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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： Li Xu Huiming Xu Changyong tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong tang Nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang jiali Wu Yu Wang Hanlin Huang jun Ke feng Chen Shengli Clinical Medical College of fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

Parrondo's paradox for chaos control and anticontrol of fractional-order systems

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Chinese Physics B 2016年第1期25卷 507-513页

作者： Marius-f Danca Wallace K S tang Department of Mathematics and Computer Science Avram Iancu University Romanian Institute for Science and Technology Department of Electronic Engineering City University of Hong Kong

We present the generalized forms of Parrondo＇s paradox existing in fractional-order nonlinear systems. The gener- alization is implemented by applying a parameter switching （PS） algorithm to the corresponding initial value problems associated with the fractional-order nonlinear systems. The PS algorithm switches a system parameter within a specific set of N 〉 2 values when solving the system with some numerical integration method. It is proven that any attractor of the concerned system can be approximated numerically. By replacing the words ＂winning＂ and ＂loosing＂ in the classical Parrondo＇s paradox with ＂order＂ and ＂chaos＂, respectively, the PS algorithm leads to the generalized Parrondo＇s paradox： chaos1 ＋ chaos2 ＋..- ＋ chaosN = order and order1 ＋ order2 ＋.-. ＋ orderN = chaos. finally, the concept is well demon- strated with the results based on the fractional-order Chen system.

关键词： Parrondo's paradox chaos control parameter switching algorithm fractional-order Chen system

基于稀疏注意力卷积ViT模型的锌浮选工况识别

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工程科学学报 2025年第2期47卷 328-338页

作者：苏越唐朝晖谢永芳高小亮张虎马炜烨汤海玚中南大学自动化学院中南大学数学与统计学院

准确识别锌浮选工况并用于指导锌浮选操作，可以提高浮选效率、优化选矿过程.目前浮选现场主要通过人工肉眼观察泡沫并依据经验判断工况，这种方法主观性强，难以客观准确地评价锌浮选工况.针对该问题，本文通过研究锌浮选泡沫视觉特征... 详细信息

准确识别锌浮选工况并用于指导锌浮选操作，可以提高浮选效率、优化选矿过程.目前浮选现场主要通过人工肉眼观察泡沫并依据经验判断工况，这种方法主观性强，难以客观准确地评价锌浮选工况.针对该问题，本文通过研究锌浮选泡沫视觉特征和浮选工况的密切联系，提出基于稀疏注意力卷积ViT模型的锌浮选工况识别方法.首先，所提模型融合了卷积神经网络（Convolutional neural networks, CNN）和视觉Transformer(Vision transformer,ViT)的结构和优点，同时感知泡沫局部空间信息和全局信息，完备表征泡沫图像.其次，模型引入稀疏的多头注意力机制，每个注意力头以不同的稀疏程度处理特征，从不同尺度下感知全局信息，同时引入注意力门控单元优化特征传递，最终实现锌浮选工况识别.实验结果表明，本文所提工况识别方法在锌浮选泡沫图像数据集上的准确率达到88.62%，解决了传统CNN和ViT模型不能充分利用泡沫图像全局信息，且无法自适应捕捉泡沫图像重要特征的问题，为浮选流程优化提供有力支持.

关键词：工况识别卷积神经网络视觉Transformer 稀疏注意力泡沫浮选

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Phase transition and dynamics of iron under ramp wave compression

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Acta Mechanica Sinica 2018年第5期34卷 902-909页

作者： T.Chong Z.P.tang f.L.Tan G.j.Wang j.H.Zhao Department of Modern Mechanics University of Science and Technology of ChinaHefei 230027China Institute of fluid Physics China Academy of Engineering PhysicsMianyang 621999China

The ramp wave compression experiments of iron with different thicknesses were performed on the magnetically driven ramp loading device *** simulations of this process were done with Hayes multi-phase equation of state (H-MEOS) and dynamic equations of phase *** calculated results of H-MEOS are in good agreement with those of shock phase transition,but are different from those under ramp wave *** reason for this is that the bulk modulus of the material in the Hayes model and the wave velocity are considered *** compression is a jump from the initial state to the final state,and the sound speed is related to the slope of the Rayleigh ***,ramp compression is a continuous process,and the bulk modulus is no longer a constant but a function of pressure and *** on Mumaghan equation of state,the first-order correction of the bulk modulus on pressure in the Hayes model was carried *** numerical results of the corrected H-MEOS agree well with those of pure iron in both ramp and shock compression phase transition *** calculated results show that the relaxation time of iron is about 30 ns and the phase transition pressure is about 13 *** are obvious differences between the isentropic and adiabatic process in terms of pressure-specific volume and *** fluctuation of the sound speed after 13 GPa is caused by the phase transition.

关键词： Ramp wave compression Polymorphic phase transition Multiphase equation of state Sound speed

基于热处理工艺的拖拉机发动机铝合金组织性能研究

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农机化研究 2025年第1期47卷 243-247页

作者：汤金金李好娜济源职业技术学院河南济源454650 郑州大学济源研究院河南济源454650

采用不同时长的热处理工艺,对拖拉机发动机铝合金组织性能进行了对比分析。结果表明:热处理后,铝合金性能得到了较大程度的提高,若优先考虑材料性能,则应该采用180℃×4 h的单级热处理时效;若优先考虑工艺效率和成本,则可以采用150℃×1... 详细信息

采用不同时长的热处理工艺,对拖拉机发动机铝合金组织性能进行了对比分析。结果表明:热处理后,铝合金性能得到了较大程度的提高,若优先考虑材料性能,则应该采用180℃×4 h的单级热处理时效;若优先考虑工艺效率和成本,则可以采用150℃×1 h+170℃×1 h的双级热处理时效。

关键词：热处理工艺拖拉机发动机铝合金组织性能

数字经济驱动扬州先进制造业与现代服务业融合的路径研究

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江苏商论 2025年第1期 66-69页

作者：唐建扬州职业大学管理学院江苏扬州225100

在先进制造业与现代服务业融合的过程中,数字经济贯穿其中。文章阐述了数字经济对“两业”融合的作用,并在目前扬州“两业”融合基础之上,总结了扬州“两业”融合中的问题,提出了数字经济促进扬州“两业”融合的路径。

关键词：数字经济先进制造业现代服务业产业融合

A PARAMETER-UNIfORM TAILORED fINITE POINT METHOD fOR SINGULARLY PERTURBED LINEAR ODE SYSTEMS＊

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journal of Computational Mathematics 2013年第4期31卷 422-438页

作者： Houde Han j.j.H. Miller Min tang Department of Mathematical Sciences Tsinghua University Beijing 100084 China Department of Mathematics Trinity College Dublin 2 Ireland Key Laboratory of Scientific and Engineering Computing Department of Mathematics and Institute of Natural Sciences Shanghai Jiao Tong University Shanghai 200240 China

In scientific applications from plasma to chemical kinetics, a wide range of temporal scales can present in a system of differential equations. A major difficulty is encountered due to the stiffness of the system and it is required to develop fast numerical schemes that are able to access previously unattainable parameter regimes. In this work, we consider an initial-final value problem for a multi-scale singularly perturbed system of linear ordi- nary differential equations with discontinuous coefficients. We construct a tailored finite point method, which yields approximate solutions that converge in the maximum norm, uniformly with respect to the singular perturbation parameters, to the exact solution. A parameter-uniform error estimate in the maximum norm is also proved. The results of numerical experiments, that support the theoretical results, are reported.

关键词： Tailored finite point method Parameter uniform Singular perturbation ODEsystem.

RP-based Abrading Technique for Graphite EDM Electrode

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journal of Materials Science & Technology 2002年第6期18卷 572-574页

作者： tang, YP Zhou, HZ Hong, j Lu, BH Xian jiaotong Univ Inst Adv Mfg Technol Xian 710049 Peoples R China

Traditional processes for machining mold cavities are lengthy and costly. EDM (electro-discharge machining) is the most commonly used technique to obtain complex mold cavities. However, some electrodes are difficult to fabricate because of the complexity. Applying RP (rapid prototyping) technology to fabricate an abrading tool which is used to abrade graphite EDM electrodes, the cost and cycle time can greatly be reduced. The paper describes the work being conducted in this area by the authors. This technique will find widespread application in rapid steel mold manufacturing.

关键词： Rapid prototyping EDM Electrode Abrading