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The cytochrome P4501A1(CYP1A1)inhibitor bergamottin enhances host tolerance to multidrug-resistant Vibrio vulnificus infection

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Chinese journal of Traumatology 2024年第5期27卷 295-304页

作者： Ruo-Bai Qiao Wei-Hong Dai Wei Li Xue Yang Dong-Mei He Rui Gao Yin-Qin Cui ri-Xing Wang Xiao-Yuan Ma Fang-jie Wang Hua-Ping Liang The College of Emergency and Trauma Hainan Medical UniversityHaikou571199China The First Research Department State Key Laboratory of Trauma and Chemical PoisoningArmy Medical Center(Daping Hospital)Army Medical UniversityChongqing400042China Emergency Department The Second Affiliated HospitalHainan Medical UniversityHaikou570311China

Purpose:Vibrio vulnificus (V. Vulnificus) infection is characterized by rapid onset, aggressive progression, and challenging treatment. Bacterial resistance poses a significant challenge for clinical anti-infection treatment and is thus the subject of research. Enhancing host infection tolerance represents a novel infection prevention strategy to improve patient survival. Our team initially identified cytochrome P4501A1 (CYP1A1) as an important target owing to its negative modulation of the body''s infection tolerance. This study explored the superior effects of the CYP1A1 inhibitor bergamottin compared to antibiotic combination therapy on the survival of mice infected with multidrug-resistantV. Vulnificus and the protection of their vital ***:An increasing concentration gradient method was used to induce multidrug-resistantV. Vulnificus development. We established a lethal infection model in C57BL/6j male mice and evaluated the effect of bergamottin on mouse survival. A mild infection model was established in C57BL/6j male mice, and the serum levels of creatinine, urea nitrogen, aspartate aminotransferase, and alanine aminotransferase were determined using enzyme-linked immunosorbent assay to evaluate the effect of bergamottin on liver and kidney function. The morphological changes induced in the presence of bergamottin in mouse organs were evaluated by hematoxylin and eosin staining of liver and kidney tissues. The bacterial growth curve and organ load determination were used to evaluate whether bergamottin has a direct antibacterial effect on multidrug-resistantV. Vulnificus. Quantification of inflammatory factors in serum by enzyme-linked immunosorbent assay and the expression levels of inflammatory factors in liver and kidney tissues by real-time quantitative polymerase chain reaction were performed to evaluate the effect of bergamottin on inflammatory factor levels. Western blot analysis of IκBα, phosphorylated IκBα, p65, and phosphorylated p65 prot

关键词： Multidrug-resistant Vibrio vulnificus Bergamottin CYP1A1 inhibitors Infection tolerance

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Effect of fluorinated additives or co-solvent on performances of graphite//LiMn2O4 cells cycled at high potential

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journal of Energy Chemistry 2021年第1期30卷 332-342,I0011页

作者： Benjamin Flamme Darius jYeadon Satyajit Phadke Mérièm Anouti Laboratoire PCM2E EA 6299-Universitéde ToursFacultédes Sciences et TechniquesParc de Grandmont37200 ToursFrance

Herein,a comprehensive study of electrochemical performances of the combined effect of fluorinated additives;fluoroethylene carbonate(FEC);and tris(2,2,2-trifluoroethyl) phosphite(TTFP) or the 2,2,2-trifluoroethyl methyl carbonate(TFEMC) as co-solvent,on Graphite//LiMn2O4 cells cycled at high potential is *** one side,each additive has a specific function,the FEC is dedicated to the negative electrode and the TTFP to the opposite *** electrolyte mixture with(4% FEC+1% TTFP) additive has shown the best ability to reduce fading of the LiMn2O4 electrode,especially at high *** the other side,by studying the comparative thermal and transport properties of the formulated electrolytes with different proportions of TFEMC,we demonstrate that the difference in charge distribution of EMC and TFEMC molecules induced by the presence of fluorine atoms,modifies the solvation model of the Li+cation,and changes its behavior at the CEI interface and impact strongly the electrochemical ***,the EIS investigation of the LMO/electrolyte interfaces in the presence of TFEMC demonstrates that despite a spontaneous chemical reactivity of the TFEMC at the cathode interface over time,the conductive and good quality CEI is formed,which positively impact the *** study shows that against LMO surface phenomena,the combination in adequate proportions of fluorinated additives or solvent can be a solution not only to avoid the oxidative reactivity of LMO-cathode,but also to prevent its harmful consequences on the Li-metal or graphite-anode by controlling the solvation of lithium-ion.

关键词： Li-ion battery LMO-cathode Fluorinated-solvent Additive Fluoro-alkylcarbonate

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Control of synthetic gene networks and its applications

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Frontiers of Electrical and Electronic Engineering in China 2017年第2期5卷 124-135页

作者： David j Menn ri-Qi Su Xiao Wang School of Biological and Health Systems Engineering Arizona State University Tempe AZ 85287 USA

Background： One of the underlying assumptions of synthetic biology is that biological processes can be engineered in a controllable way. Results： Here we discuss this assumption as it relates to synthetic gene regulatory networks （GRNs）. We first cover the theoretical basis of GRN control, then address three major areas in which control has been leveraged： engineering and analysis of network stability, temporal dynamics, and spatial aspects. Conclusion： These areas lay a strong foundation for further expansion of control in synthetic GRNs and pave the way for future work synthesizing these disparate concepts.

关键词： synthetic biology gene regulatory networks modeling GRN control stochasticity

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Electron states and electron Raman scattering in semiconductor double cylindrical quantum well wire

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Chinese Physics B 2016年第11期25卷 453-460页

作者： M Munguía-Rodríguez ri Betancourt-riera Re Betancourt-riera R riera j M Nieto jalil Departamento de Investigación en Física Universidad de Sonora Apartado Postal 5-88 83190 Hermosillo Sonora México Instituto Tecnológico de Hermosillo. Avenida Tecnologico S/N Col. Sahuaro 83170 Hermosillo Sonora México Tecnológico de Monterrey-Campus Sonora Norte. Bulevar Enrique Mazón Lopez No. 965 83000 Hermosillo Sonora México

The differential cross section for an electron Raman scattering process in a semiconductor GaAs/AlGaAs double quantum well wire is calculated,and expressions for the electronic states are *** system is modeled by considering T = 0 K and also with a single parabolic conduction band,which is split into a subband system due to the *** gain and differential cross-section for an electron Raman scattering process are *** addition,the emission spectra for several scattering configurations are discussed,and interpretations of the singularities found in the spectra are *** electron Raman scattering studied here can be used to provide direct information about the efficiency of the lasers.

关键词： Electron cylindrical confinement conduction radius decoupling AlGaAs parabolic modeled resonant

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Electron Raman scattering in semiconductor quantum well wire of cylindrical ring geometry

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Chinese Physics B 2015年第11期24卷 442-447页

作者： Re.Betancourt-riera ri.Betancourt-riera j.M.Nieto jalil R.riera Instituto Tecnol ógico de Hermosillo.Avenida Tecnol ógico S/N Col.Sahuaro Departamento de Investigaci ón en Física Universidad de Sonora Tecnol ógico de Monterrey-Campus Sonora Norte.Bulevar Enrique Mazón López No.965

We study the electron states and the differential cross section for an electron Raman scattering process in a semi- conductor quantum well wire of cylindrical ring geometry. The electron Raman scattering developed here can be used to provide direct information about the electron band structures of these confinement systems. We assume that the system grows in a GaAs/Al0.35Ga0.65As matrix. The system is modeled by considering T = 0 K and also a single parabolic con- duction band, which is split into a sub-band system due to the confinement. The emission spectra are discussed for different scattering configurations, and the selection rules for the processes are also studied. Singularities in the spectra are found and interpreted.

关键词： electron states Raman scattering selection rules quantum well wires

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Development and characterization of 3D-printed electroconductive pHEMA-co-MAA NP-laden hydrogels for tissue engineering

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Bio-Design and Manufacturing 2024年第3期7卷 262-276页

作者： Sara De Nitto Aleksandra Serafin Alexandra Karadimou Achim Schmalenberger john j.EMulvihill Maurice N.Collins DIBriS Polytechnic Inter-School Section University of Genoa16126 GenoaItaly School of Engineering Bernal InstituteUniversity of LimerickLimerick V94 T9PXIreland School of Natural Sciences Department of Biological SciencesUniversity of LimerickLimerick V94 T9PXIreland Health Research Institute University of LimerickLimerick V94 T9PXIreland AMBER University of LimerickLimerick V94 T9PXIreland

Tissue engineering(TE)continues to be widely explored as a potential solution to meet critical clinical needs for diseased tissue replacement and tissue *** this study,we developed a poly(2-hydroxyethyl methacrylate-co-methacrylic acid)(pHEMA-co-MAA)based hydrogel loaded with newly synthesized conductive poly(3,4-ethylene-dioxythiophene)(PEDOT)and polypyrrole(PPy)nanoparticles(NPs),and subsequently processed these hydrogels into tissue engineered constructs via three-dimensional(3D)*** presence of the NPs was critical as they altered the rheological properties during ***,all samples exhibited suitable shear thinning properties,allowing for the development of an optimized processing window for 3D *** were 3D printed into pre-determined disk-shaped configurations of 2 and 10 mm in height and diameter,*** observed that the NPs disrupted the gel crosslinking efficiencies,leading to shorter degradation times and compressive mechanical properties ranging between 450 and 550 *** conductivity of the printed hydrogels increased along with the NP concentration to(5.10±0.37)×10^(−7)S/*** vitro studies with cortical astrocyte cell cultures demonstrated that exposure to the pHEMA-co-MAA NP hydrogels yielded high cellular viability and proliferation ***,hydrogel antimicrobial studies with staphylococcus epidermidis bacteria revealed that the developed hydrogels affected bacterial *** together,these materials show promise for various TE strategies.

关键词： Conductive nanoparticles Hydroxyethyl methacrylate(HEMA) Ultraviolet(UV)polymerization 3D printing

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APT-联合DCE-Mri术前预测成人型弥漫性胶质瘤病理分级及IDH基因突变型

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放射学实践 2024年第8期39卷 1021-1025页

作者：陈世煌黄日升林慧宇丁增兴卢丽梅福建医科大学附属泉州市第一医院影像科福建泉州362000 福建医科大学附属泉州市第一医院放疗科福建泉州362000 泉州市儿童医院影像科福建泉州362000

目的:探讨氨基质子转移(APT)成像联合DCE-Mri对成人型弥漫性胶质瘤病理分级和IDH基因型的术前预测价值。方法:将2020年10月-2023年10月在本院诊治且经病理证实的78例脑胶质瘤患者纳入本研究。患者手术前均进行APT成像和DCE-Mri检查。依... 详细信息

目的:探讨氨基质子转移(APT)成像联合DCE-Mri对成人型弥漫性胶质瘤病理分级和IDH基因型的术前预测价值。方法:将2020年10月-2023年10月在本院诊治且经病理证实的78例脑胶质瘤患者纳入本研究。患者手术前均进行APT成像和DCE-Mri检查。依据肿瘤的组织病理学分级将患者分为2组:低级别组(Ⅱ~Ⅲ级)36例,高级别组(Ⅳ级)42例;依据患者IDH基因表达情况将患者分为2组:IDH野生型组31例,IDH突变型组47例。比较高、低病理分级组及不同IDH分型组之间病灶的APT图像信号等级(分为1~5级)和DCE-Mri参数(K_(trans)、V_(e)、rCBV、V_(p)、K_(ep)和rCBF)值的差异,对组间差异有统计学意义的指标,采用ROC曲线分析其诊断效能。结果:IDH突变型和野生型组之间年龄、性别、主诉、神经系统体征差异均无统计学意义(P>0.05);高级别组和低级别组之间年龄、性别、主诉、神经系统体征差异均无统计学意义(P>0.05),但是高级别组中IDH野生型占比更高(Pri参数的组间比较结果显示,高级别组与低级别组之间,以及IDH突变型与IDH野生型之间,K_(trans)、V_(e)和rCBV值的差异均有统计学意义(Pri定量参数能在术前较准确地预测成人型弥漫性胶质瘤的病理分级和IDH基因分型。

关键词：氨基质子转移成像动态对比增强磁共振成像脑肿瘤弥漫性胶质瘤肿瘤分级 IDH基因型

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L-arginine-induced experimental pancreatitis

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World journal of Gastroenterology 2004年第14期10卷 2003-2009页

作者： PéterHegyi ZoltánRakonczayjr RékaSári CsabaGóg jánosLonovics TamásTakács LászlóCzakó First Department of Medicine Faculty of MedicineUniversity of SzegedSzegedH6722Hungary School of Cell and Molecular BiosciencesMedical SchoolUniversity of NewcastleNewcastle upon TyneNE2 4HHUnited Kingdom First Department of Medicine Faculty of MedicineUniversity of SzegedSzegedH6722Hungary First Department of Medicine Faculty of MedicineUniversity of SzegedSzegedH6722HungarySchool of Cell and Molecular BiosciencesMedical SchoolUniversity of NewcastleNewcastle upon TyneNE2 4HHUnited Kingdom

Despite medical treatment,the lethality of severe acute pancreatitis is still high (20-30%).Therefore,it is very important to find good animal models to characterise the events of this severe *** 1984,Mizunuma et al. developed a new type of experimental necrotizing pancreatitis by intraperitoneal administration of a high dose of L-arginine in *** non-invasive model is highly reproducible and produces selective,dose-dependent acinar cell necrosis. Not only is this a good model to study the pathomechanisms of acute necrotizing pancreatitis,but it is also excellent to observe and influence the time course changes of the *** writing this review we iluminate some new aspects of cell physiology and pathology of acute necrotizing ***,the reviews about acute experimental pancreatitis usually did not discuss this model. Therefore,the aim of this manuscript was to summarise the observations and address some challenges for the future in L-arginine-induced pancreatitis.

关键词： Arginine dosage Disease Models, Animal Animals Injections, Intraperitoneal Pancreatitis, Acute Necrotizing Regeneration Research Support, Non-U.S. Gov't

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Combining PlanetScope and Sentinel-2 images with environmental data for improved wheat yield estimation

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International journal of Digital Earth 2023年第1期16卷 847-867页

作者： Nizom Farmonov Khilola Amankulova józsef Szatmári jamol Urinov Zafar Narmanov jakhongir Nosirov LászlóMucsi Department of Geoinformatics Physical and Environmental GeographyUniversity of SzegedSzegedHungary Tashkent Institute of Irrigation and Agricultural Mechanization Engineers National Research UniversityTashkentUzbekistan Department of Land resources Cadastre and GeoinformaticsKarshi Institute of Irrigation and Agrotechnology“TIIAME”National Research UniversityKarshiUzbekistan Soil Science Department of the Kashkadarya Region regional division of the Institute of Soil Science and Agrochemical Research KarshiUzbekistan

Satellite images are widely used for crop yield estimation,but their coarse spatial resolution means that they often fail to provide detailed information at thefield ***,a new generation of high-resolution satellites and CubeSat platforms has been *** this study,satellite data sources including PlanetScope and Sentinel-2 were combined with topographic and climatic variables,and the improvement in wheat yield estimation was *** yield data from a combine harvester were used to train and validate a yield estimation model based on random forest *** vegetation indices(NDVI,GNDVI,MSAVI2,MTVI2,MTCI,reNDVI,SAVI,EVI and WDVI)and spectral bands were *** the model training,the Sentinel-2 data realized a slightly higher estimation accuracy than the PlanetScope ***,combining environmental data with the PlanetScope data realized the highest estimation *** the validated models,adding the topographic and climatic datasets to the satellite data sources improved the estimation accuracy,and the results were slightly better with the Sentinel-2 data than with the PlanetScope *** data of the milk and dough stages provided the highest estimation accuracy of the wheat yield at 210–225 days after sowing.

关键词： Remote sensing BBCH-scale MSAVI2 PlanetScope random forest

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Efficacy of 6-mercaptopurine treatment after azathioprine hypersensitivity in inflammatory bowel disease

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World journal of Gastroenterology 2008年第27期14卷 4342-4346页

作者： Ferenc Nagy Tamás Molnár Zoltán Szepes Klaudia Farkas Tibor Nyári jános Lonovics First Department of Medicine University of Szeged Faculty of Medicine Institute of Medical Informatics University of Szeged Faculty of Medicine

AIM:To investigate the efficacy of 6-mercaptopurine (6-MP) in cases of azathioprine (AZA) hypersensitivity in patients with inflammatory bowel disease. METHODS: Twenty nine previously confirmed Crohn’s disease (CD) (n = 14) and ulcerative colitis (UC) (n = 15) patients with a known previous (AZA) hypersensitivity reaction were studied prospectively. The 6-MP doses were gradually increased from 0.5 up to 1.0-1.5 mg/kg per day. Clinical activity indicies (CDAI/CAI), laboratory variables and daily doses of oral 5-ASA, corticosteroids, and 6-MP were assessed before and in the first, sixth and twelfth months of treatment. RESULTS: In 9 patients, 6-MP was withdrawn in the first 2 wk due to an early hypersensitivity reaction. Medication was ineffective within 6 mo in 6 CD patients, and myelotoxic reaction was observed in two. Data were evaluated at the end of the sixth month in 12 (8 UC, 4 CD) patients, and after the first year in 9 (6 UC, 3 CD) patients. CDAI decreased transiently at the end of the sixth month, but no significant changes were observed in the CDAI or the CAI values at the end of the year. Leukocyte counts (P = 0.01), CRP (P = 0.02), and serum iron (P = 0.05) values indicated decreased inflammatory reactions, especially in the UC patients at the end of the year, making the possibility to taper oral steroid doses. CONCLUSION: About one-third of the previously AZA- intolerant patients showed adverse effects on taking 6MP. In our series, 20 patients tolerated 6MP, but it was ineffective in 8 CD cases, and valuable mainly in ulcerative colitis patients.

关键词： Inflammatory bowel disease Azathioprine 6-mercaptopurine Side effects Efficacy

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