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CD4^(+)T cells produce IfN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors

Cellular & Molecular Immunology 2024年第4期21卷 374-392页

作者： Xin Lei Daniël C.de Groot Marij j.P.Welters Tom de Wit Ellen Schrama Hans van Eenennaam Saskia j.Santegoets Timo Oosenbrug Annemarthe van der Veen joris L.Vos Charlotte L.Zuur Noel f.C.C.de Miranda Heinz jacobs Sjoerd H.van der Burg jannie Borst Yanling Xiao Department of Immunology Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands Department of Tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Medical Oncology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOS B.V. OssThe Netherlands Division of Medical Oncology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Otorhinolaryngology Leiden University Medical Center LeidenThe Netherlands Department of Pathology Leiden University Medical CenterLeidenThe Netherlands

CD4^(+)T cells can"help"or"license" conventional type 1 dendritic cells(cDC1s)to induce CD8^(+)cytotoxic T lymphocyte(CTL)anticancer responses,as proven in mouse *** recently identified cDC1s with a transcriptomic imprint of CD4^(+)T-cell help,specifically in T-cell-infiltrated human cancers,and these cells were associated with a good prognosis and response to PD-1-targeting ***,we delineate the mechanism of cDC1 licensing by CD4^(+)T cells in *** CD4^(+)T cells produce IfNβvia the STING pathway,which promotes MHC-I antigen(cross-)presentation by cDC1s and thereby improves their ability to induce CTL anticancer *** cooperation with CD40 ligand(L),IfNβalso optimizes the costimulatory and other functions of cDC1s required for CTL response ***-I-producing CD4^(+)T cells are present in diverse T-cell-infiltrated cancers and likely deliver“help”signals to CTLs locally,according to their transcriptomic profile and colocalization with“helped/licensed”cDCs and tumor-reactive CD8^(+)T *** agreement with this scenario,the presence of IfN-I-producing CD4^(+)T cells in the TME is associated with overall survival and the response to PD-1 checkpoint blockade in cancer patients.

关键词： CD4^(+)T-cell help cDC1 licensing IfN-I signaling CD40 costimulation (cross-)presentation CTL priming Tumor control

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Resurgence of dengue in the Philippines

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World journal of Virology 2024年第3期13卷 7-9页

作者： jasmine S Interior Kyrsten jannae j Bigay Remigo Angelo A Iringan Mary Beth f Tanco St.Luke's Medical Center College of Medicine-William H.Quasha Memorial Quezon 1112Philippines

The coronavirus disease 2019(COVID-19)pandemic has significantly influenced the epidemiological landscape of various infectious diseases such as *** is an endemic disease in the Philippines,which showed a significant de-cline in the number of cases beginning in March 2020 due to the stringent public health measures implemented to curb COVID-19 ***,the easing of these restrictions subsequently led to a resurgence in dengue cases,as reported by the World Health Organization,with a notable increase compared to previous *** the country navigates towards a post-pandemic phase,addressing the resurgence of dengue requires sustained efforts in vector control,surveillance,and healthcare *** article underscores the critical need for collab-orative efforts among stakeholders to mitigate the resurgence of dengue while managing the ongoing recovery from the COVID-19 pandemic.

关键词： Dengue Dengue fever COVID-19 Pandemic SARS-CoV-2 Philippines

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BaTiO_(3)solid solutions co-doped with Gd^(3+)and Eu^(3+):Synthesis,structural evolution and dielectric properties

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journal of Rare Earths 2024年第10期42卷 1920-1926页

作者： R.Martínez-López M.Pérez-Labra j.A.Romero-Serrano f.R.Barrientos-Hernández M.Reyes-Pérez M.I.Valenzuela-Carrillo G.Urbano-Reyes V.E.Reyes-Cruz G.I.Dávila-Pulido Academic Area of Earth Sciences and Materials Autonomous University of Hidalgo StateRoad Pachuca-Tulancingo Km 4.5 Mineral de La Reforma.Hidalgo42184Mexico Metallurgy and Materials Department ESIQIE-IPNUPALMZacatencoCiudad de Mexico07738Mexico Autonomous University of Coahuila Boulevard Adolfo López Mateos S/nNueva RositaCoahuila26800Mexico

In this paper,the synthesis,structural evolution,and dielectric properties of BaTiO_(3)solid solutions codoped with rare earth elements(Gd^(3+)and Eu^(3+))prepared using the solid-state reaction method are *** pure precursor powders of BaCl_3,TiO_(2),Gd_(2)O_(3),and Eu_(2)O_(3)were mixed in stoichiometric proportions,ground in an agate mortar before being uniaxially pressed at 250 MPa and sintered at 1300℃in air atmosphere for 6 h to obtain Ba_(1-3x)Gd_(2x)Ti_(1-3x)Eu_(4x)O_(3)(x=0,0.0015,0.01 and0.1).X-ray diffraction(XRD)and Rietveld's refinement results reveal the crystal phase ferroelectric tetragonal BaTiO_(3)for the samples with x=0,0.0015 and 0.01,as well as a consistent increment in the lattice parameters caused by the *** solubility limit of Gd^(3+)and Eu^(3+)in the BaTiO_(3)structure is reached for the sample with x>0.01,and the orthorhombic Eu_2TiO_(5)and monoclinic BaTi_(2)O_(5)secondary phases were *** Raman results show the characteristic peaks of ferroelectric tetragonal BaTiO_(3)around 716 cm^(-1)(LO of A1 symmetry),515 cm^(-1)(TO of A1 symmetry),and 305 cm^(-1)(B1).The maximum relative permittivity measured at 1 kHz was recorded to be 6151.8 for the sample with x=0.0015,and a decrease in the Curie temperature to 105℃with respect to the undoped sample was *** punctual microanalysis for the samples with x=0.0015,0.01,and 0.1 reveals grains composed of Ba,Ti,O,Gd,and Eu homogeneously distributed in the BaTiO_(3)*** Ba/Ti ratios for samples with x=0.0015,0.01 and 0.1 are 2.86,2.91,and 0.68,respectively,indicating substitution at the Ti site for samples with x=0.0015 and 0.01 and a substitution at the Ba site for the sample with x=0.1.

关键词： BaTiO_(3) Doping Gadolinium Europium Synthesis Rare earths

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Synthesis of Silver Nanoparticles from Honeybees and Its Antibacterial Potential

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Open journal of Medical Microbiology 2024年第1期14卷 77-92页

作者： Akamu j. Ewunkem Niore’s johnson A’lyiha f. Beard Ilunga Tshimanga Brittany justice jeffery Meixner Department of Biological Sciences Winston Salem State University Winston Salem NC USA Department of Clinical Science and Laboratory Science Winston Salem State University Winston Salem NC USA

Honeybees (Apis mellifera) are important pollinators of flowering plants and agricultural crops contributing annually to billions of dollars in revenues to crop production. Honeybees have an average lifespan between 8 weeks to 5 years. Dead honeybees are abundantly available in beehives and can be utilized as an alternative source to synthesize nanoparticles. In recent years, biologically synthesized nanoparticles have been preferred over their chemical counterparts. However, honeybee-based-green synthesis of nanoparticles has not been explored yet. Herein, we report the biosynthesis of silver nanoparticles from honeybees and its antibacterial activity. The synthesis of silver nanoparticles was monitored visually through a gradual change in color. furthermore, the biosynthesized nanoparticles were confirmed and characterized by UV-visible spectroscopy. Scanning Electron Microscope was utilized to analyze the average size and morphologies of the biosynthesized nanoparticles. Subsequently, the antibacterial potential of the biosynthesized silver nanoparticles was tested against selected Gram-positive and Gram-negative bacterial strains. It was found that a distinct color change from yellow to brown in the reaction solution suggested the formation of silver nanoparticles. The biosynthesized nanoparticles exhibited absorption maxima at 430 nm. The SEM analysis confirmed the spherical and cuboidal shape of the biosynthesized silver nanoparticles with a size range between 10 - 40 nm. furthermore, the biosynthesized silver nanoparticles exhibited strong antimicrobial potential against tested Gram-positive and Gram-negative bacteria strains by aggregating on the cell surface. This study showcases the biomedical and agricultural applications of biosynthesized silver nanoparticles from honeybee wings. .

关键词： Honeybee Bacteria Green Synthesis Nanoparticles Antimicrobial

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Ground-based and additional science support for SMILE

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Earth and Planetary Physics 2024年第1期8卷 275-298页

作者： j.A.Carter M.Dunlop C.forsyth K.Oksavik E.Donovon A.Kavanagh S.E.Milan T.Sergienko R.C.fear D.G.Sibeck M.Connors T.Yeoman X.Tan M.G.G.T.Taylor K.McWilliams j.Gjerloev R.Barnes D.D.Billet G.Chisham A.Dimmock M.P.freeman D.-S.Han M.D.Hartinger S.-Y.W.Hsieh Z.-j.Hu M.K.james L.juusola K.Kauristie E.A.Kronberg M.Lester j.Manuel j.Matzka I.McCrea Y.Miyoshi j.Rae L.Ren f.Sigernes E.Spanswick K.Sterne A.Steuwer T.Sun M.-T.Walach B.Walsh C.Wang j.Weygand j.Wild j.Yan j.Zhang Q.-H.Zhang Planetary Sciences Group School of Physics and AstronomyUniversity of LeicesterUniversity RoadLeicesterLE17RHUK Rutherford Appleton Laboratory Space Science Technology Facilities CouncilOxfordshireUK School of Space and Environment Beihang UniversityBeijing 100191China Key Laboratory of Space Environment Monitoring and Information Processing Ministry of Industry and Information TechnologyBeijing 100017China Department of Space and Climate Physics UCLMullard Space Science LaboratoryHolmbury St.MaryDorkingSurreyRH56NTUK Birkeland Centre for Space Science Department of Physics and Technology.University of BergenBergenNorway Department of Physics and Astronomy University of Calgary2500 University DriveCalgaryAlbertaCanada T2N 1N4 British Antarctic Survey CambridgeUK Swedish Institute of Space Physics KirunaSweden West Highfield Campus University of SouthamptonUniversity RoadSO171BJUK Goddard Space flight Center NASAGreenbeltMarylandUSA Athabasca University AthabascaCanada ESTEC European Space AgencyNetherlands University of Saskatchewan SaskatoonCanada The johns Hopkins University Applied Physics Laboratory LaurelMarylandUSA Swedish Institude of Space Physics UppsalaSE 75121Sweden Tongji University Shanghai 200092China Center for Space Plasma Physics Space Science Institute4765 Walnut Street Suite BBoulderColorado80301USA Polar Research Institute of China Shanghai 200136China finnish Meteorological Institute(fMI) Finland Department of Earth and Environmental Sciences(Geophysics) Ludwig Maximilian University of Munich(LMU)MunichTheresienstr.41MunichD-80333Germany Canadian Space Agency MontrealCanada GfZ German Research Centre for Geosciences PotsdamGermany Nagoya University Institute for Space Earth Environment ResearchCenter for Integrated Data ScienceNagoyaAichiJP 464-8601 Northumbria University Newcastle upon TyneTyne and WearUK NE18ST National Space Science Center Chinese Academy SciencesBeijing 100190China Arctic Geophysics University Centre in Svalbard

The joint European Space Agency and Chinese Academy of Sciences Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission will explore global dynamics of the magnetosphere under varying solar wind and interplanetary magnetic field conditions,and simultaneously monitor the auroral response of the Northern Hemisphere *** these large-scale responses with medium and fine-scale measurements at a variety of cadences by additional ground-based and space-based instruments will enable a much greater scientific impact beyond the original goals of the SMILE ***,we describe current community efforts to prepare for SMILE,and the benefits and context various experiments that have explicitly expressed support for SMILE can offer.A dedicated group of international scientists representing many different experiment types and geographical locations,the Ground-based and Additional Science Working Group,is facilitating these *** include constructing an online SMILE Data fusion facility,the discussion of particular or special modes for experiments such as coherent and incoherent scatter radar,and the consideration of particular observing strategies and spacecraft *** anticipate growing interest and community engagement with the SMILE mission,and we welcome novel ideas and insights from the solar-terrestrial community.

关键词： magnetosphere ionosphere magnetosphere-ionosphere coupling ground-based experimentation SMILE conjunctions missions

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亚热带森林植物的叶片和根系功能性状部分耦合但具有不同的群落性状分布格局

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journal of Plant Ecology 2024年第1期17卷 94-110页

作者： Wenqi Luo Oscar j Valverde-Barrantes Monique Weemstra james f Cahill jr Zi Wang Dong He Yongfa Chen Chengjin Chu Youshi Wang State Key Laboratory of Biocontrol School of Life Sciences/School of EcologySun Yat-sen UniversityGuangzhou 510275China International Center for Tropical Botany Department of Biological SciencesFlorida International UniversityMiamiFL 33199USA Department of Biological Sciences University of AlbertaEdmontonABT6G 2E9Canada School of Ecology and the Environment Xinjiang UniversityUrumqi 830046China

植物的生态过程依赖于叶片和根系的功能运行,但少有研究同时关注这两类性状在群落中的分布格局(CTD)。本文测定了广东亚热带森林44种共生木本植物的16个叶片和根系性状,旨在检验类比的叶片和根系性状是否耦合,是否沿类似的功能性状谱变... 详细信息

植物的生态过程依赖于叶片和根系的功能运行,但少有研究同时关注这两类性状在群落中的分布格局(CTD)。本文测定了广东亚热带森林44种共生木本植物的16个叶片和根系性状,旨在检验类比的叶片和根系性状是否耦合,是否沿类似的功能性状谱变异,是否表现出类似的CTD,其CTD和群落加权平均性状值(CWM)是否沿环境梯度表现出类似的响应。研究结果表明,叶片和根系性状变异的第一轴均呈显出由资源获取向资源保守变异的经济学谱,但叶片变异的第二轴主要由叶片碳含量表征,而根系变异的第二轴主要由反映菌根协作程度的根系粗细表征。类比的叶片和根系化学性状整体正相关,但形态性状的耦合程度较低。在群落水平上,叶片和根系性状第一轴的CWM均随海拔升高而变得更保守,而第二轴的变化则不一致。随土壤磷含量的降低或钾含量的升高,根系变得更细和在养分性状上更保守,而叶片性状无显著变化。当整合多维性状轴时,叶片性状呈发散格局,且随海拔、土壤磷和钾含量的增加呈收敛趋势;而根系性状呈收敛格局,但沿上述环境梯度呈发散趋势。该研究强调,叶片和根系性状与环境互作的差异可能导致不同的性状分布格局;植物可通过多样的地上和地下功能设计应对环境异质性。

关键词：性状维度群落构建叶片性状根系性状植物经济谱群落性状结构亚热带森林

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Methionine sources and genotype affect embryonic intestinal development,antioxidants,tight junctions,and growth-related gene expression in chickens

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Animal Nutrition 2024年第1期16卷 218-230页

作者： james K.Lugata Sawadi f.Ndunguru Gebrehaweria K.Reda Xénia E.Ozsváth Eszter Angyal Levente Czeglédi Gabriella Gulyás Renáta Knop jános Oláh Zoltán Mészár Rita Varga Brigitta Csernus Csaba Szabó Department of Animal Nutrition and Physiology Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary Department of Animal Husbandry Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary faculty of Agriculture and food Sciences and Environmental Management Doctoral School of Animal ScienceUniversity of DebrecenDebrecenHungary Institutes for Agricultural Research and Educational farm University of DebrecenDebrecenHungary Department of Anatomy Histology and EmbryologyFaculty of MedicineUniversity of DebrecenDebrecenHungary Department of Evolutionary Zoology and Human Biology Faculty of Science and TechnologyUniversity of DebrecenDebrecenHungary

Methionine(Met)is an essential and first limiting amino acid in the poultry diet that plays a significant role in chicken embryonic development and *** present study examined the effect of in ovo injection of DL-Met and L-Met sources and genotypes on chicken embryonic-intestinal development and *** eggs of the two genotypes,TETRA-SL layer hybrid(TSL)—commercial layer hybrid and Hungarian Partridge colored hen breed(HPC)—a native genotype,were randomly distributed into four treatments for each *** treatment groups include the following:1)control non-injected eggs(NoIn);2)saline-injected(SaIn);3)DL-Met injected(DLM);and 4)L-Met injected(LM).The in ovo injection was carried out on 17.5 d of embryonic development;after hatching,eight chicks per group were sacrificed,and the jejunum was extracted for *** results showed that both DLM and LM groups had enhanced intestinal development as evidenced by increased villus width,villus height,and villus area(Pficantly reduced crypt depth,glutathione(GSH)content,glutathione S-transferase 3 alpha(GST3),occludin(OCLN)gene expression and increased villus height to crypt depth ratio in the TSL genotype than the LM group(Pfactor 1(IGf1)gene,tricellulin(MD2),occludin(OCLN),superoxide dismutase 1(SOD1),and GST3 genes than the TSL genotype(Pfindings showed that in ovo injection of Met enhanced intestinal development,and function,with genotypes responding differently under normal *** also influenced the expression of intestinal antioxidants,tight junction,and growth-related genes.

关键词： DL-Methionine L-Methionine In ovo injection Intestinal development Poultry

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Considerations for the use of porcine organ donation models in preclinical organ donor intervention research

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Animal Models and Experimental Medicine 2024年第3期7卷 283-296页

作者： frazer I.Heinis Shaheed Merani Nicholas W.Markin Kim f.Duncan Michael j.Moulton Lance fristoe William E.Thorell Raechel A.Sherrick Tami R.Wells Matthew T.Andrews Marian Urban School of Natural Resources Institute of Agriculture and Natural ResourcesUniversity of Nebraska-LincolnLincolnNebraskaUSA Division of Transplantation and Vascular Surgery Department of SurgeryUniversity of Nebraska Medical CenterOmahaNebraskaUSA Department of Anesthesiology University of Nebraska Medical CenterOmahaNebraskaUSA Division of Cardiothoracic Surgery Department of SurgeryUniversity of Nebraska Medical CenterOmahaNebraskaUSA Clinical Perfusion Nebraska Medicine-Nebraska Medical CenterOmahaNebraskaUSA Department of Neurosurgery University of Nebraska Medical CenterOmahaNebraskaUSA Nutrition and Health Sciences College of Education and Human SciencesUniversity of Nebraska-LincolnLincolnNebraskaUSA Department of Comparative Medicine University of Nebraska Medical CenterOmahaNebraskaUSA

Use of animal models in preclinical transplant research is essential to the optimization of human allografts for clinical *** models of organ donation and preservation help to advance and improve technical elements of solid organ recovery and facilitate research of ischemia-reperfusion injury,organ preservation strategies,and future donor-based *** considerations include cost,public opinion regarding the conduct of animal research,translational value,and relevance of the animal model for clinical *** present an overview of two porcine models of organ donation:donation following brain death(DBD)and donation following circulatory death(DCD).The cardiovascular anatomy and physiology of pigs closely resembles those of humans,making this species the most appropriate for pre-clinical *** are also considered a potential source of organs for human heart and kidney *** is imperative to minimize animal loss during procedures that are surgically *** present our experience with these models and describe in detail the use cases,procedural approach,challenges,alternatives,and limitations of each model.

关键词： animal model brain death circulatory death organ transplantation

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Understanding intrarenal backflow: Intrarenal pressure during ureteroscopy and beyond

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Asian journal of Urology 2024年第2期11卷 139-142页

作者： Palle j.S.Osther Susanne S.Osther Maria P.Hesselholt Sofia Byllov Søren K.Lildal Louise f.Øbro Helene jung Urological Research Center Department of UrologyVejle Hospital(a part of Lillebaelt Hospital)University Hospital of Southern DenmarkVejleDenmark Department of Regional Health Research University of Southern DenmarkOdenseDenmark

The number of ureterorenoscopic procedures for upper urinary tract stone management has increased dramatically during recent years worldwide[1].Developments in flexible ureteroscope and laser technology have made it possible to successfully address larger and more complex stone scenarios *** the other hand,this means that more and more patients are exposed to the potential adverse effects of ureteroscopy[2].In general,ureteroscopy is considered a safe ***,serious complications and even deaths do occur,and these events are most likely underreported[3,4].

关键词： beyond likely ureter

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ITPK1 is an InsP_(6)/ADP phosphotransferase that controls phosphate signaling in Arabidopsis

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Molecular Plant 2024年第7期17卷 1151-1157页

作者： Esther Riemer Danye Qiu Debabrata Laha Robert K.Harmel Philipp Gaugler Verena Gaugler Michael frei Mohammad-Reza Hajirezaei Nargis Parvin Laha Lukas Krusenbaum Robin Schneider Adolfo Saiardi Dorothea fiedler Henning j.jessen Gabriel Schaaf Ricardo f.H.Giehi 不详

(Molecular Plant 14,1864-1880;November 12021)We identified a mistake made when calculating the absolute concentrations of inositol(pyro)phosphates derived from CE-ESl-MS measurements reported in the originally published version of our *** to a calculation error when determining concentrations per fresh biomass,the absolute values shown in the manuscript are approximately 30-fold lower than they should *** mistake affects figures 2D,3C,4C,and 7D and figures S4,S11B,S13,and *** all conclusions made in the article referred to relative differences between genotypes and treatments,they remained unaffected by these mistakes.

关键词： ipt Arabidopsis absolute

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