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Bio-Design and Manufacturing 2019年第3期2卷 172-180页

作者： Maha Alruwaili jose A.lopez Kevin McCarthy emmanuel G.Reynaud Brian j.Rodriguez Conway Institute of Biomolecular and Biomedical Research University College DublinDublinIreland School of Physics University College DublinDublinIreland School of Biomolecular and Biomedical Science University College DublinDublinIreland

extrusion-based 3D bioprinting is a direct deposition approach used to create three-dimensional(3D)tissue scaffolds typically comprising *** are hydrated polymer networks that are chemically or physically ***,3D bioprinting is performed in air,despite the hydrated nature of hydrogels and the potential advantage of using a liquid phase to provide cross-linking and otherwise functionalize the *** this work,we print gelatin alginate hydrogels directly into a cross-linking solution of calcium chloride and investigate the influence of nozzle diameter,distance between nozzle and surface,calcium chloride concentration,and extrusion rate on the dimensions of the printed *** hydrogel layer height was generally found to increase with increasing extrusion rate and nozzle distance,according to the increased volume extruded and the available space,*** addition,the hydrogel width was generally found to increase with decreasing nozzle distance and cross-linking concentration corresponding to confinement-induced spreading and low crosslinking regimes,***/height ratios of^1 were generally achieved when the nozzle diameter and distance were comparable above a certain cross-linking *** these relationships,biocompatible 3D multilayer structures were successfully printed directly into calcium chloride cross-linking solution.

关键词： Gelatin alginate Hydrogel Additive manufacturing 3D printing 3D bioprinting Biomaterials extrusion Bioplotting

Integrating VGI and 2D hydraulic models into a data assimilation framework for real time flood forecasting and mapping

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Geo-Spatial Information Science 2019年第4期22卷 223-236,I0001页

作者： antonio Annis Fernando Nardi Water Resources Research and Documentation Centre(WARReDOC) University for Foreigners of PerugiaPerugiaItaly Department of Civil and environmental engineering(DICeA) University of FlorenceFlorenceItaly Institute of Water and environment(InWe) Florida International UniversityMiamiFLUSA

Crowdsourced data can effectively observe environmental and urban ecosystem *** use of data produced by untrained people into flood forecasting models may effectively allow early Warning Systems(eWS)to better perform while support decision-making to reduce the fatalities and economic losses due to inundation *** this work,we develop a Data Assimilation(DA)method integrating Volunteered Geographic Information(VGI)and a 2D hydraulic model and we test its *** proposed framework seeks to extend the capabilities and performances of standard DA works,based on the use of traditional in situ sensors,by assimilating VGI while managing and taking into account the uncertainties related to the quality,and the location and timing of the entire set of observational *** November 2012 flood in the Italian Tiber River basin was selected as the case *** show improvements of the model in terms of uncertainty with a significant persistence of the model updating after the integration of the VGI,even in the case of use of few-selected observations gathered from social *** will encourage further research in the use of VGI for eWS considering the exponential increase of quality and quantity of smartphone and social media user worldwide.

关键词： Crowdsourced data VGI data assimilation(DA) flood forecasting 2D hydraulic modelling

Small-cell neuroendocrine carcinoma of the prostate： are heterotransplants a better experimental model？

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Asian journal of Andrology 2010年第3期12卷 308-314,I0007页

作者： Lluis-A. lopez-Barcons Stanley S. Scott Cancer Center Louisiana State University Health Sciences Center New Orleans LA 70112 USA

Small-cell neuroendocrine carcinoma of the prostate （SCNCP） is an uncommon type of prostate cancer. However, it is of clinical importance because it is one of the most aggressive tumors of the prostate with a very poor prognosis. There exist few artificially cultured tumor cell lines to study SCNCe Then, another approach to that study consists in the use of fresh tumor tissue obtained from patients and its heterotransplantation into host mice. The purpose of this review is to integrate data from more than 20 years of heterotransplantation research in the study of small-cell neuroendocrine carcinoma of the prostate （SCNCP）. Heterotransplantation has provided data regarding the histopathology, karyotype, DNA content, cell cycle frequency, tumor markers, androgen receptor expression, metastasis and take rate of this prostate disease. When possible, comparisons between original in situ specimens removed from patients and heterotransplanted tissue from host mice have been made. There are advantages, as well as limitations, that have been identified for SCNCP heterotransplants versus xenotransplantation of cultured cells. Overall, heterotransplanted tumors are better than conventional tumor xenografts at retaining tumor morphology, pathology, secretory activity and expression of tumor markers of the patient＇s original specimen. Furthermore, heterotransplanted tissue preserves the three-dimensional tumor architecture of the prostate to maintain critical stromal-epithelial cell interactions.

关键词： heterotransplant nude mice prostate small-cell neuroendocrine carcinoma xenotransplant

Simulation of Fluid Flow in a Channel Induced by Three Types of Fin-Like Motion

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journal of Bionic engineering 2007年第3期4卷 165-176页

作者： Wojciech Kowalczyk antonio Delgado Institute of Fluid Mechanics University of Erlangen-NurembergCauerstr. 4D-91058 ErlangenGermany

One of many interesting research activities in biofluidmechanics is dedicated to investigations of locomotion in water. Some of propulsion mechanisms observed in the underwater world are used in the development process of underwater autonomic vehicles （AUV）. In order to characterise several solutions according to their manoeuvrability, influence on the surrounding fluid and energetic efficiency, a detailed analysis of fin-like movement is indispensable. In the current paper an analysis of undulatory, oscillatory and combined fin-like movements by means of numerical simulation is carried out. The conservation equation of mass and the conservation equation of momentum axe solved with the Finite Volume Method （FWM） by use of the software CFX-10.0. The undulatory and oscillatory fin movements axe modelled with an equation that is implemented within an additional subroutine and joined with the main solver. N carried out in the computational domain, in which one fin is fixed in a flow-through water duct. Simulations axe carded out in the range of the Re number up to 105. The results show significant influence of applied fin motion on the velocity distribution in the surrounding fluid.

关键词： biofluid dynamics fro-like movement fish propulsion computational fluid dynamics

Watt-scale super-octave mid-infrared intrapulse difference frequency generation

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Light(Science & Applications) 2018年第1期7卷 124-131页

作者： Christian Gaida Martin Gebhardt Tobias Heuermann Fabian Stutzki Cesar jauregui jose antonio-lopez Axel Schulzgen Rodrigo Amezcua-Correa Andreas Tunnermann Ioachim Pupeza jens Limpert Institute of Applied Physics Abbe Center of PhotonicsFriedrich-Schiller-Universitat JenaAlbert-Einstein-Str.1507745 JenaGermany Helmholtz-Institute jena Frobelstieg 307743 JenaGermany Fraunhofer Institute for Applied Optics and Precision engineering Albert-Einstein-Str.707745 JenaGermany CReOL College of Optics and PhotonicsUniversity of Central FloridaOrlandoFL 32816USA Max-Planck-Institute of Quantum Optics Hans-Kopfermann-Str.185748 GarchingGermany

The development of high-power,broadband sources of coherent mid-infrared radiation is currently the subject of intense research that is driven by a substantial number of existing and continuously emerging applications in medical diagnostics,spectroscopy,microscopy,and fundamental *** of the major,long-standing challenges in improving the performance of these applications has been the construction of compact,broadband mid-infrared radiation sources,which unify the properties of high brightness and spatial and temporal *** to the lack of such radiation sources,several emerging applications can be addressed only with infrared(IR)-beamlines in largescale synchrotron facilities,which are limited regarding user access and only partially fulfill these ***,we present a table-top,broadband,coherent mid-infrared light source that provides brightness at an unprecedented level that supersedes that of synchrotrons in the wavelength range between 3.7 and 18μm by several orders of *** result is enabled by a high-power,few-cycle Tm-doped fiber laser system,which is employed as a pump at 1.9μm wavelength for intrapulse difference frequency generation(IPDFG).IPDFG intrinsically ensures the formation of carrierenvelope-phase stable pulses,which provide ideal prerequisites for state-of-the-art spectroscopy and microscopy.

关键词： pump coherent difference

The Crank-Nicolson Hermite Cubic Orthogonal Spline Collocation Method for the Heat equation with Nonlocal Boundary Conditions

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Advances in Applied Mathematics and Mechanics 2013年第4期5卷 442-460页

作者： B.Bialecki G.Fairweather j.C.lopez-Marcos Department of AppliedMathematics and Statistics Colorado School of MinesGoldenCO 80401USA Mathematical Reviews American Mathematical Society416 Fourth StreetAnn ArborMI 48103USA Departamento de Matem´atica Aplicada Universidad de ValladolidValladolidSpain

We formulate and analyze the Crank-Nicolson Hermite cubic orthogonal spline collocation method for the solution of the heat equation in one space variable with nonlocal boundary conditions involving integrals of the unknown solution over the spatial *** an extension of the analysis of Douglas and Dupont[23]for Dirichlet boundary conditions,we derive optimal order error estimates in the discrete maximum norm in time and the continuous maximum norm in *** discuss the solution of the linear system arising at each time level via the capacitance matrix technique and the package COLROWfor solving almost block diagonal linear *** present numerical examples that confirm the theoretical global error estimates and exhibit superconvergence phenomena.

关键词： Heat equation nonlocal boundary conditions orthogonal spline collocation Hermite cubic splines convergence analysis superconvergence

Uncovering the multifaceted roles played by neutrophils in allogeneic hematopoietic stem cell transplantation

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Cellular & Molecular Immunology 2021年第4期18卷 905-918页

作者： Cristina Tecchio Marco antonio Cassatella Department of Medicine Section of Hem atology and Bone Marrow Transplant UnitUniversity of VeronaVeronaItaly Department of Medicine Section of General PathologyUniversity of VeronaVeronaItaly

Allogeneic hematopoietic stem cell transplantation(alloHSCT)is a life-saving procedure used for the treatment of selected hematological malignancies,inborn errors of metabolism,and bone marrow *** role of neutrophils in alloHSCT has been traditionally evaluated only in the context of their ability to act as a first line of defense against ***,recent evidence has highlighted neutrophils as key effectors of innate and adaptive immune responses through a wide array of newly discovered ***,neutrophils are emerging as highly versatile cells that are able to acquire different,often opposite,functional capacities depending on the microenvironment and their differentiation ***,we review the current knowledge on the multiple functions that neutrophils exhibit through the different stages of alloHSCT,from the hematopoietic stem cell(HSC)mobilization in the donor to the immunological reconstitution that occurs in the recipient following HSC *** also discuss the influence exerted on neutrophils by the immunosuppressive drugs delivered in the course of alloHSCT as part of graft-versushost disease(GVHD)***,the potential involvement of neutrophils in alloHSCT-related complications,such as transplant-associated thrombotic microangiopathy(TA-TMA),acute and chronic GVHD,and cytomegalovirus(CMV)reactivation,is also *** on the data reviewed herein,the role played by neutrophils in alloHSCT is far greater than a simple antimicrobial ***,much remains to be investigated in terms of the potential functions that neutrophils might exert during a highly complex procedure such as alloHSCT.

关键词： neutrophils allogeneic hematopoietic stem cell transplantation(alloHSCT) alloHSCT-associated complications lowdensity neutrophils(LDNs) normal-density neutrophils(NDNs)

Hybrid silicon modulators

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Chinese Optics Letters 2009年第4期7卷 280-285页

作者： j.e.Bowers Department of electrical and Computer engineering University of California Santa Barbara

A number of active elements have been demonstrated using the hybrid silicon evanescent platform, including lasers, amplifiers, and detectors. In this letter, two types of hybrid silicon modulators, flflfilling the building blocks in optical communication on this platform, are presented. A hybrid silicon electroabsorp- tion modulator, suitable for high speed interconnects, with 10-dB extinction ratio at -5 V and 16-GHz modulation bandwidth is demonstrated. In addition, a hybrid silicon Mach-Zehnder modulator utilizing carrier depletion in multiple quantum wells is proved with 2 *** voltage-length product, 150-nm optical bandwidth, and a large signal modulation up to 10 Gb/s.

关键词： Bandwidth electroabsorption modulators Modulation Modulators Optical communication Quantum well lasers Semiconducting indium compounds Semiconductor quantum wells Silicon Silicon detectors

Approximate ballistics formulas for spherical pellets in free flight

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Defence Technology（防务技术） 2018年第1期14卷 1-11页

作者： e.j.Allen Department of Mathematics and Statistics Texas Tech University

The ballistics equations for spherical pellets in free flight are simplified through appropriate scaling of the pellet velocity and pellet distance. Two different drag coefficient curves are averaged to yield a single curve applicable to shot pellets and round balls. The resulting S-shaped drag coefficient curve is approximated by three straight-line segments. The scaled ballistics equations are then solved exactly and simple formulas are found for the velocity and flight time with respect to trajectory distance. The formulas are applicable to spherical shot pellets and round balls of any composition under any atmospheric conditions. The formulas are amenable to quick and easy computation and may also serve as an aid in understanding and comparing black-box ballistics calculators. For shotshell ballistics, an important assumption in the present investigation is that the pellets are moving as single, free spheres and not as a dense cloud or in a shot column, in particular, the pellets are not interacting during flight. Therefore, the formulas are most appropriate for single round balls, for large shot sizes, and for pellets of small shot size fired from open chokes. The formulas are clear and accessible, and can be implemented by military or law enforcement personnel as well as hunters and shooters. This work differs from previous investigations in that accurate ballistics formulas are derived for spherical projectiles of shotguns and muzzleloaders using realistic drag coefficients.

关键词： Ballistics Sphere Drag Shotgun Muzzleloader Nondimensionalization

Integrating Levels of Hierarchical Organization in Porous Organic Molecular Materials

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Nano-Micro Letters 2024年第5期16卷 134-153页

作者： jesus Ferrando‑Soria antonio Fernandez Instituto de Ciencia Molecular(ICMol) Universidad de Valencia46980 ValenciaSpain School of Science Loughborough UniversityLoughborough LE113TUUK

Porous organic molecular materials(POMMs)are an emergent class of molecular-based materials characterized by the formation of extended porous frameworks,mainly held by non-covalent *** represent a variety of chemical families,such as hydrogen-bonded organic frameworks,porous organic salts,porous organic cages,C-H···πmicroporous crystals,supramolecular organic frameworks,π-organic frameworks,halogen-bonded organic framework,and intrinsically porous molecular *** some porous materials such as zeolites and metal organic frameworks,the integration of multiscale has been adopted to build materials with multifunctionality and optimized ***,considering the significant role of hierarchy in porous materials and the growing importance of POMMs in the realm of synthetic porous materials,we consider it appropriate to dedicate for the first time a critical review covering both ***,we will provide a summary of literature examples showcasing hierarchical POMMs,with a focus on their main synthetic approaches,applications,and the advantages brought forth by introducing hierarchy.

关键词： Porous organic molecular materials Hierarchy Hydrogen-bonded organic frameworks Porous cages Fullerene