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Obstructive sleep apnea:Overlooked comorbidity in patients with diabetes

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World journal of diabetes 2024年第7期15卷 1448-1460页

作者： eric d Tenda joshua Henrina jin H Cha Muhammad R Triono ersananda A Putri dahliana j Aristy dicky L Tahapary division of Respirology and Critical Care Department of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo HospitalDKI JakartaJakarta Pusat 10430Indonesia Head of Research Group Artificial Intelligence and digital Health Indonesian Medical Education and Research InstituteFaculty of Medicine University of IndonesiaDKI JakartaJakarta Pusat 10430Indonesia division of endocrinology Metabolism and DiabetesDepartment of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo HospitalDKI JakartaJakarta Pusat 10430Indonesia

In this review article,we explore the interplay between obstructive sleep apnea(OSA)and type 2 diabetes mellitus(T2dM),highlighting a significant yet often overlooked *** delve into the pathophysiological links between OSA and diabetes,specifically how OSA exacerbates insulin resistance and disrupts glucose *** research examines the prevalence of OSA in diabetic patients and its role in worsening diabetes-related *** the importance of comprehensive management,including weight control and positive airway pressure therapy,the study advocates integrated approaches to improve outcomes for patients with T2dM and *** review underscores the necessity of recognizing and addressing OSA in diabetes care to ensure more effective treatment and better patient outcomes.

关键词： Obstructive sleep apnea Type 2 diabetes mellitus Macrovascular Microvascular Weight loss Positive airway pressure

Solid-liquid extraction for yttrium recovery using porous polymeric resin(XAd-7) functionalized with d_(2)eHPA

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journal of Rare earths 2024年第9期42卷 1764-1773,I0005页

作者： P.A.Martínez-Montoya R.G.Sanchez-Alvarado d.Y.Medina-Velazquez M.L.Carrera-jota P.Garnica-Chávez A.de j.Morales-Ramirez Higher School of Chemical engineering and extractive Industries ESIQIEIPNDepartment of Metallurgical EngineeringUPALM S/NCol.LindavistaGustavo A.Madero Cd.de MéxicoC.P07738Mexico Metropolitan Autonomous University Department of MaterialsBasic Sciences and EngineeringAv.San Pablo No.180Col.Reynosa TamaulipasCd.de MéxicoC.P02200Mexico Center for Research and Technological Innovation CIITECIPNCda.de CECATIs/nSanta CatarinaAzcapotzalcoC.P02250CDMXMexico

The recovery of yttrium is proposed by applying a solid-liquid extraction process using di-2-ethyl hexylphosphoric acid(d2eHPA) as extracting *** extracting agents were supported on a macro porous polymeric resin XAd-7(solid phase).Yttrium ions extraction and discharge tests were performed,firstly from a synthetic aqueous solution of 100 mg/L Y(liquid phase) at 25℃ with *** effects of pH of aqueous solutions bearing yttrium,volume fraction of extracting agents and the solid/liquid(S/L)ratio on the yttrium recovery were *** most favorable conditions for yttrium ions extraction are;20 vol% d_(2)eHPA functionalized resin,pH=1.5 and an S/L ratio of 10 mg/mL The discharge of yttrium ions was done under the same conditions of extraction stage,using a 2 mol/L [H_(2)SO_(4)] as stripping *** to 80% yttrium is extracted,while 75% yttrium is recovered in the striping *** all experiments,the reaction equilibrium is reached after 20 min,and the kinetics for the extraction stage was determined as a second-order ***,experiments were carried out to discharge the yttriumloaded resins,and it has been determined that the best pH value to strip the Y ions is *** tests of extraction and discharge for yttrium ions show that the functionalized resin can work at least five cycles without decreasing its ***,the proposed process was tested in a real solution with Y ions fro m a waste fluorescent la mp powder leached in H_(2)SO_(4),demonstrating the ability to effectively recover yttrium,separating it from various metals from the studied residue.

关键词： Yttrium recovery Rare earth solid-liquid extraction XAd-7 resin Fluorescent lamps recycling Solid-liquid kinetics extraction

Highly sensitive ratiometric fluorescent fiber matrices for oxygen sensing with micrometer spatial resolution

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Bio-design and Manufacturing 2024年第3期7卷 292-306页

作者： Giuliana Grasso Valentina Onesto Stefania Forciniti eliana d’Amone Francesco Colella Lara Pierantoni Valeria Famà Giuseppe Gigli Rui L.Reis j.Miguel Oliveira Loretta L.del Mercato nstitute of Nanotechnology National Research Council(CNR-NANOTEC)c/o Campus Ecoteknevia Monteroni73100 LecceItaly department of Mathematics and Physics“ennio de Giorgi” University of Salentoc/o Campus Ecoteknevia Monteroni73100 LecceItaly 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Government Associate Laboratory 4806-909 Braga/GuimarãesPortugal department of experimental Medicine University of Salentoc/o Campus Ecoteknevia Monteroni73100 LecceItaly

Oxygen(O_(2))-sensing matrices are promising tools for the live monitoring of extracellular O_(2) consumption levels in long-term cell *** this study,ratiometric O_(2)-sensing membranes were prepared by electrospinning,an easy,low-cost,scalable,and robust method for fabricating ***(ε-caprolactone)and poly(dimethyl)siloxane polymers were blended with tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II)dichloride,which was used as the O_(2)-sensing probe,and rhodamine B isothiocyanate,which was used as the reference *** functionalized scaffolds were morphologically characterized by scanning electron microscopy,and their physicochemical profiles were obtained by Fourier transform infrared spectroscopy,thermogravimetric analysis,and water contact angle *** sensing capabilities were investigated by confocal laser scanning microscopy,performing photobleaching,reversibility,and calibration curve studies toward different dissolved O_(2)(dO)*** sensing nanofibers showed a high response to changes in dO concentrations in the physiological-pathological range from 0.5%to 20%and good stability under ratiometric *** addition,the sensing systems were highly biocompatible for cell growth promoting adhesiveness and growth of three cancer cell lines,namely metastatic melanoma cell line SK-MeL2,breast cancer cell line MCF-7,and pancreatic ductal adenocarcinoma cell line Panc-1,thus recreating a suitable biological environment in *** O_(2)-sensing biomaterials can potentially measure alterations in cell metabolism caused by changes in ambient O_(2)content during drug testing/validation and tissue regeneration processes.

关键词： electrospinning Ruthenium(II)dichloride Oxygen sensors Ratiometric imaging Fluorescence

NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： diones Bueno Michael K.e.Schafer Sudena Wang Michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

Cytomegalovirus Transverse Myelitis Secondary to Influenza Infection and early Recovery:A Case Report

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Infectious diseases & Immunity 2024年第1期4卷 41-42页

作者： jill S.Bhavsar Lekhini K.Fultariya Poojan j.Prajapati Archi K.dhamelia jaime e.Campos department of Infectious disease Hialeah HospitalMiamiFL(affiliated with HerbertWertheim College of MedicineFlorida International University)33013USA

Immunosuppression can lead to opportunistic infections in a *** evidence of viral infections causing immunosuppression in a host for a transient period is gaining *** order to prolong their stay in the human body,viruses affect the human immune systemin various *** viral infections such as influenza can lead to transient lymphocytopenia,which lays the groundwork for more dangerous opportunistic ***(CMV)infection is a rare cause of inflammatory *** present the case of a patient with an influenza infection who progressed to severe acute respiratory distress syndrome,methicillin-resistant Staphylococcus aureus necrotizing pneumonia,and idiopathic lymphocytopenia with a Cd4 count of 61 perμL on *** 2 weeks,the patient developed complete flaccid paralysis with sensory and autonomic *** his polymerase chain reaction results of cerebrospinal fluid and blood test were positive for CMV infection,he was treated with high doses of steroids and ganciclovir *** to early diagnosis and intervention,the patient was able to recover in 2 months with only minimal residual ***,this case stresses on the importance of looking out for opportunistic infections in patients affected by severe viral infections for their early recovery.

关键词： Influenza,Human Lymphocytopenia Transverse myelitis Case report

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想象难以设想的事物:艺术镜头下的深时

装饰 2024年第8期 49-61页

作者： [美]j.d.塔拉塞克汪芸(译) 美国国家科学院《装饰》

j.d.塔拉塞克是一位策展人、研究者和作家,他热衷于通过协作与综合性的工作探索艺术与科学的交叉点。他是美国国家科学院文化项目的负责人,该项目专注于探索科学、医学、技术和文化之间的相互关系;同时,他是《莱奥纳多》(麻省理工学院出... 详细信息

j.d.塔拉塞克是一位策展人、研究者和作家,他热衷于通过协作与综合性的工作探索艺术与科学的交叉点。他是美国国家科学院文化项目的负责人,该项目专注于探索科学、医学、技术和文化之间的相互关系;同时,他是《莱奥纳多》(麻省理工学院出版)的主编。塔拉塞克是dASeR (华盛顿特区艺术科学晚会)的创始人和主持人,dASeR是每个月在美国国家科学院举办的沙龙,他主持该系列活动已逾13载。此外,塔拉塞克还担任亚利桑那州立大学和美国国家科学院联合出版的《科学技术杂志》(Science and Technology Magazine)的艺术顾问。塔拉塞克在美国国家科学院策划了多个展览,其中包括“想象深时”(Imagining deep Time,2014年)、“梦幻解剖学”(Visionary Anatomies,在2004年至2006年期间在史密森学会巡展)、“吸收+传输:迈克与道格·斯塔恩的作品”(Absorption+Transmission:Work by Mike and doug Starn)。本文即塔拉塞克为“想象深时”展览撰写的文章,展览中的艺术家以代表了个人艺术探索的多样化的形式探索了“深时”理念。

关键词：美国国家科学院史密森学会联合出版麻省理工学院华盛顿特区塔拉艺术与科学艺术顾问

Metrology for sub-Rayleigh-length target positioning in~10^(22)W/cm^(2)laser-plasma experiments

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High Power Laser Science and engineering 2024年第3期12卷 90-105页

作者： e.A.Vishnyakov A.Sagisaka K.Ogura T.Zh.esirkepov B.Gonzalez-Izquierdo C.d.Armstrong T.A.Pikuz S.A.Pikuz W.Yan T.M.jeong S.Singh P.Hadjisolomou O.Finke G.M.Grittani M.Nevrkla C.M.Lazzarini A.Velyhan T.Hayakawa Y.Fukuda j.K.Koga M.Ishino K.Kondo Y.Miyasaka A.Kon M.Nishikino Y.V.Nosach d.Khikhlukha I.P.Tsygvintsev d.Kumar j.Nejdl d.Margarone P.V.Sasorov S.Weber M.Kando H.Kiriyama Y.Kato G.Korn K.Kondo S.V.Bulanov T.Kawachi A.S.Pirozhkov eLI Beamlines Facility The Extreme Light Infrastructure ERICDolníBrežanyCzech Republic Kansai Institute for Photon Science(KPSI) QSTKyotoJapan Central Laser Facility Rutherford Appleton LaboratorySTFCHarwell OxfordDidcotUK Institute for Open and Transdisciplinary Research Initiatives Osaka UniversityOsakaJapan HB11 energy Holdings FreshwaterAustralia Key Laboratory for Laser Plasmas(Ministry of education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghaiChina Institute of Plasma Physics ASCR PragueCzech Republic FZU-Institute of Physics ASCR PragueCzech Republic Czech Technical University in Prague FNSPEPragueCzech Republic Institute of Laser engineering Osaka UniversityOsakaJapan Institute of Physics National Academy of Sciences of UkraineKyivUkraine ISTeQ AR YerevanArmenia

Tight focusing with very small f-numbers is necessary to achieve the highest at-focus ***,tight focusing imposes strong demands on precise target positioning in-focus to achieve the highest on-target irradiance We describe several near-infrared,visible,ultraviolet and soft and hard X-ray diagnostics employed in a~10^(22)W/cm^(2)laser±plasma *** used nearly 10 j total energy femtosecond laser pulses focused into an approximately1.3-μm focal spot on 5±20μm thick stainless-steel *** discuss the applicability of these diagnostics to determine the best in-focus target position with approximately 5μm accuracy(i.e.,around half of the short Rayleigh length)and show that several diagnostics(in particular,3ωreflection and on-axis hard X-rays)can ensure this *** demonstrated target positioning within several micrometers from the focus,ensuring over 80%of the ideal peak laser intensity *** approach is relatively fast(it requires 10±20 laser shots)and does not rely on the coincidence of low-power and high-power focal planes.

关键词： laser-plasma interaction precise target positioning spectroscopy ultra-high intensity X-rays

Analysis of ancient mass extinction recoveries in marine environments: generating strategies for managing outcomes of the current mass extinction

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National Science Review 2024年第1期11卷 8-10页

作者： david j.Bottjer department of earth Sciences University of Southern California

The defining feature of a mass extinction and its associated recovery is the global amount of extinction that occurred[1]. However, there is finer-scale detail to the story, as seen in the ongoing modern mass extinction(the sixth mass extinction), which exhibits variable effects among marine ecosystems and environments, and hence geographic areas [1].

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Global weirding at mass extinction horizons

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National Science Review 2024年第1期11卷 10-12页

作者： Gregory j.Retallack department of earth Sciences University of Oregon

A strong motivation for studying mass extinctions is understanding how current climatic and biodiversity crises will affect creatures living on land such as ourselves. Perhaps the question is: how bad can it get? In that case, terrestrial Permian-Triassic mass extinctions are an irresistible worst-case scenario [1].

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