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闭环胰岛素泵在年幼1型糖尿病患儿中的应用

中华医学杂志 2022年第16期102卷 1138-1138页

作者： Ware j Allen jM Boughton ck 杨舒婷(编译) 不详中南大学湘雅二医院内分泌科

近年来混合闭环胰岛素泵的开发和应用逐渐增加,但其相较于传感器增强泵的优势尚不明确,尤其对于年幼1型糖尿病儿童。为解决这一问题,研究人员在奥地利、德国、卢森堡和英国的7个中心随机招募了正在接受胰岛素泵治疗的1~7岁1型糖尿病儿童... 详细信息

近年来混合闭环胰岛素泵的开发和应用逐渐增加,但其相较于传感器增强泵的优势尚不明确,尤其对于年幼1型糖尿病儿童。为解决这一问题,研究人员在奥地利、德国、卢森堡和英国的7个中心随机招募了正在接受胰岛素泵治疗的1~7岁1型糖尿病儿童,开展了一项多中心、随机、交叉对照试验。参与者在两个为期16周的治疗期间以随机顺序接受两种治疗,对闭环系统与传感器增强泵的治疗效果进行比较。主要观察终点是两种治疗在两个16周治疗期间血糖测量值处于目标范围(TIR,3.9~10.0 mmol/l)的时间百分比差异;次要观察终点包括处于高血糖状态的时间百分比(TAR,血糖>10.0 mmol/l)、糖化血红蛋白水平、平均血糖水平,以及处于低血糖状态的时间百分比(TBR,血糖l)。研究共有74例参与者接受了随机分组,参与者的年龄为(5.6±1.6)岁,基线糖化血红蛋白水平为7.3%±0.7%。相较于使用传感器增强泵,使用闭环泵可使TIR升高8.7%(95% CI:7.4%~9.9%, P<0.001)、TAR下降8.5%(95% CI:7.1%~9.9%),糖化血红蛋白下降0.4%(95% CI:0.5%~0.3%);两种治疗的TBR相似( P=0.74)。由此,本研究得出结论,混合闭环系统相较于传感器增强泵显著改善了1型糖尿病幼儿的血糖控制,并且不增加低血糖的发生风险。未来可以通过扩大样本量进一步开展研究,明确混合闭环胰岛素泵在年幼1型糖尿病儿童中的优势,为其推广应用提供证据。

关键词：平均血糖水平观察终点高血糖状态 1型糖尿病交叉对照试验糖化血红蛋白时间百分比血糖控制

Association of oral submucous fibrosis （OSF） with outcome of squamous cell carcinoma of tongue

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中国口腔颌面外科杂志 2008年第B5期6卷 123-124页

作者： Hsiao Yl Poon ck Chan MY Wong YK Department of Dentistry Division of Oral and MaxillofacialSurgery Taichung Veterans General Hospital TaichungTaiwan China

Background: Oral squamous cell carcinoma and oral submucous fibrosis, they both are highly associated with betel quid chewing habit。like other potentially malignant disorders, oral submucous fibrosis has been known as 3-7% malignant transformation rate。Currently, some emerged evidences have supported that oral submucous fibrosis could be highly related with epithelial-mesenchymal transition (EMT) in oral mucosa, which possibly response to long-term injury from betel quid。Simultaneously, the EMT also seems to play a role in tumor invasion and metastasis in some malignant cells。It is reasonably believed that pathophysiological connections existed between fibrosis and cancer behavior。Purpose: To analysis the influence of oral submucous fibrosis on overall outcome of oral squamous cell carcinoma。Methods: Since 2002-2005, 65 patients were consecutively collected from Department of Oral and Maxillofacial Surgery, Taichung Veterans General Hospital, Taiwan, China。The inclusion criteria were previously untreated patients on tongue without pathological cervical metastasis。The cancer patients with submucous fibrosis were divided into mild, moderate, severe subgroups; patients without betel nut chewing as control group。The overall survival and disease-free rates of patients were analyzed by Kaplan-Meier analysis。Results: Conclusively, variables such as age, grading, tumor size, even status of cut margin all were not statistically difference between subgroups。The overall outcomes also have been not shown any difference between subgroups, such as disease-flee rate (P= 1.35) and overall survival rate (P=1.43)。Conclusion: In this prospective cohort study, the comorbidity of submucous fibrosis with tongue cancer patients should not be considered as a negative influence on overall outcomes。However, we need more long period follow-up these patients for confirming this primary conclusion。

关键词：口腔黏膜纤维化鳞状细胞癌舌癌

R. sinicus should be reservoir of Sl-CoV but not SARSCoV: critical comments on Ge et al.'s paper in Nature

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医学争鸣 2014年第2期5卷 25-27页

作者： XU De-Zhong Bernard ck CHOI ZHANG lei SU Hai-Xia ZHANG jing-Xia XU Rui GAO jie Clinical Epidemiology Unit Fourth Military Medical UniversityClinical Epidemiology Network in China International Clinical Epidemiology Network Department of Epidemiology Fourth Military Medical University Dalla lana School of Public Health University of Toronto Department of Epidemiology and Community Medicine University of Ottawa

The study of the origin of SARS coronavirus(SARS CoV)and SARS-like coronavirus(Sl-CoV)is very important for the prevention of novel human infections with these ***,Ge et *** that Chinese horseshoe bats are natural reservoirs of SARSCoV[1].But this conclusion is *** should be"Chinese horseshoe bats are natural reservoirs of SlCoV"[2-7].The paper also has several methodological problems,leading to errors in the conclusions.

关键词： SARS冠状病毒水蚤论文 SARS病毒人类感染自然宿主蝙蝠马蹄

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欧洲大型太阳能供热系统的应用与设计

暖通空调 2007年第4期37卷 117-120页

作者： jan-Olof Dalenbck 于国清查尔姆斯理工大学上海理工大学

结合欧洲太阳能供热系统的应用情况,介绍了常见大型太阳能供热系统的方案和特点,以及集热器、集热环路、蓄热装置等关键部件的设计方法。

关键词：太阳能供热系统设计集热器蓄热

铝－锂合金中δ’（Al＿3li）沉淀相时效粗化行为及体积分数的测定

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电子显微学报 1995年第4期14卷 297-302页

作者：袁庆龙 Davi.,ck 山西矿业学院

对经固溶处理的二种Ａｌ－Ｌｉ合金（１．９４ｗｔ．％Ｌｉ和２．７５ｗｔ．％Ｌｉ）的时效过程进行了研究。结果表明：δ’的生长速率遵从Ｏｓｔｗａｒｄ粗化动力学。１．９４ｗｔ．％Ｌｉ合金δ’产生于时效过程中，而２．７５ｗｔ．... 详细信息

对经固溶处理的二种Ａｌ－Ｌｉ合金（１．９４ｗｔ．％Ｌｉ和２．７５ｗｔ．％Ｌｉ）的时效过程进行了研究。结果表明：δ’的生长速率遵从Ｏｓｔｗａｒｄ粗化动力学。１．９４ｗｔ．％Ｌｉ合金δ’产生于时效过程中，而２．７５ｗｔ．％Ｌｉ合金的δ’产生于时效的前期阶段。前者的表现体积分数明显大于根据相图估算的数伍，真实体积分数则与此值接近；后者的体积分数低于根据相图估算的数值，这可能归咎于δ’固相线的位置、统计学误差及Ｌｉ更易在时效过程中贫化。

关键词：沉淀相时效表观体积分数铝锂合金

Non-invasive versus invasive mechanical ventilation for respiratory failure in severe acute respiratory syndrome

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中华医学杂志(英文版) 2005年第17期 7-15页

作者： loretta YC Yam,Alfred YF Chan,Thomas MT Cheung,Eva lH Tsui,jane ck Chan,Vivian CW Wong Division of Respiratory and Critical Care Medicine Department ofMedicine Pamela Youde Nethersole Eastern Hospital Hong Kong China Division of Respiratory and Critical Care Medicine Department ofMedicine Pamela Youde Nethersole Eastern Hospital Hong Kong China Division of Respiratory and Critical Care Medicine Department ofMedicine Pamela Youde Nethersole Eastern Hospital Hong Kong China Hong Kong Hospital Authority Head Office Hong Kong China Hong Kong Hospital Authority Head Office Hong Kong China Hong Kong Hospital Authority Head Office Hong Kong China

Background Severe acute respiratory syndrome is frequently complicated by respiratory failure requiringventilatory *** aimed to compare the efficacy of non-invasive ventilation against invasive mechanicalventilation treating respiratory failure in this *** Retrospective analysis was conducted on all respiratory failure patients identified from the HongKong Hospital Authority Severe Acute Respiratory Syndrome *** rate, mortality and secondaryoutcome of a hospital utilizing non-invasive ventilation under standard infection control conditions ( NIVHospital) were compared against13 hospitals using solely invasive ventilation (IMVHospitals).Multiple logisticregression analyses with adjustments for confounding variables were performed to test for association betweenoutcomes and hospital *** Both hospital groups had comparable demographics and clinical profiles, but NIV Hospital (42patients) had higher lactate dehydrogenase ratio and worse radiographic score on admission and ribavirin-corticosteroid *** to IMV Hospitals (451 patients), NIV Hospital had lower adjustedodds ratios for intubation (0.36, 95% CI 0.164 -0.791,P=0.011) and death (0.235, 95% CI 0.077 -0.716,P=0.011), and improved earlier after pulsed steroid *** were no instances of transmission ofsevere acute respiratory syndrome among health care workers due to the use of non-invasive *** Compared to invasive mechanical ventilation, non-invasive ventilation as initial ventilatory supportfor acute respiratory failure in the presence of severe acute respiratory syndrome appeared to be associated withreduced intubation need and mortality.

关键词： acute respiratory failure · infection control · invasive mechanical ventilation · non-invasive ventilation · severe acute respiratory syndrome

Situation of China's solar water heater industry,related national standards,testing and the Golden Sun certification program

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journal of Chongqing University 2008年第2期7卷 107-112页

作者：严军 H.Drück H.Müller-Steinhagen Department of Mechanical Engineering Qinghai University Institute of Thermodynamics and Thermal Engineering University of StuttgartStuttgart 70550Germany

China is the largest solar water heater producer and market in the *** the fast growth and an installed capacity that accounts for the majority of the global gross,China's per capita solar hot water capacity is still very low,implying a huge margin of market potential;and the recognition of the industry in the global market is handicapped by the scattered scale of production and inconsistent product *** ensure continued growth of China's solar water heating(SWH) industry,Chinese Government has established a series of national SWH standards,three national testing centers,and a certification program to lay the foundation for the development of the Golden Sun product labeling *** General Certification Center(CGC) developed the Golden Sun product certification and labeling system on a pass/fail basis evaluating with established *** system was designed to help manufacturers acclimate to explicit consistent requirements and to identify and fix the deficiencies in the design and execution of the program *** revision and integration of the national standards are recommended to accommodate the test procedures and requirements to new technologies and the evolving SWH *** implementation of the Golden Sun certification and labeling system are suggested to avail improving the quality control and forging internationally reputable brands of Chinese solar water heating products.

关键词： solar water heaters solar heating renewable energy resources national standards Golden Sun certification program

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Honey

明日风尚 2009年第3期 132-139页

作者： Adele leung Taylor ck(Secret Nine Production) Winky Tsang(i face) Adele leung Taylor ck(Secret Nine Production) Winky Tsang(i face)

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10分钟成就一条网虫

大众电脑 2002年第10期 63-72页

作者： ck