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Enriched electrophilic oxygen species facilitate acidic oxygen evolution on Ru-Mo binary oxide catalysts

Nano Research 2024年第3期17卷 1165-1172页

作者： Yaya Wang Yunzhou Wen Yumeng Cheng xinhong Chen Mengjiao Zhuansun tongbao Wang jun li Debora Meira huarui sun jun Wei jia Zhou Yuhang Wang Sisi he Shenzhen Key laboratory of flexible Printed Electronics Technology Harbin Institute of Technology(Shenzhen)University TownShenzhen 518055China School of Science Harbin Institute of Technology(Shenzhen)University TownShenzhen 518055China Institute of functional Nano&Soft Materials(fuNSOM) Jiangsu Key Laboratory of Advanced Negative Carbon TechnologiesSoochow UniversitySuzhou 215123China frontiers Science Center for Transformative Molecules Shanghai Jiao Tong UniversityShanghai 200240China Science Division Canadian Light SourceSaskatoonSKS7N 2V3Canada Photon Science Division Argonne National LaboratoryLemontIL60439USA School of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)University TownShenzhen 518055China

The polymer electrolyte membrane(PEM)electrolyzers are burdened with costly iridium(Ir)-based catalysts and high operation overpotentials for the oxygen evolution reaction(OER).The development of earth-abundant,highly active,and durable electrocatalysts to replace Ir is a critical step in reducing the cost of green hydrogen *** we develop a Ru5Mo4Ox binary oxide catalyst that exhibits high activity and stability in acidic *** electron-withdrawing property of Mo enriches the electrophilic surface oxygen species,which promotes acidic OER to proceed via the adsorbate evolution *** a result,we achieve a 189 mV overpotential at 10 mA·cm^(-2) and a Tafel slope of 48.8 mV·dec^(-1).Our catalyst demonstrates a substantial 18-fold increase in intrinsic activity,as evaluated by turnover frequency,compared to commercially available RuO_(2) and IrO_(2) ***,we report a stable OER operation at 10 mA·cm^(-2) for 100 h with a low degradation rate of 2.05 mV·h^(-1).

关键词： electrocatalysis oxygen evolution reaction(OER) ruthenium(Ru)-based oxide molybdenum electrophilic oxygen

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E674Q(shanghai APP mutant),a novel amyloid precursor protein mutation,in familial late-onset Alzheimer's disease

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Genes & Diseases 2024年第2期11卷 1022-1034页

作者： Yongfang Zhang xinyi xie Boyu Chen lina Pan jianping li Wanbing Wang jintao Wang Ran Tang Qiang huang xiaofen Chen Rujing Ren Zhentao Zhang Wei fu Gang Wang Department of Neurology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Medicinal Chemistry School of PharmacyFudan UniversityShanghai 201203China Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei 430060China fujian Provincial Key laboratory of Neurodegenerative Disease and Aging Research Institute of NeuroscienceSchool of MedicineXiamen UniversityXiamenFujian 361102China Shenzhen Research Institute of xiamen university ShenzhenGuangdong 518063China

Identified as the pathogenic genes of Alzheimer's disease(AD),APP,PSEN1,and PSEN2 mainly lead to early-onset AD,whose course is more aggressive,and atypical symptoms are more common than sporadic ***,a novel missense mutation,APP E674Q(also named“shanghai APP”),was detected in a Chinese index patient with typical late-onset AD(lOAD)who developed memory decline in his *** results from neuroimaging were consistent with AD,where widespread amyloidβdeposition was demonstrated in 18 f-florbetapir Positron Emission Tomography(PET).APP E674Q is close to theβ-secretase cleavage site and the well-studied Swedish APP mutation(KM670/671Nl),which was predicted to be pathogenic in *** dynamics simulation indicated that the E674Q mutation resulted in a rearrangement of the interaction mode between APP and BACE1 and that the E674Q mutation was more prone to cleavage by *** in vitro results suggested that the E674Q mutation was pathogenic by facilitating the BACE1-mediated processing of APP and the production of Aβ.furthermore,we applied an adeno-associated virus(AAV)-mediated transfer of the human E674Q mutant APP gene to the hippocampi of two-month-old C57Bl/6 j ***-E674Q-injected mice exhibited impaired learning behavior and increased pathological burden in the brain,implying that the E674Q mutation had a pathogenicity that bore a comparison with the classical Swedish ***,we report a strong amyloidogenic effect of the E674Q substitution in *** our knowledge,E674Q is the only pathogenic mutation within the amyloid processing sequence causing lOAD.

关键词： Alzheimer's disease Amyloid beta APP mutation E674Q late onset

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Nuclear reprogramming: the strategy used in normal development is also used in somatic cell nuclear transfer and parthenogenesis

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Cell Research 2007年第02期17卷 135-150页

作者： Tianlong Gao~(1,*) junke Zheng~(2,*) fengying xing~(2,*) haiyan fang~2 feng sun~1 Ayong Yan~2 xun Gong~2 hui Ding~3 fan Tang~2 hui Z Sheng~2 ~1Program for Graduation Studies,shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,shanghai 200031,china ~2Center for Developmental Biology,xinhua hospital,shanghai jiao tong university,School of Medicine,1665 Kong jiang Road,shanghai 200092,china ~3School of Animal Science and Technology,Yangzhou university,Yangzhou 225009,china 1Program for Graduation Studies Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China 2Center for Developmental Biology Xinhua Hospital Shanghai Jiao Tong University School of Medicine 1665 Kong Jiang Road Shanghai 200092 China 2Center for Developmental Biology Xinhua Hospital Shanghai Jiao Tong University School of Medicine 1665 Kong Jiang Road Shanghai 200092 China 2Center for Developmental Biology Xinhua Hospital Shanghai Jiao Tong University School of Medicine 1665 Kong Jiang Road Shanghai 200092 China 1Program for Graduation Studies Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China 2Center for Developmental Biology Xinhua Hospital Shanghai Jiao Tong University School of Medicine 1665 Kong Jiang Road Shanghai 200092 China 2Center for Developmental Biology Xinhua Hospital Shanghai Jiao Tong University School of Medicine 1665 Kong Jiang Road Shanghai 200092 China 3School of Animal Science and Technology Yangzhou University Yangzhou 225009 China 2Center for Developmental Biology Xinhua Hospital Shanghai Jiao Tong University School of Medicine 1665 Kong Jiang Road Shanghai 200092 China 2Center for Developmental Biology Xinhua Hospital Shanghai Jiao Tong University School of Medicine 1665 Kong Jiang Road Shanghai 200092 China

Somatic cell nuclear transfer(SCNT)and parthenogenesis are alternative forms of reproduction and development,building new life cycles on differentiated somatic cell nuclei and duplicated maternal chromatin,*** thepreceding paper(sun f,et al.,Cell Res 2007;17:117-134.),we showed that an"erase-and-rebuild"strategy is used innormal development to transform the maternal gene expression profile to a zygotic ***,we investigate if the samestrategy also applies to SCNT and *** relationship between chromatin and chromatin factors(Cfs)during SCNT and parthenogenesis was examined using immunochemical and GfP-fusion protein *** fromthese studies indicated that soon after nuclear transfer,a majority of Cfs dissociated from somatic nuclei and were re-distributed to the cytoplasm of the *** erasure process in oogenesis is recaptured during the initial phase in *** Cfs entered pseudo-pronuclei shortly after their *** parthenogenesis,all parthenogenotes underwentnormal oogenesis,and thus had removed most Cfs from chromosomes before the initiation of *** Cfswere subsequently re-associated with female pronuclei in time and sequence similar to that in fertilized *** these data,we conclude that the"erase-and-rebuild"process observed in normal development also occurs in SCNTand in parthenogenesis,albeit in altered *** process is responsible for transcription reprogramming in ***"erase"process in SCNT is compressed and the efficiency is compromised,which likely contribute tothe developmental defects often observed in nuclear transfer(nt)***,results from this study indicatedthat the cytoplasm of an egg contains most,if not all,essential components for assembling the zygotic program and canassemble them onto appropriate diploid chromatin of distinct origins.

关键词： nuclear reprogramming SCNT parthenogenesis chromatin factors chromatin embryogenesis

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hYDRODYNAMIC SIMUlATION TO MOlD fIlliNG UNDER COUNTER GRAVITY

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Acta Metallurgica Sinica(English letters) 2000年第2期13卷 780-783页

作者： j.M. Zeng and Y.h. Zhou 1) Institute of Materials Science, Guangxi university, Nanning 530004, china 2) Department of Materials Science and Engineering, shanghai jiao tong university, shanghai 200030, china

In situ observations of the flow morphology during mold filling under counter gravity are conducted on a perspex water model by means of flow visualization, high speed photography and pattern processing. The experimental results indicate that influences of the dynamic factors on flow morphology can be expressed quantitatively with the parameterφ(k). The flow field takes on different morphology with change in values of φ(k). for thick and thin walled castings, the main dynamic factors influencing flow morphology are gravity and surface tension respectively. Under general circumstances, f_r and W_e should be equal in their values to guarantee the similarity between the prototype and the model in simulating mold filling under counter gravity by experiment.

关键词： casting mold filling hydrodynamics

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Phase Selection in Solidi?cation of Undercooled Co–B Alloys

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journal of Materials Science & Technology 2017年第4期33卷 352-358页

作者： x.x.Wei W.xu j.l.Kang M.ferry j.f.li State Key laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240.China Australian Research Council Centre of Excellence for Design in light Metals School of Materials Science and EngineeringThe University of New South WalesSydneyNSW 2052Australia

A series Co-（18.5–20.7） at.% B melts encompassing the eutectic composition（Co81.5B18.5） were solidified at different degrees of undercooling. It is found that the metastable Co23B6 phase solidifies as a substitute for the stable Co3 B phase in the alloy melts undercooled above a critical undercooling value of -60 *** Co23B6 and α-Co phases make up a metastable eutectic. The corresponding eutectic composition and temperature are Co80.4B19.6 and 1343 K, respectively. On exposure of the metastable Co23B6 phase at a given temperature above 1208 K, it does not decompose even after several hours. But it transforms by a eutectoid reaction to α-Co ＋ Co3 B at lower temperature.

关键词： Undercooling Rapid solidi?cation Metastable phase diagram Structure evolution

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large circuit models: opportunities and challenges

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Science china(Information Sciences) 2024年第10期 25-66页

作者： lei ChEN Yiqi ChEN Zhufei ChU Wenji fANG Tsung-Yi hO Ru hUANG Yu hUANG Sadaf KhAN Min li xingquan li Yu li Yun liANG jinwei liU Yi liU Yibo liN Guojie lUO hongyang PAN Zhengyuan ShI Guangyu sun Dimitrios TSARAS Runsheng WANG Ziyi WANG xinming WEI Zhiyao xIE Qiang xU Chenhao xUE junchi YAN jun YANG Bei YU Mingxuan YUAN Evangeline f.Y.YOUNG xuan ZENG haoyi ZhANG Zuodong ZhANG Yuxiang zhao hui-ling ZhEN Ziyang ZhENG Binwu ZhU Keren ZhU sunan ZOU huawei Noah’s Ark lab School of Integrated Circuits Peking University faculty of Electrical Engineering and Computer Science Ningbo University Department of Electronic and Computer Engineering Hong Kong University of Science and Technology Department of Computer Science and Engineering The Chinese University of Hong Kong School of Integrated Circuits Southeast University huawei hiSilicon Peng Cheng laboratory School of Computer Science Peking University School of Microelectronics State Key Laboratory of Integrated Chips and System Fudan University School of Artificial Intelligence Shanghai Jiao Tong University

Within the electronic design automation(EDA) domain, artificial intelligence(AI)-driven solutions have emerged as formidable tools, yet they typically augment rather than redefine existing methodologies. These solutions often repurpose deep learning models from other domains, such as vision, text, and graph analytics, applying them to circuit design without tailoring to the unique complexities of electronic circuits. Such an “AI4EDA” approach falls short of achieving a holistic design synthesis and understanding,overlooking the intricate interplay of electrical, logical, and physical facets of circuit data. This study argues for a paradigm shift from AI4EDA towards AI-rooted EDA from the ground up, integrating AI at the core of the design process. Pivotal to this vision is the development of a multimodal circuit representation learning technique, poised to provide a comprehensive understanding by harmonizing and extracting insights from varied data sources, such as functional specifications, register-transfer level(RTl) designs, circuit netlists,and physical layouts. We champion the creation of large circuit models(lCMs) that are inherently multimodal, crafted to decode and express the rich semantics and structures of circuit data, thus fostering more resilient, efficient, and inventive design methodologies. Embracing this AI-rooted philosophy, we foresee a trajectory that transcends the current innovation plateau in EDA, igniting a profound “shift-left” in electronic design methodology. The envisioned advancements herald not just an evolution of existing EDA tools but a revolution, giving rise to novel instruments of design-tools that promise to radically enhance design productivity and inaugurate a new epoch where the optimization of circuit performance, power, and area(PPA) is achieved not incrementally, but through leaps that redefine the benchmarks of electronic systems' capabilities.

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hIGh TEMPERATURE TENSIlE fRACTURE BEhAVIOR Of [221]-ORIENTED DD100 SINGlE CRYSTAl SUPERAllOY

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Acta Metallurgica Sinica(English letters) 1999年第1期12卷 124-129页

作者： C.D. Zhou1,2), j.x. Yu1), x.P. Dong1), Y.h. Zhang1), C.Q. sun3) and T.f. li4) 1) The State Education Commission Open Research laboratory for high Temperature Materials and Testing, shanghai jiao tong university, shanghai 200030, china2) shanghai

An investigation has been made on the tensile fracture behavior of oriented single crystal DD100 superalloy at 850. The appearance of the fracture surface of DD100 reflects the glide plane decohension fracture mechanism, which is different from the fracture of oriented DD100. The tensile strength and elongation are lower than the oriented DD100. Oxygen in air has little effect on the strength of DD100 but reduces the tensile elongation obviously. Oxygen does not affect the fracture mode of DD100 but strongly accelerates the process of fracture.

关键词： single crystal superalloy high temperature fracture environmental effect

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Toward carbon neutrality by artificial photosynthesis

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frontiers in Energy 2024年第1期18卷 54-55页

作者： Baowen ZhOU Minhua ShAO Sharif Md.SADAf Shuhui sun Key laboratory for Power Machinery and Engineering of the Ministry of Education Research Center of Renewable Synthetic FuelSchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Chemical and Biological Engineering Energy InstituteThe Hong Kong University of Science and TechnologyHong KongChina Institut National de la Recherche Scientifique(INRS)-CenterÉnergie Matériaux Télécommunications VarennesQuebec J3X 1P7Canada

CO_(2)is not only the primary cause of climate change but also an abundant and recyclable carbon *** breakthrough in emerging disruptive technologies such as carbon capture and storage(CCS),power-to-x,and direct air capture(DAC)is fundamental to achieving carbon *** these technologies,artificial photosynthesis offers an attractive method for recycling carbon dioxide and water into fuels and chemicals using solar energy(CO_(2)+h_(2)O+sunlight→fuels+chemicals).It holds great promise for addressing the critical challenges associated with elevated CO_(2)concentrations and securing a sustainable supply of fuels and chemicals for economic sectors.

关键词： neutral holds breakthrough

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A perspective on the promoting effect of Ir and Au on Pd toward the ethanol oxidation reaction in alkaline media

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frontiers in Energy 2018年第4期12卷 501-508页

作者： S.Y.ShEN Y.G.GUO G.h.WEI l.x.lUO f.li j.l.ZhANG Institute of fuel Cells School of Mechanical EngineeringMOE Key Laboratory of Power & Machinery EngineeringShanghai Jiao Tong UniversityShanghai 200240China SjTU-Paris Tech Elite Institute of Technology Shanghai Jiao Tong UniversityShanghai 200240China

There remain great challenges in developing highly efficient electrocatalysts with both high activity and good stability for the ethanol oxidation reaction in alkaline media. herein, two architectures of tri-metallic PdIrAu/C electrocatalysts are designed and the promoting effect of Au and Ir on Pd toward the ethanol oxidation reaction (EOR) in alkaline media is investigated in detail. On the one hand, the tri-metallic Pd7Au7Ir/C electrocatalyst with a solid solution alloy architecture is less active relative to Pd7Ir/C and Pd/C while the stabilizing effect of Au leads to both a higher activity and a lower degradation percentage after 3000 cycles of the accelerated degradation test (ADT) on Pd7Au7Ir/C than those on Pd7Ir/C. On the other hand, the tri-metallic Pd7Ir@(1/3Au)/C electrocatalyst with a near surface alloy architecture delivers a much higher activity with an improvement up to 50.4% compared to Pd7Ir/C. It is speculated that for the tri-metallic Pd7Ir@(1/3Au)/C electrocatalyst, certain Au atoms are well designed on surfaces to introduce an electronic modification, thus leading to an anti-poisoning effect and improving the EOR activity.

关键词： fuel cells catalysts ethanol oxidation alkaline media solid solution alloy near surface alloy electrocatalysts Alkaline end of record solid solution alloy Palladium Catalysts iridium BREAKAWAY OxIDATION fuel batteries Gold

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RNA m^(6)A reader YThDf2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression

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Genes & Diseases 2024年第1期11卷 382-396页

作者： Zheng Zhang Keren Zhou li han Andrew Small jianhuang xue huilin huang hengyou Weng Rui Su Brandon Tan Chao Shen Wei li Zhicong zhao Ying Qing xi Qin Kitty Wang Keith leung Mark Boldin Chun-Wei Chen David Ann Zhijian Qian xiaolan Deng jianjun Chen Zhenhua Chen Department of Systems Biology Beckman Research Institute of City of HopeMonroviaCA 91016USA Irell and Manella Graduate School of Biological Sciences Beckman Research Institute of City of HopeDuarteCA 91010USA Gehr family Center for leukemia Research City of HopeDuarteCA 91010USA sun Yat-sen university Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060China Guangzhou laboratory GuangzhouGuangdong 510005China Bioland laboratory GuangzhouGuangdong 51005China Department of liver Surgery Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Diabetes Complications and Metabolism Beckman Research Institute of City of HopeDuarteCA 91010USA Department of Biochemistry and Molecular Biology University of FloridaGainesvilleFL 32603USA tongji hospital Affiliated to tongji university Frontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China School of Pharmacy China Medical UniversityShenyangLiaoning 110001China

As the most common internal modification of mRNA,Ne-methyladenosine(m^(6)A)and its regulators modulate gene expression and play critical roles in various biological and patholog-ical processes including *** was reported previously that m^(6)A methyltransferase(writer),methyltransferase-like 3(METTl3)adds m^(6)A in primary microRNAs(pri-miRNAs)and fa-cilitates its processing into precursor miRNAs(pre-miRNAs).however,it is unknown whether m^(6)A modification also plays a role in the maturation process of pre-miRNAs and(if so)whether such a function contributes to ***,we found that YThDf2 is aberrantly overexpressed in acute myeloid leukemia(AMl)patients,especially in relapsed patients,and plays an onco-genic role in ***,YThDf2 promotes expression of miR-126-3p(also known as miR-126,as it is the main product of precursor miR-126(pre-miR-126)),a miRNA that was reported as an oncomiRNA in AMl,through facilitating the processing of pre-miR-126 into mature ***,YThDf2 recognizes m^(6)A modification in pre-miR-126 and recruits AGO2,a regulator of pre-miRNA processing,to promote the maturation of ***2 posi-tively and negatively correlates with miR-126 and miR-126's downstream target genes,respec-tively,in AMl patients,and forced expression of miR-126 could largely rescue YThDf2/Ythdf2 depletion-mediated suppression on AMl cell growth/proliferation and leukemogenesis,indi-cating that miR-126 is a functionally important target of YThDf2 in ***,our studies not only reveal a previously unappreciated YThDf2/miR-126 axis in AMl and highlight the ther-apeutic potential of targeting this axis for AMl treatment,but also suggest that m^(6)A plays a role in pre-miRNA processing that contributes to tumorigenesis.

关键词： AMl miR-126 N^(6)-methyladenosine Pre-miRNA maturation YThDf2

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