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γ-ray Spectroscopy of Hypernuclei:Recent KEK Results and Future Plans at j-PARC

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原子核物理评论 2009年第S1期26卷 34-38页

作者： S.Ajimura K.Aoki M.Dairaku H.Fujioka T.fukuda K.Futatsugawa K.Hosomi W.Imoto M.Kawai Y.Kakiguchi S.Kinoshita T.Koike N.Maruyama M.Mimori S.Minami Y.Miura K.Miwa Y.Miyagi T.Nagae D.Nakajima H.Noumi K.S hirotori T.Suzuki T.Takahashi T.N.Takahashi K.Tanida N.Terada A.Toyoda K.Tsukada M.Ukai H.Tamura Department of Physics Osaka University High Energy Accelerator Research Organization (KEK) Department of Physics Kyoto University Department of Physics University of Tokyo Osaka Electro-Communication University Department of Physics Tohoku University RIKEN

In this proceeding,we will first outline the experimental setup and main results of the most recent hypernuclear γ-ray spectroscopy experiment (KEK-E566) performed at KEK-PS K6 beam line. The main feature and characteristics of this type of research will be emphasised. After that,the approved experimental proposal (E13) at j-PARC facility will be introduced briefly.

关键词： γ-ray spectroscopy hypernuclei

成纤维细胞体外培养结合串联质谱酰基肉碱谱诊断极长链酰基辅酶A脱氢酶缺陷症

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实用儿科临床杂志 2009年第20期24卷 1560-1562页

作者：李红马立燕马金海福田诚司长谷川有纪小林弘典山口清次宁夏医科大学附属医院儿科银川750004 日本岛根大学医学部小儿科日本岛根6938501

目的研究成纤维细胞体外培养结合串联质谱酰基肉碱谱分析对极长链酰基辅酶A脱氢酶(VLCAD)缺陷症的诊断价值。方法取健康对照标本6例,VLCAD缺陷症患儿标本9例(包括临床严重型2例,中间型3例及肌病型4例。男5例,女4例)。以棕榈酸(C16酸)为... 详细信息

目的研究成纤维细胞体外培养结合串联质谱酰基肉碱谱分析对极长链酰基辅酶A脱氢酶(VLCAD)缺陷症的诊断价值。方法取健康对照标本6例,VLCAD缺陷症患儿标本9例(包括临床严重型2例,中间型3例及肌病型4例。男5例,女4例)。以棕榈酸(C16酸)为培养溶媒底物在37℃培养箱中培养成纤维细胞株96h,应用串联质谱分析相应培养液中的酰基肉碱谱。结果与健康对照组比较,VLCAD缺陷症患儿乙酰肉碱(C2)明显降低,相应长链酰基肉碱异常增高,其中肉豆寇烯酰肉碱(C14)-酰基肉碱在临床严重型患儿中增高明显,月桂酰肉碱(C12)-酰基肉碱在临床轻型病例(包括中间型和肌病型)中增高更显著。长链酰基肉碱之和(ΣLC)及其与乙酰肉碱之比值(ΣLC/C2),VLCAD缺陷症患儿均明显高于健康对照。结论成纤维细胞体外特定条件培养结合串联质谱酰基肉碱谱分析,可诊断和鉴别VLCAD缺陷症及其临床分型,C12-酰基肉碱和C14-酰基肉碱可作为诊断标记。

关键词：极长链酰基辅酶A脱氢酶缺陷症串联质谱酰基肉碱成纤维细胞

蛋白酶激活受体2在载脂蛋白E缺陷小鼠的血管炎症和动脉粥样硬化中发挥关键作用

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中华高血压杂志 2018年第6期26卷 599-599页

作者： Hara T Phuong PT fukuda D Yamaguchi K Murata C Nishimoto S Yagi S Kusunose K Yamada H Soeki T Wakatsuki T Imoto I Shimabukuro M Sata M 刘青叶鹏

凝血系统与血管炎症密切相关,尽管其潜在机制仍不清楚。最近的研究结果表明,蛋白酶激活受体（protease-activated receptor,PAR）2——活化因子X（activated factor X,FXa）的主要受体之一——在血管细胞和白细胞中均有表达,这提示PAR-... 详细信息

凝血系统与血管炎症密切相关,尽管其潜在机制仍不清楚。最近的研究结果表明,蛋白酶激活受体（protease-activated receptor,PAR）2——活化因子X（activated factor X,FXa）的主要受体之一——在血管细胞和白细胞中均有表达,这提示PAR-2可能参与炎症性疾病的发病机制。

关键词：蛋白酶激活受体2 血管炎症载脂蛋白E缺陷动脉粥样硬化 receptor 小鼠炎症性疾病 PAR-2

Randomized trial of chemoradiotherapy and adjuvant chemotherapy with nimustine (ACNU) versus nimustine plus procarbazine for newly diagnosed anaplastic astrocytoma and glioblastoma (jCOG0305)

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中国神经肿瘤杂志 2013年第1期11卷 21-21页

作者： Shibui S Narita Y Mizusawa j Beppu T Ogasawara K Sawamura Y Kobayashi H Nishikawa R Mishima K Muragaki Y Maruyama T Kuratsu j Nakamura H Kochi M Minamida Y Yamaki T Kumabe T Tominaga T Kayama T Sakurada K Nagane M Kobayashi K Nakamura H Ito T Yazaki T Sasaki H Tanaka K Takahashi H Asai A Todo T Wakabayashi T Takahashi j Takano S Fujimaki T Sumi M Miyakita Y Nakazato Y Sato A fukuda H Nomura K Department of Neurosurgery and Neuro-Oncology National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyo 104-0045Japan

Objectives: Glioblastoma(GBM) is one of the worst cancers in terms of *** therapy consists of resection with concomitant *** to nimustine hydrochloride(ACNU),an alkylating agent,has been linked to methylguanine DNA methyltransferase(MGMT).Daily administration of procarbazine(PCZ) has been reported to decrease MGMT *** study investigated the efficacy of ACNU + PCZ compared to ACNU alone for GBM and anaplastic astrocytoma(AA).Methods: Patients(20-69 years) who had newly diagnosed AA and GBM were randomly assigned to receive radiotherapy with ACNU alone or with ACNU + *** primary endpoint was overall survival(OS).This was designed as a phase Ⅱ/Ⅲ trial with a total sample size of 310 patients and was registered as UMIN-CTR ***: After 111 patients from 19 centers in japan were enrolled,this study was terminated early because temozolomide was newly approved in *** median OS and median progression-free survival(PFS) with ACNU alone(n = 55) or ACNU + PCZ(n = 56) in the intention-to-treat population were 27.4 and 22.4 months(P = 0.75),and 8.6 and 6.9 months,*** median OS and median PFS of the GBM subgroup treated with ACNU alone(n = 40) or ACNU + PCZ(n = 41) were 19.0 and 19.5 months,and 6.2 and 6.3 months,*** 3/4 hematologic adverse events occurred in more than 40% of patients in both arms,and 27% of patients discontinued treatment because of adverse ***: The addition of PCZ to ACNU was not beneficial,in comparison with ACNU alone,for patients with newly diagnosed AA and GBM.

关键词：星形细胞母细胞随机试验放疗胶质变性化疗 MGMT

双能CT碘图用于手银屑病关节炎的初步经验:与增强MR成像对比

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国际医学放射学杂志 2017年第5期 589-589页

作者： T.fukuda Y.Umezawa S.Tojo T.Yonenaga A.Asahina H.Nakagawa 杨晓旭 Department of Radiology The Jikei University School of Medicine

摘要目的确定双能(DE)CT碘图(IOI)评价手银屑病关节炎的可行性。材料与方法本研究获机构伦理委员会批准,每位病人均签署知情同意书。研究前瞻性纳入了2015年

关键词：银屑病关节炎 DE MR CT

弯曲力矩对EFPI光纤传感器输出应变的影响

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吉林工学院学报（自然科学版） 2002年第4期23卷 7-9页

作者：崔善子逢坂胜彦高坂达郎福田武人长春工业大学化学工程学院吉林长春130012 日本大阪市立大学工学部日本大阪5588585

为了确定弯曲力矩对EFPI光纤传感器输出的影响,制作了将光纤传感器埋入其中间层的复合板试件,并对试件进行三点弯曲试验,得到了弯曲力矩与光纤传感器输出应变之间的关系。随后,用显微镜对复合板的横截面进行观察,确定光纤传感器的埋入... 详细信息

为了确定弯曲力矩对EFPI光纤传感器输出的影响,制作了将光纤传感器埋入其中间层的复合板试件,并对试件进行三点弯曲试验,得到了弯曲力矩与光纤传感器输出应变之间的关系。随后,用显微镜对复合板的横截面进行观察,确定光纤传感器的埋入位置。对光纤传感器的埋入位置偏离复合板中间层的试件,运用有限元应变分析法(FEM)计算其应变值。实验结果表明,当光纤传感器的埋入位置偏离复合板中间层时,光纤传感器的应变大于计算值,说明弯曲力矩影响光纤传感器的测试性能。

关键词： EFPI光纤传感器弯曲力矩应变三点弯曲试验高压釜复合板成型过程

超声造影在HIFU治疗肝癌近期疗效评价中的应用

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临床超声医学杂志 2009年第2期11卷 101-103页

作者：金成兵朱辉王智彪福田浩之大藤正雄张炼周昆杨炜彭松冉立烽重庆医科大学附属第二医院肿瘤中心重庆市400010 日本千叶大学中央病院第一消化内科

目的探讨超声造影在评价HIFU治疗肝癌近期疗效中的价值。方法利用三维超声造影和增强CT观察26例原发性肝癌的29个肿瘤病灶的影像学变化。结果高强度聚焦超声(HIFU)治疗前超声造影和增强CT检查,病灶表现为快进快出典型灌注模式者为27/29(... 详细信息

目的探讨超声造影在评价HIFU治疗肝癌近期疗效中的价值。方法利用三维超声造影和增强CT观察26例原发性肝癌的29个肿瘤病灶的影像学变化。结果高强度聚焦超声(HIFU)治疗前超声造影和增强CT检查,病灶表现为快进快出典型灌注模式者为27/29(93.1%)个和26/29(89.7%)个,二者比较差异无统计学意义(P>0.05);HIFU后超声造影和增强CT检查25/29个病灶(86.2%)表现为边界清楚的肿瘤灌注缺损,且可见边缘锐利光滑的环状增强带。结论超声造影和增强CT均可较准确地评价HIFU治疗肝癌的疗效,二者比较差异无统计学意义。超声造影是评价HIFU治疗肝癌后近期疗效的重要方法之一。

关键词：肝肿瘤高强度聚焦超声超声检查造影剂增强CT 疗效评价

Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby john Emma Griffin john Thornton jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-jehani Sunil A Sheth Victor S Lopez Rivera james E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami jin Soo Lee ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong juan F Arenillas Mario Martinez-Galdamez jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon john Alex Brehm Marios Psychogios William j Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters johnny Wong Mohamed Teleb jeremy Payne Hiroki fukuda Kosuke Miyake junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,p<0.0001).Embolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative *** analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p<0.0001).A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this *** There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 *** findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid