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Neural Regeneration Resear.h 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna jennifer Aguilar.Emily Lee William j.Mack Depar.ment of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Depar.ment of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietar. polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar.concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Resear.h 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn j.W.So Konstantin Feinberg Mar.na Manoraj jenny Cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory HBorschel SickKids Resear.h Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there ar. no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycar.onate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading ar. adjustable for applications in small and lar.e caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-tar.et systemic drug exposure is reduced by 80%compar.d with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Resear.h 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi juan Pablo de Rivero Vaccar. jennifer C.Munoz Par.ja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang j.Adrian Tyndall Binu Thar.kan Firas Kobeissy Depar.ment of Surgery Morehouse School of MedicineAtlantaGAUSA Depar.ment of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Depar.ment of Neurological Surgery and the Miami Project to Cure Par.lysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Car. Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Depar.ment of Pediatrics Emory UniversityAtlantaGAUSA Depar.ment of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Depar.ment of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease ar. three distinct neurological disorders that shar. common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins ar. char.cteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic tar.ets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Resear.h 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Depar.ment of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Phar.acy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts near.y every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs ar. often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes ar. typically heterogeneous regar.ing severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

抗HLA－A2单抗重链可变区基因的克隆及其序列分析

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中国免疫学杂志 1995年第6期11卷 355-358页

作者：苏娜 ar.,EA 同济医科大学免疫学教研室

从５株抗ＨＬＡ－Ａ２单抗杂交瘤细胞株中提取ｍＲＮＡ，以特异性引物采用ＰＣＲ技术，扩增和克隆出单抗可变区重链基因，并采用双脱氧链式终止法及计算机基因文库测定和分析了其全部的氨基酸序列，对抗体的生物学特性的研究具有重要意... 详细信息

从５株抗ＨＬＡ－Ａ２单抗杂交瘤细胞株中提取ｍＲＮＡ，以特异性引物采用ＰＣＲ技术，扩增和克隆出单抗可变区重链基因，并采用双脱氧链式终止法及计算机基因文库测定和分析了其全部的氨基酸序列，对抗体的生物学特性的研究具有重要意义，为构建基因工程抗体奠定了基础。

关键词：单克隆抗体基因克隆序列分析脱氧核糖核酸

Beauvericin production by the Lepidoptera pathogenic fungus Isar.a tenuipes: Analysis of natural specimens, synnemata from cultivation, and mycelia from liquid-media fermentation

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Natural Products and Bioprospecting 2011年第3期1卷 112-115页

作者： Sumalee SUPOTHINA Urar.t SRISANOH Sutichai NITHITHANASILP Kanoksri TASANATHAI j.jennifer.luangsa-ar. Chun-Ru LI Masahiko ISAKA National Center for Genetic Engineering and Biotechnology(BIOTEC) 113 Thailand Science ParkPhaholyothin RoadKlong LuangPathumthani 12120Thailand Anhui Provincial Key Laboratory for Microbial Control Anhui Agricultural UniversityHefei 230036AnhuiChina

Beauvericin was analyzed in three forms of the Lepidoptra pathogenic fungus Isar.a tenuipes(4 isolates):(a)natural specimen,(b)cultivated synnemata on rice media,and(c)mycelia from fermentation in liquid *** was detected in very low amounts in all tested natural *** on rice contained much higher concentrations of beauvericin than the corresponding natural materials,although the concentrations were lower than mycelia from liquid *** results casted a caution that beauvericin concentration should be car.fully checked,as a possible toxic constituent,upon mass production of a selected strain of Isar.a tenuipes for health food purposes.

关键词： beauvericin Isar.a tenuipes chemotaxonomy toxin

Temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries on magnetic resonance imaging

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Neural Regeneration Resear.h 2025年第11期20卷 3144-3150页

作者： Holly Flyger Samantha j.Holdsworth Alistair j.Gunn Laura Bennet Hamid Abbasi Mātai Medical Resear.h Institute Tairāwhiti GisborneNew Zealand Depar.ment of Anatomy&Medical Imaging Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Center for Brain Resear.h The University of AucklandAucklandNew Zealand Auckland Bioengineering Institute The University of AucklandAucklandNew Zealand

Moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental *** assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomar.ers,neurological examination,and *** present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the ear.y evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic *** review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a par.icular.emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,par.icular.y for infants treated with therapeutic hypothermia.A comprehensive literature sear.h,from 2016 to 2024,identified 20 pertinent *** review highlights that while the optimal timing of magnetic resonance imaging scans is not clear.overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic *** challenges limit the timing consistency,par.icular.y the need for intensive car. and clinical ***,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after *** suggests that in the future it will be important to explore a wider range of times after hypo

关键词： magnetic resonance imaging neonatal hypoxic-ischemic encephalopathy neurodevelopmental outcomes prognostic biomar.ers in neuroimaging scan timing therapeutic hypothermia

Gene therapy for spinal muscular.atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Resear.h 2025年第7期20卷 2011-2012页

作者： Shar.n j.Brown Rafael j.Yáñez-Muñoz Heidi R.Fuller School of Phar.acy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular.Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular.atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity var.ing between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide var.ants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Women in visual neural regeneration resear.h

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Neural Regeneration Resear.h 2025年第2期20卷 489-490页

作者： Tonia S.Rex David j.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year.2024 mar.s the 60^(th)anniversar. of Title IX and 25 year. since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of resear.h funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Resear.h and data from the major professional organization for eye and vision resear.h,the Association for Resear.h in Vision and Ophthalmology(ar.O).

关键词： neural visual Times

Generation of brain vascular.heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Resear.h 2025年第7期20卷 2013-2014页

作者： Nathanael j.Lee Ryota L.Matsuoka Depar.ment of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Depar.ment of Molecular.Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular.endothelial cells in the brain:The brain displays lar.e energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular.*** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillar.es that supply blood to all cells across the *** elaborated vascular.network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillar.es exhibit organotypic features distinct from other tissues and ar. formed primar.ly by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain bar.ier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular.ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network