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PanCan肺癌风险预测模型预测的精确性——基于Danish肺癌筛查试验的CT模型外部验证

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国际医学放射学杂志 2015年第6期 612-612页

作者： M.M.Winkler Wille S.j.van Riel Z.Saghir A.Dirksen j.h.pedersen C.jacobs 屈瑾 Department of Respiratory Medicine Gentofte Hospital

摘要目的肺癌风险模型行外部验证,检验其广泛性及临床有用性。Danish肺癌筛查试验(DLCST)是基于人口的前瞻性队列研究,用于评价Pan Can模型。方法 DLCST数据库

关键词：肺癌筛查 CT Danish 外部验证

无通气受限被试最大吸气CT成像吸气过程对气道管径测量的影响

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国际医学放射学杂志 2014年第6期 601-601页

作者： j.Petersen M.M.W.Wille L.L.Rakêt A.Feragen j.h.pedersen M.Nielsen 石彦姝 Department of Computer Science University of CopenhagenN?rre CampusUniversitetsparken 52100 Copenhagen ?Denmark

摘要目的研究志愿者吸气屏气检查中吸气过程对气道直径测量的影响。方法从丹麦肺癌筛查试验中选择961名正常肺活量受试者纳入本研究,所有受试者在5年内每年

关键词：气道支气管吸气过程 CT

PARAMETER ESTIMATION FOR A DISCRETELY OBSERVED STOChASTIC VOLATILITY MODEL WITh jUMPS IN ThE VOLATILITY

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Chinese Annals of Mathematics,Series B 2003年第2期24卷 227-238页

作者： jIANGWENjIANG j.pedersen SchoolofMathematicalScience YunnanNormalUniversityKunming650092China. InstituteofMathematicalSciences UniversityofAarhusAarhusDenmark.

In this paper a stochastic volatility model is considered. That is, a log price process Y whichis given in terms of a volatility process V is studied. The latter is defined such that the logprice possesses some of the properties empirically observed by Barndorff-Nielsen & jiang[6]. Inthe model there are two sets of unknown parameters, one set corresponding to the marginaldistribution of V and one to autocorrelation of V. Based on discrete time observations ofthe log price the authors discuss how to estimate the parameters appearing in the marginaldistribution and find the asymptotic properties.

关键词： Stochastic volatility models NIG distributions Central limit theorems Law of large numbers Levy processes Ornstein-Uhlenbeck processes

The prostate cancer bone marrow niche： more than just ＇fertile soil＇

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Asian journal of Andrology 2012年第3期14卷 423-427,I0007页

作者： Elisabeth A pedersen Yusuke Shiozawa Kenneth j Pienta Russell S Taichman Department of Periodontics and Oral Medicine University of Michigan School of Dentistry Ann Arbor M148109-1078 USA Departments of Urology and Internal Medicine University of Michigan Medical School Ann Arbor MI 48109-1078 USA

The hematopoietic stem cell （hSC） niche in the bone marrow has been studied extensively over the past few decades, yet the bone marrow microenvironment that supports the growth of metastatic prostate cancer （PCa） has only been recently considered to be a specialized ＇niche＇ as well. New evidence supports the fact that disseminated tumor cells （DTCs） of PCa actually target the hSC niche, displace the occupant hSCs and take up residence in the pre-existing niche space. This review describes some of the evidence and mechanisms by which DTCs act as molecular parasites of the hSC niche. Furthermore, the interactions between DTCs, hSCs and the niche may provide new targets for niche-directed therapy, as well as insight into the perplexing clinical manifestations of metastatic PCa disease.

关键词： dormancy hematopoietic stem cell metastasis niche osteoblasts prostate cancer

Identifying factors controlling the selective ethane dehydrogenation on Pt-based catalysts from DFT based micro-kinetic modeling

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journal of Energy Chemistry 2021年第7期30卷 37-40页

作者： Tao Wang Frank Abild-pedersen SUNCAT Center for Interface Science and Catalysis Department of Chemical EngineeringStanford UniversityStanfordCalifornia 94305USA SUNCAT Center for Interface Science and Catalysis Stanford Linear Accelerator CenterMenlo ParkCalifornia 94025USA

Light olefins such as ethylene and propylene are important industrial feedstocks, having essential applications in the production of plastics, ethylbenzene, and ethylene dichloride [1]. Compared with the conventional route, in which alkane steam cracking (SC) at high temperature is applied to produce ethylene and propylene, the catalytic ethane/propane non-oxidative dehydrogenation (EDh/PDh) possess the advantages of high selectivity and low energy consumption. Industrially, Pt is the major component to catalyze this reaction, but it suffers from low selectivity and fast deactivation because of favorable coke formation [2].

关键词： Ethane dehydrogenation DFT Micro-kinetic modeling Selectivity Pt

Cellulose synthesis in land plants

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Molecular Plant 2023年第7期16卷 206-231页

作者： Gustav B.pedersen Leonard Blaschek Kristian E.h.Frandsen Lise C.Noack Staffan Persson Copenhagen Plant Science Center(CPSC) Department of Plant&Environmental SciencesUniversity of CopenhagenThorvaldsensvej 401871Frederiksberg CDenmark joint International Research Laboratory of Metabolic&Developmental Sciences State Key Laboratory of Hybrid RiceSJTU-University of Adelaide Joint Centre for Agriculture and HealthSchool of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghaiChina

All plant cells are surrounded by a cell wall that provides cohesion,protection,and a means of directional growth to *** microfibrils contribute the main biomechanical scaffold for most of these *** biosynthesis of cellulose,which typically is the most prominent constituent of the cell wall and therefore Earth’s most abundant biopolymer,is finely attuned to developmental and environmental *** understanding of the machinery that catalyzes and regulates cellulose biosynthesis has substantially improved due to recent technological advances in,for example,structural biology and ***,we provide a comprehensive overview of the structure,function,and regulation of the cellulose synthesis machinery and its regulatory *** aim to highlight important knowledge gaps in the field,and outline emerging approaches that promise a means to close those gaps.

关键词： plant cell wall cellulose microfibrils cellulose synthases membrane proteins cytoskeleton protein interaction

Electronic structure factors and the importance of adsorbate effects in chemisorption on surface alloys

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npj Computational Materials 2022年第1期8卷 1560-1571页

作者： Shikha Saini joakim halldin Stenlid Frank Abild-pedersen SUNCAT Center for Interface Science and Catalysis Department of Chemical EngineeringStanford University443 Via OrtegaStanfordCA94305USA SUNCAT Center for Interface Science and Catalysis SLAC National Accelerator Laboratory2575 Sand Hill RoadMenlo ParkCA94025USA

The chemisorption energy is an integral aspect of surface chemistry,central to numerous fields such as catalysis,corrosion,and ***-structure-based methods such as the Newns-Anderson model are therefore of great importance in guiding the engineering of material surfaces with optimal ***,existing methods are inadequate for interpreting complex,multi-metallic ***,we introduce a physics-based chemisorption model for alloyed transition metal surfaces employing primarily metal d-band properties that accounts for perturbations in both the substrate and adsorbate electronic states upon ***,we show that adsorbate-induced changes in the adsorption site interact with its chemical environment leading to a second-order response in chemisorption energy with the d-filling of the neighboring *** demonstrate the robustness of the model on a wide range of transition metal alloys with O,N,Ch,and Li adsorbates yielding a mean absolute error of 0.13 eV versus density functional theory reference chemisorption energies.

关键词： alloys corrosion chemisorption

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn j.W.So Konstantin Feinberg Marina Manoraj jenny Cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory hBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus