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Fully integrated and broadband Si-rich silicon nitride wavelength converter based on Bragg scattering intermodal four-wave mixing

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photonics Research 2024年第3期12卷 I0001-I0010页

作者： VALERIO VITALI THALÍA DOMÍNGUEZ BUCIO HAO LIU jOSÉMANUEL LUQUE GONZÁLEZ FRANCISCO jURADO-ROMERO ALEjANDRO ORTEGA-MOÑUX GLENN CHURCHILL jAMES C.GATES jAMES HILLIER NIKOLAOS KALFAGIANNIS DANIELE MELATI jENS H.SCHMID ILARIA CRISTIANI pAVEL CHEBEN j.gonzalo wangüemert-pérez ÑIGO MOLINA-FERNÁNDEZ FREDERIC GARDES COSIMO LACAVA pERIKLIS pETROpOULOS Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK Electrical Computer and Biomedical Engineering DepartmentUniversity of PaviaPavia 27100Italy Telecommunication Research Institute(TELMA) Universidad de MálagaCEI Andalucı´a TECHE.T.S.I.Telecomunicación29010 MálagaSpain School of Science and Technology Nottingham Trent UniversityNottingham NG118NSUK Department of Electrical Engineering Eindhoven University of TechnologyEindhoven 5600 MBThe Netherlands Department of Materials Science and Engineering University of IoanninaIoannina 45110Greece Centre de Nanosciences et de Nanotechnologies UniversitéParis-SaclayCNRS91120 PalaiseauFrance Advanced Electronics and photonics Research Center National Research Council CanadaOttawaOntario K1A 0R6Canada

Intermodal four-wave mixing(FWM)processes have recently attracted significant interest for all-optical signal processing applications thanks to the possibility to control the propagation properties of waves exciting distinct spatial modes of the same *** allows,in principle,to place signals in different spectral regions and satisfy the phase matching condition over considerably larger bandwidths compared to intramodal ***,the demonstrations reported so far have shown a limited bandwidth and suffered from the lack of on-chip components designed for broadband manipulation of different *** demonstrate here a silicon-rich silicon nitride wavelength converter based on Bragg scattering intermodal FWM,which integrates mode conversion,multiplexing and de-multiplexing functionalities *** system enables wavelength conversion between pump waves and a signal located in different telecommunication bands(separated by 60 nm)with a 3 dB bandwidth exceeding 70 nm,which represents,to our knowledge,the widest bandwidth ever achieved in an intermodal FWM-based system.

关键词： scattering pump modal

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Ultra-broadband nanophotonic phase shifter based on subwavelength metamaterial waveguides

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photonics Research 2020年第3期8卷 359-367页

作者： DAVID GONZáLEZ-ANDRADE jOSéMANUEL LUQUE-GONZáLEZ j.gonzalo wangüemert-pérez ALEjANDRO ORTEGA-MONUX pAVEL CHEBEN íNIGO MOLINA-FERNáNDEZ AITOR V.VELASCO Instituto deóptica Daza de Valdés Consejo Superior de Investigaciones Cientificas(CSIC)Madrid 28006Spain Departamento de Ingenieria de Comunicaciones ETSI TelecomunicaciónUniversidad de MálagaMálaga 29071Spain National Research Council Canada Ottawa K1A 0R6Canada Bionand Center for Nanomedicine and Biotechnology Parque Tecnológico de AndaluciaMálaga 29590Spain

Optical phase shifters are extensively used in integrated optics not only for telecom and datacom applications but also for sensors and quantum *** various active solutions have been demonstrated,progress in passive phase shifters is still *** we present a new type of ultra-broadband 90°phase shifter,which exploits the anisotropy and dispersion engineering in subwavelength metamaterial *** Floquet–Bloch calculations predict a phase-shift error below 1.7°over an unprecedented operation range from 1.35 to 1.75μm,i.e.,400 nm bandwidth covering the E,S,C,L,and U telecommunication *** flat spectral response of our phase shifter is maintained even in the presence of fabrication errors up to 20 nm,showing greater robustness than conventional *** device was experimentally demonstrated using standard220 nm thick SOI wafers,showing a fourfold reduction in the phase variation compared to conventional phase shifters within the 145 nm wavelength range of our measurement *** proposed subwavelength engineered phase shifter paves the way for novel photonic integrated circuits with an ultra-broadband performance.

关键词： waveguides phase maintained

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polarization-independent multimode interference coupler with anisotropy-engineered bricked metamaterial

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photonics Research 2022年第4期10卷 I0001-I0009页

作者： Carlos perez-Armenta Alejandro Ortega-Monux jose Manuel Luque-Gonzalez Robert Halir pedro j.Reyes-Iglesias jens Schmid pavel Cheben Inigo Molina-Fernandez j.gonzalo wanguemert-perez Telecommunication Research Institute(TELMA) Universidad de MalagaCEI Andalucia TECHE.T.S.I.Telecomunicacion29010 MalagaSpain Bionand Center for Nanomedicine and Biotechnology Parque Tecnologico de AndaluciaMalaga 29590Spain National Research Council Canada OttawaOntario K1A 0R6Canada

Many applications, including optical multiplexing, switching, and detection, call for low-cost and broadband photonic devices with polarization-independent operation. While the silicon-on-insulator platform is well positioned to fulfill most of these requirements, its strong birefringence hinders the development of polarizationagnostic devices. Here we leverage the recently proposed bricked metamaterial topology to design, for the first time, to our knowledge, a polarization-independent 2 × 2 multimode interference coupler using standard 220 nm silicon thickness. Our device can be fabricated with a single etch step and is optimized for the O-band,covering a wavelength range of 160 nm with excess loss, polarization-dependent loss, and imbalance below 1 dB and phase errors of less than 5°, as demonstrated with full three-dimensional finite-difference time-domain simulations.

关键词： polarization multimode multiplexing

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Sensitivity-based Vulnerability Assessment of State Estimation

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journal of Modern power Systems and Clean Energy 2021年第4期9卷 886-896页

作者： gonzalo E.Constante-Flores Antonio j.Conejo jiankang wang Department of Electrical and Computer Engineering The Ohio State UniversityColumbusUSA Department of Integrated Systems Engineering and the Department of Electrical and Computer Engineering The Ohio State UniversityColumbusUSA

We propose a technique to assess the vulnerability of the power system state estimation. We aim at identifying the measurements that have a high potential of being the target of false data injection attacks. From the perspective of the adversary, such measurements have the following characteristics: ① being influential on the variable estimates;② corrupting their measured values is likely to be undetected. Additionally, such characteristics should not change significantly with the system operation condition. The proposed technique provides a systematic way of identifying the measurements with such characteristics. We illustrate our methodology on a 4-bus system, the New England 39-bus system, and the IEEE 118-bus test system, respectively.

关键词： False data injection attack state estimation sensitivity analysis singular value decomposition

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Effect of full-fat sunflower or flaxseed seeds dietary inclusion on performance,egg yolk fatty acid profile and egg quality in laying hens

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Animal Nutrition 2020年第2期6卷 179-184页

作者： Yandy j.Aguillón-páez Laura A.Romero gonzalo j.Diaz Facultad de Ciencias Agropecuarias Universidad de CundinamarcaFusagasugá252211Colombia Facultad de Medicina Veterinaria y de Zootecnia Universidad Nacional de ColombiaBogotá111321Colombia

A study was conducted to evaluate the effect of the dietary inclusion of full-fat flaxseed of full-fat sunflower seeds on performance parameters,egg quality parameters and egg yolk fatty acid profile in laying hens.A total of 150 Babcock Brown hens at 27 weeks of age were distributed in 3 experimental treatments,as follows:T1,control;T2,diet containing 13.5% full-fat whole flaxseed seeds;and T3,diet containing 13.5% full-fat ground sunflower *** and water were provided ad libitum and the experiment lasted for 8 *** significant differences were found on egg quality parameters,but total egg production and rate of lay were significantly(p p receiving sunflower seeds compared with the control,and significant differences(p polyunsaturated,omega-6(n-6) and omega-3(n-3) fatty acids were observed,as well as in the n-6:n-3 *** results show that the dietary inclusion of 13.5% flaxseed full-fat seeds significantly increases the n-3 polyunsaturated fatty acid(pUFA) content in the eggs and lowers the n-6:n-3 ratio without affecting performance *** of full-fat sunflower seeds increases the n-6 pUFA content but affects total egg production and rate of *** studies are needed to determine the level of inclusion of full-fat sunflower seeds that does not affect performance.

关键词： Flaxseed Sunflower polyunsaturated fatty acid Laying hens Egg quality performance

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Mechanical characterization and induced crystallization in nanocomposites of thermoplastics and carbon nanotubes

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npj Computational Materials 2020年第1期6卷 413-423页

作者： Eduardo R.Cruz-Chú gonzalo j.Villegas-Rodríguez Tobias jäger Luca Valentini Nicola M.pugno Konstantinos Gkagkas Frauke Gräter Laboratorios de Investigación y Desarrollo Facultad de Ciencias y FilosofíaUniversidad Peruana Cayetano HerediaLimaPeru Molecular Biomechanics Group Heidelberg Institute for Theoretical StudiesHeidelbergGermany Civil and Environmental Engineering Department University of Perugia and INSTM Research UnitTerniItaly Laboratory of Bio-inspired BionicNanoMeta Materials MechanicsUniversity of TrentoTrentoItaly School of Engineering and Materials Science Queen Mary University of LondonLondonUK Advanced Technology Group Toyota Motor EuropeZaventemBelgium Interdisciplinary Center for Scientific Computing(IWR) Heidelberg UniversityHeidelbergGermany

Nanocomposites built from polymers and carbon nanotubes(CNTs)are a promising class of *** modeling can provide nanoscale views of the polymer–CNT interface,which are much needed to foster the manufacturing and development of such ***,setting up periodic nanocomposite models is a challenging *** we propose a computational workflow based on Molecular Dynamics simulations.

关键词： materials composites crystallization

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Clinical features of AIDS patients with Hodgkin's lymphoma with isolated bone marrow involvement:report of 12 cases at a single institution

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Cancer Biology & Medicine 2015年第1期12卷 41-45页

作者： Marcelo Corti Maria Villafa?e gonzalo Minue Ana Campitelli Marina Narbaitz Leonardo Gilardi HIV/AIDS Department F.J.Mu?iz Hospital Hematology Unit F.J.Mu?iz Hospital Histopathology Laboratory F.J.Mu?iz Hospital National Academy of Medicine Histopathology Laboratory Sociedad Iberoamericana de Informacion Cientifica Scientific Coordination

Objective： To study the main clinical and histopathological features of 12 patients with Hodgkin＇s lymphoma （HL） diagnosed primarily from bone marrow （BM） involvement. Methods： We included 12 acquired immunodeficiency syndrome （AIDS） patients with HL assisted in the F. j. Mufiiz Infectious Diseases Hospital since january 2002 to December 2013. The diagnosis of ilL with primary BM involvement in patients was confirmed by clinical, histopathological, and immunohistochemical findings. Results： All patients presented ＂B＂ symptoms and pancytopenia. All of them had stage IV neoplasm disease because of BM infiltration. The median of CD4＋ T-cell counts was 114 cells/μL, and mixed cellularity （MC） was the most frequent histopathological subtype of 92% cases. Conclusion： When other causes are excluded, BM biopsy should be performed in AIDS patients with ＂B＂ symptoms and pancytopenia to evaluate BM infiltration by atypical lymphocytes.

关键词： Acquired immunodeficiency syndrome (AIDS) Hodgkin's lymphoma (HL) bone marrow (BM)

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Improving outcomes in pancreatic cancer: Key points in perioperative management

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World journal of Gastroenterology 2014年第39期20卷 14237-14245页

作者： josé M álamo Luis M Marín gonzalo Suarez Carmen Bernal juan Serrano Lydia Barrera Miguel A Gómez jordi Muntané Francisco j padillo Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREH o Ciberehd) Instituto de Salud Carlos Ⅲ 28029 Madrid Spain Francisco j padillo Department of General Surgery Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla 41013 Seville Spain

This review focused in the perioperative management of patients with pancreatic cancer in order to improve the outcome of the disease. We consider that the most controversial points in pancreatic cancer management are jaundice management, vascular resection and neo-adjuvant therapy. preoperative biliary drainage is recommended only in patients with severe jaundice, as it can lead to infectious cholangitis, pancreatitis and delay in resection, which can lead to tumor progression. The development of a phase III clinical trial is mandatory to clarify the role of neo-adjuvant radiochemotherapy in pancreatic adenocarcinoma. Venous resection does not adversely affect postoperative mortality and morbidity, therefore, the need for venous resection should not be a contraindication to surgical resection in selected patients. The data on arterial resection alone, or combined with vascular resection at the time of pancreatectomy are more heterogeneous, thus, patient age and comorbidity should be evaluated before a decision on operability is made. In patients undergoing R0 resection, arterial resection can also be performed.

关键词： pancreatic cancer Obstructive jaundice preoperative drainage Neo-adjuvant therapy Vascular resection

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Brain metastasis in advanced colorectal cancer： results from the South Australian metastatic colorectal cancer (SAmCRC) registry

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Cancer Biology & Medicine 2017年第4期14卷 371-376页

作者： gonzalo Tapia Rico Timothy j. price Christos Karapetis Cynthia piantadosi Rob padbury Amitesh Roy Guy Maddern james Moore Scott Carruthers David Roder Amanda R. Townsend Department of Medical Oncology The Queen Elizabeth Hospital and University of Adelaide Adelaide SA 5011 Australia Department of Medical Oncology Flinders Medical Center and Flinders University Adelaide SA 5042 Australia Department of Surgery Flinders Medical Center Bedford Park SA 5042 Australia Department of Surgery The Queen Elizabeth Hospital Adelaide SA 5011 Australia Department of Surgery University of South Australia Adelaide SA 5005 Australia Department of Surgery Royal Adelaide Hospital Adelaide SA 5000 Australia Department of Radiation Oncology Royal Adelaide Hospital Adelaide SA 5000 Australia Department of Epidemiology University of South Australia Adelaide SA 5005 Australia

Objective:Brain metastasis is considered rare in metastatic colorectal cancer(mCRC);thus,surveillance imaging does not routinely include the *** reported incidence of brain metastases ranges from 0.6% to 3.2%.Methods:The South Australian mCRC Registry(SAmCRC)was analyzed to assess the number of patients presenting with brain metastasis during their *** to small numbers,a descriptive analysis is ***:Only 59 patients of 4,100 on the registry at the time of analysis had developed brain metastasis(1.4%).The clinical characteristics of those with brain metastasis were as follows:the median age was 65.3 years and 51% were *** the V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS)mutation status of the tumor was known,the majority harbored a KRAS mutation(55%);31(53%)underwent craniotomy and 55(93%)underwent whole-brain *** median survival time from diagnosis of brain metastasis was 4.2 months(95% confidence interval 2.9–5.5).patients who underwent craniotomy and radiotherapy had superior survival compared to those who underwent whole-brain radiotherapy(8.5 months vs.2.2 months,respectively).Data from the SAmCRC(a population-based registry)confirm that brain metastases are rare and the median time to development is approximately 2 ***:Brain metastasis is a rare outcome in advanced *** within the registry tended to be female,young in age,and harbored with higher rates of KRAS *** routine surveillance brain scanning should be considered remains controversial given the relative rarity of developing brain metastases in mCRC and ultimately,most patients with central nervous system involvement die from their extracranial disease.

关键词： Brain metastasis colorectal cancer survival surveillance

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Chitosan DNA nanoparticles for oral gene delivery

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World journal of Medical Genetics 2016年第3期6卷 22-33页

作者： Bhavika j patel Nithin K Vignesh gonzalo Hortelano Department of Health Sciences McMaster University Department of Biology School of Science and Technology Nazarbayev University School of Biomedical Engineering McMas-ter University Department of pathology and Molecular Medicine McMaster University

Gene therapy is a promising technology with potential applications in the treatment of medical conditions, both congenital and acquired. Despite its label as breakthrough technology for the 21st century, the simple concept of gene therapy - the introduction of a functional copy of desired genes in affected individuals - is proving to be more challenging than expected. Oral gene delivery has shown intriguing results and warrants further exploration. In particular, oral administration of chitosan DNA nano-particles, one the most commonly used formulations of therapeutic DNA, has repeatedly demonstrated successful in vitro and in vivo gene transfection. While oral gene therapy has shown immense promise as treatment options in a variety of diseases, there are still signifcant barriers to overcome before it can be considered for clinical applications. In this review we provide an over-view of the physiologic challenges facing the use of chitosan DNA nanoparticles for oral gene delivery at both the extracellular and intracellular level. From administration at the oral cavity, chitosan nanoparticles must traverse the gastrointestinal tract and protect its DNA contents from signifcant jumps in pH levels, various intestinal digestive enzymes, thick mucus layers with high turnover, and a proteinaceous glycocalyx meshwork. Once these extracellular barriers are overcome, chitosan DNA nanoparticles must enter intestinal cells, escape endolysosomes, and disassociate from genetic material at the appropriate time allowing transport of genetic material into the nucleus to deliver a therapeutic ef-fect. The properties of chitosan nanoparticles and modified nanoparticles are discussed in this review. An understanding of the barriers to oral gene delivery and how to overcome them would be invaluable for future gene therapy development.

关键词： Gene therapy Oral gene delivery Chitosan nanoparticles Glycocalyx pH Enzymes Endolysosomal escape Intracellular transport Nuclear transport Mucus

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