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吸气阻力:一种新的呼吸技术显著提高上、下腔静脉血流量比

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国际医学放射学杂志 2015年第1期 93-94页

作者： A.Gutzeit j.e.roos K.Hergan C.von Weymarn S.Wlti C.Reischauer Institute of Radiology and Nuclear Medicine Clinical Research Unit of St.Anna Hospital Luzern

目的肺动脉内的最优对比是通过对比强化血液流经上腔静脉(SVC)的最大量来实现,而最小量非对比血液应当起自下腔静脉(IVC)。这项研究旨在证实"吸气阻力"是

关键词：吸气阻力最大量 SVC 上腔静脉 IVC 下腔静脉肺动脉

下肢周围动脉闭塞性疾病病人行心电图触发非对比增强MR血管成像(TRANCe)和数字减影血管造影(DSA)的对比研究

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国际医学放射学杂志 2011年第6期 603-603页

作者： A.Gutzeit R.Sutter j.M.Froehlich j.e.roos T.Sautter e.Schoch 刘珍珍 Department of Radiology Cantonal Hospital WinterthurBrauerstrasse 158401 WinterthurSwitzerland

目的对心电触发非对比增强MR血管成像(TRANCe)和数字减影血管造影(DSA)诊断下肢(包括足部)周围动脉闭塞的诊断价值进行前瞻性对比研究。方法43例有症状的周围动脉闭塞疾病(PAOD)病人在DSA检查前进行TRANCe检查。将MR血管成像(MRA)显示下肢

关键词：非对比增强MR血管成像数字减影血管造影下肢周围动脉闭塞性疾病肾毒性

NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

利用CT扫描以搜索、辨认和确定为特征检出肺结节:眼睛追踪研究

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国际医学放射学杂志 2015年第2期 173-173页

作者： G.D.Rubin j.e.roos M.Tall B.Harrawood S.Bag D.L.Ly 焦慧 Duke Clinical Research Institute Department of Radiology Duke University School of Medicine Durham NC

摘要目的探讨放射科医生在CT影像上用眼睛追踪来搜索、辨认和确认肺结节的作用。材料与方法本研究经机构伦理委员会审议通过。所有受试者提供了知情同意书,依照

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Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Weighted Bergman kernels and virtual Bergman kernels

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Science China Mathematics 2005年第z1期48卷 225-237页

作者： Guy roos Nevski Prospekt 113/4-53 191024 St Petersburg Russian Federation

We introduce the notion of virtual Bergman kernel and study some of its applications.

关键词： Bergman kernel, weighted Bergman kernel, virtual Bergman kernel.

New classes of domains with explicit Bergman kernel

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Science China Mathematics 2004年第3期47卷 352-371页

作者： roos GUY Henan University Kaifeng 475001 China Nevski Prospekt 113/4-53 191024 St Petersburg Russian Federation

We introduce two classes of egg type domains, built on general boundedsymmetric domains, for which we obtain the Bergman kernel inexplicit formulas. As an auxiliary tool, we compute the integralof complex powers of the generic norm on a bounded symmetricdomains using the well-known integral of Selberg. Thisgeneralizes matrix integrals of Hua and leads to a specialpolynomial with integer or half-integer coefficients attached toeach irreducible bounded symmetric domain.

关键词： Cartan domain, Bergman kernel, holomorphic automorphism group, boundedsymmetric domain, Hua integral.

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown Rafael j.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

STABILIZeD FeM FOR CONVeCTION-DIFFUSION PROBLeMS ON LAYeR-ADAPTeD MeSHeS

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journal of Computational Mathematics 2009年第2期27卷 266-279页

作者： Hans-Grg roos TU Dresden Germany

The application of a standard Galerkin finite element method for convection-diffusion problems leads to oscillations in the discrete solution, therefore stabilization seems to be necessary. We discuss several recent stabilization methods, especially its combination with a Galerkin method on layer-adapted meshes. Supercloseness results obtained allow an improvement of the discrete solution using recovery techniques.

关键词： Singular perturbations Convection-diffusion Finite element method Stabi-lization Layer-adapted mesh Superconvergenee Recovery