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Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael j.l.e Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark l.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

A MICROMECHANICAl MODEl FOR γ-TiAl BASE PST CRYSTAlS

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Acta Metallurgica Sinica(English letters) 2005年第6期18卷 686-694页

作者： j.l. Su G.K. Hu School of Mechanics-Electrics Engineering Fujian Agriculture and Forestry University Fuzhou 350002 China Department of Applied Mechanics Beijing Institute of Technology Beijing 100081 China

An analytical micromechanical method is proposed to examine the dependence of plastic deformation on the microstructure for a PST crystal. The sub-domain microstructure of the γ phase and the effect of the α2 phase are taken into account by a proper micromechanical formulation, the dislocation slip and twinning deformation mechanisms are considered in the context of crystal plasticity. The model can well predict the dependence of stress-strain relations on loading angle with respect to the microstructure. The influence of the twinning and lamellar spacing on the deformation behavior and biaxial yield surfaces for PST crystals are also examined.

关键词： TiAI alloy crystal plasticity micromechanical model yield surface

Stress reduction via neuro-emotional technique to achieve the simultaneous resolution of chronic low back pain with multiple inflammatory and biobehavioural indicators:A randomized,double-blinded,placebo-controlled trial

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journal of Integrative Medicine 2022年第2期20卷 135-144页

作者： Peter Bablis Henry Pollard Anthony l.rosner Universal Health New South Wales 2028Australia School of Medical and Applied Sciences University of Central QueenslandBrisbaneNew South Wales 4000Australia Medical Information Services MA 02479-4149United States

Background:Beginning with the concepts of stress developed by Selye,an approach to stress and pain management,known as neuro-emotional technique(NET),has been *** is a treatment approach based on the principle that the stressor effects of dormant and/or current unresolved issues or trauma are what determine one’s bodily *** responses are relatively personalized to the conditioned,experiential and emotional reality of the ***:To determine the effect of NET on patients with chronic low back pain(ClBP)over ***,setting,participants,and interventions:In a randomized,double-blinded,placebo-controlled study conducted in a single clinic,NET or control treatments were given twice weekly for 4 weeks in a population of 112 *** outcome measures:Outcome measures,including Oswestry Disability Index,Quadruple Visual Analogue Scale,the psychoneuroimmunology markers of blood serum levels of C-reactive protein,tumour necrosis factor-a,interleukin-1(Il-1),Il-6,and Il-10,and 10 dimensions of the Short Form Health Survey scale,were assessed at baseline and at 1,3 and 6 months following the intervention ***:Compared to placebo,NET produced clinical and statistical significance(Plines of virtually all physiological,pain and disability markers,accompanied by gains in quality-of-life indicators at 0(baseline),1,3 and 6 *** of the percentages of patients whose 5 biomarkers lay outside the normative range were achieved at 1,3 and 6 months by NET but not control ***:A randomized,controlled trial of ClBP patients indicated that 8 NET interventions,compared to placebo,produced clinically and statistically significant reductions in pain,disability and inflammatory biomarkers,and improvements in quality-of-life measures.

关键词： Neuro-emotional technique Biopsychosocial model Emotion Mind-body therapies Inflammation Biomarker

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james l.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Diorgano, Dichloro-tin (IV) Complexes of 4-X-Benzohydroxamic Acid (X=Cl, OCH_3): Synthesis, Characterization, Antitumor Activity in Vitro and the Crystal Structure of trans- [Me_2Sn (l_2) _2]

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Chinese Chemical letters 2003年第8期14卷 840-843页

作者： jing Hua ZHAO Tai Gang lIANG Qing Shan lI Armando j.l. Pombeiro SchoolofPharmaceuticalScience ShanxiMedicalUniversityTaiyuan030001

A series of diorganotin (IV) derivatives of R2Snl2 (R = Me, Et, n-Bu, ph or Cl; l = l1 or l2) and their corresponding mixed-ligand complexes R2Sn (l1)(l2) have been prepared and the structure of trans-Me2Sn (l2) 2 was characterized by FT-IR, 1H, 13C and 119Sn NMR spectroscopies, MS, elemental analysis, melting points and X-ray diffraction. The structure-activity relationships were discussed.

关键词： Diorganotin X-ray diffraction antitumor activity synthesis.

NUMERICAl STUDY OF TURBUlENT IMPINGING jET WITH A REFINED k-ε MODEl

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journal of Hydrodynamics 2000年第4期12卷 8-15页

作者： Xu, j.l. Xu, Z. Huang, S.j. Zhang, K.Y. Xiao, M. 2nd Dep. Nanjing Univ. of Aeron. and Astron. Nanjing 210016 China

A refined k-Ε model re-considering the fluctuating pressure diffusion term in the dissipation rate equation (Ε-equation) is provided and used in the numerical study of circular semi-confined turbulent impinging jet. The results are compared with those of the standard k-Ε model and show that the predicting ability of the refined k-Ε model is much improved, especially for the turbulent kinetic energy k. So it is necessary to consider the effect of the fluctuating pressure diffusion term and to model this term correctly and exactly in the near wall region with the great adverse pressure gradient, where the effect of the pressure fluctuating is important. Therefore we can conclude that the new modeling idea expressed in this paper is correct and effective.

关键词： Computer simulation jets Mathematical models Turbulence

SYNTHESIS AND SOlID STATE SINTERING OF W-Ni-Fe NANO-COMPOSITE POWDERS

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Acta Metallurgica Sinica(English letters) 2000年第3期13卷 917-920页

作者： Qu, X.H. Fan, j.l. li, Y.M. Huang, B.Y. Central South Univ of Technology Changsha China

The mixture of 90 wt%W, 7 wt%Ni and 3 wt%Fe elemental powders was milled in a planetary high-energy ball mill. The evolution of the structure during milling and the sintering behavior of the milled powders were tested. The results showed that by mechanical alloying W(Ni, Fe) supersaturated solid solution with nano-meter size formed, which can enhance the sintering process. Fully dense alloy from the milled powders was obtained through solid state sintering. The tensile strength of the obtained alloy is over 900 MPa which is comparable to that of the alloy sintered by traditional liquid-phase sintering from un-milled powders of the same composition.

关键词： Tungsten alloys Nickel alloys Iron alloys Mechanical alloying Powder metals Sintering Morphology Tensile strength

Measurements of γ/γ' lattice Misfit and γ' Volume Fraction for a Ru-containing Nickel-based Single Crystal Superalloy

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journal of Materials Science & Technology 2011年第10期27卷 899-905页

作者： X.P. Tan j.l. liu X P Song T. jin X.F. Sun Z.Q. Hu Superalloy Division Institute of Metal Research Chinese Academy of Sciences- Shenyang 110016 China Analysis and Testing Division Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

A conventional X-ray difFractometer has been used to determine the -y/y＇ lattice misfit and γ＇ volume fraction for a Ru-containing nickel-based single crystal superalloy at room temperature. The rocking curve was used to characterize the distribution of subgrains. The diffraction peaks obtained by w-20 scan were used to determine the γ/γ＇ lattice misfit and γ＇ volume fraction. A three peaks fitting model was proposed. The peak fitting results are in good agreement with the model. The X-ray diffraction results indicate that the nickel-based single crystal superalloy was not a perfect monocrystalline material, which is comprised of many subgrains; and each subgrain also consists of large numbers of mosaic structures. In addition, two anomalous reflection phenomena were found during the experiment and discussed with respect to their occurrence and impact on the measurement. The experimental results show that the γ/γ＇ lattice misfit and ~/r volume fraction will be various at the different regions of its dendritic microstructure. The average γ/γ＇ lattice misfit and γ＇ volume fraction of the experimental alloy are approximately-0.2% and 70%, respectively. Furthermore, the γ＇ volume fraction calculated by atom microprobe （AP） data is also basically consistent with the experimental results.

关键词： Nickel-based superalloy Microstructure X-ray diffraction lattice misfit y' volume fraction