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Taking FAIR on the ChIN:The Chemistry Implementation Network

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Data Intelligence 2020年第1期2卷 131-138,310页

作者： Simon j.coles jeremy g.Frey Egon L.Willighagen Stuart j.Chalk School of Chemistry Faculty of Engineering and Physical SciencesUniversity of SouthamptonSouthampton SO171BJUK Department of Bioinformatics Maastricht UniversityMaastrichtLimburg 6200 MDThe Netherlands Department of Chemistry University of North FloridaJacksonvilleFL 32224-7699USA

The Chemistry Implementation Network(ChIN)is focused on supporting the FAIR Data needs of the research community regarding chemical related *** Implementation Network is a consortium drawn from a community,in this case the chemistry discipline,committed to defining and constructing standards,materials and software in the spirit of the FAIR data principles and under the structure of the gO FAIR ***,as a core science the ChIN has to reach beyond the chemistry community and support the use of chemical information in other *** will be facilitated through connections in the gO FAIR ecosystem of Implementation *** of the FAIR chemical concepts that need to be supported include molecular and materials structures,chemical reactions,nomenclature and other chemical terminology and *** ChIN aims to drive forward the application of the FAIR Data Principles relating to the full range of chemistry concepts that are key to the transparent and efficient communication of chemical *** the goal of FAIR chemistry data will require a culture change across the *** this is best addressed once a critical mass of tools and approaches has been developed.

关键词： Chemistry Chemical information Chemistry data Chemical data standards Infrastructure Nomenclature Molecular structure Materials structure Chemical reactions Education Community engagement Endorsement and governance

A hybrid organic-inorganic polariton LED

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Light(Science & Applications) 2019年第1期8卷 475-485页

作者： Rahul jayaprakash Kyriacos georgiou Harriet Coulthard Alexis Askitopoulos Sai K.Rajendran David M.coles Andrew j.Musser jenny Clark Ifor D.W.Samuel graham A.Turnbull Pavlos g.Lagoudakis David g.Lidzey Department of Physics and Astronomy The University of SheffieldHicks BuildingHounsfield RoadSheffield S37RHUK Department of Physics and Astronomy University of SouthamptonSouthampton SO171BJUK Skolkovo Institute of Science and Technology MoskvaRussia Organic Semiconductor Centre SUPASchool of Physics and AstronomyUniversity of St AndrewsSt.AndrewsFife KY169SSUK Baker Laboratory Cornell University259 East AvenueIthacaNY 14850USA

Polaritons are quasi-particles composed of a superposition of excitons and photons that can be created within a strongly coupled optical ***,we describe a structure in which a strongly coupled microcavity containing an organic semiconductor is coupled to a second microcavity containing a series of weakly coupled inorganic quantum *** show that optical hybridisation occurs between the optical modes of the two cavities,creating a delocalised polaritonic *** electrically injecting electron–hole pairs into the inorganic quantum-well system,we are able to transfer energy between the cavities and populate organic-exciton *** approach represents a new strategy to create highly efficient devices for emerging‘polaritonic’technologies.

关键词： state. inorganic polar

血吸虫对吡喹酮抗药性的研究Ⅰ.微粒化吡喹酮对小鼠感染曼氏血吸虫不同分离株的疗效

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中国血吸虫病防治杂志 2002年第5期14卷 326-330页

作者：梁幼生,戴建荣,朱荫昌,徐明,许永良,杭盘宇,g.C.coles,M.j.Doenhoff 江苏省血吸虫病防治研究所江苏省血吸虫病防治研究所江苏省血吸虫病防治研究所江苏省血吸虫病防治研究所江苏省血吸虫病防治研究所江苏省血吸虫病防治研究所英国Bristol大学医学院临床兽医系英国Wales大学生物科学学院无锡214064 无锡214064 无锡214064 无锡214064 无锡214064 无锡214064

目的　测定 5个曼氏血吸虫吡喹酮抗性株和 5个曼氏血吸虫吡喹酮敏感株对吡喹酮的敏感性 ,了解用不同方法配制吡喹酮对化疗效果的影响。方法　用不同虫株尾蚴分别感染 CD1 小鼠 ,在感染后第 5 8— 6 0天以 3× 2 0 0 m g/ kg微粒化吡喹... 详细信息

目的　测定 5个曼氏血吸虫吡喹酮抗性株和 5个曼氏血吸虫吡喹酮敏感株对吡喹酮的敏感性 ,了解用不同方法配制吡喹酮对化疗效果的影响。方法　用不同虫株尾蚴分别感染 CD1 小鼠 ,在感染后第 5 8— 6 0天以 3× 2 0 0 m g/ kg微粒化吡喹酮作灌胃治疗 ,化疗后第 2 1天剖杀小鼠收集成虫 ,比较减虫率。用同一虫株的尾蚴感染 CD1 小鼠 ,感染后第 5 8— 6 2天以 5× 10 0 mg/ kg微粒化、未微粒化及加甘油未微粒化吡喹酮治疗感染小鼠 ,化疗后第 2 1天剖杀小鼠收集成虫 ,比较减虫率。结果　 5个吡喹酮敏感株的减虫率为 91.8%一 10 0 % ;5个吡喹酮抗性株的减虫率为 5 9.6 %一 74 .4 %。 5× 10 0 m g/ kg微粒化吡喹酮组减虫率为 73.0 % ,而未微粒化组和加甘油组为 4 7.9%和 5 0 .0 %。结论 5个曼氏血吸虫抗性株对吡喹酮的敏感性显著低于 5个敏感株 ;吡喹酮配制方法影响化疗结果 ,微粒化吡喹酮化疗效果优于另 2种未微粒化吡喹酮。

关键词：曼氏血吸虫吡喹酮抗药性

肺静脉的常规处理及无缝合技术处理:适应证从修复术后肺静脉狭窄到早期肺静脉异常的演变

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世界核心医学期刊文摘（心脏病学分册） 2005年第6期1卷 51-52页

作者： coles j.g. Konstantinov I.E. 刘少伟

We have previously reported a limited but favorable experience with a novel sutureless technique for surgical management of postoperative pulmonary vein stenosis occurring after repair of total anomalous pulmonary venous drainage. Because this technique requires integrity of the retrocardiac space for hemostasis, extension of the technique to the primary repair of pulmonary vein anomalies requires evaluation. This analysis reviews our experiencewith the sutureless technique in patients with postrepair pulmonary vein stenosis, as well as our extension of the technique into primary repair of pulmonary vein anomalies. Retrospective univariable-multivariable analysis of all pulmonary vein stenosis procedures and sutureless pulmonary vein procedures over a 20-year period was performed. Cox proportional hazards modeling was used to identify variables associated with freedom from reoperation or death. Sixty patients underwent 73 procedures, with pulmonary vein stenosis present in 65 procedures. The sutureless technique was used in 40 procedures. Freedom from reoperation or death at 5 years after the initial procedure was 49%. Unadjusted freedom from reoperation or death was greater with the sutureless technique for patients with postrepair pulmonary vein stenosis(P=.04). By using multivariable analysis, a higher pulmonary vein stenosis score was associated with greater risk of reoperation or death. After adjustment, the sutureless repair was associated with a nonsignificant trend toward greater freedom from reoperation or death(P=.12). Despite the absence of retrocardiac adhesions, operative mortality was not increased with the sutureless technique(P=.64). Techniques to control bleeding(intrapleural hilar reapproximation)and improve exposure(inferior vena cava division)were identified. The sutureless technique for postrepair pulmonary vein stenosis is associated with encouraging midterm results. Extension of the indications for the technique to primary repair appears safe

关键词：静脉狭窄缝合技术修复术手术死亡率早期修复分离术下腔静脉中期疗效复位术多元分析

曼氏血吸虫吡喹酮敏感株与抗性株尾蚴对吡喹酮的反应性

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曼氏血吸虫吡喹酮敏感株与抗性株尾蚴对吡喹酮的反应性

曼氏血吸虫吡喹酮抗性株与敏感株某些生物学特性

中国动物学会全国第九次寄生虫学学术讨论会

作者：梁幼生戴建荣朱荫昌李洪军徐明许永良杭盘宇 g.C coles M.j.Doenhoff 江苏省血吸虫病防治研究所英国Bristol大学医学院临床兽医系英国Wales大学生物科学学院

目的比较曼氏血吸虫吡喹酮敏感株与抗性株尾蚴阶段对吡喹酮的反应性,旨在运用敏感株与抗性株反应性间的差异,建立现场监测吡喹酮抗性的方法。方法将各虫株尾蚴分别暴露于10、10、6×10、4×10mol/L吡喹酮溶液中,0、20、40、60、80、100 ...

目的比较曼氏血吸虫吡喹酮敏感株与抗性株尾蚴阶段对吡喹酮的反应性,旨在运用敏感株与抗性株反应性间的差异,建立现场监测吡喹酮抗性的方法。方法将各虫株尾蚴分别暴露于10、10、6×10、4×10mol/L吡喹酮溶液中,0、20、40、60、80、100 min后,解剖镜下观察尾蚴的泳动、收缩和断尾率的变化。结果尾蚴暴露于10mol/L吡喹酮中即刻停止泳动、沉底并伴有强直性收缩;5 min后开始出现体与尾部不协调的快速蠕动,

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曼氏血吸虫吡喹酮抗性株与敏感株某些生物学特性

中国动物学会全国第九次寄生虫学学术讨论会

作者：梁幼生戴建荣朱荫昌李洪军徐明司进许水良杭盘宇 g.C coles M.j.Doenhoff 江苏省血吸虫病防治研究所英国Bristol大学医学院临床兽医系英国Wales大学生物科学学院

目的探讨因吡喹酮抗性产生而导致曼氏血吸虫抗性虫株繁殖力发生改变的可能性。方法以抗性株与敏感株毛蚴和尾蚴定量感染光滑双脐螺和CD小鼠,宿主体内观察比较曼氏血吸虫吡喹酮抗性株和敏感株生物学特性:对螺感染率、感染性螺存活期、在...

目的探讨因吡喹酮抗性产生而导致曼氏血吸虫抗性虫株繁殖力发生改变的可能性。方法以抗性株与敏感株毛蚴和尾蚴定量感染光滑双脐螺和CD小鼠,宿主体内观察比较曼氏血吸虫吡喹酮抗性株和敏感株生物学特性:对螺感染率、感染性螺存活期、在螺体内产尾蚴量、尾蚴和虫卵开放前期及虫卵孵化率。结果单只螺暴露于单个毛蚴2h,抗性株与敏感株对螺感染率为19.8%和8.9%,二者间差异有非常显著性(P=0.006);逸蚴期间,塞内加

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曼氏血吸虫吡喹酮抗性的遗传学分析

曼氏血吸虫吡喹酮抗性的遗传学分析

多发性硬化症的治疗时机窗:单克隆抗体治疗的依据

中国动物学会全国第九次寄生虫学学术讨论会

作者：梁幼生戴建荣朱荫昌李洪军徐明司进许永良杭盘宇 g.C coles M.j.Doenhoff 江苏省血吸虫病防治研究所英国Bristol大学医学院临床兽医系英国Wales大学生物科学学院

目的探索曼氏血吸虫吡喹酮抗性是显性或隐性遗传性状,以了解其遗传学基础。方法以W1特异性序列为引物,采用直接PCR技术鉴别单性克隆尾蚴的性别;用曼氏血吸虫吡喹酮抗性株和敏感株单性尾蚴感染远交系CD鼠,进行血吸虫抗性株与敏感株的杂...

目的探索曼氏血吸虫吡喹酮抗性是显性或隐性遗传性状,以了解其遗传学基础。方法以W1特异性序列为引物,采用直接PCR技术鉴别单性克隆尾蚴的性别;用曼氏血吸虫吡喹酮抗性株和敏感株单性尾蚴感染远交系CD鼠,进行血吸虫抗性株与敏感株的杂交实验;采用体外虫卵、毛蚴和尾蚴抗性检测法,评价F和F对吡喹喳酮的抗性程度。结果吡喹酮抗性株和敏感株杂交F和F均表现出抗性株特征。结论曼氏血吸虫吡喹酮抗性性状可能系显性遗传。

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世界核心医学期刊文摘（神经病学分册） 2006年第5期2卷 39-40页

作者： coles A.j Cox A Le Page 张慧 Department of Clinical Neurosciences Box 165 Addenbrooke's Hospital Cambridge CB2 2QQ United Kingdom

From 1991- 2002, we treated 58 patients with multiple sclerosis (MS) using the humanised monoclonal antibody, Campath-1H, which causes prolonged T lymphocyte depletion. Clinical and surrogate markers of inflammation were suppressed. In both the relapsing-remitting (RR) and secondary progressive (SP) stages of the illness, Campath-1H reduced the annual relapse rate (from 2.2 to 0.19 and from 0.7 to 0.001 respectively; both p g on the phase of the disease. Patients with SPMS showed sustained accumulation of disability due to uncontrolled progression marked by unrelenting cerebral atrophy, attributable to ongoing axonal loss. The rate of cerebral atrophy was greatest in patients with established cerebral atrophy and highest inflammatory lesion burden before treatment (2.3 versus 0.7 ml/year; p = 0.04). In contrast, patients with RR disease showed an impressive reduction in disability at 6 months after Campath-1H (by a mean of 1.2 EDSS points) perhaps owing to a suppression of on-going inflammation in these patients with unusually active disease. In addition, there was a further significant, albeit smaller, mean improvement in disability up to 36 months after treatment. We speculate that this represents the beneficial effects of early rescue of neurons and axons from a toxic inflammatory environment, and that prevention of demyelination will prevent long-term axonal degeneration. These concepts are currently being tested in a controlled trial comparing Campath-1H and IFN-beta in the treatment of drug-na ve patients with early, active RR MS.

关键词：多发性硬化症人单克隆抗体抗体治疗治疗时机依据脑萎缩率 RRMS 轴突变性年复发率早期恢复

巴西亚马孙流域热带森林的开垦与大豆生产:以朗多尼亚州维列纳市为例

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AMBIO－人类环境杂志 2005年第6期34卷 456-463页

作者： j.ChristopherBrown Matthew Koeppe Benjamin coles Kevin P.Price 潘韬堪萨斯大学地理与环境工程研究系堪萨斯大学堪萨斯大学地理系

近来巴西大豆生产的增长引发了环境保护团体以及一些学者对于亚马孙盆地的热带自然环境正在向大豆种植地转换的关注。大豆生产的支持者则认为大豆是区域的一种可行性农产品;对于环境的关注是没有根据的,因为新的大豆种植地正在替代已经... 详细信息

近来巴西大豆生产的增长引发了环境保护团体以及一些学者对于亚马孙盆地的热带自然环境正在向大豆种植地转换的关注。大豆生产的支持者则认为大豆是区域的一种可行性农产品;对于环境的关注是没有根据的,因为新的大豆种植地正在替代已经被砍伐的林地或者是转换了的土地。两种观点虽被提出却都没有对大豆生产扩充区的土地利用与土地覆被(LULC)状况进行过综合研究与估量。本案例研究是在巴西的朗多尼亚州,亚马孙盆地西南部的维列纳市(Vilhena),通过遥感手段对1996～2001年以来该市大豆种植面积的大幅度增加所伴随的土地利用与土地覆被变化状况进行评估。结果表明虽然森林变成了大豆生产基地,但是大部分的大豆生产的增长归功于对已有土地的微量扩充、已伐林地的转换以及更高的单位产量。

关键词：大豆生产热带森林亚州土地覆被变化开垦流域西亚自然环境土地利用环境保护