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Progression from ductal carcinoma in situ to invasive breast cancer:molecular features and clinical significance

signal Transduction and Targeted Therapy 2024年第5期9卷 1841-1868页

作者： jing Wang baizhou Li Meng Luo jia huang kun zhang shu zheng suzhan zhang jiaojiao zhou The key Laboratory of Cancer Prevention and Intervention China National Ministry of Educationthe Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Department of breast surgery and Oncology the Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina zhejiang Provincial Clinical Research Center for Cancer HangzhouChina Department of Pathology the Fourth Affiliated HospitalZhejiang University School of MedicineYiwuChina Department of Plastic surgery the Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Cancer Center Zhejiang UniversityHangzhouChina

Ductal carcinoma in situ(DCIs)represents pre-invasive breast *** untreated cases,25-60%DCIs progress to invasive ductal carcinoma(IDC).The challenge lies in distinguishing between non-progressive and progressive DCIs,often resulting in over-or under-treatment in many *** increasing screen-detected DCIs in these years,the nature of DCIs has aroused worldwide attention.A deeper understanding of the biological nature of DCIs and the molecular journey of the DCIs-IDC transition is crucial for more effective clinical ***,we reviewed the key signaling pathways in breast cancer that may contribute to DCIs initiation and *** also explored the molecular features of DCIs and IDC,shedding light on the progression of DCIs through both inherent changes within tumor cells and alterations in the tumor *** addition,valuable research tools utilized in studying DCIs including preclinical models and newer advanced technologies such as single-cell sequencing,spatial transcriptomics and artificial intelligence,have been systematically ***,we thoroughly discussed the clinical advancements in DCIs and IDC,including prognostic biomarkers and clinical managements,with the aim of facilitating more personalized treatment strategies in the *** on DCIs has already yielded significant insights into breast carcinogenesis and will continue to pave the way for practical clinical applications.

关键词： clinical breast alterations

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Atomistic Investigation of shock-Induced Amorphization within Micro-shear bands in hexagonal Close-Packed Titanium

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Acta Metallurgica sinica(English Letters) 2024年第9期37卷 1590-1600页

作者： z.C.Meng k.g.Wang T.Ali D.Li C.g.bai D.s.Xu s.j.Li A.h.Feng g.j.Cao j.h.Yao Q.b.Fan h.Wang R.Yang Institute of Metal Research Chinese Academy of SciencesShenyang 110016China school of Materials science and Engineering University of Science and Technology of ChinaShenyang 110016China Interdisciplinary Centre for Additive Manufacturing(ICAM) School of Materials and ChemistryUniversity of Shanghai for Science and TechnologyShanghai 200093China school of Materials science and Engineering Tongji UniversityShanghai 201804China key Laboratory for Light-Weight Materials Nanjing Tech UniversityNanjing 210009China National key Laboratory of science and Technology on Materials Under shock and Impact School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China beijing Institute of Technology Chongqing Innovation Center Chongqing 401135China

The mechanical response of a single crystal titanium sample against(0001)α surface impact was investigated using molecular dynamics ***,non-uniform plastic deformation was observed in the *** high strain rates,amorphization occurred near the edge of the contact region where severe shear strain induced a large number of stacking faults(sFs)and *** contrast,the central part of the contact region underwent less deformation with significantly fewer ***,instead of amorphization by consuming sFs and dislocations,there was a gradual increase in the density of dislocations and sFs during the process of *** local amorphous regions eventually grew into shear bands.

关键词： shock compression Amorphization shear band Titanium Molecular dynamics

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Effect of La on the Corrosion behavior and Mechanism of 3Ni Weathering steel in a simulated Marine Atmospheric Environment

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Acta Metallurgica sinica(English Letters) 2024年第2期37卷 308-324页

作者： gang Niu Rui Yuan R.D.k.Misra Na gong zhi-hui zhang hao-Xiu Chen hui-bin Wu Cheng-jia shang Xin-Ping Mao Collaborative Innovation Center of steel Technology University of Science and Technology BeijingBeijing100083China Laboratory for Excellence in Advanced steel Research Department of MetallurgicalMaterials and Biomedical EngineeringUniversity of Texas at El PasoEl PasoTX79968USA Institute of Materials Research and Engineering Agency for ScienceTechnologyand ResearchSingapore138634Singapore Department of Materials science and Engineering University of TorontoTorontoONM5S 3E4Canada

The corrosion behavior and mechanism of 3Ni weathering steel in a simulated oceanic atmospheric environment are investigated in order to comprehend the impacts of La,as determined through electrochemical analysis and rust layer *** results of this study demonstrate that the addition of La enhances the corrosion resistance of 3Ni weathering steel in the marine atmospheric environment,thereby reducing the corrosion rate and improving the protection of the rust *** influence of La on corrosion resistance can be attributed to two primary ***,La functions as a grain refiner,minimizing the potential difference of the micro-regions on the substrate surface,thereby significantly reducing the corrosion of bare steel in the marine ***,La inhibits the process of Fe_(3)O_(4) oxidation back toγ-FeOOh during corrosion at the local site,thus decreasing the formation ofγ-FeOOh and enhancing the charge transfer *** research work may serve as a reference for expanding the application of rare earth elements in the field of weathering steel.

关键词： Weathering steel Rare earth Rust layer Corrosion behavior Corrosion resistance

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Construction of 2D/2D Ti_(3)C_(2)T_(x)MXene/Cds heterojunction with photothermal effect for efficient photocatalytic hydrogen production

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journal of Materials science & Technology 2024年第4期171卷 1-9页

作者： T.Y.huang z.Yang s.Y.Yang z.h.Dai Y.j.Liu j.h.Liao g.Y.zhong z.j.Xie Y.P.Fang s.s.zhang key Laboratory for biobased Materials and Energy of Ministry of Education Guangdong Laboratory for Lingnan Modern AgricultureCollege of Materials and EnergySouth China Agricultural UniversityGuangzhou 510643China school of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China school of Chemical Engineering and Energy Technology Guangdong Provincial Key Laboratory of Distributed Energy SystemsDongguan University of TechnologyDongguan 523808China

The insensitivity of semiconductors to visible and infrared light is a key constraint on the utilization of light energy in photocatalytic *** photocatalysts with full-spectrum absorption through surface engineering is an effective approach to fully harnessing light energy in semiconductor ***,a novel stable Ti_(3)C_(2)T_(x)MXene/Cds heterojunction catalyst is obtained by in-situ epitaxial growth of two-dimensional(2D)Cds nanosheets on 2D MXene interface via a solvothermal *** exceptional light absorption properties of MXene confer outstanding full-spectrum driven photocat-alytic hydrogen evolution capability upon the heterogeneous *** unique 2D/2D structure effectively mitigated the recombination of photogenerated carriers,enhancing the photocatalytic performance of the ***,the composite catalyst exhibits a significantly higher surface temperature of 80.4℃under visible light irradiation at an intensity of 0.1 W/cm^(2),which is 1.84 times higher than that of *** irradiation of visible and near infrared light,the composite catalyst with photothermal ef-fect demonstrates a remarkable hydrogen evolution rate of 65.4 mmol g^(-1)h^(-1),which is 7.2 times higher than that of Cds *** study introduces a novel approach for constructing full-spectrum absorption catalysts and expands the application of the photothermal effect in photocatalytic hydrogen evolution research.

关键词： Two-dimensional structure heterostructure Photothermal effect Photocatalyst hydrogen evolution

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Modulating p-type doping of two-dimensional material palladium diselenide

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Nano Research 2024年第4期17卷 3232-3244页

作者： jiali Yang Yu Liu En-Yang Wang jinbo Pang shirong huang Thomas gemming jinshun bi Alicja bachmatiuk hao jia shu-Xian hu Chongyun jiang hong Liu gianaurelio Cuniberti Weijia zhou Mark h Rümmeli Institute for Advanced Interdisciplinary Research(iAIR) University of JinanJinan 250022China Institute for Materials Chemistry Leibniz Institute for Solid State and Materials Research Dresden(IFW Dresden)20 Helmholtz StrasseDresden 01069Germany state key Lab of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China College of Energy Soochow Institute for Energy and Materials Innovations Soochow UniversitySuzhou 215006China key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of jiangsu Province Soochow UniversitySuzhou 215006China school of Integrated Circuits University of Chinese Academy of SciencesBeijing 101408China Institute of Microelectronics of Tianjin binhai New Area Tianjin 300451China Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China Lukasiewicz Research Network PORT Polish Center for Technology DevelopmentStablowicka 147Wroclaw 54-066Poland school of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China College of electronic information and optical engineering Nankai UniversityTianjin 300350China Centre of Polymer and Carbon Materials Polish Academy of SciencesM.Curie Sklodowskiej 34Zabrze 41-819Poland Center for Energy and Environmental Technologies VŠB-Technical University of Ostrava17.Listopadu 15Ostrava 70833Czech Republic state key Laboratory of Crystal Materials Center of Bio&Micro/Nano Functional MaterialsShandong UniversityJinan 250100China Dresden Center for Computational Materials science Technische Universität DresdenDresden 01062Germany Dresden Center for Intelligent Materials(gCL DCIM) Technische Universität DresdenDresden 01062Germany Institute for Materials science and Max bergmann Center of biomaterials Technische Universität DresdenDresden 01069Germany Center for Advancing Electronics Dresden Technische Universität DresdenDresden 01069Germany

The van der Waals heterostructures have evolved as novel materials for complementing the si-based semiconductor ***-10 noble metal dichalcogenides(e.g.,Pts_(2),Ptse_(2),Pds_(2),and Pdse_(2))have been listed into two-dimensional(2D)materials toolkit to assemble van der Waals *** them,Pdse_(2) demonstrates advantages of high stability in air,high mobility,and wide tunable ***,the regulation of p-type doping of Pdse_(2) remains unsolved problem prior to fabricating p–n junction as a fundamental platform of semiconductor ***,a quantitative method for the controllable doping of Pdse_(2) is yet to be *** this study,the doping level of Pdse_(2) was correlated with the concentration of Lewis acids,for example,snCl_(4),used for *** the transfer characteristics,the threshold voltage(the gate voltage corresponding to the minimum drain current)increased after snCl_(4) soaking ***_(2) transistors were soaked in snCl_(4) solutions with five different *** threshold voltages from the as-obtained transfer curves were extracted for linear fitting to the threshold voltage versus doping concentration correlation *** study provides in-depth insights into the controllable p-type doping of Pdse_(2).It may also push forward the research of the regulation of conductivity behaviors of 2D materials.

关键词： two-dimensional(2D)materials Lewis acid treatment p-type doping field-effect transistors transfer characteristic

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Enriched electrophilic oxygen species facilitate acidic oxygen evolution on Ru-Mo binary oxide catalysts

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Nano Research 2024年第3期17卷 1165-1172页

作者： Yaya Wang Yunzhou Wen Yumeng Cheng Xinhong Chen Mengjiao zhuansun Tongbao Wang jun Li Debora Meira huarui sun jun Wei jia zhou Yuhang Wang sisi he shenzhen key Laboratory of Flexible Printed Electronics Technology Harbin Institute of Technology(Shenzhen)University TownShenzhen 518055China school of science Harbin Institute of Technology(Shenzhen)University TownShenzhen 518055China Institute of Functional Nano&soft Materials(FUNsOM) Jiangsu Key Laboratory of Advanced Negative Carbon TechnologiesSoochow UniversitySuzhou 215123China Frontiers science Center for Transformative Molecules Shanghai Jiao Tong UniversityShanghai 200240China science Division Canadian Light SourceSaskatoonSKS7N 2V3Canada Photon science Division Argonne National LaboratoryLemontIL60439USA school of Materials science and Engineering Harbin Institute of Technology(Shenzhen)University TownShenzhen 518055China

The polymer electrolyte membrane(PEM)electrolyzers are burdened with costly iridium(Ir)-based catalysts and high operation overpotentials for the oxygen evolution reaction(OER).The development of earth-abundant,highly active,and durable electrocatalysts to replace Ir is a critical step in reducing the cost of green hydrogen *** we develop a Ru5Mo4Ox binary oxide catalyst that exhibits high activity and stability in acidic *** electron-withdrawing property of Mo enriches the electrophilic surface oxygen species,which promotes acidic OER to proceed via the adsorbate evolution *** a result,we achieve a 189 mV overpotential at 10 mA·cm^(-2) and a Tafel slope of 48.8 mV·dec^(-1).Our catalyst demonstrates a substantial 18-fold increase in intrinsic activity,as evaluated by turnover frequency,compared to commercially available RuO_(2) and IrO_(2) ***,we report a stable OER operation at 10 mA·cm^(-2) for 100 h with a low degradation rate of 2.05 mV·h^(-1).

关键词： electrocatalysis oxygen evolution reaction(OER) ruthenium(Ru)-based oxide molybdenum electrophilic oxygen

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sTCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.z.bai Y.bai O.bakina A.barnyakov V.blinov V.bobrovnikov D.bodrov A.bogomyagkov A.bondar I.boyko z.h.bu F.M.Cai h.Cai j.j.Cao Q.h.Cao X.Cao z.Cao Q.Chang k.T.Chao D.Y.Chen h.Chen h.X.Chen j.F.Chen k.Chen L.L.Chen P.Chen s.L.Chen s.M.Chen s.Chen s.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen h.Y.Cheng j.Cheng s.Cheng T.g.Cheng j.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko j.M.Dias D.z.Ding L.Y.Dong W.h.Dong V.Druzhinin D.s.Du Y.j.Du z.g.Du L.M.Duan D.Epifanov Y.L.Fan s.s.Fang z.j.Fang g.Fedotovich C.Q.Feng X.Feng Y.T.Feng j.L.Fu j.gao Y.N.gao P.s.ge C.Q.geng L.s.geng A.gilman L.gong T.gong b.gou W.gradl j.L.gu A.guevara L.C.gui A.Q.guo F.k.guo j.C.guo j.guo Y.P.guo z.h.guo A.guskov k.L.han L.han M.han X.Q.hao j.b.he s.Q.he X.g.he Y.L.he z.b.he z.X.heng b.L.hou T.j.hou Y.R.hou C.Y.hu h.M.hu k.hu R.j.hu W.h.hu X.h.hu Y.C.hu j.hua g.s.huang j.s.huang M.huang Q.Y.huang W.Q.huang X.T.huang X.j.huang Y.b.huang Y.s.huang N.hüsken V.Ivanov Q.P.ji j.j.jia.s.jia.z.k.jia.h.b.jia.g j.jiang s.z.jiang j.b.jiao z.jiao h.j.jing X.L.kang X.s.kang b.C.ke M.kenzie A.khoukaz I.koop E.kravchenko A.kuzmin Y.Lei E.Levichev C.h.Li C.Li D.Y.Li F.Li g.Li g.Li h.b.Li h.Li h.N.Li h.j.Li h.L.Li j.M.Li j.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.h.Li s.Li T.Li W.j.Li X.Li X.h.Li X.Q.Li X.h.Li Y.Li Y.Y.Li z.j.Li h.Liang j.h.Liang Y.T.Liang g.R.Liao L.z.Liao Y.Liao C.X.Lin D.X.Lin X.s.Lin b.j.Liu C.W.Liu D.Liu F.Liu g.M.Liu h.b.Liu j.Liu j.j.Liu j.b.Liu k.Liu k.Y.Liu k.Liu L.Liu Q.Liu s.b.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu z.Q.Liu z.Y.Liu z.W.Liu I.Logashenko Y.Long C.g.Lu j.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu z.Lu P.Lukin F.j.Luo T.Luo X.F.Luo Y.h.Luo h.j.Lyu X.R.Lyu j.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas s.Malde D.Matvienko z.X.Meng R.Mitchell A.Nefediev Y.Nefedov s.L.Olsen Q.Ouyang P.Pakhlov g.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei h.P.Peng L.Peng X.Y.Peng X.j.Peng k.Peters s.Pivovarov E.Pyata b.b.Qi Y.Q.Qi W.b.Qian Y.Qian C.F.Qiao j.j.Qin j.j.Qin L.Q.Qin X.s.Qin T.L.Qiu j.Rademacker C.F.Redmer h.Y.sang Anhui University Hefei 230039China beihang University Beijing 100191China budker Institute of Nuclear Physics Novosibirsk 630090Russia CAs key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central south University Changsha 410083China China University of geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China goethe University Frankfurt D-60325 Frankfurt am MainGermany guangxi Normal University Guilin 541004China guangxi Uninversity Nanning 530004China hangzhou Institute for Advanced study UCASHangzhou 310024China hebei Normal University Shijiazhuang 050024China hebei University Baoding 071002China hefei University of Technology Hefei 230601China helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany henan Normal University Xinxiang 453007China henan University Kaifeng 475004China high Energy Physics Center Chung-Ang UniversitySeoul 06974Korea higher school of Economy 11 Pokrovsky bulvar Moscow 109028Russia huangshan University Huangshan 245000China hubei University of Automotive Technology Shiyan 442002China hunan Normal University Changsha 410081China hunan University of science and Technology Xiangtan 411201China hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced science Facilities Shenzhen 518107China Institute of high Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China jilin University Changch

The superτ-charm facility(sTCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 geV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** sTCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the bEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the standard *** sTCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the sTCF,describes conceptual designs of the sTCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity sTCF detector conceptual design

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Rescattering of stimulated Raman side scattering in nonuniform plasmas

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Matter and Radiation at Extremes 2024年第5期9卷 68-76页

作者： s.Tan Q.Wang Y.Chen W.b.Yao C.z.Xiao j.F.Myatt school of Physics and Electronics Hunan UniversityChangsha 410082China Institute of Applied Physics and Computational Mathematics Beijing 100094China school of Electrical and Information Engineering Anhui University of Science and TechnologyHuainanAnhui 232001China Department of Electrical and Computer Engineering University of Alberta9211116 St.NWEdmontonAlberta T6G 1H9Canada

Rescattering of stimulated Raman side scattering(sRss)is observed for the first time via two-dimensional(2D)particle-in-cell(PIC)*** construct a theoretical model for the rescattering process,which can predict the region of occurrence of mth-order sRss and estimate its *** rescattering process is identified by the 2D PIC simulations under typical conditions of a direct-drive inertial confinement fusion *** electrons produced by second-order sRss propagate nearly perpendicular to the density gradient and gain nearly the same energy as in first-order sRss,but there is no cascade acceleration to produce superhot *** studies for a wide range of ignition conditions show that sRss and associated rescatterings are robust and important processes in inertial confinement fusion.

关键词： nonuniform acceleration scattering

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Two haplotype-resolved genome assemblies for AAb allotriploid bananas provide insights into banana subgenome asymmetric evolution and Fusarium wilt control

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Plant Communications 2024年第2期5卷 243-260页

作者： Wen-zhao Xie Yu-Yu zheng Weidi he Fangcheng bi Yaoyao Li Tongxin Dou Run zhou Yi-Xiong guo guiming Deng Wenhui zhang Min-hui Yuan Pablo sanz-jimenez Xi-Tong zhu Xin-Dong Xu zu-Wen zhou zhi-Wei zhou jia-Wu Feng siwen Liu Chunyu Li Qiaosong Yang Chunhua hu huijun gao Tao Dong jiangbo Dang Qigao guo Wenguo Cai jianwei zhang ganjun Yi jia-Ming song Ou sheng Ling-Ling Chen Institute of Fruit Tree Research Guangdong Academy of Agricultural SciencesKey Laboratory of South Subtropical Fruit Biology and Genetic Resource UtilizationMinistry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of Tropical and Subtropical Fruit Tree ResearchGuangzhou 510640China College of Informatics Huazhong Agricultural UniversityWuhan 430070China state key Laboratory for Conservation and Utilization of subtropical Agro-bioresources College of Life Science and TechnologyGuangxi UniversityNanning 530004China College of horticulture and Landscape Architecture Southwest UniversityChongqing 400715China

bananas(Musa spp.)are one of the world’s most important fruit crops and play a vital role in food security for many developing *** banana cultivars are triploids derived from inter-and intraspecific hybrid-izations between the wild diploid ancestor species Musa acuminate(AA)and ***(bb).We report two haplotype-resolved genome assemblies of the representative AAb-cultivated types,Plantain and silk,and precisely characterize ancestral contributions by examining ancestry mosaics across the *** asymmetric evolution is observed in their subgenomes,which can be linked to frequent homol-ogous exchange *** reveal the genetic makeup of triploid banana cultivars and verify that subge-nome b is a rich source of disease resistance *** 58.5%and 59.4%of Plantain and silk genes,respectively,are present in all three haplotypes,with>50%of genes being differentially expressed alleles in different *** observed that the number of upregulated genes in Plantain is significantly higher than that in silk at one-week post-inoculation with Fusarium wilt tropical race 4(Foc TR4),which con-firms that Plantain can initiate defense responses faster than ***,we compared genomic and transcriptomic differences among the genes related to carotenoid synthesis and starch metabolism between Plantain and *** study provides resources for better understanding the genomic architecture of culti-vated bananas and has important implications for Musa genetics and breeding.

关键词： bananas Plantain silk asymmetric evolution homologous exchange Fusarium wilt

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ground-based and additional science support for sMILE

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Earth and Planetary Physics 2024年第1期8卷 275-298页

作者： j.A.Carter M.Dunlop C.Forsyth k.Oksavik E.Donovon A.kavanagh s.E.Milan T.sergienko R.C.Fear D.g.sibeck M.Connors T.Yeoman X.Tan M.g.g.T.Taylor k.McWilliams j.gjerloev R.barnes D.D.billet g.Chisham A.Dimmock M.P.Freeman D.-s.han M.D.hartinger s.-Y.W.hsieh z.-j.hu M.k.james L.juusola k.kauristie E.A.kronberg M.Lester j.Manuel j.Matzka I.McCrea Y.Miyoshi j.Rae L.Ren F.sigernes E.spanswick k.sterne A.steuwer T.sun M.-T.Walach b.Walsh C.Wang j.Weygand j.Wild j.Yan j.zhang Q.-h.zhang Planetary sciences group School of Physics and AstronomyUniversity of LeicesterUniversity RoadLeicesterLE17RHUK Rutherford Appleton Laboratory space Science Technology Facilities CouncilOxfordshireUK school of space and Environment Beihang UniversityBeijing 100191China key Laboratory of space Environment Monitoring and Information Processing Ministry of Industry and Information TechnologyBeijing 100017China Department of space and Climate Physics UCLMullard Space Science LaboratoryHolmbury St.MaryDorkingSurreyRH56NTUK birkeland Centre for space science Department of Physics and Technology.University of BergenBergenNorway Department of Physics and Astronomy University of Calgary2500 University DriveCalgaryAlbertaCanada T2N 1N4 british Antarctic survey CambridgeUK swedish Institute of space Physics KirunaSweden West highfield Campus University of SouthamptonUniversity RoadSO171BJUK goddard space Flight Center NASAGreenbeltMarylandUSA Athabasca University AthabascaCanada EsTEC European Space AgencyNetherlands University of saskatchewan SaskatoonCanada The johns hopkins University Applied Physics Laboratory LaurelMarylandUSA swedish Institude of space Physics UppsalaSE 75121Sweden Tongji University Shanghai 200092China Center for space Plasma Physics Space Science Institute4765 Walnut Street Suite BBoulderColorado80301USA Polar Research Institute of China Shanghai 200136China Finnish Meteorological Institute(FMI) Finland Department of Earth and Environmental sciences(geophysics) Ludwig Maximilian University of Munich(LMU)MunichTheresienstr.41MunichD-80333Germany Canadian space Agency MontrealCanada gFz german Research Centre for geosciences PotsdamGermany Nagoya University Institute for Space Earth Environment ResearchCenter for Integrated Data ScienceNagoyaAichiJP 464-8601 Northumbria University Newcastle upon TyneTyne and WearUK NE18ST National space science Center Chinese Academy SciencesBeijing 100190China Arctic geophysics University Centre in Svalbard

The joint European space Agency and Chinese Academy of sciences solar wind Magnetosphere Ionosphere Link Explorer(sMILE)mission will explore global dynamics of the magnetosphere under varying solar wind and interplanetary magnetic field conditions,and simultaneously monitor the auroral response of the Northern hemisphere *** these large-scale responses with medium and fine-scale measurements at a variety of cadences by additional ground-based and space-based instruments will enable a much greater scientific impact beyond the original goals of the sMILE ***,we describe current community efforts to prepare for sMILE,and the benefits and context various experiments that have explicitly expressed support for sMILE can offer.A dedicated group of international scientists representing many different experiment types and geographical locations,the ground-based and Additional science Working group,is facilitating these *** include constructing an online sMILE Data Fusion Facility,the discussion of particular or special modes for experiments such as coherent and incoherent scatter radar,and the consideration of particular observing strategies and spacecraft *** anticipate growing interest and community engagement with the sMILE mission,and we welcome novel ideas and insights from the solar-terrestrial community.

关键词： magnetosphere ionosphere magnetosphere-ionosphere coupling ground-based experimentation sMILE conjunctions missions

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