable proportion of heat,which can reach up to 38.9%with the Reynolds number ranging from 797.1 to *** heat transfer characteristics in the heat sink will shift from impingement dominated heat transfer to the channel-convection dominated heat transfer as the jet impingement distance increases.A correlation is proposed to predict the average Nusselt number on the stagnation area for the heat sink with different structure parameters,and the deviations of predictions from the numerical results are less than 10%.

关键词： hybrid heat sink impingement microchannel thermal management high heat flux

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