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Effect of Applied Pressure on the joining of Combustion Synthesized Ni_3Al Intermetallics with Al Alloy

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journal of Materials Science & Technology 2008年第1期24卷 123-126页

作者： G.S.Cho j.h.Yang K.h.Choe K.W.lee A.Ikenaga Advanced Material Processing Team Korea Institute of Industrial Technology 7-47 Songdo-Dong Yeonsu-Ku Incheon 406-840 Korea Department of Metallurgy and Materials Science Graduate School of Engineering Osaka Prefecture University 1-1 Gakuen-Cho Sakai Osaka 599-8531 Japan

We focused on the surface reinforcement of ligth weight casting alloys with Ni-AI intermetallic compounds by in-situ combustion reaction to improve the surface properties of non-ferrous casting *** our previous works,green compact of elemental Ni and Al powders were reacted to form Ni-3Al intermetallic compound by ShS （Self-propagating high temperature synthesis） reaction with the heat of molten Al alloy and simultaneously bonded with Al casting *** some defects such as tiny cracks and porosities were remained in the reacted *** we applied pressure to prevent thermal cracks and fill up the pores with liquid Al alloy by squeeze casting *** compressed Al alloy bonded with the Ni-3Al intermetallic compound was sectioned and observed by optical microscopy and scanning electron microscopy （SEM）.The stoichiometric compositions of the intermetallics formed around the bonded interface and in the reacted compact were identified by energy dispersive spectroscopy （EDS） and electron probe micro analysis （EPMA）. Si rich layer was formed on the Al alloy side near the bonded interface by the sequential solidification of Al *** porosities observed in the reacted Ni-3Al compact were filled up with the liquid AI *** Si particles from the molten Al alloy were detected in the pores of reacted Ni-3Al intermetallic *** Al casting alloy and Ni-3Al intermetallic compound were joined very soundly by applying pressure to the liquid Al alloy.

关键词： joining Combustion synthesis Ni3AI Intermetallic compound Squeeze casting

APPLICATION OF Ct-PARAMETER FOR CREEP-FATIGUE CRACK GROWTh WITh SLOW LOAD RISING CONDITION

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Acta Metallurgica Sinica(English Letters) 1999年第1期12卷 22-30页

作者： lee, j.h. Yoon, K.B. Kim, Y.j. Back, U.B. Korea Inst of Nuclear Safety Taejon South Korea

Most of the assessment equations for Ct which is a wellknown fracture parameter characterizing high temperature crack growth rates, have limited applicability to constant load conditions after sudden loading. however, crack growth due to creep can also occur under load varying conditions when load rising time is so long that accumulated creep deformation near the crack tip is not *** this paper, the estimation equation of the Ctparameter which can be applied to the case of slow load rising, i.e., (Ct)r, is explained. And the correlation between (Ct)r at the end of the load increasing period and Ct at the beginning of the succeeding load hold period is discussed. Finite element analyses of several cases with various loading conditions were performed and results were presented to show the effectiveness of the proposed Ct estimation scheme. The general applicability of the equation is also discussed.

关键词： creep fatigue crack time dependent fracture mechanics Ctparameter,C*integral

Pazopanib in advanced soft tissue sarcomas

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Signal Transduction and Targeted Therapy 2019年第1期4卷 538-547页

作者： Alex T.j.lee Robin L.jones Paul h.huang Division of Molecular Pathology The Institute of Cancer ResearchLondonUK Sarcoma Unit The Royal Marsden NHS Foundation TrustLondonUK Division of Clinical Studies Institute of Cancer ResearchLondonUK

Pazopanib is the first and only tyrosine kinase inhibitor currently approved for the treatment of multiple histological subtypes of soft tissue sarcoma(STS).Initially developed as a small molecule inhibitor of vascular endothelial growth factor receptors,preclinical work indicates that pazopanib exerts an anticancer effect through the inhibition of both angiogenic and oncogenic signaling *** the establishment of optimal dosing and safety profiles in early phase studies and approval for the treatment of advanced renal cell carcinoma,pazopanib was investigated in STS.A landmark phase III randomized study demonstrated improved progression-free survival with pazopanib compared to that with placebo in pretreated patients with STS of various *** efficacy of pazopanib in specific STS subtypes has been further described in real-world-based case series in both mixed and subtype-specific STS *** present,there are no clinically validated predictive biomarkers for use in selecting patients with advanced STS for pazopanib therapy,limiting the clinical effectiveness and cost-effectiveness of the *** this review,we summarize the preclinical and clinical data for pazopanib,outline the evidence base for its effect in STS and explore reported studies that have investigated putative biomarkers.

关键词： sarcoma clinical approval

Vibration-controlled Transient Elastography for Assessment of Liver Fibrosis at a USA Academic Medical Center

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journal of Clinical and Translational hepatology 2022年第2期10卷 197-206页

作者： Max Shen Anna lee jay h.Lefkowitch howard j.Worman Department of Medicine Vagelos College of Physicians and SurgeonsColumbia UniversityNew YorkNYUSA Department of Pathology and Cell Biology Vagelos College of Physicians and SurgeonsColumbia UniversityNew YorkNYUSA

Background and Aims:Vibration-controlled transient elastography(VCTE)is a noninvasive tool that uses liver stiffness measurement(LSM)to assess *** real-life data during everyday clinical practice in the USA are lacking,we describe the patterns of use and diagnostic performance of VCTE in patients at an academic medical center in New York ***:Patients who received VCTE scans were included if liver biopsy was performed within 1 *** performance of VCTE in differentiating dichotomized fibrosis stages was assessed via area under the receiver operating characteristics(AUROC).Fibrosis stage determined from VCTE LSM was compared to liver ***:Of 109 patients,49 had nonalcoholic fatty liver disease,16 chronic hepatitis C,15 congestive hepatopathy,and 22 at least two *** was 0.90 for differentiating cirrhosis(stage 4)with a positive predictive value(PPV)range of 0.28 to 0.45 and negative predictive value range of 0.96 to *** 31(32%)patients,VCTE fibrosis stage was at least two stages higher than liver biopsy fibrosis *** of thirty-five pa-tients considered to have cirrhosis by VCTE had stage 0 to 2 and 12 stage 3 fibrosis on liver ***:VCTE has reasonable diagnostic accuracy and is reliable at ruling out ***,because of its low PPV,caution must be exercised when used to diagnose cirrhosis,as misdiagnosis can lead to unnecessary health care *** routine practice,VTCE is also sometimes performed for disease etiologies for which it has not been robustly validated.

关键词： Chronic liver disease Cirrhosis hepatitis Liver histopathology Nonalcoholic fatty liver disease

NEURAL NETWORK MODELING FOR ESTIMATION OF SCOUR DEPTh AROUND BRIDGE PIERS

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journal of hydrodynamics 2007年第3期19卷 378-386页

作者： lee T. L. jENG D. S. ZhANG G. h. hONG j. h. Department of Construction Technology Leader University Tainan 709 China School of Civil Engineering The University of Sydney NSW 2006 Australia Department of Resource and Environment Leader University Tainan 709 China Department of Civil Engineering National Chung Hsing University Taichung 402 China

It is essential to predict the scour depth around bridge piers for hydraulic engineers involved in the economical design of bridge pier foundation. Conventional investigations have long been of the opinion that empirical scour prediction equations based on laboratory data over predict scour depths. In this article, the Back-Propagation Neural Network （BPN） was applied to predict the scour depth in order to overcome the problem of exclusive and the nonlinear relationships. The observations obtained from thirteen states in USA was verified by the present model. From the comparison with conventional experimental methods, it can be found that the scour depth around bridge piers can be efficiently predicted using the BPN.

关键词： Back-Propagation Neural Network (BPN) prediction bridge pier scour depth

hR-TEM and FIB-SEM characterization of formation of eutectic-like structure from amorphous GdAlO_3-Al_2O_3 system

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中国有色金属学会会刊：英文版 2012年第S3期22卷 579-584页

作者： Y.h.hAN Y.hARADA j.F.ShACKELFORD jaehyung lee K.KAKEGAWA School of Materials Science and Engineering Yeungnam University Department of Chemical Engineering and Materials Science University of California at Davis Graduate School of Engineering Chiba University

The crystallization process of the eutectic composition of GdAlO_3-Al_2O_3 from the amorphous phase prepared by rapid-quenching of melt that leads to the formation of a cantaloupe skin-like microstructure was investigated using focused ion-beam scanning electron microscopy (FIB-SEM) and high-resolution transmission electron microscopy (hR-TEM).The amorphous films were heat-treated at temperatures between 1000 °C and 1500 °C for up to 30min to form the eutectic phases of GdAlO_3 and Al_2O_*** GdAlO_3 and Al_2O_3 crystal phases that formed from the amorphous phase were identified by FIB-SEM and *** components began to crystallize and grow from the amorphous phase separately at different *** formation process of these crystal phases was different from that of the ordinary eutectic microstructure solidified from the GdAlO_3-Al_2O_3 ***,the observed structure is termed "eutectic-like" for *** microstructures formed from the amorphous phases at sufficiently high temperatures consisted of ultra-fine microstructures of individually crystallized components and were similar to ordinary eutectic *** heat-treating the amorphous films at 1500 °C for either 2 min,8min or 30min,the ultra-fine components of GdAlO_3 and Al_2O_3 were found to crystallize following a eutectic-like stage after 8min of heat treatment.

关键词： eutectic amorphous GdAlO3-Al2O3 eutectic-like hR-TEM FIB-SEM Crystallization

Synchronization criteria for coupled hopfield neural networks with time-varying delays

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Chinese Physics B 2011年第11期20卷 140-150页

作者： M.j.Park O.M.Kwon ju h.Park S.M.lee E.j.Cha School of Electrical Engineering Chungbuk National University Department of Electrical Engineering Yeungnam University School of Electronic Engineering Daegu University Department of Biomedical Engineering School of MedicineChungbuk National University

This paper proposes new delay-dependent synchronization criteria for coupled hopfield neural networks with time-varying delays. By construction of a suitable Lyapunov Krasovskii＇s functional and use of Finsler＇s lemma, novel synchronization criteria for the networks are established in terms of linear matrix inequalities （LMIs） which can be easily solved by various effective optimization algorithms. Two numerical examples are given to illustrate the effectiveness of the proposed methods.

关键词： hopfield neural networks coupling delay synchronization Lyapunov method

A STUDY OF CARBIDE GROWTh IN MAR-M247 LC ALLOY BY DIRECTIONAL SOLIDIFICATION METhOD

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Acta Metallurgica Sinica(English Letters) 1996年第6期9卷 509-514页

作者： j.h.lee j. Chen S.j. Choe Y.T. lee and h.M. Kim(high Temperature Materials Laboratory, Korea Institute of Machinery & Materials, 66 Sangnam Dong,Changwon, Kyungnam,641010, Korea ) Korea Inst of machinery & Materials Changwon South Korea

The carbide growth behavior of MAR-M247 LC alloy was investigated by directional solidification and quench method. The carbide volume fraction, trapping and growth behavior were correlated with the growth *** was found that the carbide volume fraction decreased at slower growth *** decreasing was caused by lower solidliquid interface trapping ability at slower growth rate.

关键词： carbide,directional solidification,trapping growth

Viscosity method for hierarchical fixed point and variational inequalities with applications

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Applied Mathematics and Mechanics(English Edition) 2011年第2期32卷 241-250页

作者：张石生王雄瑞 h.W.j.lee 陈志坚 Department of Mathematics Yibin University Department of Applied Mathematics The Hong Kong Polytechnic University

A viscosity method for a hierarchical fixed point solving variational inequality problems is presented. The method is used to solve variational inequalities, where the involved mappings are non-expansive. Solutions are sought in the set of the fixed points of another non-expansive mapping. As applications, we use the results to study problems of the monotone variational inequality, the convex programming, the hierarchical minimization, and the quadratic minimization over fixed point sets.

关键词： hierarchical fixed point non-expansive mapping fixed point viscosity approximation hierarchical minimization