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抗血管生成癌症治疗:分子超声和一种临床转录对比剂(BR55)监测

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国际医学放射学杂志 2010年第5期 486-487页

作者： M.A.Pysz k.Foygel j.Rosenberg S.S.Gambhir M.Schneider j.k.willmann 卞读军 Department of Radiology Molecular Imaging Program at StanfordStanford University School of Medicine

关键词：抗血管生成 kDR BR55 VEGFR 对比剂

对比增强MR血管造影鉴别胃周和胃底粘膜下静脉曲张

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放射学实践 2003年第9期18卷 647-647页

作者： j.k.willmann P.B.Auerfeind T.Boehm 关键华中科技大学同济医学院附属同济医院

在肿瘤生长中肿瘤血管源性标记物的表达水平:运用分子靶向微泡和超声成像进行纵向评估

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国际医学放射学杂志 2011年第3期 278-278页

作者： N.Deshpande k.Foygel j.Rosenberg j.k.willmann 焦慧 Molecular Imaging Program at Stanford Department of RadiologyStanford University School of Medicine

目的针对肿瘤生长中活体的肿瘤血管内皮细胞,评价分子靶向微泡(MB)和超声的应用在无创性评估3种血管源性标记物αvβ3整合蛋白、endoglin和血管内皮生长因子

关键词：肿瘤生长标记物靶向微泡表达水平血管源性分子

Insm1:orchestrating cellular mimicry in the thymus medulla

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Cellular & Molecular Immunology 2024年第4期21卷 414-416页

作者： k.D.james j.E.Cowan UCL Institute of Immunity and Transplantation The Pears BuildingRowland Hill StreetLondonNW32PPUK

The thymus is the primary production site for a functional and self-tolerant T-cell *** establishment of immune tolerance is mediated by the generation and presentation of tissue-restricted self-antigens(TRAs)by medullary thymic epithelial cells(mTECs),which screen T-cell receptors for self-reactivity to eliminate autoreactive T *** studies have extended our understanding of mTEC heterogeneity by examining the mechanisms by which mTECs mimic the peripheral self[1].

关键词： medullary eliminate restricted

在动物内比较三维分子靶向超声成像和三维动态对比增强超声对结肠癌早期抗血管生成治疗疗效评估

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国际医学放射学杂志 2017年第2期 219-219页

作者： H.j.Wang A.M.Lutz D.Hristov L.Tian j.k.willmann 杨科 Department of Radiology Molecular Imaging Program at StanfordSchool of MedicineStanford University

摘要目的在动物内比较用靶向临床分级的血管内皮生长因子受体2(VEGFR2)的微气泡进行三维分子靶向超声成像和用非靶向微气泡进行三维动态对比增强超声对人结

关键词：超声成像对比增强超声三维动态分子靶向抗血管生成动物

Use of donepezil for neurocognitive recovery after brain injury in adult and pediatric populations:a scoping review

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Neural Regeneration Research 2024年第8期19卷 1686-1695页

作者： Avery L.Miller Nathan k.Evanson j.Michael Taylor University of Cincinnati College of Medicine CincinnatiOHUSA Department of Pediatrics University of CincinnatiCincinnatiOHUSA Department of Neurology and Rehabilitation Medicine University of CincinnatiCincinnatiOHUSA Division of Pediatric Rehabilitation Medicine Cincinnati Children’s Hospital Medical CenterCincinnatiOHUSA Division of Neurology Cincinnati Children’s Hospital Medical CenterCincinnatiOHUSA

There are few pharmacologic options for the treatment of cognitive deficits associated with traumatic brain injury in pediatric *** inhibitors such as donepezil have been evaluated in adult patients after traumatic brain injury,but relatively less is known about the effect in pediatric *** goal of this review is to identify knowledge gaps in the efficacy and safety of acetylcholinesterase inhibito rs as a potential a djuvant treatment fo r neurocognitive decline in pediatric patients with traumatic brain *** queried PubMed to identify literature published from database inception thro ugh june 2023 desc ribing the use of donepezil in young adult traumatic brain injury and pediatric patients with predefined *** on preselected search criteria,340 unique papers we re selected for title and abstra ct ***-two reco rds were reviewed in full after eliminating preclinical studies and pape rs outside the scope of the *** adult traumatic brain injury,we review results from 14 papers detailing 227 subjects where evidence suggests donepezil is well tole rated and shows both objective and patient-reported efficacy for reducing cognitive *** children,3 pape rs report on 5 children recovering from traumatic brain injury,showing limited *** additional 15 pediatric studies conducted in populations at risk for cognitive dysfunction provide a broader look at safety and efficacy in 210 patients in the pediatric age *** its promise for efficacy in adults with traumatic brain injury and tole rability in pediatric patients,we believe further study of donepezil for children and adolescents with traumatic brain injury is warranted.

关键词： acetylcholinesterase inhibitor adult cognition donepezil pediatrics traumatic brain injury

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双定向超声对比剂在体评价肿瘤血管形成

国际医学放射学杂志 2008年第A6期31卷 490-490页

作者： j.k.willmann A.M.Lutz R.Paulmurugan M.R.Patel j.Rosen-berg 李芳 Molecular Imaging Program at Stanford Department of Radiology and Bio-X ProgramStanford University School of Medicinethe James H Clark Center318 Campus DrEast Wing1st FloorStan-ford CA 94305-5427USA.

目的研制并验证双定向超声对比剂(imagingagent),即将微气泡(MBs)附着到血管内皮生长因子受体2(vascular endothelial growth factor receptor,VEGFR2)

关键词：超声对比剂肿瘤血管双定 VEGFR 整联蛋白抗体标记人卵巢癌 targeted 微气泡实验

Unmixing detrital zircon U-Pb ages reveals tectonic and climatic depositional influences on the Carboniferous Ansilta Formation,Calingasta-Uspallata Basin,Western Argentina

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Geoscience Frontiers 2024年第4期15卷 61-77页

作者： j.R.Malone j.E.Malone j.L.Isbell D.H.Malone j.P.Craddock k.N.Pauls Department of Geological Sciences Jackson School of GeosciencesUniversity of Texas at AustinAustinTX 78712USA Iowa Geological Survey University of IowaIowa CityIA 52240USA Department of Geosciences University of Wisconsin-MilwaukeeMilwaukeeWI 53211USA Department of Geography Geology and the EnvironmentIllinois State UniversityNormalIL 61790-4400USA

The Late Paleozoic Ice Age(LPIA)was a principal control of sedimentation across Gondwana from the late Devonian through early *** assess the hypothesis that glacial to interglacial transitions in western Argentina were the primary control influencing sediment routing patterns among the various Carboniferous-Permian basins in western *** Carboniferous Ansilta Formation consists of glaciomarine,nearshore,and fluvial systems deposited during the LPIA along the eastern margin of the Calingasta-Uspallata Basin in *** lower,glacially influenced succession of the Ansilta Formation records at least five glacial advances;the upper succession of consists of progradational shallow marine,deltaic,and fluvial *** combine 1225 new U-Pb zircon ages from six samples of the Carboniferous Ansilta Formation in the Calingasta-Uspallata Basin with 5864 U-Pb ages from 147 pub-lished samples in the detrital Pymix forward mixture model to characterize provenance *** the glacially influenced lower Ansilta Formation,sediment was derived locally from the Protoprecordillera,which was a prominent highland with alpine glaciers flowing west and east into the Calingasta-Uspallata and Paganzo basins,***,there was little or no connection between these two basins during Serpukhovian-Bashkirian *** fluvial/deltaic upper Ansilta had distal sediment sources in the Sierras ***,our results support the collapse of the Protoprecordillera topographic barrier,enabling drainage patterns connecting the Paganzo and Calingasta-Uspallata basins by late Pennsylvanian-early Permian time.

关键词： Late Paleozoic Ice Age Argentina Calingasta-Uspallata Basin Ansilta Formation Detrital zircon provenance

Supposition of graphene stacks to estimate the contact resistance and conductivity of nanocomposites

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 663-676页

作者： Y.ZARE M.T.MUNIR G.j.WENG k.Y.RHEE Biomaterials and Tissue Engineering Research Group Department of Interdisciplinary TechnologiesBreast Cancer Research CenterMotamed Cancer InstituteTehran ***Iran College of Engineering and Technology American University of the Middle EastEgaila 54200Kuwait Department of Mechanical and Aerospace Engineering Rutgers UniversityNew BrunswickNJ 08903U.S.A. Department of Mechanical Engineering(Bk21 Four) College of EngineeringKyung Hee UniversityYongin 446701Republic of Korea

In this study,the effects of stacked nanosheets and the surrounding interphase zone on the resistance of the contact region between nanosheets and the tunneling conductivity of samples are evaluated with developed equations superior to those previously *** contact resistance and nanocomposite conductivity are modeled by several influencing factors,including stack properties,interphase depth,tunneling size,and contact *** developed model's accuracy is verified through numerous experimental *** further validate the models and establish correlations between parameters,the effects of all the variables on contact resistance and nanocomposite conductivity are ***,the contact resistance is primarily dependent on the polymer tunnel resistivity,contact area,and tunneling *** dimensions of the graphene nanosheets significantly influence the conductivity,which ranges from 0 S/m to90 S/*** increased number of nanosheets in stacks and a larger gap between them enhance the nanocomposite's ***,the thicker interphase and smaller tunneling size can lead to higher sample conductivity due to their optimistic effects on the percolation threshold and network efficacy.

关键词： graphene polymer composite stacked nanosheet tunneling conductivity contact resistance interphase