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Hepatocellular carcinoma in patients with chronic hepatitis C virus infection without cirrhosis

World journal of Gastroenterology 2010年第32期16卷 4061-4065页

作者： Kathryn L nash Tracy Woodall Ashley SM Brown Susan e Davies Graeme jM Alexander Department of Hepatology University of CambridgeAddenbrooke's HospitalHills RoadCambridge CB2 2QQUnited Kingdom Department of Hepatology Mailpoint 255Southampton General HospitalTremona RoadSouthamptonHampshire SO16 6YDUnited Kingdom Liver Unit Department of MedicineSt Mary's HospitalPraed StreetLondon W2 1NYUnited Kingdom Department of Histopathology University of CambridgeAddenbrooke's HospitalHills RoadCambridge CB2 2QQUnited Kingdom

AIM:To investigate and characterise patients with chronic hepatitis C virus(HCV) infection presenting with hepatocellular carcinoma(HCC) in the absence of ***:Patients with chronic hepatitis C infection without cirrhosis presenting with HCC over a 2-year period were *** clinical case notes,blood test results and histological specimens were reviewed to identify whether additional risk factors for the development of HCC were ***:Six patients(five male,one female) with chronic hepatitis C infection without cirrhosis presented to a single centre with HCC over a 2-year *** patients were treated by surgical resection and one patient underwent liver *** of generous histological specimens confirmed the presence of HCC and the absence of cirrhosis in all *** degree of fibrosis of the background liver was staged as mild(n = 1),moderate(n = 4) or bridging fibrosis(n = 1).Review of the clinical case notes revealed that all cases had an additional risk factor for the development of HCC(four had evidence of past hepatitis B virus infection;two had a history of excessive alcohol consumption;a further patient had prolonged exposure to immune suppression).CONCLUSION:HCC does occur in patients with non-cirrhotic HCV infection who have other risk factors for hepatocarcinogenesis.

关键词： Hepatitis C virus Hepatocellular carcinoma Non-cirrhotic Screening

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Predicting Interdiffusion in High Temperature Coatings

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Tsinghua Science and Technology 2005年第6期10卷 704-708页

作者： j. e. Morral Department of Materials Science and engineering Ohio State University Columbus Ohio 43210 USA

Interdiffusion can be a major cause of failure in coated parts that see service at elevated temperatures. Ways to measure the extent of interdiffusion and mathematical equations for predicting these measures are given. The equations are based on the error function solution to the diffusion equation and do not take into account variations of the diffusivity with composition. Also, when the substrate of the coating is multiphase, the equations do not take into account the precipitate morphology, but do take into account that precipitates can act as sinks or sources of solute as the average composition of the substrate varies. The equations are meant to be alloy design tools that indicate how changing substrate or coating chemistry will reduce the extent of interdiffusion.

关键词： interdiffusion high temperature coatings multicomponent diffusion multiphase diffusion coating design

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SURFACe TReATMeNT OF POLY (eTHYLeNe TeRePHTHALATe) FABRIC WITH POLYeTHYLeNeIMINe

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Chinese journal of Polymer Science 1997年第4期15卷 311-318页

作者： O.j.ATeIZA I.HOLMe j.e.McINTYRe Department of Textile Industries The University of Leeds Leeds LS2 9JT UKDepartment of Textile Industries The University of Leeds Leeds LS2 9JT UKDepartment of Textile Industries The University of Leeds Leeds LS2 9JT UK

A branched polyethyleneimine (BPeI) was applied to poly(ethylene terephthalate)(PeT) fabric to improve its surface moisture absorption so that the fabric becomes lessliable to retention of electrostatic charg. The durability of this treatment was assessed bywashing and followed by measurement of charge development on the fabric. The treatedsamples showed improved surface wetting compared to the untreated. The results areconsistent with attachment of the BPeI to the PeT surface by a cross-linking mechanism.

关键词： Surface modification Polyester Antistatic Polyethyleneimine treatment

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Meeting the Challenges of Taxing Multinational enterprises in New Zealand

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Belt and Road Initiative Tax journal 2021年第2期2卷 59-63页

作者： john nash International Revenue Strategy New Zealand Inland Revenue

There have been significant concerns globally regarding the undertaxation of multinational enterprises(MNes).New Zealand has considerably relied on MNes in terms of income tax *** a full range of measures to combat base erosion and profit shifting(BePS)by MNes have been implemented,guided by the products emanating from the OeCD’s BePS Action *** law changes have been buttressed by the New Zealand tax administration through undertaking a robust intelligence-led tax compliance programme targeting high risk sectors and issues involving *** there have been some trade-offs in taking this approach,but New Zealand regards the desired behavioural shifts by MNes as a direct result of this substantial work on BePS,with little material impact on the level of foreign direct investment.

关键词： MNes BePS Compliance Foreign investment

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effect of pulsed ultrasound assisted extraction and aqueous acetone mixture on total hydrolysable tannins from pomegranate peel

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Food Bioscience 2022年第1期45卷 185-196页

作者： e.j.Rifna Madhuresh Dwivedi Department of Food Process engineering National Institute of Technology RourkelaRourkelaOdishaIndia

Pomegranate peels are disposed of as waste even though it is an eminent source of total hydrolysable tannins(THT)and possesses a great worth for *** present study was carried out with the hypothesis that pulsed system ultrasound-assisted extraction(PSUAe)technique optimization would aid in retaining high extract yield and THT recovery yield from pomegranate peel extract(PPe)with enhanced antioxidant *** extraction was performed at various conditions regarding solvent concentration(30-90% of acetone),solvent-feed ratio(10-30 mL/g),extraction time(10-20 min),and ultrasound amplitude(40-80%)for maximum extract yield,THT and antioxidant activity(AA).To model and optimize the process conditions tools namely response surface methodology(RSM)and artificial neural network(ANN)were *** solvent concentration,solvent-feed ratio,extraction time,and amplitude the optimal conditions attained with aid of RSM and ANN were:56%,26.5 mL/g,15 min,55%,and 45%,23 mL/g,15 min,50% *** extract yield and THT content determined with RSM and ANN optimized values were 51.2%,86.4 mg TAe/g,and 62%,98.1 mg TAe/g,*** mean square error value displayed the minimum and R^(2) exhibited maximum value in case of ANN compared to RSM *** significantly augmented the AA of PPe to 77.2±0.50% compared to 49.7±0.35% of conventional *** and HPLC analysis established that PPe produced from PSUAe contains a significant amount of THT compounds(gallic acid and tannic acid derivative).SeM elucidated that the sonication effect resulted in peel cell wall disruptions ensuing in elevated extraction of ***,this pulsed mode of ultrasound extraction could be regarded as an easy,cost-effective,and competent technique for the extraction of preferred natural THT from pomegranate peels that possess high prospective to be applied in food and nutraceutical formulations.

关键词： Pomegranate peel Pulsed ultra-sonication Hydrolysable tannins Antioxidant activity ANN modeling

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endometrial mesenchymal stem cells as a cell based therapy for pelvic organ prolapse

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World journal of Stem Cells 2016年第5期8卷 202-215页

作者： Stuart j emmerson Caroline e Gargett the Ritchie Centre Hudson Institute of Medical Research Department of Obstetrics and Gynaecology Monash University

Pelvic organ prolapse(POP) occurs when the pelvic organs(bladder, bowel or uterus) herniate into the vagina, causing incontinence, voiding, bowel and sexual dysfunction, negatively impacting upon a woman's quality of life. POP affects 25% of all women and results from childbirth injury. For 19% of all women, surgical reconstructive surgery is required for treatment, often augmented with surgical mesh. The surgical treatment fails in up to 30% of cases or results in adverse effects, such as pain and mesh erosion into the bladder, bowel or vagina. Due to these complications the Food and Drug Administration cautioned against the use of vaginal mesh and several major brands have been recently been withdrawn from market. In this review we will discuss new cell-based approaches being developed for the treatment of POP. Several cell types have been investigated in animal models, including a new source of mesenchymal stem/stromal cells(MSC) derived from human endometrium. The unique characteristics of endometrial MSC, methods for their isolation and purification and steps towards their development for good manufacturing practice production will be described. Animal models that could be used to examine the potential for this approach will also be discussed as will a rodent model showing promise in developing an endometrial MSC-based therapy for POP. The development of a preclinical large animal model for assessing tissue engineering constructs for treating POP will also be mentioned.

关键词： endometrium Mesenchymal stem cells endometrial mesenchymal stem cells Pelvic organ prolapse Mesh Tissue engineering Regenerative medicine

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cardiGAN:A generative adversarial network model for design and discovery of multi principal element alloys

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journal of Materials Science & Technology 2022年第30期125卷 81-96页

作者： Z.Li W.T.nash S.P.O’Brien Y.Qiu R.K.Gupta N.Birbilis College of engineering and Computer Science The Australian National UniversityA.C.T.Acton 2601Australia Department of Materials Science and engineering Monash UniversityClaytonVictoria 3800Australia Department of Materials Science and engineering North Carolina State UniversityRaleighNC 27695USA

Multi-principal element alloys(MPeAs),inclusive of high entropy alloys(HeAs),continue to attract significant research attention owing to their potentially desirable *** MPeAs remain under extensive research,traditional(***)alloy production and testing are both costly and timeconsuming,partly due to the inefficiency of the early discovery process which involves experiments on a large number of alloy *** is intuitive to apply machine learning in the discovery of this novel class of materials,of which only a small number of potential alloys have been probed to *** this work,a proof-of-concept is proposed,combining generative adversarial networks(GANs)with discriminative neural networks(NNs),to accelerate the exploration of novel *** applying the GAN model herein,it was possible to directly generate novel compositions for MPeAs,and to predict their *** verify the predictability of the model,alloys designed by the model are presented and a candidate produced-as *** suggests that the model herein offers an approach that can significantly enhance the capacity and efficiency of development of novel MPeAs.

关键词： Alloy design Machine learning Generative adversarial network Neural network Multi-principal element alloy High entropy alloys

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enhancing Tax Administration Capacity Building in Developing Countries: A New Zealand Perspective

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Belt and Road Initiative Tax journal 2022年第1期3卷 25-29页

作者： john nash New Zealand Inland Revenue

For developing countries,raising revenues and protecting their tax bases are more important than ever in recovering from the *** a small developed country,New Zealand endeavours to provide capacity building assistance to developing regions,especially the Pacific *** provided encompasses the development of core taxation systems as well as international tax matters such as the establishment of exchange of information programmes and the implementation of international tax *** in partnership with international and regional organisations has proved beneficial,as demonstrated in the Pacific Initiative delivered over the last two ***-effective and well-organised virtual delivery of training courses has functioned particularly well during the pandemic and will continue to feature prominently in future assistance work.

关键词： Capacity building Tax administration Developing countries Assistance efficient targeted partnership

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Analysis of Ground Level enhancement events of 1989 September 29;2001April 15 and 2005 january 20

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Research in Astronomy and Astrophysics 2022年第10期22卷 86-102页

作者： R.e.Ugwoke A.A.Ubachukwu j.O.Urama O.Okike j.A.Alhassan A.e.Chukwude Department of Physics Federal University of Technology OwerriImo state Nigeria Department of Physics and Astronomy University of NigeriaNsukkaNigeria Department of Industrial Physics Ebonyi State UniversityAbakalikiNigeria

We present the results of analyses of the ground level enhancements(GLes)of cosmic ray(CR)events on 1989September 29;2001 April 15 and 2005 january *** involves examination of hourly raw CR counts of an array of neutron monitors(NMs)spread across different geographical latitudes and *** awk script and computer codes implemented in R software,the pressure corrected raw data plots of the NMs were grouped into low-,mid-and *** results show both similarities and differences in the structural patterns of the GLe *** an attempt to explain why the CR count during the decay phase of GLes is always higher than the count before peak,we interpreted all counts prior to the peak as coming from direct solar neutrons and those in the decay phase including the peak as coming from secondary CR neutrons generated by the interactions of primary CRs with the atoms and molecules in the *** identified NMs that detected these primary neutrons and found that they are close in *** authors seemingly identified these two species as impulsive and gradual *** there are a number of unexplained manifestations of GLe signals,some of the results suggest that geomagnetic rigidity effectively determines the intensity of CRs at low-and *** impact is apparently insignificant in high-latitude ***,the results presented should be validated before making any firm ***,the contributions of the ever-present and intractable CR diurnal anisotropies to GLe signals should be accounted for in future work.

关键词： Sun coronal mass ejections(CMes)-Sun flares-Sun particle emission

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Low Power Laser Surfi-Sculpt

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稀有金属材料与工程 2011年第S4期40卷 147-150页

作者： j.e.Blackburn P.A.Hilton Laser and Sheet Processes Group TWI LtdCambridgeCB21 6ALUnited Kingdom

The functional properties of materials can be enhanced using surface features,for instance;to improve the thermal properties of heat *** development of the laser Surfi-Sculpt process over the past decade has resulted in a technology capable of producing a wide variety of features in metallic ***,the potential for producing similar features in polymeric and ceramic substrates also *** the potential for utilizing high power focused laser beams to produce surface features using this process has been *** paper details the results of recent trials performed with a 200 Yb-fibre laser and a galvanometer driven beam scanner for producing surface features using the Surfi-Sculpt process.A compact,cheap,easily robotically automated,laser Surfi-Sculpt machine,being able to operate at atmospheric pressure may have potential in a range of industry sectors.

关键词： laser surfacing Yb-fibre surfi-sculpt

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