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A new series of chiral catalysts for the enantioselective borane reduction of ketones

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Chinese journal of Chemistry 1997年第5期15卷 459-463页

作者： Shen, ZX Zhang, YW Lu, j Xu, XN Lu, CR Suzhou Univ Sch Chem & Chem Engn Suzhou 215006 Jiangsu Peoples R China

A new series of 1,3,2-oxazaborolidine catalysts substituted in position 4 by the (CH3)(3)C(CH2)(n) group (n=2, 3, 4, 5) were synthesized and applied to the borane reduction of prochiral ketones. The relationship betwe... 详细信息

关键词： oxazaborolidine enantioselective borane reduction enantioselectivity

Forkhead box protein P1, a key player in neuronal development?

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Neural Regeneration Research 2018年第5期13卷 801-802页

作者： Luca Braccioli Cora H.Nijboer Paul j.Coffer Laboratory of Neuroimmunology and Developmental Origins of Disease (NIDOD) University Medical Center Utrecht University Regenerative Medicine Center University Medical Center Utrecht Utrecht University Center for Molecular Medicine and Division of Pediatrics University Medical Center Utrecht Utrecht University

Forkhead box protein P1（FOXP1）is a transcription factor belonging to the forkhead box（FOX）proteins,a family of transcriptional regulators sharing a highly conserved forkhead DNA-binding domain（Bacon and Rappold,2012）.Previous reports have proposed a role for FOXP1 in functionally regulating the central nervous system（CNS）,while mutations in FOXP1 have been implicated in cognitive abnormalities（Bacon and Rappold, 2012）.

关键词： a key player in neuronal development Forkhead box protein P1

Study on the Regulation of Diorganogermanium Compounds on the Maillard Reaction of Histidine and Glycine by fluorescence Spectrum

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Chinese Chemical Letters 1998年第12期9卷 0-0页

作者： Chen, j Ma, GX Li, Xj Zhang, SG Li, DQ Chinese Acad Sci Changchun Inst Appl Chem Lab Rare Earth Chem & Phys Changchun 130022 Peoples R China

The suppression of diorganogermanium compounds on the Maillard reaction of histidine(His) and glycine (Gly) with glucose has been determined by fluorescence spectrum underphysiological conditions. The title compounds ... 详细信息

关键词： Diorganogermanium compounds maillard reaction fluorescence spectrum

Impact of time delay and cooperation strategy on the stability of a predator-prey model with Holling type III functional response

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International journal of Biomathematics 2023年第3期16卷 165-193页

作者： I.Benamara A.El Abdllaouit j.Mikramt Laboratory of Mathematics Computer Science&Applications-Security of Information Department of Mathematics Faculty of Sciences Mohammed V University in RabatMorocco

In this paper,we propose and analyze a delayed predator-prey model with Holling type III functional response taking into account cooperation behavior in *** time delay is introduced in the attack rate to represent the time necessary to trigger the *** analytical result is followed by an ecological *** investigate the effect of hunting cooperation on both the number and the level of positive steady *** observe that the level of the positive equilibrium decreases when increasing the hunting cooperation ***,we study the impact of the delay as well as the cooperation in hunting on the dynamics of the *** prove that the presence of delay in the attack rate induces stability switches around the coexisting equilibrium when predators *** addition,we consider the discrete delay as a bifurcation parameter and prove that the model undergoes a Hopf-bifurcation at the coexisting equilibrium when the delay crosses some critical *** simulations are presented to confirm our analytical findings.

关键词： Predator-prey system Holling type III discrete delay cooperative hunting Hopf-bifurcation switch of stability

Contributions of neurotropic human herpesviruses herpes simplex virus 1 and human herpesvirus 6 to neurodegenerative disease pathology

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Neural Regeneration Research 2018年第2期13卷 211-221页

作者： jessica M.Hogestyn David j.Mock Margot Mayer-Proschel Department of Neuroscience University of Rochester Department of Biomedical Genetics University of Rochester

Human herpesviruses （HVs） have developed ingenious mechanisms that enable them to traverse the defenses of the central nervous system （CNS）. The ability of HVs to enter a state of latency, a defining char- acteristic of this viral family, allows them to persist in the human host indefinitely. As such, HVs represent the most frequently detected pathogens in the brain. Under constant immune pressure, these infections are largely asymptomatic in healthy hosts. However, many neurotropic HVs have been directly connected with CNS pathology in the context of other stressors and genetic risk factors. In this review, we discuss the potential mechanisms by which neurotropic HVs contribute to neurodegenerative disease （NDD） patholo- gy by highlighting two prominent members of the HV family, herpes simplex virus 1 （HSV-1） and human herpesvirus 6 （HHV-6）. We （i） introduce the infectious pathways and replicative cycles of HSV-1 and HHV-6 and then （ii） review the clinical evidence supporting associations between these viruses and the NDDs Alzheimer＇s disease （AD） and multiple sclerosis （MS）, respectively. We then （iii） highlight and dis- cuss potential mechanisms by which these viruses exert negative effects on neurons and glia. Finally, we （iv） discuss how these viruses could interact with other disease-modifying factors to contribute to the initiation and/or progression of NDDs.

关键词： herpes simplex virus 1 human herpesvirus 6 central nervous system neurodegeneration demyelination Alzheimer's disease multiple sclerosis viral latency viral reactivation

Crystallization Study of Cu_(56)Zr_7Ti_(37) Metallic Glass by Electrical Resistivity Measurement

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journal of Materials Science & Technology 2011年第3期27卷 275-279页

作者： Ansu j.Kailath Kalpalata Dutta Thomas C. Alex Amitava Mitra National Metallurgical Laboratory

In this paper, the crystallization behaviour of amorphous Cu56Zr7Ti37 alloy using thermal electrical resistivity （TER） and differential scanning calorimetry （DSC） studies has been described. Isochronal TER and DSC measurements indicate that crystallization occurs in two stages. Isothermal crystallization studies of the alloy by TER show that the kinetics conforms to johnson-Mehl-Avrami model. Avrami exponents derived from kinetics, between 1.1 and 1.2, imply that the crystallization processes are diffusion controlled with near zero nucleation. Activation energy has been found to increase with the transformed volume fraction. A plausible explanation has been presented by separating the contributions due to nucleation and crystal growth towards total activation energy.

关键词： Metallic glass Crystallization Electrical resistivity Avrami exponent Activation energy

Voltage regulation in LV grids by coordinated volt-var control strategies

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journal of Modern Power Systems and Clean Energy 2014年第4期2卷 319-328页

作者： Miguel jUAMPErez Guangya YANG Søren Bækhøj KjÆR Center for Electric Power and Energy Department of Electrical EngineeringTechnical University of DenmarkElektrovej Building 3252800 Kgs.LyngbyDenmark Danfoss Solar Inverters A/S Ulsnæs 16300 Gra°stenDenmark

The increasing penetration level of photovoltaic(PV)power generation in low voltage(LV)networks results in voltage rise issues,particularly at the end of the *** order to mitigate this problem,several strategies,such as grid reinforcement,transformer tap change,demand-side management,active power curtailment,and reactive power optimization methods,show their contribution to voltage support,yet still *** paper proposes a coordinated volt-var control architecture between the LV distribution transformer and solar inverters to optimize the PV power penetration level in a representative LV network in Bornholm Island using a multi-objective genetic *** approach is to increase the reactive power contribution of the inverters closest to the transformer during overvoltage *** standard reactive power control concepts,cosu(P)and Q(U),are simulated and compared in terms of network power losses and voltage level along the *** a practical implementation,a reconfigurable hardware is used for developing a testing platform based on real-time measurements to regulate the reactive power *** proposed testing platform has been developed within *** project,which targets to study the approaches for large PV power integration into the network,without the need of reinforcement.

关键词： Voltage regulation Reactive power optimization Genetic algorithm

Characteristics of lipids and their feeding value in swine diets

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journal of Animal Science and Biotechnology 2016年第3期7卷 249-271页

作者： Brian j.Kerr Trey A.Kellner Gerald C.Shurson USDA-ARS-National Laboratory for Agriculture and the Environment AmesIA 50011USA Department of Animal Science Iowa State UniversityAmesIA 50011USA Department of Animal Science University of MinnesotaSt.PaulMN 55108USA

In livestock diets, energy is one of the most expensive nutritional components of feed formulation. Because lipids are a concentrated energy source, inclusion of lipids are known to affect growth rate and feed efficiency, but are also known to affect diet palatability, feed dustiness, and pellet quality. In reviewing the literature, the majority of research studies conducted on the subject of lipids have focused mainly on the effects of feeding presumably high quality lipids on growth performance, digestion, and metabolism in young animals. There is, however, the wide array of composition and quality differences among lipid sources available to the animal industry making it essential to understand differences in lipid composition and quality factors affecting their digestion and metabolism more fully. In addition there is often confusion in lipid nomenclature, measuring lipid content and composition, and evaluating quality factors necessary to understand the true feeding value to animals. Lastly, advances in understanding lipid digestion, post-absorption metabolism, and physiological processes（e.g., cell division and differentiation, immune function and inflammation）; and in metabolic oxidative stress in the animal and lipid peroxidation, necessitates a more compressive assessment of factors affecting the value of lipid supplementation to livestock diets. The following review provides insight into lipid classification, digestion and absorption, lipid peroxidation indices, lipid quality and nutritional value, and antioxidants in growing pigs.

关键词： Digestion Energy Lipids Peroxidation Pigs

Skin and composite grafts

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Plastic and Aesthetic Research 2022年第1期9卷 455-465页

作者： Katherine Hicks j.Regan Thomas Department of Otolaryngology Head&Neck Surgery University of Texas Medical BranchGalvestonTX 77019USA Department of Otolaryngology Head&Neck Surgery Northwestern McGaw Medical CenterChicagoIL 60611USA

Skin grafts may be used for coverage of facial defects in situations in which alternative methods of reconstruction,such as local flaps,are not an *** may also be beneficial for patients who wish to avoid or who are not good candidates for more complex ***-thickness skin grafts often have a better color and texture match to adjacent skin when compared to split-thickness grafts;however,split-thickness grafts have lower metabolic demand and increased survival *** grafts may be very useful in the repair of defects with unique contour and support requirements,such as the nasal ala and *** all grafts,thoughtful planning and sound surgical technique are critical in achieving the best possible functional and aesthetic result.

关键词： Split-thickness skin grafts full-thickness skin grafts composite grafts nasal reconstruction eyelid reconstruction