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Automated Exudates Detection in Retinal Fundus Image Using Morphological Operator and Entropy Maximization Thresholding

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journal of Biomedical Science and Engineering 2019年第3期12卷 212-224页

作者： G. H. kom B. C. Wouantsa Tindo j. R. Mboupda Pone A. B. Tiedeu Research Unit of Automation and Applied Informatics (URAIA) Department of Electrical Engineering IUT-FV Bandjoun University of Dschang Bandjoun Cameroon Research Group on Medical Technologies Applied to the Tropics (GRETMAT) Laboratory of Electronics and Signal Processing (LETS) ENSP University of Yaoundé I Yaoundé Cameroon Research Unit for Condensed Matter Electronics and Signal Processing (LAMACETS) Department of Physics University of Dschang Dschang Cameroon Signal Image and Systems Laboratory Ebolowa Cameroon

Blindness which is considered as degrading disabling disease is the final stage that occurs when a certain threshold of visual acuity is overlapped. It happens with vision deficiencies that are pathologic states due to many ocular diseases. Among them, diabetic retinopathy is nowadays a chronic disease that attacks most of diabetic patients. Early detection through automatic screening programs reduces considerably expansion of the disease. Exudates are one of the earliest signs. This paper presents an automated method for exudates detection in digital retinal fundus image. The first step consists of image enhancement. It focuses on histogram expansion and median filter. The difference between filtered image and his inverse reduces noise and removes background while preserving features and patterns related to the exudates. The second step refers to blood vessel removal by using morphological operators. In the last step, we compute the result image with an algorithm based on Entropy Maximization Thresholding to obtain two segmented regions (optical disk and exudates) which were highlighted in the second step. Finally, according to size criteria, we eliminate the other regions obtain the regions of interest related to exudates. Evaluations were done with retinal fundus image DIARETDB1 database. DIARETDB1 gathers high-quality medical images which have been verified by experts. It consists of around 89 colour fundus images of which 84 contain at least mild non-proliferative signs of the diabetic retinopathy. This tool provides a unified framework for benchmarking the methods, but also points out clear deficiencies in the current practice in the method development. Comparing to other recent methods available in literature, we found that the proposed algorithm accomplished better result in terms of sensibility (94.27%) and specificity (97.63%).

关键词： Diabetic Retinopathy Retinal Fundus Image Exudates Entropy Maximization Thresholding

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原子吸收分光光度法中的有机络合剂

化学试剂 1984年第2期 101-106页

作者： j.komárek L.Sommer 北京中医学院分析化学教研组

在原子吸收分光光度法中,有机分析试剂可产生各种不同的影响:(1) 改变元素的原子化过程(这取决于原子化的方式和机理),有时提高自由原子的生成效率;(2) 在特定分析元素的AAS测定过程中,试剂可抑制或减少来自共存元素的干扰;(3) 用非水... 详细信息

在原子吸收分光光度法中,有机分析试剂可产生各种不同的影响:(1) 改变元素的原子化过程(这取决于原子化的方式和机理),有时提高自由原子的生成效率;(2) 在特定分析元素的AAS测定过程中,试剂可抑制或减少来自共存元素的干扰;(3) 用非水溶剂萃取金属螯合物或离子缔合络合物的方法可以达到预先富集的目的,然后将萃取液喷雾到火焰中或用无火焰技术处理。当应用有机溶剂时,有机溶剂也可影响特定体系的AAS行为。

关键词：原子化器有机配位体配位原子非挥发性碳化物分析元素干扰元素配位体碳化合物原子吸收分光光度法原子吸收光度法二乙基二硫代氨基甲酸盐金属鳌合物火焰温度

Folded novel accurate analytical and semi-analytical solutions of a generalized Calogero–Bogoyavlenskii–Schiff equation

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Communications in Theoretical Physics 2021年第9期73卷 26-36页

作者： Mostafa M A Khater S K Elagan M A El-Shorbagy S H Alfalqi j F Alzaidi Nawal A Alshehri Department of Mathematics Faculty of ScienceJiangsu University212013ZhenjiangChina Department of Mathematics Obour High Institute For Engineering and Technology11828CairoEgypt Department of Mathematics Faculty of ScienceTaif University P.O.Box 11099Taif 21944Saudi Arabia Department of Mathematics College of Science and Humanities in Al-KharjPrince Sattam bin Abdulaziz UniversityAl-Kharj 11942Saudi Arabia Department of Basic Engineering Science Faculty of EngineeringMenoufia UniversityShebin El-Kom 32511Egypt Department of Mathematics Faculty of Science and ArtsMahayil Asir King Khalid UniversityAbhaSaudi Arabia

This paper studies the analytical and semi-analytic solutions of the generalized Calogero–Bogoyavlenskii–Schiff(CBS)*** model describes the(2+1)–dimensional interaction between Riemann-wave propagation along the y-axis and the x-axis *** extended simplest equation(ESE)method is applied to the model,and a variety of novel solitarywave solutions is *** solitary-wave solutions prove the dynamic behavior of soliton waves in *** accuracy of the obtained solution is verified using a variational iteration(VI)semi-analytical *** analysis and the match between the constructed analytical solution and the semi-analytical solution are sketched using various diagrams to show the accuracy of the solution we *** adopted scheme’s performance shows the effectiveness of the method and its ability to be applied to various nonlinear evolution equations.

关键词： generalized Calogero-Bogoyavlenskii-Schiff equation accurate analytical semianalytical solutions

单侧髌股关节不稳病人对侧无症状关节的影像特点

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国际医学放射学杂志 2015年第1期 77-77页

作者： S.Demehri G.K.Thawait A.A.Williams A.kom Pel j.j.Elias j.A.Carrino Russell H.Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine

目的验证以下假说:在4D CT下显示单侧髌股关节不稳病人对侧无症状关节存在骨关节炎异常形态学及影像特征。材料与方法本回顾性研究获得了伦理委员会的批

关键词：髌股关节不稳对侧单侧关节运动器官无症状病人

SCFβ-TRCP E3 ubiquitin ligase targets the tumor suppressor ZNRF3 for ubiquitination and degradation

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Protein & Cell 2018年第10期9卷 879-889页

作者： Yanpeng Ci Xiaoning Li Maorong Chen jiateng Zhong Brian j. North Hiroyuki Inuzuka Xi He Yu Li jianping Guo Xiangpeng Dai School of Life Science and Technology Harbin Institute of Technology Harbin 150001 China Department of Pathology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA Department of Biochemistry and Molecular Biology Shanxi Medical University Taiyuan 030001 China The FM Kirby Neurobiology Center Children's Hospital Boston Harvard Medical School Boston MA 02115 USA Department of Oncology The First Affiliated Hospital of Xinxiang Medical University Xinxiang 453100 China Center for Advanced Stem Cell and Regenerative Research Tohoku University Graduate School of DentistrySendai 980-8575 Japan

Wnt signaling has emerged as a major regulator of tissue development by governing the self-renewal and maintenance of stem cells in most tissue types. As a key upstream regulator of the Wnt pathway, the transmem- brane E3 ligase ZNRF3 has recently been established to play a role in negative regulation of Wnt signaling by targeting Frizzled （FZD） receptor for ubiquitination and degradation. However, the upstream regulation of ZNRF3, in particular the turnover of ZNRF3, is still unclear. Here we report that ZNRF3 is accumulated in the presence of proteasome inhibitor treatment independent of its E3-ubiquitin ligase activity. Furthermore, the Cullin f-specific SCF complex containing β-TRCP has been identified to directly interact with and ubiqui- tinate ZNRF3 thereby regulating its protein stability. Similar with the degradation of β-catenin by β-TRCP, ZNRF3 is ubiquitinated by β-TRCP in both cki-phos- phorylation- and degron-dependent manners. Thus, our findings not only identify a novel substrate for β-TRCP oncogenic regulation, but also highlight the dual regu- lation of Wnt signaling by β-TRCP in a context-dependent manner where β-TRCP negatively regulates Wnt signaling by targeting β-catenin, and positively regulates Wnt signaling by targeting ZNRF3.

关键词： ZNRF3 β-TRCP Wnt ubiquitination cki

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发生于乳房复发性粘液样肉瘤后的双侧乳房癌

德国医学 1996年第2期13卷 119-122页

作者： B.R.Titius U-j.Ghring A.Scharl 武忠弼 Institut für Pathologie Universitt zu KlnJoseph-Stelzmann-Str.9D-5093KlnGermany 同济医科大学

肉瘤在乳房恶性肿瘤中的发生率仅占0.5%～3%,脂肪肉瘤则仅占乳腺肉瘤的0.3%,因而与四肢及腹膜后的肉瘤相比仅属罕见。一些脂肪肉瘤是在乳腺纤维腺瘤的基础上恶变而成,或由叶状囊性肉瘤转化而来,其余则为乳腺的原发性肉瘤。本瘤首先由 Vi... 详细信息

肉瘤在乳房恶性肿瘤中的发生率仅占0.5%～3%,脂肪肉瘤则仅占乳腺肉瘤的0.3%,因而与四肢及腹膜后的肉瘤相比仅属罕见。一些脂肪肉瘤是在乳腺纤维腺瘤的基础上恶变而成,或由叶状囊性肉瘤转化而来,其余则为乳腺的原发性肉瘤。本瘤首先由 Virchow 于1857年描述,第一例由 Neumann于1862年报道,迄今共报道近百例。本文1例为26岁患者,原患粘液样内瘤,组织学上未分化并继之以双侧乳房癌。

关键词：乳腺癌粘液样肉瘤病理

疲劳量表-14在汽车装配作业工人中的信度和效度检验

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工业卫生与职业病 2016年第5期42卷 346-350页

作者：李玉珍王伟凌瑞杰贾宁张雪艳陈松林顾缨缨王未来单琳琳赵霞顾永恩王忠旭中国疾病预防控制中心职业卫生与中毒控制所北京100050 东风日产有限公司湖北襄阳441004 湖北省职业病防治院湖北武汉430015 温州市疾病预防控制中心浙江温州325001 武汉科技大学医学院湖北武汉430065

目的检验疲劳量表-14（Fatigue Scale-14,FS-14）在汽车装配作业工人中的信度和效度。方法采用FS-14对588名汽车装配作业工人进行调查,选用项目区分度对FS-14进行项目分析;采用Cronbachsα系数评估量表内部一致性信度,Spearman-Brow... 详细信息

目的检验疲劳量表-14（Fatigue Scale-14,FS-14）在汽车装配作业工人中的信度和效度。方法采用FS-14对588名汽车装配作业工人进行调查,选用项目区分度对FS-14进行项目分析;采用Cronbachsα系数评估量表内部一致性信度,Spearman-Brown系数评估量表分半信度;运用各条目得分与总分的相关性和因子分析方法验证量表的各条目与量表一致性和结构效度。结果项目分析：躯体疲劳和脑力疲劳维度能够区分调查对象的不同躯体疲劳和脑力疲劳水平（P〈0.01）;信度：量表的Cronbachsα系数为0.809,躯体疲劳和脑力疲劳2个维度的Cronbachsα系数分别为0.800和0.677,Spearman-Brown系数为0.676;效度：各条目得分与总分之间的Pearson相关系数为0.369~0.690（P〈0.01）,kom值为0.852。共提取3个公因子,累计方差贡献率为48.839%;每个公因子均涵盖了躯体疲劳和脑力疲劳。结论FS-14在汽车装配作业工人中具有较好的信度和效度,而脑力疲劳维度需根据实际工作进一步完善修订。

关键词：疲劳量表-14 汽车装配信度效度