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Synthesis of Donor-Acceptorπ-Conjugated Macrocycles by Post-functionalization

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Chinese journal of Chemistry 2021年第10期39卷 2705-2710页

作者： junting wang Qingyun wan junzhi Liu Department of Chemistry and State Key Laboratory of Synthetic Chemistry The University of Hong KongPokfulam RoadHong KongChina

Main observation and conclusion In this paper,two novel donor-acceptor(D-A)macrocyclic compounds 5 and 7 were successfully synthesized by post-functionalization of a planar dimer macrocycle(1)and a highly twisted trimer macrocycle(2),respectively,via controllable oxidation of methoxy groups and condensation between diketones and phenylenediamine in *** with unembellished 9,10-dimethoxyphenanthrene,the resultant dibenzo[a,c]phenazine motif is electron-deficient rather than electron-rich,yielding two D-Aπ-conjugated macrocycles with more contractive energy *** functional theory(DfT)calculations further support the unequivocal evidence of the D-A properties of macrocycles 5 and *** difference of their photophysical properties was investigated by the aid of ultraviolet-visible absorption and fluorescence ***,the stacking patterns of 7 and its contrastπ-conjugated macrocycle trimer(2)were compared via the analysis of X-ray single crystal,in which the electron-deficient dibenzo[a,c]phenazine unit provides extra interaction sites,resulting in orderly arrangement of 7 in the solid state.

关键词： Macrocycles Post-functionalization Donor-acceptor systems Oxidation Stacking interactions

A comprehensive review of radiation effects on solder alloys and solder joints

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Defence Technology（防务技术） 2024年第9期39卷 86-102页

作者： Norliza Ismail wan Yusmawati wan Yusoff Nor Azlian Abdul Manaf Azuraida Amat Nurazlin Ahmad Emee Marina Salleh Department of Physics Centre for Defence Foundation StudiesUniversiti Pertahanan Nasional MalaysiaKem Sungai BesiKuala Lumpur 57000Malaysia Department of Mineral and Geoscience Malaysia Mineral Research CentreJalan Sultan Azlan ShahIpoh 31400PerakMalaysia

In the realm of military and defence applications, exposure to radiation significantly challenges the performance and reliability of solder alloys and joints in electronic systems. This comprehensive review examines radiation-induced effects on solder alloys and solder joints in terms of microstructure and mechanical properties. In this paper, we evaluate the existing literature, including experimental studies and fundamental theory, to provide a comprehensive overview of the behavior of solder materials under radiation. A review of the literature highlights key mechanisms that contribute to radiation-induced changes in the microstructure, such as the formation of intermetallic compounds, grain growth,micro-voids and micro-cracks. Radiation is explored as a factor influencing solder alloy hardness,strength, fatigue and ductility. Moreover, the review addresses the challenges and limitations inherent in studying the effects of radiation on solder materials and offers recommendations for future research. It is crucial to understand radiation-induced effects on solder performance to design robust and radiationresistant electronic systems. A review of radiation effects on solder materials and their applications in electronics serves as a valuable resource for researchers, engineers, and practitioners in that field.

关键词： Defence technology Solder alloy Solder joints Radiation-induced effect Microstructure Mechanical properties

Mathematical Model for Tempering Time Effect on Quenched Steel Based on Hollomon Parameter

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journal of Materials Science & Technology 2005年第6期21卷 803-806页

作者： Nong wan Weihao XIONG jinping SUO State Key Laboratory of Die & Mould Technology Huazhong University of Science and Technology Wuhan 430074 China Department of Mechanical Engineering Wuhan Polytechnic University Wuhan 430023 China

Through the differentiating and integrating process, a mathematical model for tempering time effect on quenched steel was derived based on the attribute of state function and the general equation of Hollomon parameter, which correlates the tempering hardness with the tempering time at different tempering temperature. Using the established model, the linear relationship between the tempering hardness and the tempering time in logarithm was proved theoretically, and the tempering hardness for various tempering time was reduced to the measurement and calculation of a hardness experiment tempered for 1 h at different tempering temperatures. Moreover, the hardness of steel 42CrMo and T8Mn tempered for various times at 200-600℃ was calculated using this method. The predicted results are in good agreement with those of the available experiments.

关键词： Tempering Time effect Mathematical model Hollomon parameter

scEMAIL: Universal and Source-free Annotation Method for scRNA-seq Data with Novel Cell-type Perception

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Genomics, Proteomics & Bioinformatics 2022年第5期20卷 939-958页

作者： Hui wan Liang Chen Minghua Deng School of Mathematical Sciences Peking UniversityBeijing 100871China Huawei Technologies Co. Ltd.Beijing 100080China Center for Statistical Science Peking UniversityBeijing 100871China Center for Quantitative Biology Peking UniversityBeijing 100871China

Current cell-type annotation tools for single-cell RNA sequencing(sc RNA-seq)data mainly utilize well-annotated source data to help identify cell types in target ***,on account of privacy preservation,their requirements for raw source data may not always be *** this case,achieving feature alignment between source and target data explicitly is ***,these methods are barely able to discover the presence of novel cell types.A subjective threshold is often selected by users to detect novel *** propose a universal annotation framework for sc RNA-seq data called sc EMAIL,which automatically detects novel cell types without accessing source data during *** new cell-type identification,a novel cell-type perception module is designed with three ***,an expert ensemble system measures uncertainty of each cell from three complementary ***,based on this measurement,bimodality tests are applied to detect the presence of new cell ***,once assured of their presence,an adaptive threshold via manifold mixup partitions target cells into‘‘known”and‘‘unknown”*** adaptation is then conducted to alleviate the batch *** gather multi-order neighborhood messages globally and impose local affinity regularizations on‘‘known”*** constraints mitigate wrong classifications of the source model via reliable self-supervised information of *** EMAIL is accurate and robust under various scenarios in both simulation and real *** is also flexible to be applied to challenging single-cell ATAC-seq data without loss of *** source code of sc EMAIL can be accessed at https://***/aster-ww/sc EMAIL and https://***/biocode/tools/BT007335/releases/v1.0.

关键词： Cell-type annotation Transfer learning Privacy preservation Single-cell RNA sequencing Gene expression

Legacy effects of historical woodland changes on contemporary plant functional composition

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forest Ecosystems 2023年第5期10卷 569-578页

作者： ji-Zhong wan Chun-jing wang State Key Laboratory of Plateau Ecology and Agriculture Qinghai UniversityXining 810016China Departamento de Ecología Facultad de Ciencias BiologicasPontificia Universidad Catolica de ChileCP 8331150SantiagoChile Centro de Cambio Global UC Facultad de Ciencias BiologicasPontificia Universidad Catolica de ChileCP 8331150SantiagoChile

Considering the legacy of plant functional composition can help assess ecosystem functions and ecosystem services across different spatial scales under land cover *** plants likely respond to natural and anthropogenic perturbations due to historical events(e.g.,agricultural development),thus contemporary plant functional composition may be explained by historical woodland change,a type of land cover *** propose that historical woodland changes may have legacy effects on contemporary plant functional ***,we used partial least squares regression and linear mixed model analyses to test this assumption by coupling data on community weighted means(CWM)and community weighted variance(CWV)of vegetation plots and calculating the time of woodland existence across different periods from AD 0 to *** found that the legacy effects of historical land cover changes on CWM and CWV during the existence time of woodland,particularly from AD 0 to 900,were drivers of contemporary plant functional composition at large spatial ***,historical woodland changes can affect contemporary plant functional composition,depending on the biome ***,the CWM of plant height,seed mass,and seed length showed the strongest correlations with woodland changes from AD 1910 to 2010 in tropics with year-round rain,and the CWM of leaf traits correlated with woodland changes from AD 0 to 1700 in tropics with summer *** study provides the effective evidence on the legacy of historical woodland changes and the effects on contemporary plant functional composition,which is crucial with respect to effective management of plant diversity and assessing ecosystem functions and services from local to global scales over time.

关键词： Biome Community weighted means Global scale Historical woodland Land cover Plant functional trait

Evaluation of fitness of design in urban historical context： from the perspectives of residents

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frontiers of Architectural Research 2013年第1期2卷 85-93页

作者： Hesamaddin Sotoudeh wan Mohd Zakri wan Abdullah Architecture Department Faculty of Built Environment Universiti Teknologi Malaysia Johor 81310 Malaysia

Historic city cores in many countries either fell into neglect or suffered from harmful developments. Due to a variety of reasons, conservation projects failed to preserve sociocultural assets of historic environments. One of these reasons is that experts who involve in the development of historical context completely disregard the communities in such historic areas or their inhabitants. This paper Looks into residents＇ preferences on infiU design projects as part of urban development in historical contexts. It aims to investigate preference ratings of those residents who Live in urban historical context in terms of the quality of new infill design and its relationship to the historical surroundings. This research attempts to evaluate the best design strategies from the point view of the residents as well as the effects of cognitive properties on their preferences. Methodologically, a case study approach was adopted with 204 residents as participants in this survey. The contributive elements that are essential to the quality of fitness are identified through quantitative analysis. The findings of this research indicate that the most preferred design strategies are ＂Literal Replication＂ and ＂Invention within Style＂ from the perspective of the residents, who prefer, to a greater degree, new buildings in historical context replicating something from their surroundings. These findings are useful to experts and major organisations to conduct successful infill development, with consideration of the perceptions of the residents on the changes in their historical context.

关键词： Residents' preferences Desisn quality fitness Historical context

Improved Test Case Selection Algorithm to Reduce Time in Regression Testing

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Computers, Materials & Continua 2022年第7期72卷 635-650页

作者： Israr Ghani wan M.N.wan-Kadir Adila firdaus Arbain Noraini Ibrahim School of Computing Faculty of EngineeringUniversiti Teknologi Malaysia(UTM)Johor Bahru81310Malaysia

Regression testing(RT)is an essential but an expensive activity in software *** confirms that new faults/errors will not have occurred in the modified *** efficiency can be improved through an effective technique of selected only modified test cases that appropriate to the modifications within the given time ***,several test case selection approaches have been introduced,but either these techniques were not sufficient according to the requirements of software tester experts or they are ineffective and cannot be used for available test suite specifications and *** address these limitations,we recommend an improved and efficient test case selection(TCS)algorithm for *** proposed technique decreases the execution time and redundancy of the duplicate test cases(TC)and detects onlymodified changes that appropriate to themodifications in test *** reduce execution time for TCS,evaluation results of our proposed approach are established on fault detection,redundancy and already executed test *** indicate that proposed technique decreases the inclusive testing time of TCS to execute modified test cases by,on average related to a method of Hybrid Whale Algorithm(HWOA),which is a progressive TCS approach in regression testing for a single product.

关键词： Test case selection regression testing change detection TCS algorithm test suite minimization

Uncovering pharmacological mechanisms of Phellinus linteus on focal segmental glomeruloscleosis rats through tandem mass tag-based quantitative proteomic analysis,network pharmacology analysis and experimental validation

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journal of Traditional Chinese Medicine 2023年第4期43卷 744-750页

作者： wan feng YANG Ruchun TANG Yuewen Department of Nephrology Key Laboratory of Kidney Disease Prevention and Control TechnologyHangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical UniversityHangzhou 310007China

OBjECTIVE:To explore the underlying molecular mechanism of Phellinus linteus(***).METHODS:We used a tandem mass tag-based quantitative proteomic method to determine the differentially expressed *** pharmacology analysis was used to analysis the main components of *** and construct the compound-target *** blotting and quantitative real-time polymerase chain reaction(qRT-PCR)were used to validate the analyses ***:The expression levels of thrombospondin-1(TSP-1)and transforming growth factor(TGf)-β1/Smad3 signaling pathway proteins were significantly upregulated in focal segmental glomeruloscleosis(fSGS)*** *** reduced the expression levels of TSP-1 and TGf-β1 signaling pathway *** pharmacology analysis revealed that protocatechualdehyde was the main active *** in vivo and in vitro experiments validated the results of proteomic and network pharmacology ***:Our results suggested that *** may inhibit renal sclerosis by inhibiting TSP-1-activated TGf-β1 signaling and may have potential applications in the treatment of fSGS.

关键词： Phellinus glomerulosclerosis focal segmental thrombospondin 1 transforming growth factor beta1 smad3 protein

Performance evaluation of HY-2 series satellites in marine gravity field recovery

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Geodesy and Geodynamics 2024年第4期15卷 397-403页

作者： Ruijie Hao Xiaoyun wan Keyan Zhang School of Land Science and Technology China University of Geosciences(Beijing)Beijing100083China School of Geospatial Engineering and Science Sun Yat-Sen UniversityZhuhai519082China

China has successfully launched four Haiyang-2(HY-2)series altimetry ***-2A has attracted significant attention in gravity field recovery,but the performance of other HY-2 series satellites,including HY-2B/C/D,is seldom *** study evaluated the performance of all the HY-2 series satellites in recovering marine gravity ***,the crossover discrepancies in sea surface height of the four satellites,HY-2A,HY-2B,HY-2C,and HY-2D,were analyzed to assess their altimetry *** was found that HY-2B had the best altimetry quality,followed by ***,different combina-tions of altimetry data were used to calculate vertical deflections and gravity anomalies in the South China Sea(112°E-119°E,12°N-20°N).The results showed that combining data from HY-2B,HY-2C,and HY-2D improved the inversion accuracy of gravity anomalies by 0.3 mGal compared to using HY-2A data ***-2C and HY-2D contributed to enhancing the accuracy of the east component of vertical deflections.

关键词： Satellite altimetry HY-2 Sea surfaceheight Marinegravityfield