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国际医学放射学杂志 2012年第5期 503-503页

作者： d.T.L.Wong M.j.Weightman M.Baumert H.Tayeb j.d.richardson R.Puri 陈谦 Cardiovascular Research Centre Royal Adelaide Hospital and Discipline of MedicineUniversity of AdelaideAdelaideSouth Australia

摘要目的为了研究网格标记心肌负荷评估是否可以显示心肌梗死边缘部位并确定病人室性心律失常的危险性,因为心肌梗死边缘部位可能是在ST段抬高性心肌梗死(STEMI)后发生室性心律失常的一个重要因素。方法45例STEMI病人在经皮冠状动脉介入... 详细信息

摘要目的为了研究网格标记心肌负荷评估是否可以显示心肌梗死边缘部位并确定病人室性心律失常的危险性,因为心肌梗死边缘部位可能是在ST段抬高性心肌梗死(STEMI)后发生室性心律失常的一个重要因素。方法45例STEMI病人在经皮冠状动脉介入(PCI)术后第3d和第90d接受心脏MR(CMR)检查。通过网格标记图像计算周缘峰值收缩应变值(CS)和应变速率(CSR)。根据钆延迟强化区域分布的不同,将心肌分为梗死区、边缘区、邻近区、远处区。

关键词：网络标记边缘区心肌梗死室性心律失常心脏MRI

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急性心肌梗死后心脏MRI的作用

国际医学放射学杂志 2012年第5期 507-507页

作者： d.T.L.Wong j.d.richardson R.Puri A.j.Nelson A.G.Bertaso K.S.L.Teo 戴玲玲 Cardiovascular Research Centre Royal Adelaide HospitalAdelaideAustralia

摘要背景对心肌梗死处理措施的进步大大减少了其发病率和死亡率。方法在经过急性治疗后,一些诊断和预后的问题仍然有待解决,因此心脏影像起着重要的作用。结果有些病人在梗死后将经受早期机械性并发症,而其他病人可能会有严重的心室功... 详细信息

摘要背景对心肌梗死处理措施的进步大大减少了其发病率和死亡率。方法在经过急性治疗后,一些诊断和预后的问题仍然有待解决,因此心脏影像起着重要的作用。结果有些病人在梗死后将经受早期机械性并发症,而其他病人可能会有严重的心室功能障碍。此外,许多病人要承担遗留的冠状动脉疾病的重大负担,这些冠状动脉疾病解释了功能性缺血性状态和(或)疑似心肌缺血范围的生存能力。结论在评价心脏功能、压力负荷实验和心肌组织表征方面,心脏磁共振成像(CMR)显示出其无与伦比的优势。

关键词： MRI 心肌梗死心肌缺血活力

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal j.Goldschmidt-Clermont Aisha Khan George jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander j.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi james d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

TIC-Tox: A preliminary discussion on identifying the forcing agents of dBP-mediated toxicity of disinfected water

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journal of Environmental Sciences 2017年第8期29卷 208-216页

作者： Michael j.Plewa Elizabeth d.Wagner Susan d.richardson Safe Global Water Institute and the Department of Crop Sciences University of Illinois at Urbana-Champaign department of Chemistry and Biochemistry University of South Carolina

The disinfection of drinking water is a major public health achievement; however, an unintended consequence of disinfection is the generation of disinfection by-products（dBPs）. Many of the identified dBPs exhibit in vitro and in vivo toxicity, generate a diversity of adverse biological effects, and may be hazards to the public health and the *** a few dBPs are regulated by several national and international agencies and it is not clear if these regulated dBPs are the forcing agents that drive the observed toxicity and their associated health effects. In this study, we combine analytical chemical and biological data to resolve the forcing agents associated with mammalian cell cytotoxicity of drinking water samples from three cities. These data suggest that the trihalomethanes（THMs） and haloacetic acids may be a small component of the overall cytotoxicity of the organic material isolated from disinfected drinking water. Chemical classes of nitrogen-containing dBPs, such as the haloacetonitriles and haloacetamides, appear to be the major forcing agents of toxicity in these samples. These findings may have important implications for the design of epidemiological studies that primarily rely on the levels of THMs to define dBP exposure among populations. The TIC-Tox approach constitutes a beginning step in the process of identifying the forcing agents of toxicity in disinfected water.

关键词： dBPs CHO cell cytotoxicity Toxicity Additivity

A catalyst for integrating analytical biology,analytical chemistry, and engineering to improve drinking water safety: The groundbreaking work of dr. Michael Plewa

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journal of Environmental Sciences 2022年第7期34卷 6-9页

作者： Susan d.richardson department of Chemistry and Biochemistry University of South CarolinaColumbiaSC 29208USA

It is interesting how a random encounter can profoundly change your life. My random encounter was with a young graduate student from Michael Plewa’s laboratory. The location was the 1999 American Chemical Society (ACS) Conference, where, following his talk, this promising researcher was being unfairly criticized by a well-established scientist. I disagreed with this scientist’s criticism, and I encouraged the student how I thought his work was important.

关键词： breaking integrating analytical

A new technique helps to uncover unknown peptides and disinfection by-products in water

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journal of Environmental Sciences 2016年第4期28卷 6-8页

作者： Susan d.richardson Cristina Postigo department of Chemistry and Biochemistry University of South Carolina department of Environmental Chemistry Institute for Environmental Assessment and Water Research-Spanish National Research Council(IDAEA-CSIC)

Environmental water samples can be extremely complex,with potentially thousands of molecules that can derive from natural organic matter（NOM）and thousands that derive from anthropogenic *** complex as these samples are,drinking water can be even more *** to disinfectants that are used to treat drinking water（e.g.,chlorine,chloramines,

关键词： disinfection by-products(dBPs) drinking water Halogenated peptides Liquid chromatography Natural organic matter(NOM) Non-targeted analysis Tandem mass spectrometry Water contaminants

do dBPs swim in salt water pools? Comparison of 60 dBPs formed by electrochemically generated chlorine vs. conventional chlorine

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journal of Environmental Sciences 2022年第7期34卷 232-241页

作者： Caroline O.Granger Susan d.richardson department of Chemistry and Biochemistry University of South Carolina631 Sumter St.ColumbiaSC 29208USA

disinfectants are added to swimming pools to kill harmful pathogens. Although liquid chlorine(sodium hypochlorite) is the most commonly used disinfectant, alternative disinfection techniques like electrochemically generated mixed oxidants or electrochemically generated chlorine, often referred to as salt water pools, are growing in popularity. However, these disinfectants react with natural organic matter and anthropogenic contaminants introduced to the pool water by swimmers to form disinfection byproducts(dBPs). dBPs have been linked to several adverse health effects, such as bladder cancer, adverse birth outcomes, and asthma. In this study, we quantified 60 dBPs using gas chromatography-mass spectrometry and assessed the calculated cytotoxicity and genotoxicity of an indoor community swimming pool before and after switching to a salt water pool with electrochemically generated chlorine. Interestingly, the total dBPs increased by 15% upon implementation of the salt water pool, but the calculated cytotoxicity and genotoxicity decreased by 45% and 15%, respectively. Predominant dBP classes formed were haloacetic acids, with trichloroacetic acid and dichloroacetic acid contributing 57% of the average total dBPs formed. Haloacetonitriles, haloacetic acids, and haloacetaldehydes were the primary drivers of calculated cytotoxicity, and haloacetic acids were the primary driver of calculated genotoxicity. diiodoacetic acid, a highly toxic iodinated dBP, is reported for the first time in swimming pool water. Bromide impurities in sodium chloride used to electrochemically generate chlorine led to a 73% increase in brominated dBPs, primarily driven by bromochloroacetic acid. This study presents the most extensive dBP study to-date for salt water pools.

关键词： disinfection byproducts Swimming pools Cytotoxicity Genotoxicity GC-MS

Formation of iodo-trihalomethanes, iodo-haloacetic acids, and haloacetaldehydes during chlorination and chloramination of iodine containing waters in laboratory controlled reactions

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journal of Environmental Sciences 2017年第8期29卷 127-134页

作者： Cristina Postigo Susan d.richardson damia Barceló Water and Soil Quality Research Group Department of Environmental Chemistry Institute of Environmental Assessment and Water Research (IDAEA-CSIC) Barcelona Spain department of Chemistry and Biochemistry University of South Carolina SC 29208 United States Catalan Institute for Water Research(ICRA) Parc Científic i Tecnològic de la Universitat de Girona17003 GironaSpain

Iodine containing disinfection by-products（I-dBPs） and haloacetaldehydes（HALs） are emerging disinfection by-product（dBP） classes of concern. The former due to its increased potential toxicity and the latter because it was found to be the third most relevant dBP class in mass in a U.S. nationwide drinking water study. These dBP classes have been scarcely investigated, and this work was performed to further explore their formation in drinking water under chlorination and chloramination scenarios. In order to do this, iodo-trihalomethanes（I-THMs）,iodo-haloacetic acids（I-HAAs） and selected HALs（mono-HALs and di-HALs species, including iodoacetaldehyde） were investigated in dBP mixtures generated after chlorination and chloramination of different water matrices containing different levels of bromide and iodide in laboratory controlled reactions. Results confirmed the enhancement of I-dBP formation in the presence of monochloramine. While I-THMs and I-HAAs contributed almost equally to total I-dBP concentrations in chlorinated water, I-THMs contributed the most to total I-dBP levels in the case of chloraminated water. The most abundant and common I-THM species generated were bromochloroiodomethane, dichloroiodomethane, and chlorodiiodomethane. Iodoacetic acid and chloroiodoacetic acid contributed the most to the total I-HAA concentrations measured in the investigated disinfected water. As for the studied HALs, dihalogenated species were the compounds that predominantly formed under both investigated treatments.

关键词： Iodinated disinfection by-products Chlorination Chloramination drinking water Mass spectrometry Iodo-trihalomethanes Iodo-haloacetic acids Haloacetaldehydes

Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis