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Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： jie jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

HCV genotypes in hepatitis C patients and their clinical significances

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World journal of Gastroenterology 1999年第6期5卷 547-549页

作者： Huang f zhao GZ Li Y China Med Univ Affiliated Hosp 2 Dept Infect Dis Shenyang 110003 Liaoning Prov Peoples R China

INTRODUCTIONIt has been discovered that hepatitis C virus (HCV) presents considerable nucleotide variation and has many genotypes. At least twelve, 5 of which prevalent, i.e.: Ⅰ/1a, Ⅱ/1b, Ⅲ/2a, Ⅳ/2b, and Ⅴ/3a types. The different genotypes of HCV may possess some retationship with regional distribution, clinical manifestation, response to treatment and prognosis of HCV infection, thus to study the genotypes of HCV further in different areas is of practical value. We detected HCV genotypes in 94 patients with hepatitis C and in 6 patients with primary hepatocarcinoma by PCR assay with four kinds of type-specific primers with a view to study the distribution of HCV genotypes in hepatitis C in Shenyang area and their clinical significances.

关键词： hepatitis C hepatitis C virus genotyping

Gas Line Pressure fluctuation Analysis of a Gas-Liquid Reactor

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journal of Thermal Science 2005年第3期14卷 267-271页

作者： j.j.j. CHEN j.C. zhao Chemical & Materials Engineering Department The University of Auckland Private Bag 92019 Auckland New Zealand ProfessorChemical & Materials Engineering Department The University of Auckland Private Bag 92019 Auckland New Zealand

To ensure efficient operation of metallurgical gas-liquid reactors, the gas bubbles must be uniformly distributed. for high temperature metallurgical reactors, it is impractical and unsafe to carry out visual observations. An air-water model was used to study the relationship between the bubble flow patterns and the pressure fluctuation signals. The fluctuation signals captured in the time domain were transformed into the frequency domain. Various parameters obtained from the transformed data were analysed for their suitability for delineating the bubble flow patterns observed. These parameters and the flow patterns were found to be well-correlated using the gas flow number.

关键词： gas liquid reactors bubble distribution signal analysis

EffECT Of LOW-fREQUENCY ELECTROMAGNETIC fIELD ON THE AS-CASTING MICROSTRUCTURES AND MECHANICAL PROPERTIES Of HDC 2024 ALUMINUM ALLOY

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Acta Metallurgica Sinica(English Letters) 2008年第3期21卷 205-210页

作者： Q.f. Zhu Z.H. zhao j.Z. Cui Y.B. Zuo f. Qu Key Laboratory of Electromagnetic Processing of Materials Ministry of Education Northeastern Univer- sity Shenyang 110004 China

The influences of the low frequency electromagnetic field on the horizontal direct chill casting process were investigated experimentally. Ingots of 2024 aluminum alloy with a cross size of 40 mm× 200 mm were produced by the conventional horizontal chill casting process and low frequency electromagnetic horizontal chill casting processre- spectively. The as-cast structures and the mechanical property of the ingots were examined. The results showed that the low frequency electromagnetic field could sub- stantially refine the microstructures and pronouncedly reduce the macrosegregation in the horizontal direct chill casting process. Moreover, the surface quality of the ingot was prominently improved by the low frequency electromagnetic field. The fracture strength and elongation percentage of the ingot was increased with the low frequency electromagnetic field.

关键词： Horizontal direct chill casting Low frequency electromagnetic field 2024 aluminum alloy Microstructures Macrosegregation

PROPERTIES Of THREE-DIMENSIONAL MOVEMENT Of SANDY WATER DISCHARGED INTO A LAKE

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journal of Hydrodynamics 2001年第2期13卷 72-76页

作者： Deng, Y. Li, j. Li, K.f. zhao, W.Q. State Key Lab. of High Speed flow Sichuan Univ. Chengdu 610065 China

A Random Trajectory Model (RTM) for solid-liquid two-phase flow based on the Lagrangian Method is presented in this paper. The effects of water drag force, pressure gradient force, buoyancy and virtual mass force on the particles were included and the turbulent dispersion was modeled by random method. Three-dimensional k-Ε model was used to calculate the flow field. A pumped-storage power station, with a natural lake as its upper pool, was taken as a case for the study. Averaged movement trajectories, velocities and the volume-concentration distributions for 5 groups of sediment particles, were predicted with RTM. The possible silted locations in the lake were also predicted.

关键词： Boundary conditions Computer simulation Lakes Sand Three dimensional Two phase flow Velocity

Specialized deep neural networks for battery health prognostics:Opportunities and challenges

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journal of Energy Chemistry 2023年第12期87卷 416-438,I0011页

作者： jingyuan zhao Xuebing Han Minggao Ouyang Andrew f.Burke Institute of Transportation Studies University of CaliforniaDavisCA 95616USA State Key Laboratory of Automotive Safety and Energy Tsinghua UniversityBeijing 100084China

Lithium-ion batteries are key drivers of the renewable energy revolution,bolstered by progress in battery design,modelling,and ***,achieving high-performance battery health prognostics is a significant *** the availability of open data and software,coupled with automated simulations,deep learning has become an integral component of battery health *** offer a comprehensive overview of potential deep learning techniques specifically designed for modeling and forecasting the dynamics of multiphysics and multiscale battery *** this,we provide a concise summary of publicly available lithium-ion battery test and cycle *** providing illustrative examples,we emphasize the efficacy of five techniques capable of enhancing deep learning for accurate battery state prediction and health-focused *** of these techniques offers unique benefits.(1)Transformer models address challenges using self-attention mechanisms and positional encoding methods.(2) Transfer learning improves learning tasks within a target domain by leveraging knowledge from a source domain.(3) Physics-informed learning uses prior knowledge to enhance learning algorithms.(4)Generative adversarial networks(GANs) earn praise for their ability to generate diverse and high-quality outputs,exhibiting outstanding performance with complex datasets.(5) Deep reinforcement learning enables an agent to make optimal decisions through continuous interactions with its environment,thus maximizing cumulative *** this Review,we highlight examples that employ these techniques for battery health prognostics,summarizing both their challenges and *** methodologies offer promising prospects for researchers and industry professionals,enabling the creation of specialized network architectures that autonomously extract features,especially for long-range spatial-temporal connections across extended *** outcomes could include improved accura

关键词： Lithium-ion batteries State of health Lifetime Deep learning Transformer Transfer learning Physics-informed learning Generative adversarial networks Reinforcement learning Open data

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有限性与延展性:新中国国家安全思想的演进

国际安全研究 2025年第1期43卷 73-95,157页

作者：祁昊天赵书韫北京大学国际关系学院国家安全学系北京100871

文章从国家安全本体论、安全体系认识论与安全实践方法论三个维度考察新中国的国家安全思想,以社会主义革命和建设时期、改革开放和社会主义现代化建设新时期以及中国特色社会主义新时代进行时间分段,讨论新中国国家安全思想的演进。有... 详细信息

文章从国家安全本体论、安全体系认识论与安全实践方法论三个维度考察新中国的国家安全思想,以社会主义革命和建设时期、改革开放和社会主义现代化建设新时期以及中国特色社会主义新时代进行时间分段,讨论新中国国家安全思想的演进。有限性与延展性是这一演进过程中安全思想的连贯体现,分别涵盖了安全目标、认知与方法在各阶段静态与动态、横向与纵向的特征。虽然新中国在不同时期面临不同的安全环境和安全需求,安全形势愈加复杂,但是安全思想和实践总体符合安全有限、延展演进的特征。安全具有弹性但不可过载,不存在绝对安全的空间,而狭义的、单一领域或维度的安全亦无法有效支撑对国家安全的维护,特别是在愈加复杂和不确定的国家安全环境中更是如此。新中国国家安全思想“有限—延展”的演进特征反映了安全环境的客观变化与领导人主观能动的决策部署。

关键词：国家安全思想演进有限性延展性

Sun's Log-concavity Conjecture on the Catalan–Larcombe–french Sequence

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Acta Mathematica Sinica,English Series 2016年第5期32卷 553-558页

作者： james j.Y.zhao Center for Applied Mathematics Tianjin University

Let {Pn},n≥0 denote the Catalan-Larcombe-french sequence, which naturally came from the series expansion of the complete elliptic integral of the first kind. In this paper, we prove the strict log-concavity of the sequence { n√Pn}n≥1, which was originally conjectured by Z. W. Sun. We also obtain the strict log-concavity of the sequence {n√Vn}n≥1, where {Vn}n≥0 is the fennessey-Larcombe- french sequence arising from the series expansion of the complete elliptic integral of the second kind.

关键词： The Catalan-Larcombe-french sequence the fennessey-Larcombe-french sequence logconcavity three-term recurrence relation

A New Emission Mode of PSR B1859+07

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Research in Astronomy and Astrophysics 2023年第10期23卷 176-183页

作者： Tao Wang P.f.Wang j.L.Han Yi Yan Ye-zhao Yu feifei Kou National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China The key Laboratory for Radio Astronomy and Technology Chinese Academy of SciencesBeijing 100101China Qiannan Normal University for Nationalities Duyun 558000China Xinjiang Astronomical Observatories Chinese Academy of SciencesUrumqi 830011China

Previous studies have identified two emission modes in PSR B1859+07: a normal mode that has three prominent components in the average profile, with the trailing one being the brightest, and an anomalous mode(i.e., the A mode) where emissions seem to be shifted to an earlier phase. Within the normal mode, further analysis has revealed the presence of two submodes, i.e., the cW mode and c B mode, where the central component can appear either weak or bright. As for the anomalous mode, a new bright component emerges in the advanced phase while the bright trailing component in the normal mode disappears. New observations of PSR B1859+07 using the fivehundred-meter Aperture Spherical Radio Telescope(fAST) have revealed the existence of a previously unknown emission mode, dubbed the Af mode. In this mode, all emission components seen in the normal and anomalous modes are detected. Notably, the mean polarization profiles of both the A and Af modes exhibit a jump in the orthogonal polarization angle modesin the bright leading component. The polarization angles for the central component in the original normal mode follow two distinct orthogonal polarization modes in the A and Af modes respectively. The polarization angles for the trailing component show almost the same but a small systematic shift in the A and Af modes, roughly following the values for the c W and cB modes. Those polarization features of this newly detected emission mode imply that the anomalous mode A of PSR B1859+07 is not a result of “phase shift”or “swooshes” of normal components, but simply a result of the varying intensities of different profile ***, subpulse drifting has been detected in the leading component of the Af mode.

关键词： (stars:)pulsars:individual(PSR B1859+07) polarization plasmas